Phentolamine Mesylate

Phase 3Small molecule

NNovalar Pharmaceuticals, Inc.

Phentolamine Mesylate is one of 8 small molecule programs targeting Lidocaine. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

LidocaineCompleted

Sex DifferencesRecruiting

LidocainePreclinical

Completed

Sex DifferencesPhase 3

Recruiting

Competition

Competitive Landscape

7 competitors in Sex Differences

#DrugCompanyPhaseTrials

Inderal

Mylan Pharmaceuticals Inc

Phase 3

2 2

Bronitin Mist

LLongeveron Inc.

Approved

1 3

Phenylephrine Hydrochloride

Bayer

Phase 3

2 4

Phentolamine Mesylate

NNovalar Pharmaceuticals, Inc.

Phase 3

2 5

Alcohol

Astellas

Phase 1

2 6

Nipride

EExela Pharma Sciences, LLC.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

Phase 1Recruiting

Obesity

NCT05219799

Q4 2027

Post-ApprovalRecruiting

Sex Differences

NCT05997732

Clinical

Trials by Indication[1]

Sex Differences2 trials

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Completed·UUniversity of Alberta·N/A·NCT05525416·17 enrolled

Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

Recruiting·UUniversity of Alberta·Phase 4·NCT05997732·30 enrolled

Efficacy2 trials

Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Maxillary Procedures

Completed·NNovalar Pharmaceuticals, Inc.·Phase 3·NCT00309335·240 enrolled

Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Mandibular Procedures

Completed·NNovalar Pharmaceuticals, Inc.·Phase 3·NCT00309361·240 enrolled

Blood Pressure1 trial

Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage

Completed·TThe George Institute·N/A·NCT00226096·404 enrolled

Lidocaine1 trial

Reversing the Effects of 2% Lidocaine

Completed·—·N/A·NCT02861378·38 enrolled

Cardiovascular1 trial

A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems

Terminated·—·Phase 1·NCT03098680·18 enrolled

3 more indications

Safety and Efficacy1 trial

Study of NV-101 for Safety and Efficacy in Pediatric Dental Patients Undergoing Procedures

Completed·NNovalar Pharmaceuticals, Inc.·Phase 2·NCT00309322·150 enrolled

Erectile Dysfunction1 trial

Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00080808·111 enrolled

Obesity1 trial

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Recruiting·UUniversity of Missouri-Columbia·Phase 1·NCT05219799·72 enrolled

Sources

References

[1]
ClinicalTrials.gov — 10 trial records for Phentolamine Mesylate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Phentolamine Mesylate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Phentolamine Mesylate. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Novalar Pharmaceuticals, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: NNovalar Pharmaceuticals, Inc.

Phentolamine Mesylate

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q4 2027

Trials by Indication[1]

Sex Differences2 trials

Efficacy2 trials

Blood Pressure1 trial

Lidocaine1 trial

Cardiovascular1 trial

Safety and Efficacy1 trial

Erectile Dysfunction1 trial

Obesity1 trial

References

Drug Info

Quick Facts

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