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Other/Dysphagia

Dysphagia

15

Pipeline Programs↗

25

Active Trials↗

10

Companies Involved↗

Dysphagia is an emerging landscape with 15 programs across 10 companies. 2 programs are in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

50/100

Pipeline Velocity

36/100

Mech. Concentration

18/100

Completion Rate

78/100

Attrition Rate

11/100

Pipeline

Programs by Phase

Preclinical12

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Lidocaine

MEDRx USA, Inc.

Fentanyl

Cephalon

Propofol

Fresenius Kabi USA, LLC

Omeprazole

Dexcel Pharma Technologies Ltd.

Phase 1

No programs

Phase 21

Pravastatin

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Phase 32

Methylprednisolone

Pfizer

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Approved

No programs

Analysis

Trial Status

55

clinical trials

Completed21 · 38%

Recruiting14 · 25%

Not yet recruiting8 · 15%

Unknown status3 · 5%

Withdrawn3 · 5%

Terminated3 · 5%

Other3 · 5%

Clinical Trials

Trial Activity

55 trials

Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial

Recruiting·TThe Third Affiliated hospital of Zhejiang Chinese Medical University·Phase 4·NCT06737549·144 enrolled

Corticosteroids for Post-Extubation Dysphagia

Recruiting·UUniversity of Colorado, Denver·Phase 2·NCT06670521·80 enrolled

Use of the Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

Recruiting·National Institute of Allergy and Infectious Diseases (NIAID)·Preclinical·NCT07027826·70 enrolled

The Effects of Pacifier-Activated Lullaby on Oral Feeding Among Preterm Infants

Recruiting·NNemours Children's Clinic·Preclinical·NCT07819734·46 enrolled

Impact of Wearable Biofeedback for the Rehabilitation and Tele-rehabilitation of Neurogenic Dysphagia

Recruiting·UUniversity of Illinois at Urbana-Champaign·Phase 2·NCT06638944·120 enrolled

Impact of Preoperative Respiratory Strength Training on Postoperative Health for Heart Transplant Recipients

Recruiting·VVanderbilt University Medical Center·Preclinical·NCT06190171·90 enrolled

Impact of Lingual Endurance Exercise on Rehabilitation of Swallowing Impairments After Ischemic Stroke

Recruiting·UUniversity of Cincinnati·Preclinical·NCT06072924·70 enrolled

TRADstat: Novel Treatment of Radiation Associated Dysphagia With Statins

Recruiting·PPeter MacCallum Cancer Centre, Australia·Phase 2·NCT07217938·48 enrolled

Digital Intelligent Tongue-Pressure Biofeedback Resistance Training for Post-Stroke Dysphagia: A Randomized Controlled Trial

Recruiting·FFirst People's Hospital of Foshan·Phase 2·NCT07798401·80 enrolled

A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's

Recruiting·NNorthwestern University·Phase 3·NCT04664634·60 enrolled

Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions

Recruiting·JJohns Hopkins University·Preclinical·NCT07780981·25 enrolled

Phagenyx® Registry Study: Evaluating Swallowing Therapy Outcomes and Recovery in the U.S.

Recruiting·PPhagenesis Ltd.·N/A·NCT06866418·600 enrolled

Effect of an Oral Neuromuscular Training Device on Dysphagia: an Assessor-blinded Randomized Controlled Trial

Recruiting·UUniversity of Aarhus·Preclinical·NCT07451028·100 enrolled

Efficacy and Safety of Onabotulinum Toxin A (Botox) Injections in the Upper Esophageal Sphincter for the Treatment of Pharyngo-esophageal Dysphagia Due to Cricopharyngeal Dysfunction- A Randomized Double Blinded Placebo Controlled Trial

Recruiting·AAll India Institute of Medical Sciences·Preclinical·NCT04695600·100 enrolled

Autologous Muscle Derived Cells for Gastro-Intestinal Repair (AMDC-GIR) for Tongue Dysphagia

Active, not recruiting·—·Phase 1·NCT02838316·18 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)