Opioids

Phase 3Small molecule

SSahlgrenska University Hospital

Opioids is one of 75 small molecule programs targeting Emergence Delirium. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Emergence DeliriumNot yet recruiting

Rib FractureActive, not recruiting

Quality of LifeSuspended

Erector Spinae Plane BlockCompleted

Chronic PainActive, not recruiting

Emergence DeliriumPhase 3

Not yet recruiting

Rib FracturePreclinical

Active, not recruiting

Quality of LifePreclinical

Suspended

Erector Spinae Plane BlockPreclinical

Completed

Chronic PainPhase 2

Active, not recruiting

Competition

Competitive Landscape

77 competitors in Chronic Pain

#DrugCompanyPhaseTrials

Marinol

Intuniv

2 3

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

2 4

Pitocin

RRetrophin

Approved

1 5

Norpramin

VValidus Pharmaceuticals

Approved

1 6

Decadron

AAspen Global Incorporated

Approved

1 7

Ultram

WWim Janssens

Approved

—8

Dilaudid

RRhodes Pharmaceuticals, L.P.

Advil

Epsom Salt

FFresenius Kabi USA, LLC

Approved

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

ApprovedNot yet recruiting

Emergence Delirium

NCT07800845

Q1 2027

N/ANot yet recruiting

Pain Management

NCT03734731

Q3 2027

Post-ApprovalActive, not recruiting

Inguinal Hernia

NCT05929937

Clinical

Trials by Indication[1]

Epidural Analgesia2 trials

Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum

Completed·ZZuyderland Medisch Centrum·N/A·NCT05731973·50 enrolled

Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study

Completed·OOdense University Hospital·Phase 4·NCT02359175·161 enrolled

Head and Neck Cancer1 trial

Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2·NCT04221165·49 enrolled

Critically Ill1 trial

Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults

Completed·—··NCT03435614·29 enrolled

Surgery1 trial

Opioid-Free Orthopaedic Surgery

Completed·OOrthoCarolina Research Institute, Inc.·N/A·NCT04176783·511 enrolled

Chronic pain1 trial

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

Active, not recruiting·NNorthwestern University·Phase 2·NCT05463367·60 enrolled

17 more indications

Erector Spinae Plane Block1 trial

Erector Spinae Plane Block Versus Paravertebral Block

Completed·UUniversity of Alberta·N/A·NCT03471442·48 enrolled

Femoral Nerve Block1 trial

Retrospective Femoral Nerve Block Study

Completed·NNationwide Children's Hospital··NCT01293136·400 enrolled

Treatment1 trial

Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma

Completed·SSahlgrenska University Hospital·N/A·NCT02132416·92 enrolled

Spine Surgery1 trial

Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery

Recruiting·SStony Brook University·N/A·NCT06570577·60 enrolled

Dexmedetomidine1 trial

Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care

Terminated·WWalid HABRE·Phase 3·NCT03151863·33 enrolled

Injury1 trial

Exploring the Safety and Efficacy of Low-dose Ketamine Infusions for Pain Control in Acute Burn Injury

Withdrawn·UUniversity of Kansas Medical Center·Phase 4·NCT03095222

Vertebral Compression Fracture1 trial

Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures

Withdrawn·UUniversity of California, Davis·Phase 4·NCT03651804

Critically Ill Patients1 trial

Opioid Withdrawal Symptoms in Critically Ill Patients

Completed·MMahidol University··NCT03374722·55 enrolled

Inguinal hernia1 trial

No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair

Active, not recruiting·CClayton Petro·Phase 4·NCT05929937·904 enrolled

Completed·SSt. Justine's Hospital·Phase 3·NCT05099055·42 enrolled

Thoracic Surgery1 trial

Pectoralis and Serratus Nerves Block in Thoracic Surgery

Unknown status·SSoroka University Medical Center·Phase 2·NCT03023982·168 enrolled

Quality of Life1 trial

Procedures of Locoregional Analgesia and Quality of Life in Palliative Care Units

Suspended·UUniversity Hospital, Limoges·N/A·NCT01094912·38 enrolled

Hysterectomy1 trial

ICE-T Pain Regimen for Total Laparoscopic Hysterectomy

Completed·MMetroHealth Medical Center·Phase 4·NCT03987022·66 enrolled

Trauma1 trial

A Prospective Randomized Controlled Trial of Pain as Indication for Operative Treatment of Traumatic Rib Fractures.

Withdrawn·SSahlgrenska University Hospital·Preclinical·NCT02094807

Emergence Delirium1 trial

The Effect of Remifentanil on Postoperative Emergence Delirium in Pediatric Urology Patients

Not yet recruiting·KKonya City Hospital·Approved·NCT07800845·88 enrolled

Sources

References

[1]
ClinicalTrials.gov — 23 trial records for Opioids. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Opioids compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Opioids. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Sahlgrenska University Hospital company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: SSahlgrenska University Hospital

Opioids

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q3 2027

Trials by Indication[1]

Epidural Analgesia2 trials

Head and Neck Cancer1 trial

Critically Ill1 trial

Surgery1 trial

Chronic pain1 trial

Erector Spinae Plane Block1 trial

Femoral Nerve Block1 trial

Treatment1 trial

Spine Surgery1 trial

Dexmedetomidine1 trial

Injury1 trial

Vertebral Compression Fracture1 trial

Critically Ill Patients1 trial

Inguinal hernia1 trial

Analgesic1 trial

Pain Management1 trial

Spinal Anesthesia1 trial

Thoracic Surgery1 trial

Quality of Life1 trial

Hysterectomy1 trial

Trauma1 trial

Emergence Delirium1 trial

References

Drug Info

Quick Facts

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