dihydroartemisinin-piperaquine

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

MalariaEffectivenessPregnancyDrug

79 competitors in Malaria

#DrugCompanyPhaseTrials

1

Daraprim

CClinique Sainte Clotilde

Approved

—2

dihydroartemisinin-piperaquine

GSK

Phase 3

513

Rabies Vaccine

Novartis

Phase 3

84

Krintafel

GGlaxo Dba Glaxosmithkline

Phase 3

35

Artemether-Lumefantrine (AL)

Novartis

Phase 3

116

Artesunate-Amodiaquine

Sanofi

Phase 3

197

R21/matrix-M

UUniversity of Oxford

Phase 3

48

Pyramax

SShin Poong Pharmaceutical Co. Ltd.

Phase 3

29

Biltricide

Bayer

Preclinical

110

Stelara

Johnson & Johnson

Preclinical

—Show 16 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Malaria51 trials

Intermittent Preventive Treatment of Malaria in Schoolchildren

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT00852371·780 enrolled

Malaria Therapeutic Efficacy Study (TES) Kenya

Completed·JJhpiego·Phase 4·NCT04767191·400 enrolled

Impact of Dihydroartemisinin-piperaquine Plus Primaquine on Malaria Transmission in Lampung Province, Sumatra

Completed·IIndonesia University·Phase 4·NCT01389557·77 enrolled

Show 48 more trials

Malaria Active Epidemiology and Treatment Study

Completed·—·N/A·NCT01280162·222 enrolled

Assessing the Efficacy of Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria Infection in Children

Completed·CCenters for Disease Control and Prevention·Phase 3·NCT01082705·323 enrolled

Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)

Completed·RRadboud University Medical Center·N/A·NCT00868465·600 enrolled

Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi

Unknown status·KKamuzu University of Health Sciences·Phase 3·NCT02721420·375 enrolled

Comparing Chemoprevention Approaches for School-based Malaria Control

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT05244954·746 enrolled

Triple Antimalarial Combination to Accelerate the Parasite Clearance and to Prevent the Selection of Resistant Parasites

Unknown status·NNurex S.r.l.·Phase 2·NCT03697668·50 enrolled

Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia

Active, not recruiting·PPATH·Phase 3·NCT06516042·10,350 enrolled

Effectiveness and Safety of Intermittent Preventive Treatment for Malaria Using Either Dihydroartemisinin-piperaquine or Artesunate-amodiaquine in Reducing Malaria Related Morbidities and Improving Cognitive Ability in School-aged Children in Tanzania

Completed·NNational Institute for Medical Research, Tanzania·Phase 3·NCT03640403·1,555 enrolled

Post-discharge Malaria Chemoprevention(PMC) Study

Completed·LLiverpool School of Tropical Medicine·Phase 3·NCT02671175·1,049 enrolled

Improving Anti-malarial Treatment Options in Guinea-Bissau - Part A

Completed·BBandim Health Project·Phase 4·NCT01704508·346 enrolled

Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Sickle Cell Anaemia

Completed·LLiverpool School of Tropical Medicine·Phase 3·NCT04844099·723 enrolled

Pharmacokinetics and Pharmacodynamics of the Gametocytocidal and Post-treatment Chemoprotective Effects of Antimalarials

Active, not recruiting·JJohns Hopkins Bloomberg School of Public Health·Phase 2/3·NCT04009343·182 enrolled

Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprophylaxis in Tanzania

Completed·RRichard Mwaiswelo·N/A·NCT05874869·13,800 enrolled

Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger

Completed·EEpicentre·Phase 4·NCT01755559·663 enrolled

Efficacy and Safety of Dihydroartemisinin-piperaquine (DHP) for the Treatment of Uncomplicated Malaria

Completed·MMenzies School of Health Research··NCT02353494·130 enrolled

Adjunctive Ivermectin Mass Drug Administration for Malaria Control

Unknown status·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT04844905·24,000 enrolled

Perennial Malaria Chemoprevention in the Malaria Vaccine Era

Not yet recruiting·SStanford University·Phase 4·NCT07322068·1,290 enrolled

Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study

Completed·LLiverpool School of Tropical Medicine·Phase 2·NCT02511353·141 enrolled

RHOST-cRCT, Reactive Household-based Self-administered Treatment Against Residual Malaria Transmission

Completed·LLondon School of Hygiene and Tropical Medicine·N/A·NCT02878200·2,236 enrolled

Interactions Between HIV and Malaria in African Children

Completed·UUniversity of California, San Francisco·Phase 3·NCT00527800·351 enrolled

Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa

Completed·—·Phase 3·NCT02974348·300 enrolled

Pharmacokinetics of Dihydroartemisinin-Piperaquine in the Treatment of Uncomplicated Malaria in Children in Burkina Faso

Completed·UUniversity of California, San Francisco·Phase 4·NCT00845533

Mass Drug Administrations of DHA-PQP to Accelerate Towards Malaria Elimination in Magude District, Southern Mozambique

Completed·CCentro de Investigacao em Saude de Manhica·N/A·NCT02914145·240,502 enrolled

Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda

Unknown status·MMalaria Consortium·Phase 4·NCT05323721·6,805 enrolled

Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for Treating Malaria

Completed·BBandim Health Project·Phase 4·NCT04897919·474 enrolled

Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria

Completed·GSK·Phase 3·NCT02802501·150 enrolled

Improving Maternal heAlth by Reducing Malaria in African HIV Women

Completed·BBarcelona Institute for Global Health·Phase 3·NCT03671109·666 enrolled

Safety of Antimalarials in the FIRst trimEster

Recruiting·LLiverpool School of Tropical Medicine·Phase 3·NCT06962319·1,510 enrolled

Study of Malaria Vaccine RTS,S/AS01E in Plasmodium Falciparum-infected and Uninfected Adults Pre-treated With Anti-malarial Therapy

Completed·PPATH·Phase 2·NCT04661579·620 enrolled

Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 3·NCT03576313·4,939 enrolled

Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated Malaria

Not yet recruiting·—·Phase 4·NCT07403643·60 enrolled

Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT02612545·216 enrolled

Evaluation of the Implementation and Effectiveness of Intermittent Preventive Treatment for Malaria Using Dihydroartemisinin-piperaquine on Reducing Malaria Burden in School Aged Children in Tanzania

Completed·NNational Institute for Medical Research, Tanzania·Phase 4·NCT04245033·4,100 enrolled

Evaluation of 4 Artemisinin-based Combinations for Treating Uncomplicated Malaria in African Children

Completed·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT00393679·4,112 enrolled

Evaluation of Reactive Focal Mass Drug Administration for Malaria Elimination in Swaziland

Completed·UUniversity of California, San Francisco·Phase 3·NCT02315690·4,000 enrolled

Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)

Completed·—·Phase 4·NCT03178643·246 enrolled

Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda

Completed·GGrant Dorsey, M.D, Ph.D.·Phase 3·NCT04336189·2,757 enrolled

Malaria Therapeutic Efficacy Study, Rwanda

Completed·JJhpiego·Phase 4·NCT04767217·528 enrolled

Evaluation of Community-based Mass Screening and Treatment for Malaria in Western Kenya

Completed·SSimon Kariuki·Phase 3·NCT02987270·90,000 enrolled

Chemopreventive Therapy for Malaria in Ugandan Children

Completed·UUniversity of California, San Francisco·Phase 3·NCT00948896·600 enrolled

In-vivo Efficacy and Safety of Artemether/Lumefantrine Vs Dihydroartemisinin-piperaquine for Treatment of Uncomplicated Malaria and Assessment of Parasite Genetic Factors Associated With Parasite Clearance or Treatment Failure

Completed·NNational Institute for Medical Research, Tanzania·Phase 4·NCT02590627·509 enrolled

Comparing Chemoprevention Drugs for School-based Malaria Control

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT05980156·646 enrolled

Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria

Completed·IInstitute of Tropical Medicine, Belgium·Phase 3·NCT00852423·3,428 enrolled

Malaria in Early Life Study

Completed·GGadjah Mada University·N/A·NCT02001428·757 enrolled

After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding

Active, not recruiting·UUniversity of North Carolina, Chapel Hill·Preclinical·NCT06870344·36,000 enrolled

Cluster Randomized Trial of Intermittent Preventive Treatment of Malaria in School-age Children to Improve the Health of Students and Decrease Community Transmission

Not yet recruiting·UUniversity of California, San Francisco·Approved·NCT07246525·4,800 enrolled

Single-Use Antimalarial Monoclonal Antibodies for Post-Discharge Malaria Prevention in Children With Severe Anaemia or Severe Malaria in Kenya: A Multi-Centre, Parallel-Group, Two-Arm Randomised Placebo-Controlled Non-Inferiority Trial

Active, not recruiting·LLiverpool School of Tropical Medicine·Phase 3·NCT07082205·398 enrolled

The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy: a Longitudinal Study

Completed·IInfectious Diseases Research Collaboration, Uganda·Approved·NCT06347471·160 enrolled

Treatment5 trials

P.Vivax Treatment Trial

Completed·UUniversity of Oxford·Phase 1/2·NCT02802813·41 enrolled

Cardiac Safety of Repeated Doses of Dihydroartemisinin-Piperaquine for the Use in Mass Treatment Campaigns

Completed·LLihir Medical Centre·Phase 3·NCT02605720·78 enrolled

Surveillance and Treatment With Dihydroartemisinin-piperaquine Plus Primaquine

Completed·IIndonesia University·Phase 4·NCT01878357·1,488 enrolled

Show 2 more trials

School-Based Treatment With ACT to Reduce Transmission

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 4·NCT02009215·10,746 enrolled

Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates

Completed·IInstitut de Recherche en Sciences de la Sante, Burkina Faso·Phase 4·NCT04816461·526 enrolled

Pregnancy4 trials

Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa

Completed·LLiverpool School of Tropical Medicine·Phase 3·NCT03208179·4,680 enrolled

Randomised Trial of 3 Artemisinin Combination Therapy for Malaria in Pregnancy

Completed·UUniversity of Oxford·Phase 3·NCT01054248·511 enrolled

Efficacy,Safety and Tolerability of Dihydroartemisinin-Piperaquine for Uncomplicated Malaria in Pregnancy in Ghana

Completed·KKwame Nkrumah University of Science and Technology·Phase 3·NCT01231113·417 enrolled

Show 1 more trial

Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy

Active, not recruiting·MMenzies School of Health Research·Phase 3·NCT05426434·1,172 enrolled

Plasmodium falciparum malaria4 trials

Effect of Imatinib on Suppression of Malaria Parasites in Patients With Uncomplicated Plasmodium Falciparum Malaria

Completed·HHuLow·Phase 1·NCT02614404·15 enrolled

Efficacy of Artemether-lumefantrine, Artesunate-amodiaquine and Dihydroartemisinin-piperaquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Malawi

Completed·CCenters for Disease Control and Prevention·N/A·NCT01326754·498 enrolled

Dihydroartemisinin- Piperaquine Versus Artemether- Lumefantrine in the Treatment Uncomplicated Plasmodium Falciparum Malaria in Sudan

Unknown status·UUniversity of Khartoum·Phase 4·NCT01075945·140 enrolled

Show 1 more trial

Artemisinin-based Combination Therapy for Treatment of Plasmodium Falciparum Malaria in North Sumatera, Indonesia

Completed·LLondon School of Hygiene and Tropical Medicine·Phase 4·NCT02325180·338 enrolled

Efficacy2 trials

Phase 2 Efficacy Study of Primaquine and Methylene Blue

Completed·UUniversity of California, San Francisco·Phase 2·NCT02831023·80 enrolled

Therapeutic Efficacy Study of AL and DP in Western Kenya

Completed·KKenya Medical Research Institute·N/A·NCT05060198·340 enrolled

Details

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