Sulfamethoxazole-Trimethoprim

ApprovedSmall molecule

NNational Institute of Allergy and Infectious Diseases (NIAID)

Sulfamethoxazole-Trimethoprim is one of 107 small molecule programs targeting Pneumonia. It is currently in Approved.

Indications

Total Trials

Active Trials

106

Competitors

Pipeline

Status by Indication[3][1]

Indication

PneumoniaActive, not recruiting

Otitis MediaActive, not recruiting

Diabetic FootActive, not recruiting

Urinary Tract InfectionActive, not recruiting

PneumoniaApproved

Active, not recruiting

Otitis MediaPreclinical

Active, not recruiting

Diabetic FootPreclinical

Active, not recruiting

Urinary Tract InfectionApproved

Active, not recruiting

Competition

Competitive Landscape

547 competitors in Pneumonia

#DrugCompanyPhaseTrials

Sulfamethoxazole-Trimethoprim

NNational Institute of Allergy and Infectious Diseases (NIAID)

Approved

6 2

Jakafi

Incyte

Preclinical

1 3

Acanya

Pfizer

Preclinical

1 4

Primaquine

Sanofi

Preclinical

1 5

Avlosulfon

AAlmirall, S.A.

Preclinical

4 6

Gantanol

CConrado Roberto Hoffmann Filho

Preclinical

2 7

Virazole

CConrado Roberto Hoffmann Filho

Preclinical

2 8

Retrovir

BBp Consulting, Inc

Preclinical

2 9

Advil

KKenvue Brands

Preclinical

2 10

Mycifradin

PPharmacia and Upjohn

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Post-ApprovalRecruiting

Antibiotic Prophylaxis

NCT06709196

Clinical

Trials by Indication[1]

Pneumonia6 trials

A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000655·300 enrolled

Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00001014·302 enrolled

A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000715·240 enrolled

Show 3 more trials

Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00000816·370 enrolled

Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000730·240 enrolled

Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00001013·364 enrolled

Interaction2 trials

Evaluation of the Interaction Between Low Dose Sulfamethoxazole-Trimethoprim and Zidovudine

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000732·10 enrolled

Evaluation of the Interaction Between High Dose Sulfamethoxazole/Trimethoprim and Zidovudine

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000734·10 enrolled

Antibiotics2 trials

Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome

Recruiting·—·Phase 1·NCT05302531·10 enrolled

Prophylactic Antibiotics in Measles

Completed·BBandim Health Project·Phase 3·NCT00168532·218 enrolled

Bacterial Infections1 trial

A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive Children

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000811·690 enrolled

Antibiotic Prophylaxis1 trial

Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

Recruiting·RRigshospitalet, Denmark·Phase 4·NCT06709196·248 enrolled

7 more indications

Otitis media1 trial

Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media

Completed·UUMC Utrecht·N/A·NCT00189098·101 enrolled

Urinary Tract Infection1 trial

Efficacy of Fosfomycin-Trometamol in Urinary Tract Infection Prophylaxis After Kidney Transplantation

Completed·JJOSE MANUEL ARREOLA GUERRA·Phase 4·NCT01820897·130 enrolled

Unknown status·UUniversidad Complutense de Madrid·N/A·NCT01137903·88 enrolled

Sources

References

[1]
ClinicalTrials.gov — 19 trial records for Sulfamethoxazole-Trimethoprim. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Sulfamethoxazole-Trimethoprim compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Sulfamethoxazole-Trimethoprim. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — National Institute of Allergy and Infectious Diseases (NIAID) company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: NNational Institute of Allergy and Infectious Diseases (NIAID)

Sulfamethoxazole-Trimethoprim

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Trials by Indication[1]

Pneumonia6 trials

Interaction2 trials

Antibiotics2 trials

Bacterial Infections1 trial

Antibiotic Prophylaxis1 trial

Otitis media1 trial

Urinary Tract Infection1 trial

Prospective1 trial

Tics1 trial

Prevention1 trial

Treatment1 trial

Diabetic Foot1 trial

References

Drug Info

Quick Facts

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