Xe-133

(Xenon)

ApprovedSmall molecule

Xenon is a radioactive gas used in medical imaging to help doctors see how well your lungs are working and to evaluate blood flow to the brain.[2] Xe-133 is currently approved and in use across 24 indications[4].[1]

Xe-133 is one of 603 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

Total Trials

Active Trials

602

Competitors

Pipeline

Status by Indication[4][1]

Indication

Coronary Artery DiseaseActive, not recruiting

Hip FractureActive, not recruiting

BronchiectasisActive, not recruiting

Brain InjuryActive, not recruiting

DeliriumActive, not recruiting

Panic DisorderActive, not recruiting

Cerebral InfarctionActive, not recruiting

Chronic Obstructive Pulmonary DiseaseActive, not recruiting

Acute Lung InjuryActive, not recruiting

Nausea and VomitingActive, not recruiting

Coronary Artery DiseasePhase 3

Active, not recruiting

Hip FracturePhase 2

Active, not recruiting

BronchiectasisPreclinical

Active, not recruiting

Brain InjuryPhase 3

Active, not recruiting

DeliriumPhase 2

Active, not recruiting

Panic DisorderPhase 2

Active, not recruiting

Cerebral InfarctionPhase 3

Active, not recruiting

Chronic Obstructive Pulmonary DiseasePhase 1

Active, not recruiting

Acute Lung InjuryPreclinical

Active, not recruiting

Nausea and VomitingApproved

Active, not recruiting

Showing 10 of 23 indications

Competition

Competitive Landscape

557 competitors in Chronic Obstructive Pulmonary Disease

#DrugCompanyPhaseTrials

Xe-133

NNobilis Therapeutics Inc.

Approved

29 2

Veramyst

GSK

Preclinical

26 3

Flovent

GSK

Preclinical

6 4

Spiriva

Boehringer Ingelheim

Preclinical

15 5

Aclidinium Bromide

AstraZeneca

Preclinical

21 6

Formoterol Fumarate

AstraZeneca

Preclinical

11 7

Proventil

Mylan Pharmaceuticals Inc

Preclinical

3 8

Duragesic

CCephalon

Preclinical

2 9

Narcan

SScienture

Preclinical

1 10

Coumadin

AAbbott

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1Active, not recruiting

Major Depressive Disorder

NCT03748446

Q1 2027

Recruiting

Bronchiectasis

NCT04793867

Q2 2027

Phase 1/2Not yet recruiting

Autism Spectrum Disorder

NCT07435103

Q4 2029

Phase 2Recruiting

Subarachnoid Hemorrhage

NCT04696523

Clinical

Trials by Indication[1]

Coronary Artery Bypass3 trials

A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon

Completed·RRWTH Aachen University·Phase 3·NCT01285271·30 enrolled

Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery

Completed·AAir Liquide Santé International·Phase 3·NCT01294163·509 enrolled

Xenon in Off-pump Coronary Artery Bypass Graft Surgery

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT01757106·42 enrolled

Anesthesia2 trials

Xenon-anesthesia on Patients Undergoing Major Liver-resection

Withdrawn·RRWTH Aachen University·Phase 4·NCT03504033

Sympathetic Neural Outflow During Xenon Anesthesia in Humans

Completed·AAir Liquide Santé International·Phase 1·NCT01043419·8 enrolled

Hypothermia1 trial

Xenon and Therapeutical Hypothermia After Successful Cardiopulmonary Resuscitation

Terminated·RRWTH Aachen University·Phase 2·NCT01262729·5 enrolled

Nephrectomy1 trial

PaNeX: Partial Nephrectomy Under Xenon

Completed·RRWTH Aachen University·Phase 3·NCT01839084·46 enrolled

Subarachnoid Hemorrhage1 trial

Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage

Recruiting·TTurku University Hospital·Phase 2·NCT04696523·160 enrolled

21 more indications

General Anesthesia1 trial

General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.

Terminated·AAir Liquide SA·Phase 3·NCT00919126·102 enrolled

Nausea and vomiting1 trial

Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia

Completed·RRWTH Aachen University·Phase 4·NCT00793663·220 enrolled

Sedation1 trial

RELIEF OF PSYCHOEMOTIONAL STRESS USING XENON SEDATION

Recruiting·TThe S.N. Fyodorov Eye Microsurgery State Institution·Phase 1·NCT06080100·140 enrolled

General Anaesthesia1 trial

Cardiovascular Safety of Xenon in General Anaesthesia, in Patient With Cardiovascular Risk in Non Cardiac Surgery

Completed·AAir Liquide Santé International·Phase 3·NCT01120405·600 enrolled

Impairment1 trial

Xenon Against Postoperative Oxygen Impairment

Unknown status·—·N/A·NCT02468531·160 enrolled

Autism Spectrum Disorder1 trial

Xenon Therapy for Children With Autism Spectrum Disorder

Not yet recruiting·TThe Children's Hospital of Zhejiang University School of Medicine·Phase 1/2·NCT07435103·72 enrolled

Panic Disorder1 trial

Xenon Inhalation for Treatment of Panic Disorder

Unknown status·NNobilis Therapeutics Inc.·Phase 2/3·NCT04432155·200 enrolled

Carotid Endarterectomy1 trial

Hemodynamic Stability During Carotid Endarterectomy.Comparison of LENOXe™ (Xenon 100% v/v) Versus Sevoflurane

Completed·AAir Liquide Santé International·Phase 4·NCT00937807·84 enrolled

Cerebral Infarction1 trial

Neuroprotective Effects of Xenon Treatment in Patients with Cerebral Infarction

Completed·NNegovsky Reanimatology Research Institute·Phase 3·NCT05335109·40 enrolled

Brain Ischemia1 trial

Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients

Completed·TTurku University Hospital·Phase 2·NCT00879892·110 enrolled

Volume1 trial

Influence of Xenon Anaesthesia on Transpulmonary Pressure and Tidal Volume Distribution

Completed·HHeinrich-Heine University, Duesseldorf·Phase 4·NCT02682758·20 enrolled

Bronchiectasis1 trial

Regional Phenotyping of CF and Non-CF Bronchiectasis

Recruiting·—··NCT04793867·100 enrolled

Magnetic Resonance Imaging1 trial

Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study

Terminated·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT02220426·17 enrolled

Hip Fracture1 trial

Hip Fracture Surgery in Elderly Patients

Completed·AAir Liquide Santé International·Phase 2·NCT01199276·256 enrolled

Obsessive-Compulsive Disorder1 trial

Trial of Low-Dose Xenon For The Treatment Of Obsessive-Compulsive Disorder

Withdrawn·MMclean Hospital·Phase 2·NCT02098148

Aortic dissection1 trial

Cerebral and Spinal Protection of Xenon Post-conditioning in Patients Undergoing Aortic Dissection Repair

Unknown status·—·N/A·NCT02774096·120 enrolled

Epidural Analgesia1 trial

Xenon Combined With Intraoperative Thoracic Epidural Analgesia

Completed·CCentre Leon Berard·Phase 2·NCT01696630·31 enrolled

Obese Patients1 trial

Anesthesia for Obese Patients: Desflurane Versus Xenon

Completed·—·Phase 4·NCT01167803·192 enrolled

Outcome1 trial

Outcome After 24 Months of Participants in the TOBY Xenon Study

Completed·GGuy's and St Thomas' NHS Foundation Trust··NCT03968861·69 enrolled

Humans1 trial

A Test of Neural Inertia in Humans With Xenon

Completed·UUniversity of Pennsylvania·Phase 2·NCT02768727·21 enrolled

Major Depressive Disorder1 trial

Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

Active, not recruiting·MMassachusetts General Hospital·Phase 1·NCT03748446·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 29 trial records for Xenon. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Xe-133 drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Xenon compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Xenon. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Nobilis Therapeutics Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: NNobilis Therapeutics Inc.

Xe-133

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q4 2029

Trials by Indication[1]

Coronary Artery Bypass3 trials

Anesthesia2 trials

Hypothermia1 trial

Nephrectomy1 trial

Subarachnoid Hemorrhage1 trial

General Anesthesia1 trial

Nausea and vomiting1 trial

Sedation1 trial

General Anaesthesia1 trial

Impairment1 trial

Autism Spectrum Disorder1 trial

Panic Disorder1 trial

Carotid Endarterectomy1 trial

Cerebral Infarction1 trial

Brain Ischemia1 trial

Volume1 trial

Bronchiectasis1 trial

Magnetic Resonance Imaging1 trial

Hip Fracture1 trial

Obsessive-Compulsive Disorder1 trial

Aortic dissection1 trial

Epidural Analgesia1 trial

Obese Patients1 trial

Outcome1 trial

Humans1 trial

Major Depressive Disorder1 trial

References

Drug Info

Quick Facts

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