Phenylephrine Hydrochloride

Phase 3Small molecule

Bayer

Phenylephrine Hydrochloride is one of 19 small molecule programs targeting Hypoxia. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

HypoxiaActive, not recruiting

Sex DifferencesRecruiting

HypoxiaPreclinical

Active, not recruiting

Sex DifferencesPhase 3

Recruiting

Competition

Competitive Landscape

20 competitors in Hypoxia

#DrugCompanyPhaseTrials

Actos

Takeda

Approved

1 2

Diamox

Teva

Approved

1 3

Zyrtec

KKenvue Brands

Approved

1 4

Inderal

WWyeth-Lederle Vaccines

Approved

1 5

Neptazane

WWyeth-Lederle Vaccines

Approved

2 6

Citicoline

UUniversity of Texas Southwestern Medical Center

Phase 3

1 7

Platinol

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 2

1 8

Phenylephrine Hydrochloride

Bayer

Phase 3

1 9

Nitrostat

VViatris Specialty LLC

Preclinical

1 10

Calcium

Eli Lilly

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Post-ApprovalRecruiting

Sex Differences

NCT05997732

Clinical

Trials by Indication[1]

Sex Differences2 trials

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Completed·UUniversity of Alberta·N/A·NCT05525416·17 enrolled

Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

Recruiting·UUniversity of Alberta·Phase 4·NCT05997732·30 enrolled

TED2 trials

Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED)

Completed· Bayer logo

Bayer·Phase 3·NCT00976209·331 enrolled

Safety Study Comparing Phenylephrine HCL Extended Release Tablets 30 mg and Placebo (Study CL2007-07)(P07529)(COMPLETED)

Completed· Bayer logo

Bayer·Phase 3·NCT00874120·116 enrolled

Hypoxia1 trial

Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.

Completed·UUniversity of Alberta·N/A·NCT05001048·14 enrolled

Vascular Function1 trial

The Impact of Carbon Monoxide and Altitude on Vascular Function

Completed·UUniversity of Alberta·N/A·NCT04928183·19 enrolled

Cardiovascular1 trial

A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems

Terminated·—·Phase 1·NCT03098680·18 enrolled

1 more indication

Hypotension1 trial

Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension

Completed·RRehman Medical Institute - RMI·Phase 4·NCT05348980·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 8 trial records for Phenylephrine Hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Phenylephrine Hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Phenylephrine Hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Bayer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Bayer

Phenylephrine Hydrochloride

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Trials by Indication[1]

Sex Differences2 trials

TED2 trials

Hypoxia1 trial

Vascular Function1 trial

Cardiovascular1 trial

Hypotension1 trial

References

Drug Info

Quick Facts

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