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Tractocile

(Atosiban)

Phase 1Small molecule

Atosiban is used to delay premature labor in pregnant women by reducing uterine contractions, helping to extend pregnancy when labor starts too early.[1] Tractocile is currently being investigated across 7 indications[3], with its most advanced program in Phase 1.[1]

Tractocile is one of 105 small molecule programs targeting Female Infertility. It is currently in Phase 1.

7

Indications

22

Total Trials

3

Active Trials

104

Competitors

Pipeline

Status by Indication[3][1]

Indication

Female InfertilityActive, not recruiting

Oxidative StressActive, not recruiting

WomenRecruiting

Embryo TransferUnknown status

Preterm BirthCompleted

AttentionRecruiting

InfertilityActive, not recruiting

Female InfertilityPreclinical

Active, not recruiting

Oxidative StressPreclinical

Active, not recruiting

WomenPreclinical

Recruiting

Embryo TransferPreclinical

Unknown status

Preterm BirthPreclinical

Completed

AttentionPhase 1

Recruiting

InfertilityPreclinical

Active, not recruiting

Competition

Competitive Landscape

49 competitors in Infertility

#DrugCompanyPhaseTrials

Femara

Bayer Aspirin

Nolvadex

Danocrine

Lupron

Sun Pharmaceutical Industries, Inc.

Estrace

Glucophage

Prometrium

Xylocaine

MMEDRx USA, Inc.

Clomid

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Women

NCT07185230

Clinical

Trials by Indication[1]

Preterm Labor3 trials

Nifedipine Treatment in Preterm Labor

Withdrawn·HHospital Clinico Universitario de Santiago·Phase 3·NCT01314859

Nifedipine Compared to Atosiban for Treating Preterm Labor

Completed·RRaed Salim·Phase 4·NCT00599898·145 enrolled

Tocolytic Therapy for Preterm Labor in Multiple Gestation

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT02725736·140 enrolled

Oxytocin2 trials

Oxytocin Antagonist in Patients With Repeated Failure of Implantation

Completed·AAZ Jan Palfijn Gent·Phase 4·NCT01673399·138 enrolled

Effect of Oxytocin and Vasopressin Antagonists on Uterine Contractions

Completed· Ferring logo

Ferring·Phase 2·NCT00587327·125 enrolled

Treatment2 trials

Follow up Study to Assess Long Term Safety and Outcomes in Infants and Children Born to Mothers Participating in Retosiban Treatment Studies

Completed· GSK logo

GSK·Phase 3·NCT02292784·98 enrolled

Atosiban Versus Placebo in the Treatment of Late Threatened Pre-term Birth

Completed·—·Phase 4·NCT05693688·760 enrolled

Attention2 trials

The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )

Recruiting·UUniversity of Electronic Science and Technology of China·Phase 1·NCT07140237·250 enrolled

The Effect of Oral Oxytocin and Atosiban on Social Attention

Recruiting·UUniversity of Electronic Science and Technology of China·Phase 1·NCT07093060·250 enrolled

Combination Therapy1 trial

Single Versus Combination Therapy in Acute Tocolysis

Completed·TTawam Hospital·Phase 2·NCT01429545·110 enrolled

12 more indications

In Vitro Fertilization (IVF)1 trial

Use of Atosiban in in Vitro Fertilization (IVF) Treatment

Completed·TThe University of Hong Kong·Phase 4·NCT01501214·800 enrolled

Myelomeningocele1 trial

In Utero Repair of Myelomeningocele: Atosiban Versus Terbutaline

Completed·UUniversity of Sao Paulo General Hospital··NCT04468568·25 enrolled

Pre-Term1 trial

PoC Study of OBE022 in Threatened Preterm Labour

Unknown status·OObsEva SA·Phase 2·NCT03369262·115 enrolled

Oxidative Stress1 trial

Oxidative Stress in Women Treated With Atosiban for Impending Preterm Birth

Completed·PPolish Mother Memorial Hospital Research Institute·N/A·NCT03570294·64 enrolled

Efficacy and Safety1 trial

A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour

Terminated· GSK logo

GSK·Phase 3·NCT02292771·97 enrolled

Embryo Transfer1 trial

Effect of Oxytocin Antagonists on Implantation Success Rates of Frozen-thawed Embryo Transfer

Unknown status·—·N/A·NCT03904745·250 enrolled

Preterm Birth1 trial

Perioperative Use of Atosiban for Ultrasound-indicated Cerclage to Reduce Spontaneous Preterm Birth(sPTB)

Completed·—·N/A·NCT06537778·334 enrolled

Pregnancy1 trial

Atosiban Improves Implantation and Pregnancy Rates in Patients With Repeated Implantation Failure

Completed·—·N/A·NCT01493440·71 enrolled

Women1 trial

Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions

Recruiting·NNorthwest Women's and Children's Hospital, Xi'an, Shaanxi·N/A·NCT07185230·792 enrolled

Endometriosis1 trial

The Effect of Selective Oxytocin Receptor Inhibitors on Endometriosis-related Pain

Unknown status·RRadboud University Medical Center·Phase 2·NCT05382143·10 enrolled

Vascular Function1 trial

Influence of Tocolytical Medications on Hemodynamics (Central and Peripheral) and Vascular Function in a Pilot Study to Determine the Design of the Final Study and the Final Study Itself

Completed·UUniversity Hospital, Ghent·Phase 1·NCT00679705·23 enrolled

Randomized1 trial

A Randomized Double Blind Comparison of Atosiban in Patients With RIF Undergoing IVF Treatment

Unknown status·SShanghai First Maternity and Infant Hospital·Phase 1·NCT02893722·200 enrolled

Sources

References

[1]
ClinicalTrials.gov — 22 trial records for Atosiban. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Atosiban compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Atosiban. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — GSK company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Oxytocin Receptor Antagonist[2]
Modality: Small molecule[2]
Highest Phase: Phase 1[1]
Company: GSK

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