Metadoxine

ApprovedSmall molecule

AAlcobra Ltd.

Metadoxine is one of 168 small molecule programs targeting Hepatic steatosis. It is currently in Approved.

Indications

Total Trials

Active Trials

167

Competitors

Pipeline

Status by Indication[3][1]

Indication

Hepatic SteatosisActive, not recruiting

Attention Deficit Hyperactivity DisorderActive, not recruiting

Alcoholic Fatty Liver DiseaseActive, not recruiting

Non-Alcoholic SteatohepatitisActive, not recruiting

Liver DiseaseActive, not recruiting

Hepatic SteatosisApproved

Active, not recruiting

Attention Deficit Hyperactivity DisorderPhase 1

Active, not recruiting

Alcoholic Fatty Liver DiseasePhase 2

Active, not recruiting

Non-Alcoholic SteatohepatitisPhase 3

Active, not recruiting

Liver DiseasePhase 2

Active, not recruiting

Competition

Competitive Landscape

221 competitors in Liver Disease

#DrugCompanyPhaseTrials

Metadoxine

AAlcobra Ltd.

Approved

1 2

Mounjaro

Eli Lilly

Phase 3

—3

Neurontin

VViatris Specialty LLC

Phase 3

1 4

Inderal

WWyeth-Lederle Vaccines

Phase 3

1 5

Viagra

VViatris Specialty LLC

Phase 3

1 6

Sandostatin

Sun Pharma

Phase 3

1 7

Neupogen

EEastern Cooperative Oncology Group

Promacta

3 9

Retatrutide

Ozempic

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Attention Deficit Hyperactivity Disorder2 trials

Study Comparing Two Doses of MG01CI and Placebo in Adults With Predominantly Inattentive Attention Deficit Hyperactivity Disorder

Completed·AAlcobra Ltd.·Phase 2·NCT01685281·36 enrolled

Efficacy Study of Metadoxine SR Formulation in Attention Deficit Hyperactivity Disorder (ADHD) Subjects

Completed·AAlcobra Ltd.·Phase 1·NCT00995085·43 enrolled

Liver Disease1 trial

A Novel Pharmacotherapy for Alcoholism and Alcohol Liver Disease

Completed·—·Phase 2·NCT01504295·38 enrolled

Non-Alcoholic Steatohepatitis1 trial

Clinical Trial to Evaluate the Efficacy of Metadoxine as a Therapy for Patients With Non-alcoholic Steatohepatitis

Withdrawn·HHospital General de Mexico·Phase 3·NCT02541045

Alcoholic Fatty Liver Disease1 trial

Efficacy and Safety of MG in the Patients With Alcoholic Fatty Liver Disease and Alcoholic Hepatitis

Completed·PPharmaKing·Phase 2·NCT02019056·90 enrolled

Hepatic steatosis1 trial

Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis

Unknown status·IInstituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran·Phase 4·NCT02051842·100 enrolled

3 more indications

Phase 11 trial

A Phase 1 Study to Assess Pharmacokinetics of Metadoxine (MG01CI) 1400 mg, Administered to Healthy Volunteers

Completed·AAlcobra Ltd.·Phase 1·NCT01933997·16 enrolled

Adolescent1 trial

Safety and Tolerability Study of Metadoxine Extended Release (MDX) (Previously Known as MG01CI) in PI-ADHD Adolescent Subjects

Completed·AAlcobra Ltd.·Phase 2·NCT02189772·83 enrolled

Attention Deficit Hyperactivity Disorder (ADHD)1 trial

Clinical Efficacy & Safety, of Metadoxine (MG01CI) Extended Release in Attention-Deficit Hyperactivity Disorder (ADHD)

Completed·AAlcobra Ltd.·Phase 2·NCT01243242·120 enrolled

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for Metadoxine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Metadoxine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Metadoxine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Alcobra Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: AAlcobra Ltd.

Metadoxine

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Attention Deficit Hyperactivity Disorder2 trials

Liver Disease1 trial

Non-Alcoholic Steatohepatitis1 trial

Alcoholic Fatty Liver Disease1 trial

Hepatic steatosis1 trial

Phase 11 trial

Adolescent1 trial

Attention Deficit Hyperactivity Disorder (ADHD)1 trial

References

Drug Info

Quick Facts

Related News