NSAIDs

Phase 3Small molecule

Roche

NSAIDs is one of 212 small molecule programs targeting Low back pain. It is currently in Phase 3.

Indications

Total Trials

Active Trials

211

Competitors

Pipeline

Status by Indication[3][1]

Indication

Low Back PainActive, not recruiting

Erectile DysfunctionActive, not recruiting

DysmenorrheaActive, not recruiting

Rheumatoid ArthritisActive, not recruiting

Ankylosing SpondylitisActive, not recruiting

PreventionRecruiting

Pediatric PatientsRecruiting

IntraoperativeRecruiting

Low Back PainPreclinical

Active, not recruiting

Erectile DysfunctionPreclinical

Active, not recruiting

DysmenorrheaPreclinical

Active, not recruiting

Rheumatoid ArthritisPreclinical

Active, not recruiting

Ankylosing SpondylitisPreclinical

Active, not recruiting

PreventionPreclinical

Recruiting

Pediatric PatientsPhase 3

Recruiting

IntraoperativePreclinical

Recruiting

Competition

Competitive Landscape

176 competitors in Rheumatoid Arthritis

#DrugCompanyPhaseTrials

NSAIDs

Roche

Phase 3

1 2

Actos

Takeda

Preclinical

2 3

Voltaren

Cataflam

Plaquenil

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

2 7

Velcade

SShilpa Grover, MD, MPH

Preclinical

2 8

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Preclinical

—9

Decadron

QQuince Therapeutics S.p.A.

Valium

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Post-ApprovalRecruiting

Pediatric Patients

NCT06860711

Q2 2028

N/ARecruiting

Prevention

NCT07117318

Q3 2028

N/ANot yet recruiting

Low Back Pain

NCT07353372

Clinical

Trials by Indication[1]

Low back pain3 trials

Accessible Acupuncture for the Warrior With Acute Low Back Pain

Completed·DDavid Moss·N/A·NCT04236908·276 enrolled

Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain

Recruiting·IIffat Anwar Medical Complex·N/A·NCT06453291·100 enrolled

Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.

Not yet recruiting·XXuanwu Hospital, Beijing·N/A·NCT07353372·314 enrolled

Ankylosing Spondylitis2 trials

An Observational Study of Infliximab in Participants Suffering From Ankylosing Spondylitis With Hip Involvement

Terminated· Johnson & Johnson logo

Johnson & Johnson··NCT02293681·76 enrolled

Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT02469753·188 enrolled

Systemic Juvenile Idiopathic Arthritis1 trial

A Study of Tocilizumab in Chinese Participants With Systemic Juvenile Idiopathic Arthritis (sJIA)

Completed· Roche logo

Roche·Phase 4·NCT03301883·62 enrolled

Function1 trial

Dry Needling and Spinal Manipulation vs. Interocclusal Appliance (Splint), NSAIDs and Joint Mobs for Temporomandibular Dysfunction

Completed·AAlabama Physical Therapy & Acupuncture·N/A·NCT03409874·120 enrolled

Fractures1 trial

NSAIDS vs Opioids in Tibial Fractures

Unknown status·UUniversity of Louisville·Phase 4·NCT05332314·100 enrolled

11 more indications

Prevention1 trial

Rectal NSAIDs With/Without PD Stent for PEP Prevention

Recruiting·—·N/A·NCT07117318·1,278 enrolled

Erectile Dysfunction1 trial

Association of Erectile Dysfunction With Neuropathic Pain, Disease Activity, and Functional Status in Male Patients With Axial Spondyloarthritis: A Cross-Sectional Observational Study

Completed·AAltuğ Güner··NCT07453628·90 enrolled

Effectiveness1 trial

Effectiveness Of A Physiotherapy Treatment Plan In Lateral Epicondylalgia

Completed·—·N/A·NCT05021354·90 enrolled

Rheumatoid Arthritis1 trial

Characterization of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intake in Rheumatoid Arthritis (RA) Participants on Tocilizumab (RoACTEMRA®) Treatment

Completed· Roche logo

Roche··NCT03112213·135 enrolled

Intraoperative1 trial

The Effect of Systemic Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Vs Intraoperative Infiltration of Steroids in Tonsillar Bed Following Tonsillectomy on Post Tonsillectomy Pain.

Recruiting·—·N/A·NCT07035314·75 enrolled

Pediatric Patients1 trial

Safety of Short-course of NSAIDs in Pediatric Patients With CKD

Recruiting·UUniversity of Colorado, Denver·Phase 4·NCT06860711·80 enrolled

Anastomotic Leak1 trial

Risk of NSAIDs on Anastomotic Leak for Rectal Surgery

Completed·TThird Military Medical University··NCT06155175·1,969 enrolled

Dysmenorrhea1 trial

The Effect of Kinesio Taping Application for Dysmenorrhea

Unknown status·SSaglik Bilimleri Universitesi Gulhane Tip Fakultesi·N/A·NCT02663050·150 enrolled

Breast Cancer1 trial

Perioperative Inflammation and Breast Cancer Outcome

Unknown status·SSamsung Medical Center·Phase 3·NCT02141139·1,568 enrolled

Efficacy1 trial

Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From "Real World"

Unknown status·FFen Li·Phase 4·NCT02878161·240 enrolled

Dysmenorrhea Primary1 trial

The Effect Of Acupuncture On Pain And Quality Of Life in Primary Dysmenorrhea: A Randomized-Controlled Study

Completed·AAtaturk University·Preclinical·NCT07590232·64 enrolled

Sources

References

[1]
ClinicalTrials.gov — 19 trial records for NSAIDs. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — NSAIDs compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for NSAIDs. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Roche company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Roche

NSAIDs

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q2 2028

Q3 2028

Trials by Indication[1]

Low back pain3 trials

Ankylosing Spondylitis2 trials

Systemic Juvenile Idiopathic Arthritis1 trial

Function1 trial

Fractures1 trial

Prevention1 trial

Erectile Dysfunction1 trial

Effectiveness1 trial

Rheumatoid Arthritis1 trial

Intraoperative1 trial

Pediatric Patients1 trial

Anastomotic Leak1 trial

Dysmenorrhea1 trial

Breast Cancer1 trial

Efficacy1 trial

Dysmenorrhea Primary1 trial

References

Drug Info

Quick Facts

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