Amidate

(Etomidate)

ApprovedSmall molecule

Amidate is a small molecule that works as a GABA-a Receptor; Anion Channel Positive Modulator.[2] It is being used across 16 indications, with its most advanced program in Approved.[1]

Amidate is one of 393 small molecule programs targeting Respiratory Failure. It is currently in Approved.

Indications

Total Trials

Active Trials

392

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Respiratory FailureApproved

Cognitive ImpairmentActive, not recruiting

StrokeApproved

AbortionUnknown status

Oxidative StressUnknown status

AnemiaActive, not recruiting

Coronary Artery BypassActive, not recruiting

HypertensionApproved

Heart FailureActive, not recruiting

ObesityActive, not recruiting

Respiratory FailureApproved

Approved

Cognitive ImpairmentPreclinical

Active, not recruiting

StrokeApproved

Approved

AbortionApproved

Unknown status

Oxidative StressApproved

Unknown status

AnemiaPreclinical

Active, not recruiting

Coronary Artery BypassApproved

Active, not recruiting

HypertensionApproved

Approved

Heart FailurePreclinical

Active, not recruiting

ObesityPreclinical

Active, not recruiting

Showing 10 of 15 indications

Competition

Competitive Landscape

198 competitors in Heart Failure

#DrugCompanyPhaseTrials

Amidate

Pfizer

Approved

1 2

Bayer Aspirin

Bayer

Preclinical

2 3

Brethine

Sanofi

Preclinical

1 4

Medrol

Pfizer

Preclinical

1 5

Activase

Zemplar

Adriamycin

Savaysa

Xylocaine

1 10

Tamiflu

CConrado Roberto Hoffmann Filho

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2028

Not yet recruiting

Prospective

NCT04291521

Clinical

Trials by Indication[1]

Sedation5 trials

A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients

Unknown status·SShaanxi Provincial People's Hospital·Phase 4·NCT02147678·120 enrolled

Efficacy and Safety of Etomidate Sedation in Gastric Endoscopic Submucosal Dissection

Completed·KKorea University Anam Hospital·N/A·NCT05407870·138 enrolled

Etomidate vs. Midazolam for Sedation During ERCP

Completed·—·Phase 4·NCT02027311·63 enrolled

Show 2 more trials

Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy

Completed·JJiangsu Nhwa Pharmaceutical Co., Ltd.·N/A·NCT01729897·328 enrolled

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

Completed·RRennes University Hospital·Phase 3·NCT02822144·351 enrolled

Cardiac Surgery2 trials

The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone

Completed·MMahidol University·Phase 4·NCT01495949·92 enrolled

Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC

Completed·—·Phase 4·NCT00451776·100 enrolled

Propofol2 trials

Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

Completed·OOrdu University·Phase 4·NCT02186990·90 enrolled

Etomidate Versus Propofol in CABG Surgery

Recruiting·HHartford Hospital·Phase 4·NCT06068764·300 enrolled

General Anesthesia2 trials

Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Completed·TTianjin Medical University General Hospital·N/A·NCT02711917·175 enrolled

Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia

Not yet recruiting·SSecond Hospital of Shanxi Medical University·Phase 1·NCT07012902·125 enrolled

Outcome2 trials

The Effect of Etomidate on Outcomes of Trauma Patients

Withdrawn·—·N/A·NCT00938990

The Effect of Etomidate on Patient Outcomes After Single Bolus Doses

Completed·—·N/A·NCT00441792·122 enrolled

33 more indications

Stroke1 trial

Helping Stroke Patients With ThermoSuit Cooling

Terminated·LLife Recovery Systems·N/A·NCT02453373·14 enrolled

Anemia1 trial

Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia

Unknown status·KKing Saud University·N/A·NCT04857450·60 enrolled

Randomized1 trial

Randomized Trial of Sedative Choice for Intubation

Completed·VVanderbilt University Medical Center·Phase 4·NCT05277896·2,367 enrolled

Ketamine1 trial

Ketamine Versus Etomidate for Rapid Sequence Intubation

Completed·HHennepin Healthcare Research Institute·Phase 4·NCT01823328·143 enrolled

Coronary Artery Bypass1 trial

A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

Unknown status·—·Phase 4·NCT01386229·40 enrolled

Prospective1 trial

Prospective Study of Induction Medications Used in the Trauma RSI

Not yet recruiting·UUniversity of Southern California··NCT04291521·7,000 enrolled

Remimazolam1 trial

Comparison of Remimazolam and Etomidate As Induction Agents for Electroconvulsive Treatment

Completed·YYeongseok Yun·Phase 4·NCT06664138·30 enrolled

Critically Ill1 trial

Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

Completed·MMayo Clinic·Phase 2/3·NCT02105415·160 enrolled

Recovery Quality1 trial

Effect of Remimazolam on the Recovery Quality After Day Surgery

Completed·XXijing Hospital·N/A·NCT05748665·118 enrolled

Blood Pressure1 trial

Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?

Withdrawn·UUniversity of Mississippi Medical Center·Phase 3·NCT01248234

Sevoflurane1 trial

Comparison the Effects of Etomidate and Sevoflurane During Electroconvulsive Therapy

Completed·IInonu University·Phase 4·NCT02500225·25 enrolled

After Cardiac Surgery1 trial

Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery

Completed·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT00415701·130 enrolled

Abortion1 trial

The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial

Unknown status·—·Phase 4·NCT02208596·150 enrolled

Target-controlled Infusion1 trial

Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery

Unknown status·XXijing Hospital·Phase 4·NCT02644980·110 enrolled

Mitral Valve Repair1 trial

Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair

Completed·HHeidelberg University··NCT04865614·57 enrolled

Anesthesia Induction1 trial

Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction

Unknown status·HHenan Provincial People's Hospital·Phase 4·NCT02182648·120 enrolled

Depression1 trial

Neurorestorative Effects of Electroconvulsive Therapy (ECT) in Patients With Severe Late Life Depression

Completed·UUniversitaire Ziekenhuizen KU Leuven·N/A·NCT02667353·110 enrolled

Morbidity1 trial

Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 4·NCT00440102·655 enrolled

Heart Failure1 trial

Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation

Unknown status·HHeidelberg University··NCT04934410·50 enrolled

Cognitive impairment1 trial

The Efficacy And Cognitive Impairment Of Modified Electroconvulsive Therapy

Completed·SShanghai Mental Health Center·N/A·NCT02066077·280 enrolled

Unknown status·UUniversity of Manitoba·Phase 4·NCT02924090·48 enrolled

Single Dose1 trial

Single Dose of Etomidate and Adrenal Cortex

Completed·IIstanbul University·Phase 4·NCT01792037·90 enrolled

Etomidate Combined With Propofol1 trial

The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries

Unknown status·HHenan Provincial People's Hospital·Phase 4·NCT02174120·120 enrolled

Surgery1 trial

Etomidate Induction in Hysteroscopic Surgery

Unknown status·PPeking University Third Hospital·N/A·NCT05520645·200 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Maintenance of Etomidate in General Anesthesia

Completed·HHenan Provincial People's Hospital·Phase 4·NCT05223907·1,080 enrolled

Elderly Patients1 trial

Etomidate to Improve Outcome in Elderly Patients

Completed·ZZhihong LU·N/A·NCT02910206·1,917 enrolled

Oxidative Stress1 trial

Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients

Unknown status·ZZhujiang Hospital·Phase 4·NCT02202239·60 enrolled

Tracheal Intubation1 trial

Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial

Completed·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT02643381·801 enrolled

Circadian Rhythm1 trial

Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children

Unknown status·DDu yi·Phase 4·NCT02013986·30 enrolled

Dexmedetomidine1 trial

Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus

Unknown status·TTang-Du Hospital·Phase 4·NCT02518789·132 enrolled

Post-Traumatic Stress Disorder1 trial

Effect of Ketamine and Etomidate During Rapid Sequence Intubation on Long- Term Outcomes (Long-Term Outcomes of the RSI Trial)

Enrolling by invitation·VVanderbilt University Medical Center··NCT06179485·1,756 enrolled

Regulatory

FDA Approval Timeline[4]

Sep 7, 1982

AMIDATE

NDA NDA018227

May 30, 1985

AMIDATE

NDA NDA018227

May 30, 1985

AMIDATE

NDA NDA018227

Feb 15, 1986

AMIDATE

NDA NDA018227

Jun 16, 1986

AMIDATE

NDA NDA018227

Jan 25, 1988

AMIDATE

NDA NDA018227

Jul 1, 1994

AMIDATE

NDA NDA018227

Sep 11, 1996

AMIDATE

NDA NDA018227

Apr 30, 1997

AMIDATE

NDA NDA018227

Sep 29, 1998

AMIDATE

NDA NDA018227

Feb 26, 1999

AMIDATE

NDA NDA018227

Apr 29, 1999

AMIDATE

NDA NDA018227

Apr 6, 2001

AMIDATE

NDA NDA018227

Jul 3, 2002

AMIDATE

NDA NDA018227

Jul 3, 2002

AMIDATE

NDA NDA018227

Apr 27, 2017

AMIDATE

NDA NDA018227

Sources

References

[1]
ClinicalTrials.gov — 46 trial records for Etomidate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Etomidate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Etomidate. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA018227). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: GABA-a Receptor; Anion Channel Positive Modulator[2]
Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pfizer

Amidate

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2028

Trials by Indication[1]

Sedation5 trials

Cardiac Surgery2 trials

Propofol2 trials

General Anesthesia2 trials

Outcome2 trials

Stroke1 trial

Anemia1 trial

Randomized1 trial

Ketamine1 trial

Coronary Artery Bypass1 trial

Prospective1 trial

Remimazolam1 trial

Critically Ill1 trial

Recovery Quality1 trial

Blood Pressure1 trial

Sevoflurane1 trial

After Cardiac Surgery1 trial

Abortion1 trial

Target-controlled Infusion1 trial

Mitral Valve Repair1 trial

Anesthesia Induction1 trial

Depression1 trial

Morbidity1 trial

Heart Failure1 trial

Cognitive impairment1 trial

Intravenous1 trial

Hemodynamic1 trial

Major Depression1 trial

Single Dose1 trial

Etomidate Combined With Propofol1 trial

Surgery1 trial

Safety and Efficacy1 trial

Elderly Patients1 trial

Oxidative Stress1 trial

Tracheal Intubation1 trial

Circadian Rhythm1 trial

Dexmedetomidine1 trial

Post-Traumatic Stress Disorder1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

Related News