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Xe-133

(Xenon)

Phase 2Small molecule

NNobilis Therapeutics Inc.

Xenon is a radioactive gas used in medical imaging to help doctors see how well your lungs are working and to evaluate blood flow to the brain.[1] Xe-133 is currently being investigated across 7 indications[3], with its most advanced program in Phase 2.[1]

Xe-133 is one of 132 small molecule programs targeting Bronchiectasis. It is currently in Phase 2.

7

Indications

29

Total Trials

3

Active Trials

131

Competitors

Pipeline

Status by Indication[3][1]

Indication

BronchiectasisActive, not recruiting

Acute Lung InjuryActive, not recruiting

Autism Spectrum DisorderNot yet recruiting

Interstitial Lung DiseaseActive, not recruiting

ImpairmentUnknown status

Subarachnoid HemorrhageRecruiting

Aortic DissectionActive, not recruiting

BronchiectasisPreclinical

Active, not recruiting

Acute Lung InjuryPreclinical

Active, not recruiting

Autism Spectrum DisorderPhase 2

Not yet recruiting

Interstitial Lung DiseasePreclinical

Active, not recruiting

ImpairmentPreclinical

Unknown status

Subarachnoid HemorrhagePhase 2

Recruiting

Aortic DissectionPreclinical

Active, not recruiting

Competition

Competitive Landscape

55 competitors in Autism Spectrum Disorder

#DrugCompanyPhaseTrials

Buspar

Bristol-Myers Squibb

Namenda

Lioresal

Epidiolex

Jazz Pharmaceuticals

Aricept

Marinol

Jazz Pharmaceuticals

Abilify

Neurontin

VViatris Specialty LLC

Strattera

Campral

FForest Laboratories

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 1/2Not yet recruiting

Autism Spectrum Disorder

NCT07435103

Q4 2028

Cystic Fibrosis

NCT04793867

Q4 2029

Phase 2Recruiting

Subarachnoid Hemorrhage

NCT04696523

Clinical

Trials by Indication[1]

Anesthesia2 trials

Xenon-anesthesia on Patients Undergoing Major Liver-resection

Withdrawn·RRWTH Aachen University·Phase 4·NCT03504033

Sympathetic Neural Outflow During Xenon Anesthesia in Humans

Completed·AAir Liquide Santé International·Phase 1·NCT01043419·8 enrolled

Coronary Artery Bypass2 trials

Xenon in Off-pump Coronary Artery Bypass Graft Surgery

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT01757106·42 enrolled

A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon

Completed·RRWTH Aachen University·Phase 3·NCT01285271·30 enrolled

Cerebral Infarction1 trial

Neuroprotective Effects of Xenon Treatment in Patients with Cerebral Infarction

Completed·NNegovsky Reanimatology Research Institute·Phase 3·NCT05335109·40 enrolled

General Anesthesia1 trial

General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.

Terminated·AAir Liquide SA·Phase 3·NCT00919126·102 enrolled

Nausea and vomiting1 trial

Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia

Completed·RRWTH Aachen University·Phase 4·NCT00793663·220 enrolled

22 more indications

Panic Disorder1 trial

Xenon Inhalation for Treatment of Panic Disorder

Unknown status·NNobilis Therapeutics Inc.·Phase 2/3·NCT04432155·200 enrolled

Hypothermia1 trial

Xenon and Therapeutical Hypothermia After Successful Cardiopulmonary Resuscitation

Terminated·RRWTH Aachen University·Phase 2·NCT01262729·5 enrolled

Carotid Endarterectomy1 trial

Hemodynamic Stability During Carotid Endarterectomy.Comparison of LENOXe™ (Xenon 100% v/v) Versus Sevoflurane

Completed·AAir Liquide Santé International·Phase 4·NCT00937807·84 enrolled

Brain Ischemia1 trial

Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients

Completed·TTurku University Hospital·Phase 2·NCT00879892·110 enrolled

Volume1 trial

Influence of Xenon Anaesthesia on Transpulmonary Pressure and Tidal Volume Distribution

Completed·HHeinrich-Heine University, Duesseldorf·Phase 4·NCT02682758·20 enrolled

General Anaesthesia1 trial

Cardiovascular Safety of Xenon in General Anaesthesia, in Patient With Cardiovascular Risk in Non Cardiac Surgery

Completed·AAir Liquide Santé International·Phase 3·NCT01120405·600 enrolled

Magnetic Resonance Imaging1 trial

Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study

Terminated·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT02220426·17 enrolled

Outcome1 trial

Outcome After 24 Months of Participants in the TOBY Xenon Study

Completed·GGuy's and St Thomas' NHS Foundation Trust··NCT03968861·69 enrolled

Impairment1 trial

Xenon Against Postoperative Oxygen Impairment

Unknown status·—·N/A·NCT02468531·160 enrolled

Hip Fracture1 trial

Hip Fracture Surgery in Elderly Patients

Completed·AAir Liquide Santé International·Phase 2·NCT01199276·256 enrolled

Obsessive-Compulsive Disorder1 trial

Trial of Low-Dose Xenon For The Treatment Of Obsessive-Compulsive Disorder

Withdrawn·MMclean Hospital·Phase 2·NCT02098148

Aortic dissection1 trial

Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair

Unknown status·—·N/A·NCT02774096·120 enrolled

Epidural Analgesia1 trial

Xenon Combined With Intraoperative Thoracic Epidural Analgesia

Completed·CCentre Leon Berard·Phase 2·NCT01696630·31 enrolled

Obese Patients1 trial

Anesthesia for Obese Patients: Desflurane Versus Xenon

Completed·—·Phase 4·NCT01167803·192 enrolled

Autism Spectrum Disorder1 trial

Xenon Therapy for Children With Autism Spectrum Disorder

Not yet recruiting·TThe Children's Hospital of Zhejiang University School of Medicine·Phase 1/2·NCT07435103·72 enrolled

Nephrectomy1 trial

PaNeX: Partial Nephrectomy Under Xenon

Completed·RRWTH Aachen University·Phase 3·NCT01839084·46 enrolled

Subarachnoid Hemorrhage1 trial

Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage

Recruiting·TTurku University Hospital·Phase 2·NCT04696523·160 enrolled

Major Depressive Disorder1 trial

Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

Completed·MMassachusetts General Hospital·Phase 1·NCT03748446·13 enrolled

Cystic Fibrosis1 trial

Regional Phenotyping of Cystic Fibrosis Lung Disease and Non-CF Bronchiectasis

Recruiting·CChildren's Hospital Medical Center, Cincinnati··NCT04793867·100 enrolled

Stress1 trial

RELIEF OF PSYCHOEMOTIONAL STRESS BEFORE REFRACTIVE LASER VISION CORRECTION SURGERY USING XENON SEDATION

Completed·TThe S.N. Fyodorov Eye Microsurgery State Institution·Phase 1·NCT06080100·140 enrolled

Neurocognitive Dysfunction1 trial

A Test of Neural Inertia in Humans With Xenon

Completed·UUniversity of Pennsylvania·Phase 2·NCT02768727·29 enrolled

Coronary Artery Disease1 trial

Efficacy and Safety of Xenon Anaesthesia Compared to Sevoflurane Anaesthesia and Total Intravenous Anaesthesia for On-pump Coronary Artery Bypass Graft Surgery: a Randomised, Three-arm, Single-blind, International Study

Completed·AAir Liquide Santé International·Phase 3·NCT01294163·509 enrolled

Sources

References

[1]
ClinicalTrials.gov — 29 trial records for Xenon. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Xenon compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Xenon. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Nobilis Therapeutics Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: NNobilis Therapeutics Inc.

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