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Miraclid

(Ulinastatin)

PreclinicalSmall molecule

TTechpool Bio-Pharma Co., Ltd.

Ulinastatin is used to reduce inflammation and prevent tissue damage in conditions like acute pancreatitis and sepsis, where the body's own enzymes are causing harm.[1] Miraclid is currently being investigated across 10 indications[3], with its most advanced program in Preclinical.[1]

Miraclid is one of 231 small molecule programs targeting Acute Kidney Injury. It is currently in Preclinical.

10

Indications

31

Total Trials

3

Active Trials

230

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute Kidney InjuryActive, not recruiting

HemorrhageUnknown

EncephalopathyActive, not recruiting

Inflammatory ResponseActive, not recruiting

Coronary Artery BypassActive, not recruiting

Hepatocellular CarcinomaActive, not recruiting

Aortic DissectionActive, not recruiting

Intra-Abdominal InfectionNot yet recruiting

LaparoscopicCompleted

Cardiac SurgeryCompleted

Acute Kidney InjuryPreclinical

Active, not recruiting

HemorrhagePreclinical

Unknown

EncephalopathyPreclinical

Active, not recruiting

Inflammatory ResponsePreclinical

Active, not recruiting

Coronary Artery BypassPreclinical

Active, not recruiting

Hepatocellular CarcinomaPreclinical

Active, not recruiting

Aortic DissectionPreclinical

Active, not recruiting

Intra-Abdominal InfectionPreclinical

Not yet recruiting

LaparoscopicPreclinical

Completed

Cardiac SurgeryPreclinical

Completed

Competition

Competitive Landscape

265 competitors in Hepatocellular Carcinoma

#DrugCompanyPhaseTrials

Cysteine Hydrochloride

Ibrance

Viread

Sovaldi

Hepsera

Coreg

Akero Therapeutics

Miraclid

TTechpool Bio-Pharma Co., Ltd.

Vermox

Doptelet

Valemetostat

Bristol-Myers Squibb

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

N/ANot yet recruiting

Aortic Dissection

NCT07382375

Q2 2028

PreclinicalNot yet recruiting

Intra-Abdominal Infection

NCT07672496

Clinical

Trials by Indication[1]

Cardiac Surgery3 trials

Hemostatic Effects of Ulinastatin and Tranexamic Acid in Cardiac Surgery

Completed·—·N/A·NCT01060189·426 enrolled

Protective Effect in Cardiac Surgery Patients

Unknown status·SShanghai Zhongshan Hospital·N/A·NCT04028024·90 enrolled

Ulinastatin's Anti-inflammatory Reaction in Cardiac Surgery

Completed·KKonkuk University Medical Center·Phase 4·NCT01518569·26 enrolled

Aortic dissection3 trials

Protective Effect of Ulinastatin and Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA XI)

Enrolling by invitation·NNanjing Medical University·N/A·NCT06966687·200 enrolled

AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection

Not yet recruiting·NNanjing Medical University·N/A·NCT07382375·300 enrolled

Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection

Unknown status·—·N/A·NCT01894334·220 enrolled

Inflammatory Response2 trials

Effects of Ulinastatin on Inflammatory Response During ECMO Support

Unknown status·NNanfang Hospital, Southern Medical University··NCT04990752·144 enrolled

Protective Effect of Ulinastatin Against Negative Inflammatory Response and Organ Dysfunction After Acute Type a Aortic Dissection Surgery (PANDA I)

Completed·NNanjing Medical University·N/A·NCT04711889·203 enrolled

Acute Respiratory Distress Syndrome2 trials

The Safety and Dose Response Relationship of Ulinastatin for Acute Respiratory Distress Syndrome(ARDS)

Unknown status·TTechpool Bio-Pharma Co., Ltd.·Phase 2·NCT02895191·60 enrolled

Prevention of Ulinastatin on Acute Respiratory Distress Syndrome (ARDS)

Completed·PPeking University Third Hospital·N/A·NCT03089957·840 enrolled

Cardiopulmonary Bypass2 trials

Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass

Completed·KKonkuk University Medical Center·Phase 4·NCT03154814·80 enrolled

Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary Bypass

Completed·QQin Zhang·N/A·NCT05534802·236 enrolled

18 more indications

Sepsis2 trials

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Completed·QQin Zhang··NCT06080282·567 enrolled

Risk Factors for Adverse Outcomes in Sepsis: a Multi-omics Exploration Based on Clinical Cohort Studies

Completed·QQin Zhang··NCT06541600·567 enrolled

COVID-191 trial

Ulinastatin for the Treatment of COVID-19 in Hospitalized Patients

Withdrawn·SStanford University·Phase 1/2·NCT04393311

Cognitive Dysfunction1 trial

Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction

Completed·QQin Zhang··NCT06268249·7,065 enrolled

Systemic Inflammatory Response Syndrome1 trial

Clinical Efficacy of Ulinastatin for Treatment of Sepsis With Systemic Inflammatory Response Syndrome

Unknown status·HHuashan Hospital·Phase 3·NCT05391789·120 enrolled

Septic Shock1 trial

Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China

Completed·PPeking Union Medical College Hospital·Phase 4·NCT02647554·347 enrolled

Coronary Artery Bypass1 trial

The Effect of Ulistin on Acute Renal Injury in Patients Undergoing OPCAB (Off Pump Coronary Artery Bypass): a Propensity Score Matched Study

Unknown status·—·N/A·NCT04473144·500 enrolled

Pediatric Patients1 trial

Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery

Unknown status·TTechpool Bio-Pharma Co., Ltd.·Phase 4·NCT02527811·450 enrolled

Aortic Valve Replacement1 trial

Effects of Ulinastatin on Myocardial Protection and Blood Loss in Patients Undergoing Aortic Valve Replacement

Completed·YYonsei University·Phase 4·NCT00944385

Nasopharyngeal Carcinoma1 trial

Efficacy of Ulinastatin for Reducing Radiation-Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients

Completed·SSun Yat-sen University·Phase 3·NCT03387774·179 enrolled

Acute Pancreatitis1 trial

Ulinastatin in Severe Acute Pancreatitis

Suspended·TTechpool Bio-Pharma Co., Ltd.·Phase 4·NCT01132521·252 enrolled

Encephalopathy1 trial

Ulinastatin Treatment Reduces the Incidence of Sepsis-associated Encephalopathy

Completed·SShusheng Li··NCT07090278·2,734 enrolled

Hepatocellular Carcinoma1 trial

Ulinastatin Preventing Postoperative Hepatic Failure in Hepatocellular Carcinoma (HCC)

Completed·—·N/A·NCT01643447·200 enrolled

Injury1 trial

Ulinastatin in Inhalation Lung Injury

Unknown status·—·Phase 2·NCT01287806·120 enrolled

Ulinastatin1 trial

Post-market Safety Reassessment of Ulinastatin for Injection

Unknown status·TTechpool Bio-Pharma Co., Ltd.··NCT02520570·10,000 enrolled

Mortality1 trial

Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality

Unknown status·JJinnah Postgraduate Medical Centre·Phase 4·NCT05895240·175 enrolled

Laparoscopic1 trial

Effect of Ulinastatin on Postoperative Renal Function in Patients Undergoing Robot-assisted Laparoscopic Partial Nephrectomy

Completed·YYonsei University·N/A·NCT02258906·66 enrolled

Muscle Relaxants1 trial

Effect of Ulinastatin on the Action of Nondepolarising Muscle Relaxants Rocuronium / Cisatracurium

Completed·HHuazhong University of Science and Technology·Preclinical·NCT05716256·120 enrolled

Intra-abdominal Infection1 trial

A Single-Center Randomized Controlled Pilot Study on the Effect of Ulinastatin on Systemic Immune and Inflammatory Response in Patients With Complicated Intra-Abdominal Infection

Not yet recruiting·FFujian Medical University Union Hospital·Preclinical·NCT07672496·165 enrolled

Sources

References

[1]
ClinicalTrials.gov — 31 trial records for Ulinastatin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ulinastatin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ulinastatin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Techpool Bio-Pharma Co., Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: TTechpool Bio-Pharma Co., Ltd.

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