Nicotine free cigarettes

Phase 3Small molecule

Nicotine free cigarettes is one of 209 small molecule programs targeting Nicotine Dependence. It is currently in Phase 3.

Indications

Total Trials

Active Trials

208

Competitors

Pipeline

Status by Indication[3][1]

Indication

Nicotine DependenceRecruiting

Joint Replacement SurgeryCompleted

ChildrenRecruiting

RelapseCompleted

ESSRecruiting

Tobacco UseRecruiting

SmokingRecruiting

EffectivenessRecruiting

Music InterventionNot yet recruiting

LiverActive, not recruiting

Nicotine DependencePhase 1

Recruiting

Joint Replacement SurgeryPreclinical

Completed

ChildrenPreclinical

Recruiting

RelapsePreclinical

Completed

ESSPreclinical

Recruiting

Tobacco UsePhase 3

Recruiting

SmokingPhase 3

Recruiting

EffectivenessPhase 3

Recruiting

Music InterventionPreclinical

Not yet recruiting

LiverPreclinical

Active, not recruiting

Showing 10 of 11 indications

Competition

Competitive Landscape

73 competitors in Effectiveness

#DrugCompanyPhaseTrials

Kesimpta

Novartis

Phase 3

2 2

Mounjaro

Eli Lilly

Phase 3

1 3

Actos

Takeda

Phase 3

1 4

Botulinum Toxin a

GSK

Phase 3

1 5

Droxia

TTheravia

Phase 2

9 6

Nicotine free cigarettes

Pfizer

Phase 3

3 7

Temodar

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

1 8

Welireg

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 2

1 9

Haldol

DDePuy Orthopaedics

Phase 2

1 10

Pneumococcal Conjugate Vaccine

Novartis

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Post-ApprovalRecruiting

Tobacco Use

NCT07148232

Q3 2027

N/ARecruiting

ESS

NCT05628389

Phase 1Recruiting

Nicotine Dependence

NCT07007195

Q4 2027

ApprovedActive, not recruiting

Smoking Cessation

NCT03315910

Post-ApprovalRecruiting

Smoking Cessation

NCT06832085

Phase 2Recruiting

Smoking Cessation

NCT05723588

Clinical

Trials by Indication[1]

Smoking Cessation28 trials

Mood and Smoking: A Comparison of Smoking Cessation Treatments

Completed·UUS Department of Veterans Affairs·N/A·NCT00075972·128 enrolled

Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study

Completed·JJohns Hopkins University·N/A·NCT01943994·82 enrolled

Determinants of Smoking Cessation Among Latinos

Completed·MM.D. Anderson Cancer Center·N/A·NCT01008748·200 enrolled

Show 25 more trials

Financial Incentives for Smoking Cessation Among Mothers

Completed·UUniversity of Vermont·N/A·NCT05740098·198 enrolled

D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS)

Terminated·MMclean Hospital·Phase 1/2·NCT01842334·22 enrolled

Jail-Based Use of Smoking Cessation Treatment Study

Completed·HHennepin Healthcare Research Institute·N/A·NCT03799315·66 enrolled

A Smoking Cessation Intervention for Yale Dining Employees

Completed·YYale University·Phase 4·NCT02562521·25 enrolled

Contingency Management for Smoking Cessation in Homeless Smokers

Completed·—·N/A·NCT01789710·25 enrolled

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

Recruiting·VVA Office of Research and Development·Phase 2·NCT05723588·50 enrolled

Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants

Completed·NNYU Langone Health·Phase 4·NCT03187730·410 enrolled

Smoking Cessation Using Motivational Therapy and Varenicline

Completed·PPhilip Diaz·N/A·NCT00701896·294 enrolled

Smoking Cessation for Depressed Smokers

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 1/2·NCT00494728·91 enrolled

Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation

Recruiting·TThe University of Hong Kong·N/A·NCT06931054·270 enrolled

What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes?

Unknown status·UUniversity of Bristol··NCT02681848·180,000 enrolled

Testing Integrative Smoking Cessation for HIV Patients

Completed·UUniversity of Miami·Phase 4·NCT05030766·95 enrolled

Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)

Completed·VVA Office of Research and Development·Phase 4·NCT04135937·12 enrolled

Chinese Community Smoking Cessation Project

Completed·UUniversity of California, San Francisco·N/A·NCT00139516

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

Completed·GGeorgia State University·N/A·NCT04965181·504 enrolled

Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation

Recruiting·OOttawa Heart Institute Research Corporation·Phase 4·NCT06832085·150 enrolled

Post-Discharge Smoking Cessation Strategies: Helping HAND 4

Completed·MMassachusetts General Hospital·Phase 4·NCT03603496·1,416 enrolled

Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers

Completed·MMark Vander Weg·N/A·NCT00113074·139 enrolled

CPT and Smoking Cessation

Completed·VVA Office of Research and Development·Phase 2/3·NCT01901848·69 enrolled

Effect of Smoking Cessation on Clinical and Microbiological Outcomes of the Non-surgical Periodontal Therapy

Completed·CClaudio Mendes Pannuti·N/A·NCT02744417·63 enrolled

Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer

Completed·WWake Forest University Health Sciences·Phase 1·NCT01457469·6 enrolled

In-patient Smoking Cessation Intervention Using Counseling, Spirometry and Nicotine Replacement Therapy

Unknown status·SSoroka University Medical Center·N/A·NCT02470923·90 enrolled

Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan

Not yet recruiting·SStrategic Health Research Limited·N/A·NCT06063421·438 enrolled

Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers

Completed·UUniversity of Kansas Medical Center·Phase 3·NCT02148445·398 enrolled

Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites

Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Approved·NCT03315910·807 enrolled

Smoking5 trials

Stop Smoking Therapy for Ontario Patients

Completed·CCentre for Addiction and Mental Health·N/A·NCT00352781·1,767 enrolled

PMCAN for Smokers at Smoking Hotspots

Completed·TThe University of Hong Kong·N/A·NCT02935231·32 enrolled

Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)

Completed·CCentre for Addiction and Mental Health·N/A·NCT00356993·6,009 enrolled

Show 2 more trials

Quit Smoking Study for People Who Use E-Cigarettes

Completed·UUniversity of Vermont·Phase 2·NCT04946825·396 enrolled

Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

Recruiting·DDuke University·Approved·NCT07089901·600 enrolled

Effectiveness3 trials

Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects

Recruiting·NNational Institute of Respiratory Diseases, Mexico·Phase 4·NCT06254001·134 enrolled

Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy

Completed·LLoma Linda University·Phase 4·NCT04126135·1,307 enrolled

Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO)

Terminated·UUniversity of Oklahoma·Phase 2·NCT03722966·34 enrolled

Pilot Study3 trials

The PROMPT Pilot Study

Completed·OOttawa Hospital Research Institute·N/A·NCT03626064·80 enrolled

Pilot Study of a New Nicotine Replacement Therapy

Completed·MMcNeil AB·Phase 2·NCT00764439·258 enrolled

A Pilot Study Evaluating Nicotine Lozenges and Self Help

Completed·MMayo Clinic·Phase 2·NCT00888459·60 enrolled

Treatment3 trials

Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers

Completed·UUniversity of Kansas Medical Center·Phase 4·NCT02244918·278 enrolled

STARS (Smoking Treatment And Remote Sampling) Study

Completed·MMedical University of South Carolina·Phase 1/2·NCT04525755·652 enrolled

Changing the Default for Tobacco Treatment

Completed·UUniversity of Kansas Medical Center·Phase 4·NCT02721082·1,000 enrolled

29 more indications

Nicotine Dependence3 trials

TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence

Completed·TThe Mind Research Network·N/A·NCT02534454·86 enrolled

End Nicotine Dependence Clinic

Completed·—·Phase 1·NCT03290430·56 enrolled

An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation

Recruiting·UUniversity of Houston·Phase 1·NCT07007195·132 enrolled

Schizophrenia2 trials

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 4·NCT00307203·51 enrolled

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

Completed·—·Phase 4·NCT02420015·35 enrolled

Tobacco Use2 trials

Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness

Recruiting·UUniversity of California, San Francisco·Phase 4·NCT07148232·150 enrolled

Tobacco Use Treatment in Cancer Patients

Completed·UUniversity of Florida·Phase 4·NCT03482583·90 enrolled

Cardiovascular Disease2 trials

Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk

Unknown status·UUniversity of California, Los Angeles·N/A·NCT01705951·100 enrolled

The Canadian HIV Quit Smoking Trial: Tackling the Co-morbidities of Depression and Cardiovascular Disease in HIV+ Smokers

Unknown status·OOttawa Hospital Research Institute·Phase 3·NCT01800019·256 enrolled

Tobacco2 trials

Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV)

Completed·—·Phase 2/3·NCT02797587·400 enrolled

Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties

Completed·UUniversity of Oklahoma·Phase 2·NCT05095779·165 enrolled

ESS2 trials

Phone Enabled Implementation of Cessation Support

Recruiting·UUniversity of Florida·N/A·NCT05628389·1,500 enrolled

"EASY EFFECTIVE SMOKELESS" With NICORETTE®

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT01323491·184 enrolled

Psychiatric Disorder2 trials

Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders

Completed· Pfizer logo

Pfizer·Phase 4·NCT01456936·8,144 enrolled

Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

Completed· Pfizer logo

Pfizer·Phase 4·NCT01574703·4,595 enrolled

Smokers1 trial

Risk Perception Among Quitting Smokers

Unknown status·MM.D. Anderson Cancer Center··NCT00384696·220 enrolled

Children1 trial

The "Quit-for-Kids" Project: to Increase Abstinence and Protect Children from Tobacco Smoke Exposure

Recruiting·TThe University of Hong Kong·N/A·NCT06127589·1,200 enrolled

Craving1 trial

Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving

Completed·—·Phase 1·NCT01329614·40 enrolled

Metabolism1 trial

Metabolism Informed Smoking Treatment: The MIST RCT

Completed·VVanderbilt-Ingram Cancer Center·Phase 3·NCT04590404·606 enrolled

Smoking Reduction1 trial

Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

Completed·UUniversity of Texas at Austin·Phase 1·NCT01944423·53 enrolled

Tobacco Dependence1 trial

Optimizing Tobacco Dependence Treatment in the Emergency Department

Completed·YYale University·Phase 3·NCT02896400·1,056 enrolled

Joint Replacement Surgery1 trial

Preventing Smoking Relapse After Total Joint Replacement Surgery

Completed·NNYU Langone Health·N/A·NCT03673228·21 enrolled

Acceptability1 trial

Acceptability of Less Harmful Alternatives to Cigarettes

Completed·RRoswell Park Cancer Institute·N/A·NCT00957424·67 enrolled

Withdrawal1 trial

Effects of EVT 302 With or Without NRT on Craving and Withdrawal in Healthy Male Smokers Deprived of Cigarettes

Completed·EEvotec Neurosciences GmbH·Phase 2·NCT00622752·90 enrolled

Smokeless Tobacco1 trial

Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

Completed·MMayo Clinic·Phase 2/3·NCT00939029·52 enrolled

Cannabis Dependence1 trial

Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence

Completed·MMclean Hospital·Phase 2·NCT01292642·12 enrolled

Randomized Controlled Trial1 trial

Randomized Controlled Trial of Mailed Nicotine Replacement Therapy to Canadian Smokers

Completed·CCentre for Addiction and Mental Health·Phase 4·NCT01429129·1,000 enrolled

Liver1 trial

Feasibility of Delivering VergeRx at FQHCs

Active, not recruiting·UUniversity of Virginia·N/A·NCT06161675·100 enrolled

Pulmonary Tuberculosis1 trial

Intensive Smoking-cessation Intervention Versus Smoking-cessation Advice in Smear-positive Patients With Pulmonary Tuberculosis

Completed·—·Phase 3·NCT01517022·800 enrolled

Relapse1 trial

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

Completed·—·N/A·NCT01990079·15 enrolled

Music Intervention1 trial

The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.

Not yet recruiting·PPoitiers University Hospital·N/A·NCT07412717·80 enrolled

Cycloserine1 trial

Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers

Withdrawn·NNew York State Psychiatric Institute·Phase 2·NCT01907594

Nicotine Withdrawal1 trial

Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients

Not yet recruiting·CChiao-Chiao Liao·N/A·NCT07466875·60 enrolled

MPA1 trial

Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00777569·66 enrolled

Obesity1 trial

A Randomized Controlled Trial of Once-Weekly Semaglutide for Limiting Post-Smoking Cessation Weight Gain in Adult Smokers With Overweight/Obesity

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 2·NCT06173778·197 enrolled

Breast Cancer1 trial

Pilot Study in Cancer Patients Scheduled for Surgery Evaluating Different Smoking Cessation Protocols : Nicotine Replacement (NRT), Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy

Terminated·IInstitut Cancerologie de l'Ouest·Preclinical·NCT04899492·21 enrolled

Unspecified2 trials

Cytisine vs Nicotine Replacement Therapy

Enrolling by invitation·OOttawa Hospital Research Institute·N/A·NCT03249428·200 enrolled

Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT04045964·32 enrolled

Sources

References

[1]
ClinicalTrials.gov — 80 trial records for Nicotine free cigarettes. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Nicotine free cigarettes compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Nicotine free cigarettes. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pfizer

Nicotine free cigarettes

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q3 2027

Q4 2027

Trials by Indication[1]

Smoking Cessation28 trials

Smoking5 trials

Effectiveness3 trials

Pilot Study3 trials

Treatment3 trials

Nicotine Dependence3 trials

Schizophrenia2 trials

Tobacco Use2 trials

Cardiovascular Disease2 trials

Tobacco2 trials

ESS2 trials

Psychiatric Disorder2 trials

Smokers1 trial

Children1 trial

Craving1 trial

Metabolism1 trial

Smoking Reduction1 trial

Tobacco Dependence1 trial

Joint Replacement Surgery1 trial

Acceptability1 trial

Withdrawal1 trial

Smokeless Tobacco1 trial

Cannabis Dependence1 trial

Randomized Controlled Trial1 trial

Liver1 trial

Pulmonary Tuberculosis1 trial

Relapse1 trial

Music Intervention1 trial

Cycloserine1 trial

Nicotine Withdrawal1 trial

MPA1 trial

Obesity1 trial

Breast Cancer1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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