Zocor
(simvastatin)ApprovedSmall molecule
Simvastatin is used to lower cholesterol and reduce the risk of heart disease and stroke by helping your body produce less cholesterol and break down cholesterol that's already in your blood.[2] Zocor is currently approved and in use across 101 indications[4].[1]
Zocor is one of 1690 small molecule programs targeting Polycystic Ovary Syndrome. It is currently in Approved.
101
Indications
395
Total Trials
15
Active Trials
1,689
Competitors
3
FDA Applications
NDA/BLA/ANDA regulatory filings
2
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 99 indications
Competition
Competitive Landscape
744 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Zocor
OOrganon and Co
Approved
Adenocard
AstellasPreclinical
Zolymbus
AbbViePreclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Duragesic-100
CCephalon
Preclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Sporanox
SSebela Pharmaceuticals Development LLC
Preclinical
Duragesic
CCephalon
Preclinical
Cortef
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Preclinical
Vfend
PPrism Pharmaceuticals
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Statin14 trials
Intensive Statin Therapy in Patients With AMI
Unknown status·—·Phase 2·NCT01923077·140 enrolled
Show 11 more trials
Statin Distribution
Completed·—·Phase 1·NCT02360826·32 enrolled
Interaction6 trials
Show 3 more trials
The Interaction of Herbs and Statins
Completed·—·Phase 4·NCT05072405·38 enrolled
Cholesterol6 trials
Show 3 more trials
Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) Cholesterol
Completed·—·Phase 4·NCT00762164·34 enrolled
Efficacy and Safety5 trials
Randomized Comparative Efficacy and Safety Study of Intermittent Simvastatin and Fenofibrate in Hemodialysis
Completed·—·Phase 4·NCT02886299·60 enrolled
Hypercholesterolemia5 trials
122 more indications
Atorvastatin5 trials
Breast Cancer4 trials
Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer
Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00334542·50 enrolled
Show 1 more trial
Cirrhosis4 trials
Show 1 more trial
Statins4 trials
Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers
Not yet recruiting·SShaheed Benazir Bhutto University Sheringal Dir Upper·Phase 1·NCT07378293·100 enrolled
Type 2 Diabetes3 trials
Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes
Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00004266·160 enrolled
Schizophrenia3 trials
Atherosclerosis3 trials
Heart Disease3 trials
Asthma3 trials
Subarachnoid Hemorrhage2 trials
Monotherapy2 trials
Chronic Kidney Disease2 trials
Alzheimer's Disease2 trials
Combination Therapy2 trials
Surgical2 trials
The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry
Unknown status·—·Phase 1·NCT04824898·24 enrolled
Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy
Completed·—·Phase 4·NCT05657015·30 enrolled
Clinical Trial2 trials
Myocardial Infarction2 trials
Chronic Hepatitis2 trials
Simvastatin for the Treatment of Chronic Hepatitis B
Completed·—·Phase 1·NCT00994773·32 enrolled
Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination
Completed·—·Phase 2/3·NCT03490097·100 enrolled
Metabolic Syndrome2 trials
Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome.
Completed·—·Phase 4·NCT00988364·30 enrolled
Gut Microbiomes in Patients With Metabolic Syndrome
Unknown status·—··NCT03489317·1,000 enrolled
Diabetes2 trials
The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes
Unknown status·—·N/A·NCT03771053·240 enrolled
High Potency Statins and the Risk of Diabetes
Completed·CCanadian Network for Observational Drug Effect Studies, CNODES··NCT02518503·136,966 enrolled
Cardiovascular Disease2 trials
Rheumatoid Arthritis2 trials
Hypertensive2 trials
Emotional Processing2 trials
Oxidative Stress2 trials
Uveitis2 trials
Endothelial Function2 trials
Type 2 Diabetic Patients1 trial
Type 2 Diabetes Mellitus1 trial
Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary Syndrome
Unknown status·—·Phase 4·NCT02015988·60 enrolled
Macroglobulinemia1 trial
Simvastatin in Waldenstrom's Macroglobulinemia
Terminated·—·Phase 2·NCT00575965·18 enrolled
Ventilator-Associated Pneumonia1 trial
Aneurysm1 trial
Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial
Completed·—·Phase 3·NCT00731627·803 enrolled
Acute Coronary Syndrome1 trial
Coronary Artery Disease1 trial
Essential Hypertension1 trial
Secondary Progressive Multiple Sclerosis1 trial
Acute Lymphoblastic Leukemia1 trial
Cardiovascular1 trial
Percutaneous Coronary Intervention1 trial
NAFLD1 trial
Therapeutic Effects of Compound Zhenzhu Tiaozhi Capsules in NAFLD
Unknown status·TThe First Affiliated Hospital of Guangdong Pharmaceutical University·N/A·NCT03375580·196 enrolled
Chronic Periodontitis1 trial
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.
Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2/3·NCT03745300·120 enrolled
Laparoscopic Sleeve Gastrectomy (LSG)1 trial
Alopecia Areata1 trial
Topical Simvastatin Versus Topical Steroid in Treatment of Alopecia Areata
Not yet recruiting·—·Phase 4·NCT06399783·54 enrolled
Mortality1 trial
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
Completed·—·Phase 4·NCT05230472·161 enrolled
Mucositis1 trial
Chemotherapy1 trial
Parkinson's Disease1 trial
Relapsing-Remitting Multiple Sclerosis1 trial
Adult Subject1 trial
Brain Injury1 trial
Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could it Make a Difference?
Unknown status·—·N/A·NCT05551871·60 enrolled
Peripheral Arterial Disease1 trial
Adenocarcinoma1 trial
Non-Small Cell Lung Cancer1 trial
Pulpotomy1 trial
Multiple Sclerosis1 trial
Multiple Myeloma1 trial
Locally-advanced Rectal Cancer1 trial
Drug Metabolism1 trial
Sickle Cell Disease1 trial
Cardiomyopathy1 trial
Sclerosing Cholangitis1 trial
Diabetic Retinopathy1 trial
LDL-cholesterol1 trial
Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV Disease
Unknown status·—·N/A·NCT03355027·60 enrolled
Post Operative Pain1 trial
Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
Completed·—·N/A·NCT05525013·30 enrolled
Acute Kidney Injury1 trial
High Potency Statins and Acute Kidney Injury
Completed·CCanadian Network for Observational Drug Effect Studies, CNODES··NCT02518516·2,067,639 enrolled
Dental Implant1 trial
Cognitive impairment1 trial
Trial of Simvastatin in Amnestic Mild Cognitive Impairment (MCI) Patients
Unknown status·—·Phase 4·NCT00842920·520 enrolled
Treatment Resistant Depression1 trial
Pancreatic Adenocarcinoma1 trial
Prostate Cancer1 trial
Bone Density1 trial
Magnetic Resonance Imaging (MRI)1 trial
Biliary Tract Cancer1 trial
Hepatopulmonary Syndrome1 trial
Ovarian Cancer1 trial
Morbid Obesity1 trial
Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression
Completed·—·Phase 2·NCT04301271·161 enrolled
Metformin1 trial
Effectiveness1 trial
Bariatric Surgery1 trial
Fluorouracil1 trial
Caffeine1 trial
Dyslipidemia1 trial
Solid Tumors1 trial
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
Active, not recruiting·—·Phase 1·NCT03889795·15 enrolled
Single Dose1 trial
Hyperlipidemia1 trial
Familial Hypercholesterolemia1 trial
Chronic Renal Failure1 trial
Chronic Rhinosinusitis1 trial
Efficacy Study of SIMVASTATIN to Treat Chronic Rhinosinusitis After Failure of Optimal Treatment
Terminated·—·Phase 2·NCT01771198·7 enrolled
Choroideremia1 trial
Bone Loss1 trial
Simvastatin to Prevent SCI-Induced Bone Loss
Unknown status·—·Phase 2·NCT02946424·76 enrolled
Pneumonia1 trial
Safety and Efficacy1 trial
Regulatory
FDA Approval Timeline[5]
Dec 23, 1991
ZOCOR
NDA NDA019766
Oct 9, 2007
SIMVASTATIN
NDA NDA021961
Apr 21, 2016
FLOLIPID
NDA NDA206679
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Zocor drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for simvastatin. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]FDA Orange Book — Patent and exclusivity data for Zocor. U.S. Food & Drug Administration.
- [7]
Details
Drug Info
Quick Facts
- Mechanism of Action
- HMG-Coa Reductase Inhibitor[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- OOrganon and Co