Gas-X

(Simethicone)

Phase 3Small molecule

Simethicone helps break up gas bubbles in your stomach and intestines to relieve bloating, pressure, and discomfort from excess gas.[1] Gas-X is currently being investigated across 6 indications[3], with its most advanced program in Phase 3.[1]

Gas-X is one of 152 small molecule programs targeting Dyspepsia. It is currently in Phase 3.

Indications

Total Trials

Active Trials

151

Competitors

Pipeline

Status by Indication[3][1]

Indication

DyspepsiaUnknown

Abdominal PainActive, not recruiting

Otitis MediaActive, not recruiting

Colorectal CancerActive, not recruiting

InfertilityActive, not recruiting

DyspepsiaPreclinical

Unknown

Abdominal PainPhase 2

Active, not recruiting

Otitis MediaPhase 2

Active, not recruiting

Colorectal CancerPreclinical

Active, not recruiting

InfertilityPhase 3

Active, not recruiting

Competition

Competitive Landscape

949 competitors in Colorectal Cancer

#DrugCompanyPhaseTrials

Gas-X

PPortuguese Oncology Institute, Coimbra

Phase 3

1 2

Eylea

Regeneron

Preclinical

5 3

Emend IV

PORTRAZZA

Ketalar

AAultman Health Foundation

Preclinical

1 6

Xylocaine

MMEDRx USA, Inc.

Preclinical

1 7

Versed

CConrado Roberto Hoffmann Filho

Preclinical

1 8

Ultiva

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 9

Bridion

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 10

Andriol

AAuxilium

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2029

Post-ApprovalRecruiting

Bariatric Surgery

NCT06812832

Clinical

Trials by Indication[1]

Simethicone9 trials

The Effects of Moviprep With Simethicone on Colonic Bubbles

Completed·TThomas Jefferson University·N/A·NCT01209806·140 enrolled

Small Volume Simethicone Before Gastroscopy: Any Benefit?

Completed·—·Phase 2/3·NCT02555228·54 enrolled

Effect of Simethicone on Eustachian Tube Dysfunction

Completed·UUniversity of Pittsburgh·Phase 2·NCT01312038·25 enrolled

Show 6 more trials

Ingestion of Simethicone After Capsule Ingestion and Its Impact on Quality of Video Capsule Endoscopy- a Pilot Study

Unknown status·—·N/A·NCT03166605·36 enrolled

Effect of Simethicone on Screening Colonoscopy

Completed·TTexas Tech University Health Sciences Center, El Paso·Phase 4·NCT03119168·268 enrolled

Effect of Simethicone on Reducing Bowel Interference During Tubal Resection

Completed·—·Phase 3·NCT03429621·120 enrolled

Pre-medication With N-acetylcysteine and Simethicone to Improve Mucosal Visibility During Gastroduodenoscopy

Completed·—·N/A·NCT05951712·800 enrolled

A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy Volunteers

Completed·MMcNeil AB·Phase 1·NCT04186936·48 enrolled

Does Simethicone Improve Operative Field in Gynecological Operations

Unknown status·—·Phase 3·NCT03009604·90 enrolled

Premedication1 trial

Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy

Completed·PPontificia Universidad Catolica de Chile·Phase 4·NCT01653171·230 enrolled

Pilot Study1 trial

Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation

Terminated·RRocky Mountain MS Research Group, LLC·Phase 4·NCT02217982·5 enrolled

Bariatric Surgery1 trial

Simethicone as Part of ERAS in Bariatric Surgery Patients

Recruiting·MMadigan Army Medical Center·Phase 4·NCT06812832·260 enrolled

Oral1 trial

Oral Iohexol for Fecal/Fluid Tagging for CT Colonography: A Study to Improve Image Quality by Preventing Colonic Bubbles

Completed·—·N/A·NCT01790139·84 enrolled

12 more indications

Probiotics1 trial

Infant Colic Treatment With Probiotics

Completed·MMónica Olivares Martín; PhD·Phase 2·NCT03467334·156 enrolled

Bowel Preparation1 trial

Evaluation of Oral Simethicone With Low Volume Polyethylene Glycol Bowel Preparation During Colonoscopy

Completed·—·Phase 3·NCT03410524·250 enrolled

Crying1 trial

Effects of Vivatlac Baby on Crying Behavior of Colicky Babies

Completed·—·Phase 2·NCT04487834·87 enrolled

Endoscopy1 trial

Gastric Preparation of Magnetic-controlled Capsule Endoscopy

Unknown status·—·Phase 2·NCT02846155·120 enrolled

Functional Bowel Disorder1 trial

Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders

Completed·AAbbott·Phase 3·NCT05175131·465 enrolled

Postoperative Ileus1 trial

Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery

Completed·MMcMaster University·Phase 4·NCT02161367·100 enrolled

Cognitive Functions1 trial

The Impact of Air Travel on Passenger Cognitive Functions

Unknown status·DDinara Zhumanbayeva·Phase 2/3·NCT04802785·50 enrolled

Randomized Controlled Trial1 trial

Simethicone and N-acetylcysteine in Upper Endoscopy - Prospective Double-blinded Randomized Controlled Trial

Completed·PPortuguese Oncology Institute, Coimbra·Phase 4·NCT02357303·300 enrolled

Efficacy1 trial

Efficacy of Matricariae Chamomilla L., Melissa Officinalis L. and Tyndallized Lactobacillus Acidophilus (H122) for Infantile Colics

Completed·FFederico II University·Phase 4·NCT02708238·180 enrolled

Effectiveness1 trial

The Effectiveness of Simethicone In Improving Visibility During Colonoscopy

Completed·RRamathibodi Hospital·Phase 4·NCT00615303·194 enrolled

Colorectal Cancer1 trial

Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening

Withdrawn·MMercyOne Des Moines Medical Center·N/A·NCT02523911

Unspecified1 trial

Effects of Multilac Baby on Fecal Calprotectin Levels of Colicky Babies

Unknown status·—·N/A·NCT04666324·100 enrolled

Sources

References

[1]
ClinicalTrials.gov — 25 trial records for Simethicone. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Simethicone compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Simethicone. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Portuguese Oncology Institute, Coimbra company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: PPortuguese Oncology Institute, Coimbra

Gas-X

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2029

Trials by Indication[1]

Simethicone9 trials

Premedication1 trial

Pilot Study1 trial

Bariatric Surgery1 trial

Oral1 trial

Probiotics1 trial

Bowel Preparation1 trial

Crying1 trial

Endoscopy1 trial

Functional Bowel Disorder1 trial

Postoperative Ileus1 trial

Cognitive Functions1 trial

Randomized Controlled Trial1 trial

Efficacy1 trial

Effectiveness1 trial

Colorectal Cancer1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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