Casodex
(Bicalutamide)ApprovedSmall molecule
Bicalutamide is used to treat prostate cancer by blocking male hormones that help cancer cells grow. It's often given alongside other prostate cancer treatments.[2] Casodex is currently approved and in use across 25 indications[4].[1]
Casodex is one of 515 small molecule programs targeting Breast Cancer. It is currently in Approved.
25
Indications
139
Total Trials
29
Active Trials
514
Competitors
1
FDA Application
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 25 indications
Competition
Competitive Landscape
744 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Casodex
IIstituto Clinico Humanitas
Approved
Blenoxane
Bristol-Myers SquibbPreclinical
Lexiscan
AstellasPreclinical
Voltaren
NovartisPreclinical
Zolymbus
AbbViePreclinical
Methylthioninium Chloride
PProvepharm SAS
Preclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Duragesic-100
CCephalon
Preclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Spravato
WWim Janssens
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Prostate Cancer80 trials
A Study of Definitive Therapy to Treat Prostate Cancer
Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT02716974·26 enrolled
Hormone Therapy in Treating Patients With Advanced Prostate Cancer
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003026·966 enrolled
Show 77 more trials
Androgen Deprivation Therapy +/- Bevacizumab for PSA Recurrence of Prostate Cancer After Definitive Local Therapy
Completed·—·Phase 2·NCT00776594·102 enrolled
RAD001 and Bicalutamide for Androgen Independent Prostate Cancer
Completed·—·Phase 2·NCT00630344·36 enrolled
Bevacizumab, Hormone Therapy, and Radiation Therapy in Treating Patients With Locally Advanced Prostate Cancer
Unknown status·—·Phase 2·NCT00348998·18 enrolled
Radiation Therapy With or Without Bicalutamide and Goserelin in Treating Patients With Prostate Cancer
Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00021450·819 enrolled
Docetaxel, Bevacizumab and Androgen Deprivation Therapy After Definitive Local Therapy for Prostate Cancer
Completed·—·Phase 2·NCT00658697·42 enrolled
Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer
Recruiting·—·Phase 2·NCT04734730·70 enrolled
Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer
Withdrawn·—·Phase 2·NCT00003517
Endocrine Therapy With or Without Cryoablation for Stage IV Prostate Cancer
Unknown status·TTianjin Medical University Cancer Institute and Hospital·N/A·NCT02615223·120 enrolled
Cryoablation Therapy or Radiotherapy Therapy for Stage III Prostate Cancer
Unknown status·TTianjin Medical University Cancer Institute and Hospital·N/A·NCT02605226·240 enrolled
A Study of Definitive Therapy to Treat Prostate Cancer After Prostatectomy
Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT03043807·26 enrolled
Metastatic Prostate Cancer13 trials
Androgen Deprivation Therapy +/- Radium-223 Dichloride in Metastatic Prostate Cancer With Bone Metastases
Terminated·—·Phase 2·NCT02582749·16 enrolled
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Hormone Therapy and Intensity-Modulated Radiation Therapy in Treating Patients With Metastatic Prostate Cancer
Active, not recruiting·—·Phase 2·NCT00544830·29 enrolled
Breast Cancer7 trials
Show 4 more trials
Prostate Adenocarcinoma5 trials
Show 2 more trials
Fed3 trials
24 more indications
COVID-193 trials
Triple-Negative Breast Cancer2 trials
TNBC2 trials
Trial2 trials
INTREPId (INTermediate Risk Erection PreservatIon Trial)
Active, not recruiting·—·Phase 2·NCT04025372·234 enrolled
Androgen Deprivation Therapy2 trials
Fasting Conditions2 trials
Randomized1 trial
Randomized Phase II Study of Salvage XRT + ADT +/- Abiraterone and Apalutamide for Rising PSA After RP (FORMULA-509)
Active, not recruiting·—·Phase 2·NCT03141671·345 enrolled
Salivary Gland Cancer1 trial
Glioma1 trial
Pediatrics1 trial
Fallopian Tube1 trial
Radiotherapy1 trial
Metastatic Urothelial Cancer1 trial
A Canadian Trial of Bicalutamide in Patients Receiving Maintenance Avelumab for Metastatic Urothelial Cancer.
Withdrawn·—·Phase 2·NCT06018116
Polycystic Ovary Syndrome1 trial
Bladder Cancer1 trial
A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer
Recruiting·—·Phase 2·NCT05327647·160 enrolled
Abiraterone Acetate1 trial
Neoadjuvant Therapy1 trial
Prostatic Neoplasms1 trial
Non-Muscle Invasive Bladder Urothelial Carcinoma1 trial
Regulatory
FDA Approval Timeline[5]
Oct 4, 1995
CASODEX
NDA NDA020498
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Casodex drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Bicalutamide. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Androgen Receptor Antagonist[3]
- Modality
- Small molecule[3]
- Highest Phase
- Approved[1]
- Company
- IIstituto Clinico Humanitas