Definity

ApprovedSmall molecule

MMicrovascular Therapeutics, LLC

Definity is one of 292 small molecule programs targeting Insulin resistance. It is currently in Approved.

Indications

Total Trials

Active Trials

291

Competitors

Pipeline

Status by Indication[3][1]

Indication

Insulin ResistanceActive, not recruiting

Coronary StenosisActive, not recruiting

Skin CancerActive, not recruiting

Compartment SyndromeActive, not recruiting

Aortic AneurysmActive, not recruiting

Acute Kidney InjuryActive, not recruiting

Breast CancerActive, not recruiting

Ovarian CancerActive, not recruiting

Type 1 DiabetesActive, not recruiting

Chronic Kidney DiseaseActive, not recruiting

Insulin ResistanceApproved

Active, not recruiting

Coronary StenosisPreclinical

Active, not recruiting

Skin CancerPhase 1

Active, not recruiting

Compartment SyndromePhase 2/Phase 3

Active, not recruiting

Aortic AneurysmPreclinical

Active, not recruiting

Acute Kidney InjuryPreclinical

Active, not recruiting

Breast CancerPhase 2

Active, not recruiting

Ovarian CancerPhase 1

Active, not recruiting

Type 1 DiabetesPreclinical

Active, not recruiting

Chronic Kidney DiseasePhase 2

Active, not recruiting

Showing 10 of 12 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Definity

MMicrovascular Therapeutics, LLC

Approved

2 2

Trodelvy

Gilead

Preclinical

37 3

Blenoxane

Bristol-Myers Squibb

Preclinical

1 4

Spravato

WWim Janssens

Preclinical

2 5

Nubain

AAultman Health Foundation

Preclinical

1 6

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 7

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 8

Zoladex

Luye Pharma Group Ltd.

Preclinical

8 9

QS21

MMemorial Sloan Kettering Cancer Center

Preclinical

3 10

Apatinib Mesylate

BBukwang Pharmaceutical

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 1Not yet recruiting

Soft Tissue Sarcoma

NCT07436364

Q3 2028

Phase 1Recruiting

Skin Cancer

NCT05620290

Q1 2029

Phase 2Recruiting

Breast Cancer

NCT06185972

Clinical

Trials by Indication[1]

Ultrasound3 trials

Cystic Breast Masses by Contrast Enhanced Ultrasound (CEUS)

Completed·UUniversity of Southern California··NCT02887937·135 enrolled

3-D Super Resolution Ultrasound Microvascular Imaging

Terminated·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT04136912·27 enrolled

Evaluation of Intra-operative Ultrasound Contrast Enhancement in the Evaluation of Liver Tumors

Terminated·UUniversity of Louisville·Phase 1·NCT00955097·6 enrolled

Breast Cancer2 trials

Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer

Recruiting·SSunnybrook Health Sciences Centre·Phase 2·NCT06185972·200 enrolled

Contrast Enhanced Ultrasound and Shear Wave Elastography in Measuring Response in Patients With Breast Cancer Receiving Chemotherapy Before Surgery

Terminated·UUniversity of Southern California·Phase 1·NCT02067884·34 enrolled

ESS2 trials

DEF-315 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY

Completed·LLantheus Medical Imaging·Phase 3·NCT03719612·160 enrolled

DEF-314 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY

Completed·LLantheus Medical Imaging·Phase 3·NCT03571672·153 enrolled

Renal Blood Flow1 trial

Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound

Unknown status·UUniversity of Virginia·Phase 1/2·NCT02672722·19 enrolled

Contrast Agent1 trial

Efficacy of Ultrasound Contrast Agent to Assess Renal Masses

Completed·UUniversity Health Network, Toronto·Phase 2·NCT01062178·167 enrolled

21 more indications

Cardiac1 trial

Noninvasive, Subharmonic Intra-Cardiac Pressure Measurement

Completed·TThomas Jefferson University·Phase 2·NCT03243942·56 enrolled

Coronary Stenosis1 trial

Detection of Coronary Stenosis With Intravenous Microbubbles

Withdrawn·UUniversity of Nebraska·N/A·NCT00580580

MPA1 trial

An Ascending Dose Comparison of MVT-100 to Definity in Healthy Volunteers

Completed·MMicrovascular Therapeutics, LLC·Phase 1/2·NCT03882359·16 enrolled

Intraoperative1 trial

Contrast Enhanced Intraoperative Ultrasound for Detection and Characterization of Renal Mass Undergoing Open Partial Nephrectomy

Completed·MM.D. Anderson Cancer Center·N/A·NCT01894607·11 enrolled

Heart1 trial

A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure

Completed·LLantheus Medical Imaging·Phase 4·NCT00918866·32 enrolled

Chronic Kidney Disease1 trial

A Study of Renal Microvessel Imaging for Chronic Kidney Disease

Enrolling by invitation·MMayo Clinic·Phase 2·NCT05764642·186 enrolled

Aortic Aneurysm1 trial

Evaluation of Contrast-Enhanced Ultrasound to Detect Endoleaks After Endovascular Aortic Aneurysm Repair

Completed·—··NCT01005212·20 enrolled

Trial1 trial

Academic-Industrial Partnership for Translation of Acoustic Angiography

Completed·UUNC Lineberger Comprehensive Cancer Center·Phase 4·NCT03544268·20 enrolled

Head and Neck Cancer1 trial

Novel MRI-Guided Ultrasound Stimulated Microbubble Radiation Treatment for Patients With Head and Neck Cancer

Unknown status·SSunnybrook Health Sciences Centre·Phase 1·NCT04431648·20 enrolled

Ovarian Cancer1 trial

Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary

Completed·IIcahn School of Medicine at Mount Sinai·Phase 1·NCT00626873·67 enrolled

Soft Tissue Sarcoma1 trial

Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy

Not yet recruiting·TThomas Jefferson University·Phase 1·NCT07436364·10 enrolled

Skin Cancer1 trial

MRI-Guided Focused Ultrasound Radiosensitization for Patients With Malignant Melanoma and Non Melanoma Skin Cancer

Recruiting·SSunnybrook Health Sciences Centre·Phase 1·NCT05620290·20 enrolled

Lymphedema1 trial

Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema

Completed·MMayo Clinic·Phase 1·NCT05613946·10 enrolled

Neoadjuvant Chemotherapy1 trial

Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy

Completed·SSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·N/A·NCT02115607·17 enrolled

Thrombolysis1 trial

Sonothrombolysis in Patients With STEMI

Completed·HHarald Becher·Phase 2·NCT03092089·15 enrolled

Insulin resistance1 trial

Neural Mechanism of Aldosterone-induced Insulin Resistance

Withdrawn·WWanpen Vongpatanasin·Phase 4·NCT02102243

Type 1 Diabetes1 trial

The Impact of Fitness on Vascular Dysfunction in Adolescents With Type 1 Diabetes

Completed·UUniversity of Virginia··NCT01337947·32 enrolled

Acute Kidney Injury1 trial

Evaluation of Renal Blood Flow Using Contrast Enhanced Ultrasound for Differential Diagnosis of Acute Kidney Injury in Cirrhotic Patients: A Pilot Study

Unknown status·UUniversity of Virginia·N/A·NCT02147470·25 enrolled

Prospective1 trial

A Prospective, Phase IV, Surveillance Registry Study to Evaluate the Safety of DEFINITY® in Clinical Practice

Completed·LLantheus Medical Imaging·Phase 4·NCT00625365·1,060 enrolled

Compartment Syndrome1 trial

Diagnosing Compartment Syndrome With SHAPE vs Elastography

Completed·TThomas Jefferson University·Phase 2/3·NCT05247541·15 enrolled

Alzheimer's Disease1 trial

Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound

Completed·—·N/A·NCT04118764·6 enrolled

Sources

References

[1]
ClinicalTrials.gov — 30 trial records for Definity. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Definity compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Definity. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Microvascular Therapeutics, LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: MMicrovascular Therapeutics, LLC

Definity

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q3 2028

Q1 2029

Trials by Indication[1]

Ultrasound3 trials

Breast Cancer2 trials

ESS2 trials

Renal Blood Flow1 trial

Contrast Agent1 trial

Cardiac1 trial

Coronary Stenosis1 trial

MPA1 trial

Intraoperative1 trial

Heart1 trial

Chronic Kidney Disease1 trial

Aortic Aneurysm1 trial

Trial1 trial

Head and Neck Cancer1 trial

Ovarian Cancer1 trial

Soft Tissue Sarcoma1 trial

Skin Cancer1 trial

Lymphedema1 trial

Neoadjuvant Chemotherapy1 trial

Thrombolysis1 trial

Insulin resistance1 trial

Type 1 Diabetes1 trial

Acute Kidney Injury1 trial

Prospective1 trial

Compartment Syndrome1 trial

Alzheimer's Disease1 trial

References

Drug Info

Quick Facts

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