Silver Diamine Fluoride

Phase 3Small molecule

TThe University of Hong Kong

Silver Diamine Fluoride is one of 42 small molecule programs targeting Indirect Pulp Cap. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Indirect Pulp CapUnknown status

Primary TeethCompleted

Silver Diamine FluorideUnknown status

EffectivenessRecruiting

Indirect Pulp CapPreclinical

Unknown status

Primary TeethPreclinical

Completed

Silver Diamine FluoridePhase 3

Unknown status

EffectivenessPhase 3

Recruiting

Competition

Competitive Landscape

76 competitors in Effectiveness

#DrugCompanyPhaseTrials

Kesimpta

Novartis

Phase 3

2 2

Mounjaro

Eli Lilly

Phase 3

1 3

Actos

Takeda

Phase 3

1 4

Elucirem

GGuerbet

Phase 3

1 5

Nicotine Free Cigarettes

Pfizer

Phase 3

3 6

Lidocain

Bayer

Phase 3

1 7

Botulinum Toxin a

GSK

Phase 3

1 8

Pneumococcal Conjugate Vaccine

Novartis

Phase 3

1 9

Droxia

TTheravia

Phase 2

9 10

Temodar

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Phase 2Active, not recruiting

Silver Diamine Fluoride

NCT06241261

Q4 2028

Phase 2Active, not recruiting

Silver Diamine Fluoride

NCT07455604

Clinical

Trials by Indication[1]

Silver Diamine Fluoride21 trials

Comparison of the Salivary Levels of Streptococcus Mutans in Pediatric Patients With Early Childhood Caries After the Application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish

Withdrawn·YYale University·Phase 1·NCT03089567

Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults

Unknown status·UUniversity of New England·Phase 1·NCT04255251·200 enrolled

Effectiveness of Nano-silver Fluoride and Silver Diamine Fluoride for Arresting Early Childhood Caries

Completed·—·N/A·NCT05255913·360 enrolled

Show 18 more trials

Clinical and Radiographic Evaluation of Deep Occlusal Carious Molars Treated With Partial Caries Removal With and Without Using Silver Diamine Fluoride (SDF) Prior to Resin Composite Restoration.

Unknown status·—·Phase 1·NCT04561934·40 enrolled

Staining Potential and Caries Arresting Effect of Silver Diamine Fluoride⁄Potassium Iodide and Silver Diamine Fluoride

Unknown status·—·Phase 4·NCT04196829·15 enrolled

Effectiveness of Silver Diamine Fluoride as Cavity Disinfectant After Atraumatic Restorative Treatment in Primary Teeth

Completed·NNourhan M.Aly·Phase 2·NCT03855527·60 enrolled

Treatment of Primary Molars With Deep Caries Using Silver Diamine Fluoride

Unknown status·—·Phase 4·NCT03563534·20 enrolled

Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children

Not yet recruiting·OOctober University for Modern Sciences and Arts·N/A·NCT07382245·60 enrolled

Comparison of Cariostatic Effect of Nano-Silver Fluoride Versus Silver Diamine Fluoride

Active, not recruiting·—·Phase 1·NCT05941429·78 enrolled

Silver Diamine Fluoride/ Potassium Iodide in Indirect Pulp Capping of Young Permanent Molars

Completed·NNourhan M.Aly·Phase 2/3·NCT04236830·108 enrolled

The Anticariogenic Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish

Completed·—·Phase 1·NCT06316323·49 enrolled

Discoloration of Carious Primary Teeth After Application of Silver Diamine Fluoride Versus Sodium Fluoride Varnish

Unknown status·—·Phase 4·NCT03557996·42 enrolled

Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel

Active, not recruiting·TThe University of Hong Kong·Phase 2·NCT06241261·630 enrolled

Preventing Early Childhood Caries With a Silver Diamine Fluoride Gel

Active, not recruiting·TThe University of Hong Kong·Phase 2·NCT07455604·1,500 enrolled

Arrest of Interproximal Caries Lesion With 38% Silver Diamine Fluoride Solution

Completed·PPostgraduate Institute of Dental Sciences Rohtak·Phase 3·NCT05791669·45 enrolled

Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers

Unknown status·TThe University of Hong Kong·N/A·NCT03185104·196 enrolled

Silver Diamine Fluoride After Minimal Caries Removal Technique in Asymptomatic Young Permanent Teeth With Deep Caries

Unknown status·—·Phase 4·NCT03568474·40 enrolled

Efficacy of Silver Diamine Fluoride and Its Parental Perception

Suspended·UUniversity of Baghdad·Phase 2/3·NCT04213573·60 enrolled

Evaluation Of Fluoride Uptake By Dentine Following Silver Diamine Fluoride Under Resin Modified Glass Ionomer Restoration In Carious Primary Molars

Completed·—·Phase 4·NCT04777968·20 enrolled

Silver Diamine Fluoride in Preventing Occlusal Caries in Primary Teeth

Unknown status·TThe University of Hong Kong·Phase 2/3·NCT05084001·769 enrolled

Clinical Effectiveness and Parental Acceptance of Silver Diamine Fluoride in Preschool Children: A Non-randomized Trial

Completed·—·N/A·NCT06293547·48 enrolled

Carious Primary3 trials

Application of SDF Verses NaF Varnish in Treatment of Carious Primary Teeth

Unknown status·—·Phase 4·NCT03554980·46 enrolled

Parental Satisfaction of Hall Technique Versus SDF in the Management of Carious Primary Molars

Unknown status·—·N/A·NCT05249231·22 enrolled

The Efficiency and Gingival Health Status of Hall Versus SDF Techniques in the Management of Carious Primary Molars

Unknown status·SSarah Abdalla Ibrahim Abdalla·Phase 3·NCT04889196·40 enrolled

Primary Teeth2 trials

The Antibacterial Effect of Nanosilver Fluoride on Primary Teeth

Terminated·NNour Ammar, BDS·Phase 3·NCT05221749·50 enrolled

SDF With or Without Fluoride Varnish for Caries Arrest in Primary Teeth of Young Children

Completed·BBeaty Dent·N/A·NCT07153328·104 enrolled

Early Childhood Caries2 trials

Early Childhood Caries in Jordanian Children

Completed·KKing Abdullah University Hospital·N/A·NCT05748054·159 enrolled

Effect Of Silverdiamine Fluoride Gel, Sodium Fluoride With CPP-ACP, APF On Early Childhood Caries - A Randomised Controlled Trial

Completed·UUniversity of Jazan·Phase 2·NCT07371117·90 enrolled

Adult1 trial

Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults

Completed·TThe University of Hong Kong·Phase 2/3·NCT02360124·323 enrolled

6 more indications

Fluoride1 trial

Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas

Completed·TThe University of Hong Kong·Phase 2/3·NCT02742142·534 enrolled

Effectiveness1 trial

SDF Effectiveness on Arresting Caries in Children

Recruiting·UUmm Al-Qura University·Phase 4·NCT05872542·60 enrolled

Post Operative Pain1 trial

Post-operative Pain and Child Behavior of Hall Technique Versus SDF in the Management of Carious Primary Molars: RCT

Unknown status·NNoura Mohamed Alhosaini·Phase 3·NCT04794426·40 enrolled

Children1 trial

Pharmacokinetics of Advantage Arrest in Children

Completed·AAdvantage Silver Dental Arrest, LLC·Phase 2·NCT04186663·59 enrolled

Indirect Pulp Cap1 trial

Comparing Two Indirect Pulp Capping Agents for Permanent Teeth

Unknown status·—·N/A·NCT05425368·30 enrolled

Cavities of Teeth1 trial

Phase III RCT of the Effectiveness of Silver Diamine Fluoride in Arresting Cavitated Caries Lesions

Terminated·UUniversity of Michigan·Phase 3·NCT03649659·830 enrolled

Sources

References

[1]
ClinicalTrials.gov — 35 trial records for Silver Diamine Fluoride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Silver Diamine Fluoride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Silver Diamine Fluoride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — The University of Hong Kong company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TThe University of Hong Kong

Silver Diamine Fluoride

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Q4 2028

Trials by Indication[1]

Silver Diamine Fluoride21 trials

Carious Primary3 trials

Primary Teeth2 trials

Early Childhood Caries2 trials

Adult1 trial

Fluoride1 trial

Effectiveness1 trial

Post Operative Pain1 trial

Children1 trial

Indirect Pulp Cap1 trial

Cavities of Teeth1 trial

References

Drug Info

Quick Facts

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