VivoSeq
Neurology

Cerebral Palsy

61

Pipeline Programs↗

34

Active Trials↗

37

Companies Involved↗

Cerebral Palsy is a moderately active landscape with 61 programs across 37 companies. The most active players are Acorda Therapeutics, Rohto Pharmaceutical Co., Ltd., Roche. 10 therapies are approved with 11 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

65/100

Pipeline Velocity

51/100

Mech. Concentration

10/100

Completion Rate

82/100

Attrition Rate

11/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

A

Acorda Therapeutics

2 programs

Phase 1R

Rohto Pharmaceutical Co., Ltd.

1 program

Phase 2Roche logo

Roche

1 program

Phase 2E

Eastern Cooperative Oncology Group

1 program

Phase 2EMD Serono logo

EMD Serono

1 program

Phase 2E

Ever Neuro Pharma GmbH

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical16

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Epoetin Alfa

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Propofol

Fresenius Kabi Oncology Ltd.

Bupivacaine

Innocoll

Phase 18

Methylphenidate

Novartis

Modafinil

Nuvo Research GmbH

Hucb

StemCyte Taiwan Co., Ltd.

CD133

Royan Institute

Trihexyphenidyl

Wyeth-Lederle Vaccines

Phase 216

Epoetin Beta

Roche

Filgrastim

Eastern Cooperative Oncology Group

Metformin

EMD Serono

Mannitol

B. Braun Medical Inc.

Cerebrolysin

Ever Neuro Pharma GmbH

Phase 311

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Valbenazine

Neurocrine Biosciences

Ibuprofen

Kenvue Brands

Dysport

Ipsen

Incobotulinumtoxina

Merz Pharmaceuticals GmbH

Approved10

Baclofen

Novartis

Diazepam

Akero Therapeutics

Magnesium Sulfate

Fresenius Kabi Oncology Ltd.

Ropivacaine

Fresenius Kabi Oncology Ltd.

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Analysis

Modality Breakdown

84%

Small molecule

53 of 63 classified programs — the dominant modality here.

16%ALL OTHERSCell therapy914%Protein / enzyme12%

Small molecule leads; the ring shows all 63 classified programs, each share of the total. Modality classified for 99% of 83 pipeline programs.

Analysis

Trial Status

129

clinical trials

Completed63 · 49%
Unknown status17 · 13%
Not yet recruiting15 · 12%
Recruiting13 · 10%
Terminated10 · 8%
Withdrawn4 · 3%
Other7 · 5%

Clinical Trials

Trial Activity

129 trials

Evaluating Bone Marrow Cell Transplant for Treating Cerebral Palsy From Brain Hypoxia
Recruiting·VVinmec Research Institute of Stem Cell and Gene Technology·Phase 2·NCT06629324·58 enrolled
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
Recruiting·UUniversity of California, Los Angeles·Phase 4·NCT06189781·90 enrolled
Isolated Versus Combined Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy
Recruiting·Ibadat International University, Islamabad·Preclinical·NCT07694804·63 enrolled
Ecological Validity of Clinical Gait Analysis in Children With Cerebral Palsy: Influence of the Hawthorne Effect and Dual-tasks. A Pilot Study
Recruiting·RRoessingh Research and Development·N/A·NCT05417399·15 enrolled
Robot-assisted Hand Training to Induce Manual Functional Change and Cerebral Neural Plasticity in Children With Cerebral Palsy
Recruiting·CCook Children's Health Care System·Preclinical·NCT06450158·80 enrolled
Near-infrared Spectroscopy and Electroencephalography to Assess and Train Cortical Activation During Motor Tasks
Recruiting·National Institutes of Health Clinical Center (CC)·N/A·NCT01829724·320 enrolled
Effect of Lower Extremity Modified Constraint-induced Movement Therapy on Locomotion in Children With Hemiplegia
Recruiting·CCairo University·Preclinical·NCT07686809·30 enrolled
Effect Of Fully Immersive Mixed Reality Versus Standard Physical Therapy For Improving Balance And Coordination In Adolescent With Spastic Diplegic Cerebral Palsy" A Randomized Controlled Trial
Recruiting·Ibadat International University, Islamabad·Preclinical·NCT07685327·40 enrolled
Bridging the Gap: Implementing A Powered Mobility Intervention Into Early Childhood Settings for Young Children With Cerebral Palsy (GMFCS IV-V)
Recruiting·OOregon Health and Science University·Preclinical·NCT07220590·70 enrolled
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Recruiting·HHugo W. Moser Research Institute at Kennedy Krieger, Inc.·N/A·NCT05197946·300 enrolled
Comparative Effect of Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation Technique on Hands Dexterity in Cerebral Palsy
Recruiting·RRiphah International University·Preclinical·NCT07673289·26 enrolled
Agilik@Home: Demonstrate the Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy
Recruiting·IIRCCS Eugenio Medea·Preclinical·NCT06622655·40 enrolled
A Natural History Study Evaluating the Use of Multimodal Signal Acquisition Techniques to Characterize Movement in Children and Young Adults With Movement Disorders
Recruiting·National Institutes of Health Clinical Center (CC)·N/A·NCT06498596·30 enrolled
Study to Assess the Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Dyskinesia Due to Cerebral Palsy
Active, not recruiting·Neurocrine Biosciences logoNeurocrine Biosciences·Phase 3·NCT05206513·86 enrolled
Stem Cell and Conditioned Medium for Cerebral Palsy
Active, not recruiting·PPT. Prodia Stem Cell Indonesia·Phase 1/2·NCT04314687·78 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)