artemether-lumefantrine (AL)

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

COVID-19MalariaPlasmodium Falciparum Malaria

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

1

artemether-lumefantrine (AL)

Novartis

Approved

12

Spikevax

Moderna

Preclinical

213

Bnt162b2

BioNTech

Preclinical

294

Aquasol E

NNational Eye Institute (NEI)

Preclinical

15

Piperacillin/tazobactam

Pfizer

Preclinical

16

Glucocorticoid

AbbVie

Preclinical

17

Nadroparin

GSK

Preclinical

18

Calcium

Eli Lilly

Preclinical

—9

HB-Admscs

HHope Biosciences Research Foundation

Preclinical

410

Aprotinin

Bayer

Preclinical

1Show 13 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Malaria11 trials

Evaluation of 4 Artemisinin-based Combinations for Treating Uncomplicated Malaria in African Children

Completed·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT00393679·4,112 enrolled

OPTImizing Malaria And HIV Treatment in a Shifting Landscape in Africa

Recruiting·YYale University·Phase 4·NCT06967519·380 enrolled

In Vivo Efficacy of Artemether-Lumefantrine and Artesunate-Amodiaquine for Uncomplicated P. Falciparum Malaria

Completed·CCenters for Disease Control and Prevention·Phase 4·NCT02637128·452 enrolled

Show 8 more trials

Impact of Malaria Mass Drug Administration on Malaria Prevalence in Under 15 Children and Pregnant Women

Completed·NNoguchi Memorial Institute for Medical Research·N/A·NCT07358767·3,300 enrolled

Interactions Between Artemether-lumefantrine and Antiretrovirals in HIV-patients With Uncomplicated Malaria in Tanzania

Completed·UUniversity of Copenhagen·Phase 4·NCT00885287·830 enrolled

Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Uncomplicated Malaria in South Kivu, DR Congo

Completed·MMedecins Sans Frontieres, Netherlands·Phase 4·NCT02741024·288 enrolled

A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines

Recruiting·UUniversity of Oxford·Phase 3·NCT05951595·1,680 enrolled

Efficacy, Safety and Pharmacokinetics of Artemether-lumefantrine Dispersible Tablet in the Treatment of Malaria in Infants < 5 kg

Completed·Novartis·Phase 2/3·NCT01619878·20 enrolled

Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for Treating Malaria

Completed·BBandim Health Project·Phase 4·NCT04897919·474 enrolled

Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites

Completed·Medicines for Malaria Venture·Phase 1·NCT04310085·16 enrolled

Malaria Therapeutic Efficacy Study, Rwanda

Completed·JJhpiego·Phase 4·NCT04767217·528 enrolled

Efficacy1 trial

Therapeutic Efficacy Study of AL and DP in Western Kenya

Completed·KKenya Medical Research Institute·N/A·NCT05060198·340 enrolled

Pregnancy1 trial

Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics

Recruiting·—·Phase 4·NCT05757167·2,500 enrolled

COVID-191 trial

Malaria as a Risk Factor for COVID-19 in Western Kenya and Burkina Faso

Completed·LLiverpool School of Tropical Medicine·Phase 3·NCT04695197·143 enrolled

Plasmodium falciparum malaria1 trial

Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique

Completed·CCentro de Investigacao em Saude de Manhica·N/A·NCT06970600·352 enrolled

Details

Drug Info

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