Folfirinox

Phase 3Small molecule

Folfirinox is one of 206 small molecule programs targeting Pancreatic Ductal Adenocarcinoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

205

Competitors

Pipeline

Status by Indication[3][1]

Indication

Pancreatic Ductal AdenocarcinomaRecruiting

Colorectal CancerActive, not recruiting

Pancreatic CancerTerminated

Gastric CancerRecruiting

Gastric or Gastroesophageal Junction AdenocarcinomaRecruiting

Pancreas CancerActive, not recruiting

Metastatic Pancreatic CancerActive, not recruiting

Locally AdvancedUnknown status

NeoadjuvantActive, not recruiting

Metastatic Pancreatic Ductal AdenocarcinomaNot yet recruiting

Pancreatic Ductal AdenocarcinomaPhase 2

Recruiting

Colorectal CancerPhase 3

Active, not recruiting

Pancreatic CancerPhase 3

Terminated

Gastric CancerPhase 2

Recruiting

Gastric or Gastroesophageal Junction AdenocarcinomaPreclinical

Recruiting

Pancreas CancerPhase 2

Active, not recruiting

Metastatic Pancreatic CancerPhase 2

Active, not recruiting

Locally AdvancedPreclinical

Unknown status

NeoadjuvantPhase 2

Active, not recruiting

Metastatic Pancreatic Ductal AdenocarcinomaPhase 2

Not yet recruiting

Competition

Competitive Landscape

306 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

Folfirinox

PPhanes Therapeutics

Phase 3

23 2

Medrol

Pfizer

Preclinical

1 3

Byetta

AstraZeneca

Preclinical

1 4

Ayvakit Sprinkle

MMemorial Sloan Kettering Cancer Center

Preclinical

1 5

Xylocaine

MMEDRx USA, Inc.

Preclinical

1 6

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

1 8

Active Comparator

Moderna

Preclinical

1 9

Secretin-Ferring

Ferring

Preclinical

1 10

Sulfonylureas

Eli Lilly

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Gastric Cancer

NCT03825861

Q1 2027

Phase 2Active, not recruiting

Metastatic Pancreatic Cancer

NCT05360732

Q2 2027

Phase 2Active, not recruiting

Pancreatic Cancer

NCT03563248

Phase 2Recruiting

Pancreatic Ductal Adenocarcinoma

NCT05132504

Phase 2Active, not recruiting

Pancreas Cancer

NCT04594772

Q3 2027

Phase 1Recruiting

Pancreatic Adenocarcinoma

NCT03484299

Clinical

Trials by Indication[1]

Pancreatic Cancer23 trials

Neoadjuvant Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer (NORPACT-2)

Active, not recruiting·OOslo University Hospital··NCT04423731·251 enrolled

Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer

Recruiting·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT05462496·25 enrolled

Study of Modified FOLFIRINOX in Advanced Pancreatic Cancer

Completed·YYale University·Phase 2·NCT01523457·75 enrolled

Show 20 more trials

Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer

Terminated·UUniversity of Alabama at Birmingham·Phase 1·NCT03600623·25 enrolled

Losartan and Nivolumab in Combination With FOLFIRINOX and SBRT in Localized Pancreatic Cancer

Active, not recruiting·MMassachusetts General Hospital·Phase 2·NCT03563248·168 enrolled

NeoFOL-R Trial (Perioperative Versus Adjuvnat FOLFIRINOX in Resectable Pancreatic Cancer)

Recruiting·SSeoul National University Hospital·Phase 3·NCT05529940·609 enrolled

Study of Neoadjuvent Chemotherapy Followed by SBRT in Patients With Resectable and Borderline Resectable Pancreatic Cancer

Withdrawn·IIndiana University·Phase 2·NCT04130399

Effects of Folfirinox and Stereotactic Body Radiation Therapy for Advanced Pancreatic Cancer

Completed·UUniversity of Louisville·Phase 2·NCT02128100·5 enrolled

FOLFIRINOX for Unresectable Locally Advanced and Borderline Resectable Pancreatic Cancer

Terminated·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT01688336·9 enrolled

Timing of Start of systemIc Treatment for Asymptomatic Metastasized Pancreatic Cancer

Unknown status·—·Phase 3·NCT04897854·184 enrolled

FOLFIRINOX Followed by Ipilimumab With Pancreatic Tumor Vaccine in Treatment of Metastatic Pancreatic Cancer

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT01896869·83 enrolled

Observational Retrospective Study of Evaluation of Prognostic Factors in Advanced Pancreatic Cancer Patients Treated With FOLFIRINOX

Completed·AAzienda Ospedaliero, Universitaria Pisana··NCT03590275·343 enrolled

A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer

Unknown status·SSilenseed Ltd·Phase 2·NCT01676259·80 enrolled

First-line Metastatic Pancreatic Cancer : FOLFIRINOX +/- LV5FU2 in Maintenance Versus Firgem

Completed·FFederation Francophone de Cancerologie Digestive·Phase 2·NCT02352337·276 enrolled

Neoadjuvant Triple Therapy for (Borderline) Resectable Pancreatic Cancer (PREOPANC-5)

Recruiting·AAmsterdam UMC, location VUmc·Phase 1/2·NCT06384560·66 enrolled

Neoadjuvant FOLFIRINOX or Nab-paclitaxel With Gemcitabine for Borderline Resectable Pancreatic Cancer

Unknown status·NNagoya University·Phase 2·NCT02717091·50 enrolled

FOLFIRINOX + NIS793 in Pancreatic Cancer

Terminated·—·Phase 1·NCT05417386·4 enrolled

Phase II Study of Preoperative FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel in Patients With Resectable Pancreatic Cancer

Terminated·MMassachusetts General Hospital·Phase 2·NCT02243007·7 enrolled

Proton w/FOLFIRINOX-Losartan for Pancreatic Cancer

Unknown status·MMassachusetts General Hospital·Phase 2·NCT01821729·50 enrolled

Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer

Completed·PPancreatic Cancer Research Team·Phase 1/2·NCT01488552·60 enrolled

mFOLFIRINOX as Adjuvent Chemotherapy in Treating Chinese Pancreatic Cancer Patients

Recruiting·SSun Yat-sen University·Phase 2·NCT04084496·80 enrolled

Immunotherapy Study in Borderline Resectable or Locally Advanced Unresectable Pancreatic Cancer

Terminated·NNewLink Genetics Corporation·Phase 3·NCT01836432·302 enrolled

Phase II Study of Preoperative FOLFIRINOX Followed by Accelerated Short Course Radiation Therapy for Borderline-Resectable Pancreatic Cancer

Completed·MMassachusetts General Hospital·Phase 2·NCT01591733·48 enrolled

Pancreatic Adenocarcinoma6 trials

Pancreatic Adenocarcinoma Signature Stratification for Treatment

Completed·UUniversity Health Network, Toronto·Phase 2·NCT04469556·150 enrolled

Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma

Recruiting·UUniversity of Louisville·Phase 1·NCT03484299·20 enrolled

Study of FOLFIRINOX Electrochemotherapy in the Treatment of Pancreatic Adenocarcinoma

Withdrawn·TThe University of Texas Health Science Center, Houston·Phase 1·NCT02592395

Show 3 more trials

A Randomized Phase II/Genomic Trial of Two Chemotherapy Regimens in Patients With Resected Pancreatic Adenocarcinoma

Completed·—·Phase 2·NCT01839799·32 enrolled

Perioperative FOLFIRINOX for Patients With Resectable Pancreatic Adenocarcinoma: A Pilot Study

Terminated·UUniversity of Chicago·Phase 1·NCT02782182·1 enrolled

First Line Treatment of Patients With Metastatic Pancreatic Adenocarcinoma.

Completed·IInstitut du Cancer de Montpellier - Val d'Aurelle·Phase 1/2·NCT01964287·78 enrolled

Pancreatic Ductal Adenocarcinoma3 trials

A Study of the Safety and Tolerance of CAN04 in Combination With FOLFIRINOX in Subjects With Metastatic Pancreatic Ductal Adenocarcinoma

Completed·CCantargia AB·Phase 1·NCT04990037·25 enrolled

Eryaspase With Modified FOLFIRINOX in Advanced Pancreatic Ductal Adenocarcinoma

Completed·GGeorgetown University·Phase 1·NCT04292743·19 enrolled

Phase II Study of Neoadjuvant Folfirinox Chemotherapy Followed by Pembrolizumab Followed by Surgery for Patients With Localized, Resectable Adenocarcinoma of the Pancreas

Recruiting·BBaylor College of Medicine·Phase 2·NCT05132504·30 enrolled

Pancreatic Carcinoma2 trials

Pressure Enabled Drug Delivery By Pancreatic Retrograde Venous Infusion For Advanced Pancreatic Carcinoma

Withdrawn·RRoger Williams Medical Center·Phase 1·NCT04270929

A Phase II, Plateform Study, Open-label, Evaluating the Efficacy and Safety of Neoadjuvant Treatment in Patients With Surgically Resecable Pancreatic Adenocarcinoma

Not yet recruiting·GGustave Roussy, Cancer Campus, Grand Paris·Phase 2·NCT07808567·42 enrolled

Adenocarcinoma2 trials

Study Evaluating Efficacy and Safety of FFX Versus Combination of CPI-613 With mFFX in Patients With Metastatic Adenocarcinoma of the Pancreas

Completed·CCornerstone Pharmaceuticals·Phase 3·NCT03504423·528 enrolled

Pancreatic Tumor Cell Vaccine (GVAX), Cyclophosphamide, SBRT, and FOLFIRINOX in Patients With Resected Adenocarcinoma of the Pancreas

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT01595321·19 enrolled

19 more indications

Neoadjuvant2 trials

A Phase II Study of Neoadjuvant FOLFIRINOX

Completed·IIndiana University·Phase 2·NCT02178709·48 enrolled

CEND-1 in Combination with Neoadjuvant FOLFIRINOX with or Without Panitumumab

Active, not recruiting·AAnup Kasi·Phase 1/2·NCT05121038·50 enrolled

First-line Treatment1 trial

ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic Study

Completed·AAbility Pharmaceuticals SL·Phase 1/2·NCT04431258·150 enrolled

Gastric Cancer1 trial

Neoadjuvant FOLFIRINOX in the Treatment of Locally Advanced Gastric Cancer

Recruiting·IInstituto do Cancer do Estado de São Paulo·Phase 2·NCT03825861·27 enrolled

Nab-paclitaxel1 trial

Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

Recruiting·UUNC Lineberger Comprehensive Cancer Center·Phase 1/2·NCT06483555·104 enrolled

Cholangiocarcinoma1 trial

Second Line Chemotherapy FOLFIRINOX in Irresectable Cholangiocarcinoma

Completed·—·Phase 2·NCT02456714·30 enrolled

Total Neoadjuvant Therapy1 trial

Brazilian Total Neoadjuvant Therapy Trial

Unknown status·HHospital Israelita Albert Einstein·Phase 3·NCT05081687·150 enrolled

Metastasis1 trial

Systemic Chemotherapy Plus PD-1 for Metastasis ICC

Withdrawn·SSun Yat-sen University·Phase 2·NCT04398927

Gemcitabine1 trial

A Study of Neoadjuvant FOLFIRINOX and FDR-Gemcitabine With Concurrent IMRT in Patients

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT01661088·25 enrolled

Adjuvant Chemotherapy1 trial

The ADAPTA Study: ADjuvant chemotherAPy After Curative Intent resecTion of Ampullary Cancer.

Recruiting·FFondazione Poliambulanza Istituto Ospedaliero··NCT06068023·400 enrolled

Prospective1 trial

A Multicenter Prospective Phase II Study of Modified FOLFIRINOX for 1st Line Treatment for Advanced Urachus Cancer

Unknown status·—·Phase 2·NCT04611724·35 enrolled

Locally Advanced1 trial

Pancreatic Locally Advanced Irresectable Cancer Ablation

Unknown status·—·N/A·NCT03690323·228 enrolled

Sorafenib1 trial

HAIC of FOLFOX Plus Sorafenib vs HAIC of FOLFIRINOX Plus Sorafenib for Advcanced HCC

Unknown status·SSun Yat-sen University·Phase 2·NCT03812783·100 enrolled

Liver Metastases1 trial

Intensified Chemotherapy in CRC After Resection of Liver Metastases

Completed·IInstitut du Cancer de Montpellier - Val d'Aurelle·Phase 2/3·NCT00208260·124 enrolled

Neuroendocrine Carcinoma1 trial

FOLFIRINOX in Metastatic High Grade Gastroenteropancreatic Neuroendocrine Carcinomas

Terminated·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT03042780·2 enrolled

Metastatic Pancreatic Cancer1 trial

Redefining The Use Of A FOLFIRINOX-Like Regimen In the Front Line In Older Patients With Metastatic Pancreatic Cancer

Active, not recruiting·FFox Chase Cancer Center·Phase 2·NCT05360732·37 enrolled

Gastric or Gastroesophageal Junction Adenocarcinoma1 trial

A Phase 1/2, Open-Label, Dose Escalation and Expansion Study With PT886 Followed by a Multi-cohorT Study in Patients With Advanced Gastrointestinal Cancers, Including GastrIc, Gastroesophageal JuNction, Pancreatic Ductal or Biliary Tract AdEnocarcinomas of PT886, in Combination With ChemotherApy, Targeted Therapy, and/or an Immune ChecKpoint Inhibitor. The TWINPEAK Study

Recruiting·PPhanes Therapeutics·Preclinical·NCT05482893·350 enrolled

Pancreas Cancer1 trial

An Adaptive Approach to Neoadjuvant Therapy to Maximize Resection Rates for Pancreatic Adenocarcinoma: A Phase II Trial

Active, not recruiting·UUniversity of Cincinnati·Phase 2·NCT04594772·32 enrolled

Metastatic Pancreatic Ductal Adenocarcinoma1 trial

Efficacy and Safety of Serplulimab in Combination With Bevacizumab and FOLFIRINOX or NALIRIFOX as Second-Line Therapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma: An Open-Label, Single-Arm, Phase II Study

Not yet recruiting·SShanghai General Hospital, China·Phase 2·NCT07733050·34 enrolled

Colorectal Cancer1 trial

Tailoring the Decision for Adjuvant Chemotherapy Using Circulating Tumour DNA, in Patients With Stage III Colorectal Cancer

Active, not recruiting·UUNICANCER·Phase 3·NCT07340567·2,450 enrolled

Sources

References

[1]
ClinicalTrials.gov — 56 trial records for Folfirinox. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Folfirinox compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Folfirinox. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Phanes Therapeutics company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: PPhanes Therapeutics

Folfirinox

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q3 2027

Trials by Indication[1]

Pancreatic Cancer23 trials

Pancreatic Adenocarcinoma6 trials

Pancreatic Ductal Adenocarcinoma3 trials

Pancreatic Carcinoma2 trials

Adenocarcinoma2 trials

Neoadjuvant2 trials

First-line Treatment1 trial

Gastric Cancer1 trial

Nab-paclitaxel1 trial

Cholangiocarcinoma1 trial

Total Neoadjuvant Therapy1 trial

Metastasis1 trial

Gemcitabine1 trial

Adjuvant Chemotherapy1 trial

Prospective1 trial

Locally Advanced1 trial

Sorafenib1 trial

Liver Metastases1 trial

Neuroendocrine Carcinoma1 trial

Metastatic Pancreatic Cancer1 trial

Gastric or Gastroesophageal Junction Adenocarcinoma1 trial

Pancreas Cancer1 trial

Metastatic Pancreatic Ductal Adenocarcinoma1 trial

Colorectal Cancer1 trial

References

Drug Info

Quick Facts

Related News