Stem cell

Phase 3Cell therapy

NNeurogen Brain and Spine Institute

Stem cell is one of 561 small molecule programs targeting Cerebral Palsy. It is currently in Phase 3.

Indications

Total Trials

Active Trials

560

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cerebral PalsyActive, not recruiting

Muscular DystrophyActive, not recruiting

IschemiaActive, not recruiting

StrokeActive, not recruiting

LymphomaActive, not recruiting

Long COVID-19Active, not recruiting

LeukemiaActive, not recruiting

ParalysisActive, not recruiting

Amyotrophic Lateral SclerosisActive, not recruiting

Myocardial IschemiaActive, not recruiting

Cerebral PalsyPhase 1/Phase 2

Active, not recruiting

Muscular DystrophyPhase 1/Phase 2

Active, not recruiting

IschemiaPhase 1/Phase 2

Active, not recruiting

StrokePhase 1

Active, not recruiting

LymphomaPhase 2

Active, not recruiting

Long COVID-19Phase 1

Active, not recruiting

LeukemiaPhase 1

Active, not recruiting

ParalysisPhase 3

Active, not recruiting

Amyotrophic Lateral SclerosisPhase 2

Active, not recruiting

Myocardial IschemiaPhase 1/Phase 2

Active, not recruiting

Showing 10 of 21 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Stem cell

NNeurogen Brain and Spine Institute

Phase 3

1 2

Avastin

BBio-Thera Solutions

Preclinical

153 3

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 4

Voltaren

Novartis

Preclinical

1 5

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 6

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 7

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 8

Tricor

JJagotec

Preclinical

1 9

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

1 10

Avastin

Roche

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2035

Phase 2Not yet recruiting

Allogeneic Hematopoietic Stem Cell Transplantation

NCT07493538

Clinical

Trials by Indication[1]

Muscular Dystrophy3 trials

Stem Cell Therapy in Muscular Dystrophy

Withdrawn·NNeurogen Brain and Spine Institute·Phase 1·NCT02241928

Cell Therapy in Limb Girdle Muscular Dystrophy

Withdrawn·NNeurogen Brain and Spine Institute·Phase 1·NCT02245711

Study Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Muscular Dystrophy.

Unknown status·—·Phase 1/2·NCT01834066·25 enrolled

Completed·SStempeutics Research Pvt Ltd·Phase 1/2·NCT00883727·20 enrolled

Myocardial Ischemia1 trial

Stem Cell Therapy for Vasculogenesis in Patients With Severe Myocardial Ischemia

Completed·RRigshospitalet, Denmark·Phase 1/2·NCT00260338·31 enrolled

22 more indications

Biliary Atresia1 trial

Stem Cell Applications in Biliary Atresia Patients

Recruiting·NNecmi Kadıoğlu Hospital·N/A·NCT06564740·64 enrolled

Multiple Myeloma1 trial

Rituximab, Yttrium Y 90 Ibritumomab Tiuxetan, Melphalan, and Autologous Peripheral Stem Cell Transplant in Treating Patients With Previously Treated Multiple Myeloma

Completed·MMayo Clinic·Phase 1·NCT00477815·30 enrolled

Duchenne Muscular Dystrophy1 trial

Stem Cell Therapy in Duchenne Muscular Dystrophy

Withdrawn·NNeurogen Brain and Spine Institute·Phase 1·NCT02241434

Stroke1 trial

Autologous Stem Cell Therapy in Stroke

Withdrawn·NNeurogen Brain and Spine Institute·Phase 1·NCT02245698

Premature Ovarian Failure1 trial

"It is a Real" The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian Failure

Completed·—·Phase 1/2·NCT02372474·112 enrolled

Diabetic Neuropathy1 trial

The Peripheral Mobilized Mononuclear Cell-based Therapy in Patient With Diabetic Neuropathy

Withdrawn·SSeoul National University Hospital·N/A·NCT02315235

Stem Cells1 trial

Role of Stem Cells, Platelet Rich Plasma in Treatment of Scars

Completed·HHeba Mohamed Saad Eldien·N/A·NCT03264573·40 enrolled

Pregnancy1 trial

Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure

Completed·—·Phase 1/2·NCT02151890·10 enrolled

Long COVID-191 trial

Stem Cell Study for Long COVID-19 Neurological Symptoms

Unknown status·CCharles Cox·Phase 1·NCT06156241·12 enrolled

Cerebral Palsy1 trial

Safety and Efficacy of Bone Marrow Derived Autologous Cells Treatment of Cerebral Palsy in Subjects Above 15 Years

Unknown status·—·Phase 1/2·NCT01834664·100 enrolled

Heart Failure1 trial

A Trial of Autologous Bone Marrow Derived Stem Cells in Paediatric Heart Failure

Completed·GGreat Ormond Street Hospital for Children NHS Foundation Trust·N/A·NCT02479776·10 enrolled

COVID-191 trial

ASC Therapy for Patients With Severe Respiratory COVID-19

Withdrawn·RRigshospitalet, Denmark·Phase 1/2·NCT04341610

Chronic Lymphocytic Leukemia1 trial

Donor Stem Cell Transplant in Treating Patients With Previously Treated Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00612716·6 enrolled

Ischemia1 trial

Clinical Trial I/II Opened, Randomized and Controlled for the Study of the Use of Stem Cells Therapy in Insulinized Diabetic Patients Type 2 With Critical Ischemia in Lower Limbs (CLI): Study of the Needs of Insulin

Terminated·AAndalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud·Phase 1/2·NCT02287974·20 enrolled

Diabetic Foot1 trial

Clinical Application of Mesenchymal Stem Cells Seeded in Chitosan Scaffold for Diabetic Foot Ulcers

Unknown status·—·Phase 1·NCT03259217·40 enrolled

Allogeneic Hematopoietic Stem Cell Transplantation1 trial

MT2025-35 Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning Treosulfan and Fludarabine, With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological Diseases

Not yet recruiting·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT07493538·132 enrolled

Acute Myeloid Leukemia1 trial

Allogeneic Hematopoietic Stem Cell Transplantation (AlloSCT) Initial Salvage Therapy for Induction Failure Acute Myeloid Leukemia (AML)

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT02441803·11 enrolled

Breast Cancer1 trial

Treatment of Breast Cancer-related Lymphedema With Stem Cells and Fat Grafting

Completed·OOdense University Hospital·Phase 2·NCT03776721·80 enrolled

Paralysis1 trial

Efficacy of Stem Cell Transplantation Compared to Rehabilitation Treatment of Patients With Cerebral Paralysis

Completed·GGeneral Hospital of Chinese Armed Police Forces·Phase 3·NCT01929434·300 enrolled

Lymphoma1 trial

Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT02961816

Leukemia1 trial

A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT01287104·34 enrolled

Osteoarthritis1 trial

Mesenchymal Stem Cell Transplantation in Osteoarthritis of Hip Joint

Completed·RRoyan Institute·Phase 1·NCT01499056·6 enrolled

Sources

References

[1]
ClinicalTrials.gov — 31 trial records for Stem cell. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Stem cell compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Stem cell. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Neurogen Brain and Spine Institute company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Cell therapy[2]
Highest Phase: Phase 3[1]
Company: NNeurogen Brain and Spine Institute

Stem cell

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2035

Trials by Indication[1]

Muscular Dystrophy3 trials

Amyotrophic Lateral Sclerosis2 trials

Cell Therapy2 trials

Bone1 trial

Myocardial Ischemia1 trial

Biliary Atresia1 trial

Multiple Myeloma1 trial

Duchenne Muscular Dystrophy1 trial

Stroke1 trial

Premature Ovarian Failure1 trial

Diabetic Neuropathy1 trial

Stem Cells1 trial

Pregnancy1 trial

Long COVID-191 trial

Cerebral Palsy1 trial

Heart Failure1 trial

COVID-191 trial

Chronic Lymphocytic Leukemia1 trial

Ischemia1 trial

Diabetic Foot1 trial

Allogeneic Hematopoietic Stem Cell Transplantation1 trial

Acute Myeloid Leukemia1 trial

Breast Cancer1 trial

Paralysis1 trial

Lymphoma1 trial

Leukemia1 trial

Osteoarthritis1 trial

References

Drug Info

Quick Facts

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