Platelet Rich Fibrin

Phase 3Biologic

GGovernment Dental College and Research Institute, Bangalore

Platelet Rich Fibrin is one of 110 biologic programs targeting Pain. It is currently in Phase 3.

Indications

Total Trials

Active Trials

109

Competitors

Pipeline

Status by Indication[3][1]

Indication

PeriodontitisRecruiting

Apical PeriodontitisNot yet recruiting

SurgeryCompleted

SurgicalUnknown status

ESSCompleted

Connective Tissue GraftCompleted

Endodontic TreatmentUnknown status

Platelet-Rich FibrinCompleted

Randomised Controlled TrialRecruiting

HealingCompleted

PeriodontitisPhase 2

Recruiting

Apical PeriodontitisPhase 3

Not yet recruiting

SurgeryPreclinical

Completed

SurgicalPreclinical

Unknown status

ESSPreclinical

Completed

Connective Tissue GraftPreclinical

Completed

Endodontic TreatmentPreclinical

Unknown status

Platelet-Rich FibrinPreclinical

Completed

Randomised Controlled TrialPhase 2

Recruiting

HealingPreclinical

Completed

Showing 10 of 11 indications

Competition

Competitive Landscape

51 competitors in ESS

#DrugCompanyPhaseTrials

Lexapro

AbbVie

Approved

7 2

Proamatine

Takeda

Approved

2 3

Quviviq

Idorsia Pharmaceuticals Ltd.

Approved

1 4

Darzalex

Johnson & Johnson

Phase 2

1 5

Platelet Rich Fibrin

GGovernment Dental College and Research Institute, Bangalore

Phase 3

1 6

Decadron

AAspen Global Incorporated

Phase 2

1 7

Revlimid

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 2

1 8

Kyprolis

VVirionyx Corporation Limited

Phase 2

1 9

Mineral Trioxide Aggregate

JJordan University of Science and Technology

Phase 3

2 10

Ritalin

Novartis

Phase 1

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

ApprovedNot yet recruiting

Apical Periodontitis

NCT06776289

Q2 2028

PreclinicalNot yet recruiting

Peri-Implant Mucosa Thickness

NCT07750756

Clinical

Trials by Indication[1]

Platelet-rich Fibrin4 trials

Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 4·NCT02369250·110 enrolled

Extraction and Socket Preservation Before Implant Placement Using Freezed Dried Allograft (FDBA) and Platelet-Rich Fibrin in Smokers

Completed·KKing Saud University·N/A·NCT05161455·40 enrolled

Platelet-rich Fibrin on Nerve Regeneration After Bilateral Sagittal Split Osteotomy

Unknown status·SShiraz University of Medical Sciences·N/A·NCT03159338·25 enrolled

Show 1 more trial

Effect of Injectable Platelet-rich Fibrin on the En Masse Retraction of Maxillary Anterior Teeth

Unknown status·—·N/A·NCT05608356·26 enrolled

Dental Implant2 trials

Impact of Biological Factors on Dental Implant

Not yet recruiting·—·N/A·NCT06037070·10 enrolled

Assessment of Keratinized Gingiva With and Without PRF Application in Patients With Dental Implant

Unknown status·UUniversity of Baghdad·Phase 3·NCT04864197·10 enrolled

Chronic Periodontitis2 trials

Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2·NCT02120872·90 enrolled

PLATELET RICH FIBRIN COMBINED WITH 1.2% ATORVASTATIN FOR TREATMENT OF INTRABONY DEFECTS IN CHRONIC PERIODONTITIS

Completed·GGovernment Dental College and Research Institute, Bangalore·Phase 2·NCT02119520·96 enrolled

Third Molar Surgery2 trials

Investigation of Effectiveness of Local Antibiotic With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo

Completed·CCeren Melahat Donmezer··NCT05678296·60 enrolled

Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar Surgery.

Completed·BBeste Erismen··NCT06262945·60 enrolled

Endodontic Treatment1 trial

Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents

Unknown status·NNahda University·N/A·NCT05517187·40 enrolled

20 more indications

Healing1 trial

ASSESSMENT OF SOFT TISSUE HEALING OVER IMMEDIATELY PLACED IMPLANT SEALED WITH PLATELETS RICH FIBRIN (PRF) VERSUS DIODE LASER

Completed·NNourhan M.Aly·N/A·NCT05517733·16 enrolled

ESS1 trial

Clinical and Radiographic Assessment of PRF Versus Lutein Placement

Completed·MMansoura University·N/A·NCT06358352·30 enrolled

Bone Graft1 trial

PRF and Bone Graft in Endodontic Surgeries

Completed·SSaraswati Dental College·Phase 4·NCT04377698·20 enrolled

Treatment1 trial

Evaluation of Platelets Rich Fibrin and Nanohydroxyapatite in the Treatment of Intrabony Defects

Completed·KKing Abdulaziz University·Phase 1·NCT02810548·60 enrolled

Soft Tissue Augmentation1 trial

Clinical Evaluation of Soft Tissue Augmentation Using CTG and PRF Around Immediately Placed Dental Implants Versus Immediate Implant Alone in Esthetic Zone .

Completed·AAbeer hassan sharafuddin·N/A·NCT03413553·20 enrolled

Quality of Life1 trial

The Effect of Periodontal Dressings and Various Materials on the Donor Site's Quality of Life After Free Gingival Graft Surgery

Recruiting·IIzmir Katip Celebi University·N/A·NCT06782035·36 enrolled

Completed·—·N/A·NCT06764732·45 enrolled

Periodontitis1 trial

3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV

Recruiting·MMahsa University·Phase 2·NCT07293962·14 enrolled

Pain1 trial

Platelet Rich Fibrin VS Hyaloronic Acid in Management of Pain After Harvesting a Free Gingival Graft

Unknown status·Mmostafa soliman·N/A·NCT03814707·26 enrolled

Antibiotics1 trial

Comparison The Postoperative Effects of Local and Systemic Antibiotics Applied With Platelets Rich Fibrin

Completed·CCeren Melahat Donmezer··NCT04989127·75 enrolled

Stress urinary incontinence1 trial

Comparison Between Two Techniques in Treatment of Female Stress Urinary Incontinence

Completed·KKafrelsheikh University·Phase 3·NCT07366762·40 enrolled

Connective Tissue Graft1 trial

Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment

Completed·KKırıkkale University·N/A·NCT02397122·40 enrolled

Randomised Controlled Trial1 trial

Evaluation of Effect of Platelet-Rich Fibrin on Orthodontic Tooth Movement: a Split Mouth Randomised Controlled Trial

Recruiting·—·Phase 1/2·NCT06634017·15 enrolled

Thin Gingival Phenotype1 trial

Comparative Efficacy of Injectable Platelet-Rich Fibrin Versus Hyaluronic Acid for Gingival Phenotype Modification: A Randomized Split-Mouth Clinical Trial

Completed·UUniversity of Yaounde 1·Preclinical·NCT07879534·11 enrolled

Peridontal Disease1 trial

Comparative Evaluation of the Regenerative Potential of Platelet- Rich Fibrin (PRF) and Emdogain® in the Surgical Treatment of Class II Furcation Defects of Mandibular Molars

Completed·MMedical University of Sofia·Preclinical·NCT07841301·21 enrolled

Peri-implant Mucosa Thickness1 trial

Hyaluronic Acid Versus I-PRF Combined With Microneedling for Peri Implant Soft Tissue Enhancement: A Randomized Controlled Clinical Trial

Not yet recruiting·AAin Shams University·Preclinical·NCT07750756·42 enrolled

Apical Periodontitis1 trial

Endodontic Microsurgery With and Without Platelet-Rich Fibrin

Not yet recruiting·MMark Schachman·Approved·NCT06776289·20 enrolled

Unspecified1 trial

Bioactive Glass and Platelet Rich Fibrin in Intrabony Defects

Completed·—·Phase 3·NCT02982681·10 enrolled

Sources

References

[1]
ClinicalTrials.gov — 31 trial records for Platelet Rich Fibrin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Platelet Rich Fibrin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Platelet Rich Fibrin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Government Dental College and Research Institute, Bangalore company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Biologic[2]
Highest Phase: Phase 3[1]
Company: GGovernment Dental College and Research Institute, Bangalore

Platelet Rich Fibrin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q2 2028

Trials by Indication[1]

Platelet-rich Fibrin4 trials

Dental Implant2 trials

Chronic Periodontitis2 trials

Third Molar Surgery2 trials

Endodontic Treatment1 trial

Healing1 trial

ESS1 trial

Bone Graft1 trial

Treatment1 trial

Soft Tissue Augmentation1 trial

Quality of Life1 trial

Mineral Trioxide Aggregate1 trial

Surgical1 trial

Surgery1 trial

Periodontitis1 trial

Pain1 trial

Antibiotics1 trial

Stress urinary incontinence1 trial

Connective Tissue Graft1 trial

Randomised Controlled Trial1 trial

Thin Gingival Phenotype1 trial

Peridontal Disease1 trial

Peri-implant Mucosa Thickness1 trial

Apical Periodontitis1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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