Benzocaine

ApprovedSmall molecule

Pfizer

Benzocaine is one of 58 small molecule programs targeting Acute otitis media. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute Otitis MediaActive, not recruiting

PharyngitisActive, not recruiting

ToothacheActive, not recruiting

Acute Otitis MediaPhase 2

Active, not recruiting

PharyngitisPhase 3

Active, not recruiting

ToothacheApproved

Active, not recruiting

Competition

Competitive Landscape

37 competitors in Acute Otitis Media

#DrugCompanyPhaseTrials

Cipro

Bayer

Approved

—2

Amoxil

GGlobal Antibiotics Research and Development Partnership

Approved

2 3

Zithromax

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

1 4

Singulair

OOrganon and Co

Approved

1 5

Decadron

AAspen Global Incorporated

Omnicef

3 7

Ketek

Sanofi

Phase 3

1 8

GSK 257049

GSK

Phase 3

2 9

Pneumococcal Vaccine

GSK

Phase 3

2 10

Infanrix

GSK

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

N/ARecruiting

Photobiomodulation

NCT06691269

Clinical

Trials by Indication[1]

Acute otitis media2 trials

Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media

Completed·OOtic Therapy, LLC·Phase 2·NCT02092454·65 enrolled

Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media

Completed·AArbor Pharmaceuticals, Inc.·Phase 2·NCT01588535·38 enrolled

Analgesia2 trials

Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn

Terminated·TTel-Aviv Sourasky Medical Center·Phase 1/2·NCT01274247·21 enrolled

Emla Cream Versus Benzocaine on Analgesia

Completed·—·Phase 1·NCT05060913·70 enrolled

Tics1 trial

Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis

Completed·UUniversity of Michigan·Phase 4·NCT01951820·64 enrolled

Toothache1 trial

Benzocaine Gel Toothache Dose-Response Study

Completed· Pfizer logo

Pfizer·Phase 4·NCT00474175·577 enrolled

Pharyngitis1 trial

Efficacy and Tolerability of Ambroxol Lozenge 20 mf in Relieving Pain of Sore Throat in Pat. With Acute/Viralpharyngitis

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 3·NCT00148499·751 enrolled

9 more indications

Metabolism1 trial

Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans

Completed·VVanderbilt University Medical Center·Phase 1·NCT02537314·27 enrolled

Photobiomodulation Therapy1 trial

Effectiveness of Laser Photobiomodulation Therapy in Reducing Child Pain During Local Anesthesia Injection

Unknown status·AAliaa Hamouda·N/A·NCT05861154·64 enrolled

Photobiomodulation1 trial

Photobiomodulation and Tooth Analgesia

Recruiting·UUniversity of Maryland, Baltimore·N/A·NCT06691269·200 enrolled

Pain Perception1 trial

Pre Injection Use of Cryoanesthesia Versus Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections

Completed·—·Phase 4·NCT06165432·60 enrolled

Satisfaction1 trial

Effects of Topical Lidocaine and Benzocaine on Pain Level and Injection Satisfaction

Completed·TTC Erciyes University·Phase 3·NCT07242157·60 enrolled

Efficacy and Safety1 trial

A Study to Determine the Efficacy and Safety of a Benzocaine Lozenge for Treatment of Sore Throat.

Completed·MMcNeil AB·Phase 3·NCT03432923·260 enrolled

Pain1 trial

Benzocaine Versus Placebo Spray for Pain Relief at Hysterosalpingogram

Completed·UUniversity of Pennsylvania·Phase 4·NCT01925469·30 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Efficacy1 trial

Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel

Unknown status·TThe University of Texas Health Science Center, Houston·Phase 4·NCT00846690·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 16 trial records for Benzocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Benzocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Benzocaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pfizer

Benzocaine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Trials by Indication[1]

Acute otitis media2 trials

Analgesia2 trials

Tics1 trial

Toothache1 trial

Pharyngitis1 trial

Metabolism1 trial

Photobiomodulation Therapy1 trial

Photobiomodulation1 trial

Pain Perception1 trial

Satisfaction1 trial

Efficacy and Safety1 trial

Pain1 trial

Blood Pressure1 trial

Efficacy1 trial

References

Drug Info

Quick Facts

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