Minocycline /d

ApprovedSmall molecule

UUniversity of Florida

Minocycline /d is one of 271 small molecule programs targeting Low back pain. It is currently in Approved.

Indications

Total Trials

Active Trials

270

Competitors

Pipeline

Status by Indication[3][1]

Indication

Low Back PainActive, not recruiting

Peripheral NeuropathyActive, not recruiting

Brain InjuryActive, not recruiting

Fragile X SyndromeActive, not recruiting

Intracerebral HemorrhageActive, not recruiting

HypertensionActive, not recruiting

PeriodontitisActive, not recruiting

Breast CancerActive, not recruiting

Ischemic StrokeActive, not recruiting

Low Back PainPhase 2

Active, not recruiting

Peripheral NeuropathyPhase 2

Active, not recruiting

Brain InjuryPhase 2

Active, not recruiting

Fragile X SyndromePreclinical

Active, not recruiting

Intracerebral HemorrhagePhase 3

Active, not recruiting

HypertensionApproved

Active, not recruiting

PeriodontitisApproved

Active, not recruiting

Breast CancerPhase 2

Active, not recruiting

Ischemic StrokePhase 3

Active, not recruiting

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Minocycline /d

UUniversity of Florida

Approved

1 2

Adriamycin

GGynecologic Oncology Group

Preclinical

87 3

DATROWAY

Daiichi Sankyo

Preclinical

4 4

Cymbalta

Alnylam Pharmaceuticals

Preclinical

3 5

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 6

Zinecard

CChildren's Oncology Group

Preclinical

2 7

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 8

Chirocaine

PPurdue Pharma LP

Preclinical

1 9

Paracetamol

GSK

Preclinical

1 10

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2028

Post-ApprovalRecruiting

Hypertension

NCT06246396

Q4 2028

Phase 3Not yet recruiting

Intracerebral Hemorrhage

NCT07338175

Clinical

Trials by Indication[1]

Hypertensive2 trials

Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients

Withdrawn·UUniversity of Florida·Phase 1/2·NCT02133885

Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients

Completed·UUniversity of Florida·Phase 2·NCT02133872·34 enrolled

Periodontitis2 trials

Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis

Completed·—·Phase 4·NCT05530252·51 enrolled

Locally Delivered Minocycline in Advanced Periodontitis

Completed·MMahsa University·Phase 4·NCT04076098·40 enrolled

Hypertension1 trial

Antihypertensive Mechanisms of Minocycline in Resistant Hypertension

Recruiting·UUniversity of Florida·Phase 4·NCT06246396·120 enrolled

Brain Injury1 trial

Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

Enrolling by invitation·UUniversity of California, San Francisco·Phase 2·NCT05826912·672 enrolled

Breast Cancer1 trial

Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer

Completed·OOhio State University Comprehensive Cancer Center·Phase 2·NCT02203552·56 enrolled

9 more indications

Adult1 trial

Impact of DFD-29 on Microbial Flora of Healthy, Adult Human Subjects When Administered Over 16 Weeks

Completed·UUnknown Sponsor·Phase 1·NCT05597462·60 enrolled

Peripheral Neuropathy1 trial

Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel

Completed·—·Phase 2·NCT02297412·47 enrolled

Helicobacter Pylori Eradication1 trial

Effectiveness of Minocycline-Containing Bismuth Quadruple Therapy for Helicobacter Pylori Eradication

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT04558502·339 enrolled

Intracerebral Hemorrhage1 trial

Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage

Not yet recruiting·—·Phase 3·NCT07338175·1,192 enrolled

Fragile X Syndrome1 trial

Trial of Minocycline to Treat Children With Fragile X Syndrome

Completed·UUniversity of California, Davis·N/A·NCT01053156·66 enrolled

Ischemic stroke1 trial

Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke

Completed·—·Phase 3·NCT05836740·1,724 enrolled

Fasting Conditions1 trial

Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fasting Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT02312297·28 enrolled

Minocycline1 trial

Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fed Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT02312609·18 enrolled

Low back pain1 trial

Evaluating the Role of Neuroinflammation in Low Back Pain

Completed·MMarco Loggia·Phase 2·NCT03106740·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 16 trial records for Minocycline /d. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Minocycline /d compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Minocycline /d. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Florida company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: UUniversity of Florida

Minocycline /d

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2028

Q4 2028

Trials by Indication[1]

Hypertensive2 trials

Periodontitis2 trials

Hypertension1 trial

Brain Injury1 trial

Breast Cancer1 trial

Adult1 trial

Peripheral Neuropathy1 trial

Helicobacter Pylori Eradication1 trial

Intracerebral Hemorrhage1 trial

Fragile X Syndrome1 trial

Ischemic stroke1 trial

Fasting Conditions1 trial

Minocycline1 trial

Low back pain1 trial

References

Drug Info

Quick Facts

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