Guideline Directed Medical Therapy

PreclinicalSmall molecule

Guideline Directed Medical Therapy is one of 69 small molecule programs targeting Ischemic Cardiomyopathy. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Ischemic CardiomyopathyActive, not recruiting

Ventricular TachycardiaActive, not recruiting

Heart FailureActive, not recruiting

Ischemic CardiomyopathyPreclinical

Active, not recruiting

Ventricular TachycardiaPreclinical

Active, not recruiting

Heart FailurePreclinical

Active, not recruiting

Competition

Competitive Landscape

687 competitors in Heart Failure

#DrugCompanyPhaseTrials

Bayer Aspirin

Bayer

Preclinical

2 2

Brethine

Sanofi

Preclinical

1 3

Medrol

Pfizer

Preclinical

1 4

Amidate

Pfizer

Preclinical

1 5

LCZ696

Novartis

Preclinical

15 6

Monoferric

PPharmacosmos A/S

Preclinical

5 7

Activase

Zemplar

Bystolic

VVitae Pharmaceuticals Inc., an Allergan affiliate

Preclinical

4 10

Savaysa

Daiichi Sankyo

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2028

N/ANot yet recruiting

Ischemic Cardiomyopathy

NCT07349979

Q2 2028

Post-ApprovalNot yet recruiting

Heart Failure

NCT07295522

Q4 2030

N/ARecruiting

Heart Failure

NCT04331769

Q4 2031

N/ARecruiting

Clinical Trial

NCT07433504

Clinical

Trials by Indication[1]

Heart Failure3 trials

Asses the Anti-inflammatory Effects of Short Term Copaxone Therapy on Patients the Acute Decompensated Heart Failure

Completed·HHadassah Medical Organization·Phase 2·NCT06003972·14 enrolled

Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?

Not yet recruiting·IIRCCS Policlinico S. Donato·Phase 4·NCT07295522·368 enrolled

Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

Recruiting·AAncora Heart, Inc.·N/A·NCT04331769·400 enrolled

Clinical Trial2 trials

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

Terminated·EEdwards Lifesciences·N/A·NCT03016975·12 enrolled

A Prospective, Multicenter, Randomized Controlled Clinical Trial of Transcatheter Tricuspid Valve Clipping Systems.

Recruiting·SShanghai Huihe Medical Technology Co., Ltd·N/A·NCT07433504·132 enrolled

Ventricular Tachycardia1 trial

Radiofrequency Ablation for Polymorphic Ventricular Tachycardia With Heart Failure (RFCA for PMVT-HF)

Completed·QQian Feng·N/A·NCT07130175·118 enrolled

Percutaneous Coronary Intervention1 trial

Impact of Potassium Competitive Acid Blockers After Percutaneous Coronary Intervention for Efficacy and Safety Outcome: Target Trial Emulation Study.

Recruiting·SSamsung Medical Center··NCT07068490·100,000 enrolled

Ischemic Cardiomyopathy1 trial

PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy

Not yet recruiting·NNanjing First Hospital, Nanjing Medical University·N/A·NCT07349979·654 enrolled

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for Guideline Directed Medical Therapy. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Guideline Directed Medical Therapy compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Guideline Directed Medical Therapy. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — IRCCS Policlinico S. Donato company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: IIRCCS Policlinico S. Donato

Guideline Directed Medical Therapy

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2028

Q2 2028

Q4 2030

Q4 2031

Trials by Indication[1]

Heart Failure3 trials

Clinical Trial2 trials

Ventricular Tachycardia1 trial

Percutaneous Coronary Intervention1 trial

Ischemic Cardiomyopathy1 trial

References

Drug Info

Quick Facts

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