Ifex
(ifosfamide)ApprovedSmall molecule
Ifosfamide is a chemotherapy drug used to treat various cancers including testicular cancer, lymphomas, and sarcomas. It works by damaging cancer cell DNA to prevent them from growing and dividing.[2] Ifex is currently approved and in use across 48 indications[4].[1]
Ifex is one of 501 small molecule programs targeting Lymphoma. It is currently in Approved.
48
Indications
309
Total Trials
22
Active Trials
500
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 47 indications
Competition
Competitive Landscape
401 competitors in Lymphoma
#DrugCompanyPhaseTrials
1Ifex
BBaxter Healthcare Corporation
Approved
Zofran
NovartisPreclinical
Norvir
AbbViePreclinical
Cabenuva
GSKPreclinical
Emend
CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Preclinical
Nuvigil
NNuvo Research GmbH
Preclinical
Elitek
AAzienda U.S.L. 1 di Massa e Carrara
Preclinical
Decadron
QQuince Therapeutics S.p.A.
Preclinical
Solu-Medrol
MMassachusetts Eye and Ear Infirmary
Preclinical
Systemic Therapy
Bristol-Myers SquibbPreclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Lymphoma43 trials
Show 40 more trials
Intensive Chemotherapy and Rituximab in the Treatment of Burkitt Lymphoma
Terminated·—·Phase 2·NCT00126191·10 enrolled
R-ICE and High-Dose Cyclophosphamide With PET/CT for Diffuse Large B-Cell Non-Hodgkin's Lymphoma
Terminated·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00809341·27 enrolled
Study of Combination of PIGEV Before Autologous Stem Cell Transplant in Patients With Hodgkin's Lymphoma
Unknown status·—·Phase 1·NCT01884428·24 enrolled
Soft Tissue Sarcoma23 trials
Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003212·780 enrolled
Show 20 more trials
Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma
Unknown status·EEuropean Paediatric Soft Tissue Sarcoma Study Group·Phase 3·NCT00334854·250 enrolled
Ph II Nintedanib vs. Ifosfamide in Soft Tissue Sarcoma
Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 2·NCT02808247·80 enrolled
Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00002641·350 enrolled
Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 1·NCT00030784·28 enrolled
Osteosarcoma13 trials
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Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma
Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00245011·11 enrolled
Germ Cell Tumor12 trials
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Acute Lymphoblastic Leukemia11 trials
Show 8 more trials
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia
Unknown status·—·Phase 3·NCT00764907·4,000 enrolled
50 more indications
Neuroblastoma7 trials
Show 4 more trials
Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas
Completed·—·Phase 2·NCT00165139·20 enrolled
Therapy Based on Stage of Disease and Risk Assessment in Treating Children With Neuroblastoma
Completed·—·Phase 3·NCT00002802·500 enrolled
Leukemia7 trials
Show 4 more trials
Rhabdomyosarcoma6 trials
Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma
Unknown status·EEuropean Paediatric Soft Tissue Sarcoma Study Group·Phase 3·NCT00379457·600 enrolled
Show 3 more trials
Stem Cell Transplantation5 trials
High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer
Completed·—·Phase 1·NCT00002854·33 enrolled
Breast Cancer4 trials
Show 1 more trial
Combination Chemotherapy in Treating Patients With Metastatic Breast Cancer
Completed·—·Phase 2·NCT00006260·36 enrolled
Ewing sarcoma4 trials
Diffuse Large B-Cell Lymphoma4 trials
R-ICE and Lenalidomide in Treating Patients With First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma
Active, not recruiting·—·Phase 1/2·NCT02628405·30 enrolled
Small Cell Lung Cancer4 trials
Radiation Therapy3 trials
Anaplastic Large Cell Lymphoma3 trials
Chemotherapy3 trials
Advanced Sarcoma2 trials
Bone Marrow Transplantation2 trials
Lung Cancer2 trials
Non-Small Cell Lung Cancer2 trials
Nasopharyngeal Carcinoma2 trials
Cervical Cancer2 trials
NeoAdjuvant Chemotherapy Followed by Radical Hysterectomy (OP) Versus Primary Chemo-RADiation in Cervical Cancer FIGO Stage IB2 and IIB
Unknown status·—·Phase 3·NCT02422563·534 enrolled
Newly Diagnosed2 trials
Ewing's Sarcoma2 trials
Refractory Solid Tumors2 trials
Recurrent or Refractory Solid Tumors1 trial
Hypofractionated Radiotherapy1 trial
Ifosfamide, Doxorubicin and Hypofractionated Radiotherapy in Neoadjuvant Sarcoma Treatment
Unknown status·—·Phase 2·NCT02812654·70 enrolled
Patients With Advanced Solid Tumors1 trial
Lymphoblastic Lymphoma1 trial
Malignant Peripheral Nerve Sheath Tumor1 trial
Squamous Cell Carcinoma1 trial
Malignant Solid Tumors1 trial
Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
Terminated·—·Phase 1/2·NCT00788125·7 enrolled
Advanced Malignancy1 trial
T-cell non-Hodgkin lymphoma1 trial
Neoadjuvant Chemotherapy1 trial
Pancreatic Cancer1 trial
Glioma1 trial
Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas
Unknown status·GGerman Society for Pediatric Oncology and Hematology GPOH gGmbH·Phase 3·NCT00278278·150 enrolled
Chronic Myelomonocytic Leukemia1 trial
Central Nervous System Germ Cell Tumor1 trial
Efficacy and Safety1 trial
Bladder Cancer1 trial
Testicular Cancer1 trial
Vomiting1 trial
Prognosis1 trial
Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients
Unknown status·FFondazione IRCCS Istituto Nazionale dei Tumori, Milano·Phase 2·NCT02099188·27 enrolled
B-cell Malignancies1 trial
Children1 trial
Advanced Solid Tumors1 trial
Unspecified1 trial
High-dose ICE With Amifostine
Completed·—·Phase 2·NCT00003657·24 enrolled
Regulatory
FDA Approval Timeline[5]
Dec 30, 1988
IFEX
NDA NDA019763
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Ifex drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for ifosfamide. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- BBaxter Healthcare Corporation