isolated perfusion

Phase 3Small molecule

NNational Cancer Institute (NCI)

isolated perfusion is one of 229 small molecule programs targeting Astrocytoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

228

Competitors

Pipeline

Status by Indication[3][1]

Indication

AstrocytomaActive, not recruiting

Lung CancerActive, not recruiting

Malignant GliomaActive, not recruiting

Liver CancerActive, not recruiting

Colorectal CancerActive, not recruiting

MelanomaActive, not recruiting

Soft Tissue SarcomaActive, not recruiting

AstrocytomaPhase 1

Active, not recruiting

Lung CancerPhase 1

Active, not recruiting

Malignant GliomaPhase 1/Phase 2

Active, not recruiting

Liver CancerPhase 2

Active, not recruiting

Colorectal CancerPhase 2

Active, not recruiting

MelanomaPhase 3

Active, not recruiting

Soft Tissue SarcomaPhase 3

Active, not recruiting

Competition

Competitive Landscape

949 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

isolated perfusion

NNational Cancer Institute (NCI)

Phase 3

4 2

Eylea

Regeneron

Preclinical

5 3

Emend IV

Andriol

1 5

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 6

Vascepa

AAmarin Pharma Inc.

Preclinical

1 7

Gas-X

PPortuguese Oncology Institute, Coimbra

Preclinical

1 8

Ketalar

AAultman Health Foundation

Preclinical

1 9

Xylocaine

MMEDRx USA, Inc.

Preclinical

1 10

Versed

CConrado Roberto Hoffmann Filho

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Colorectal Cancer4 trials

Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver

Unknown status·MMedical Research Council·Phase 3·NCT00002692·312 enrolled

Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Completed·UUNICANCER·Phase 2·NCT00006050

Isolated Hepatic Perfusion With Melphalan in Treating Patients With Unresectable Colorectal Cancer That Has Metastasized to the Liver

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT00089401·8 enrolled

Show 1 more trial

Isolated Hepatic Perfusion With Melphalan Followed by Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00103298

Liver Cancer3 trials

Hepatic Arterial Infusion With Melphalan in Treating Patients With Unresectable Liver Cancer

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00030082

Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT00019786·67 enrolled

Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer

Completed·DDelcath Systems Inc.·Phase 2·NCT00096083·56 enrolled

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00020007

2 more indications

Astrocytoma1 trial

IL-4(38-37)-PE38KDEL Immunotoxin in Treating Patients With Recurrent Malignant Astrocytoma

Unknown status·—·Phase 1·NCT00003842·30 enrolled

Malignant Glioma1 trial

Immunotoxin Therapy in Treating Patients With Malignant Glioma

Completed·NNew Approaches to Brain Tumor Therapy Consortium·Phase 1/2·NCT00006268

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for isolated perfusion. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — isolated perfusion compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for isolated perfusion. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — National Cancer Institute (NCI) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: NNational Cancer Institute (NCI)

isolated perfusion

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Colorectal Cancer4 trials

Liver Cancer3 trials

Melanoma1 trial

Soft Tissue Sarcoma1 trial

Lung Cancer1 trial

Astrocytoma1 trial

Malignant Glioma1 trial

References

Drug Info

Quick Facts

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