Alpha tocopherol

Phase 3Small molecule

TThammasat University

Alpha tocopherol is one of 101 small molecule programs targeting Tetralogy of Fallot. It is currently in Phase 3.

Indications

Total Trials

Active Trials

100

Competitors

Pipeline

Status by Indication[3][1]

Indication

Tetralogy of FallotActive, not recruiting

Down SyndromeActive, not recruiting

Beta-Thalassemia MajorActive, not recruiting

Oxidative StressActive, not recruiting

Chronic Kidney DiseaseActive, not recruiting

DiabetesCompleted

Tetralogy of FallotPhase 1

Active, not recruiting

Down SyndromePhase 3

Active, not recruiting

Beta-Thalassemia MajorPreclinical

Active, not recruiting

Oxidative StressPreclinical

Active, not recruiting

Chronic Kidney DiseasePhase 3

Active, not recruiting

DiabetesPhase 1

Completed

Competition

Competitive Landscape

540 competitors in Chronic Kidney Disease

#DrugCompanyPhaseTrials

Alpha tocopherol

TThammasat University

Phase 3

1 2

Aranesp

Amgen

Preclinical

40 3

Uloric

Takeda

Preclinical

3 4

Sovaldi

Gilead

Preclinical

1 5

Glucotrol

Pfizer

Preclinical

1 6

Vemlidy

Gilead

Preclinical

1 7

Flomax

Activase

Miochol

BBausch Health Americas, Inc.

Preclinical

2 10

Genotropin

EMD Serono

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Oxidative Stress1 trial

Oxidative Stress and Hemodialysis Access Failure

Completed·NNational Institute of Environmental Health Sciences (NIEHS)··NCT00410449·35 enrolled

Down syndrome1 trial

Multicenter Vitamin E Trial in Aging Persons With Down Syndrome

Completed·NNew York State Institute for Basic Research·Phase 3·NCT01594346·349 enrolled

Chronic Kidney Disease1 trial

Efficacy of Alpha Tocopherol for Prevention of Contrast-induced Nephropathy in Chronic Kidney Disease (CKD) Patients

Unknown status·TThammasat University·Phase 3·NCT01061320·200 enrolled

Tetralogy of Fallot1 trial

Effect of Parenteral Alpha-Tocopherol in the Definitive Surgery of Tetralogy of Fallot

Completed·—·Phase 1·NCT07194304·60 enrolled

Effectiveness1 trial

Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly.

Completed·YYolanda de Diego Otero·Phase 2·NCT02793648·50 enrolled

3 more indications

Beta-Thalassemia Major1 trial

The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major

Completed·IIndonesia University·N/A·NCT03948737·40 enrolled

Treatment1 trial

The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain

Terminated·UUniversity Health Network, Toronto·Phase 2·NCT00188669·48 enrolled

Diabetes1 trial

Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 1·NCT00862433·50 enrolled

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for Alpha tocopherol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Alpha tocopherol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Alpha tocopherol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Thammasat University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TThammasat University

Alpha tocopherol

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Oxidative Stress1 trial

Down syndrome1 trial

Chronic Kidney Disease1 trial

Tetralogy of Fallot1 trial

Effectiveness1 trial

Beta-Thalassemia Major1 trial

Treatment1 trial

Diabetes1 trial

References

Drug Info

Quick Facts

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