VivoSeq
Other

Chronic Pain

156

Pipeline Programs↗

53

Active Trials↗

66

Companies Involved↗

Chronic pain is a highly competitive landscape with 156 programs across 66 companies. The most active players are Scienture, Javelin Pharmaceuticals, Maastricht Radiation Oncology. 48 therapies are approved with 23 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

78/100

Pipeline Velocity

49/100

Mech. Concentration

19/100

Completion Rate

78/100

Attrition Rate

12/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

S

Scienture

1 program

Phase 1J

Javelin Pharmaceuticals

1 program

Phase 1M

Maastricht Radiation Oncology

1 program

Phase 1P

Pharmaceutical Research Management srl

1 program

Phase 2T

Tris Pharma, Inc.

1 program

Phase 2Q

Quantum Biopharma

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical37

Morphine Sulfate

Merck & Co.

Alcohol

Astellas

Duloxetine Hydrochloride

Eli Lilly

Duloxetine

Alnylam Pharmaceuticals

Tramadol Hydrochloride

Haisco Pharmaceutical Group Co., Ltd.

Phase 19

Naloxone

Scienture

Cannabidiol

Jazz Pharmaceuticals

Ketorolac

Javelin Pharmaceuticals

Ropivacaine

Fresenius Kabi Oncology Ltd.

Dextromethorphan

Pfizer

Phase 239

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Diclofenac Sodium

Cerimon Pharmaceuticals

Riboflavin

Cornea and Laser Eye Institute

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Psilocybin

COMPASS Pathways

Phase 323

Tapentadol

Collegium Pharmaceutical, Inc.

Gabapentin

Viatris Specialty LLC

Pregabalin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Dextromethorphan Hydrobromide

Boehringer Ingelheim

Tramadol Plus Acetaminophen

Johnson & Johnson

Approved48

Pramipexole

Boehringer Ingelheim

Hydromorphone

Rhodes Pharmaceuticals, L.P.

Methadone

Hikma Pharmaceuticals LLC

Ibuprofen

Kenvue Brands

Ketamine

Aultman Health Foundation

Analysis

Modality Breakdown

99%

Small molecule

187 of 189 classified programs — the dominant modality here.

1%ALL OTHERSPeptide21%

Small molecule leads; the ring shows all 189 classified programs, each share of the total. Modality classified for 99% of 194 pipeline programs.

Analysis

Trial Status

197

clinical trials

Completed98 · 50%
Recruiting25 · 13%
Unknown status17 · 9%
Not yet recruiting15 · 8%
Terminated13 · 7%
Withdrawn11 · 6%
Other18 · 9%

Clinical Trials

Trial Activity

197 trials

Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients
Recruiting·SSalem Anaesthesia Pain Clinic·N/A·NCT05618002·150 enrolled
Effect of Esketamine and Lidocaine on Postoperative Chronic Pain and Long-term Survival in Patients Undergoing Hepatectomy
Recruiting·WWest China Hospital·N/A·NCT06778460·304 enrolled
Combined THC and CBD for OUD and Chronic Pain
Recruiting·YYale University·Phase 2·NCT06544291·147 enrolled
Psilocybin-facilitated Treatment for Chronic Pain
Recruiting·UUniversity of Alabama at Birmingham·Phase 1·NCT05068791·30 enrolled
SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery
Recruiting·MMedipol University·N/A·NCT07436806·40 enrolled
HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain
Recruiting·RRhode Island Hospital·N/A·NCT06931158·340 enrolled
Efficacy and Safety of Liposomal Bupivacaine Injection for Paravertebral Nerve Block in the Treatment of Acute and Chronic Pain After Thoracoscopic Pneumonectomy: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial
Recruiting·TThe Second Affiliated Hospital of Chongqing Medical University·Phase 4·NCT06569953·284 enrolled
Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
Recruiting·MMayo Clinic·Phase 2·NCT06837857·200 enrolled
Mechanism of Chronic Pain in Patients With IBD
Recruiting·QQueen Mary University of London·N/A·NCT04995224·25,600 enrolled
The Role of Brain Dopamine in Chronic Pain
Recruiting·UUniversity of Rochester·Phase 2·NCT05285683·10 enrolled
Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy
Recruiting·—·N/A·NCT06910644·90 enrolled
Intravenous Lidocaine on Chronic Pain in Patients Undergoing Hepatectomy
Recruiting·WWest China Hospital·Phase 2·NCT05492669·260 enrolled
Different Treatments in Chronic Pain Patients.
Recruiting·UUniversity Ghent·N/A·NCT05768477·1,000 enrolled
Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.
Recruiting·—·Phase 1/2·NCT06431165·69 enrolled
Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer
Recruiting·—·Phase 1/2·NCT05156060·64 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)