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Curcumin

ApprovedSmall molecule

Curcumin is a natural compound from turmeric that is being studied for potential anti-inflammatory and antioxidant effects, though it is not approved as a prescription drug by the FDA and is mainly sold as a dietary supplement.[2] Curcumin is currently approved and in use across 59 indications[4].[1]

Curcumin is one of 1269 small molecule programs targeting Systemic Lupus Erythematosus. It is currently in Approved.

59

Indications

83

Total Trials

8

Active Trials

1,268

Competitors

Pipeline

Status by Indication[4][1]

Indication

Systemic Lupus ErythematosusActive, not recruiting

Nicotine DependenceActive, not recruiting

Denture StomatitisActive, not recruiting

Oral Lichen PlanusActive, not recruiting

Colonic NeoplasmActive, not recruiting

Familial Adenomatous PolyposisActive, not recruiting

ArthritisActive, not recruiting

ToxicityActive, not recruiting

AdenomaActive, not recruiting

Cognitive ImpairmentActive, not recruiting

Systemic Lupus ErythematosusPhase 2

Active, not recruiting

Nicotine DependencePhase 3

Active, not recruiting

Denture StomatitisPhase 3

Active, not recruiting

Oral Lichen PlanusPhase 3

Active, not recruiting

Colonic NeoplasmPhase 3

Active, not recruiting

Familial Adenomatous PolyposisPhase 2

Active, not recruiting

ArthritisPhase 1

Active, not recruiting

ToxicityPhase 3

Active, not recruiting

AdenomaPhase 1

Active, not recruiting

Cognitive ImpairmentPhase 2

Active, not recruiting

Showing 10 of 59 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Curcumin

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Blenoxane

Bristol-Myers Squibb

Lupron

EEastern Cooperative Oncology Group

MS Contin

HHikma Pharmaceuticals LLC

Chantix

PPrism Pharmaceuticals

QS21

MMemorial Sloan Kettering Cancer Center

Neoadjuvant Therapy

SSun Yat-sen University

Fentanyl Citrate

IINSYS Therapeutics Inc

Conventional Chemotherapy

SShanghai Jiao Tong University School of Medicine

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 1/2Recruiting

Study completion

NCT05688488

Q3 2027

Phase 2Not yet recruiting

Alzheimer's Disease

NCT06470061

Q4 2028

Phase 3Recruiting

Recurrence Free Survival

NCT02064673

Q4 2030

Phase 3Recruiting

Prostate Cancer

NCT03769766

Clinical

Trials by Indication[1]

Chronic Kidney Disease3 trials

Curcumin and Exercise in Chronic Kidney Disease

Withdrawn·UUniversity of Iowa·Phase 2·NCT04132648

Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease

Completed·IInstituto Nacional de Cardiologia Ignacio Chavez·Phase 3·NCT01831193·120 enrolled

Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease

Completed·DDiana Jalal·Phase 2·NCT03223883·94 enrolled

Breast Cancer3 trials

"Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer

Completed·NNational Center of Oncology, Armenia·Phase 2·NCT03072992·150 enrolled

A "Window Trial" on Curcumin for Invasive Breast Cancer Primary Tumors

Completed·MMedical University of South Carolina·Phase 1·NCT03980509·22 enrolled

Phase II Study of Curcumin vs Placebo for Chemotherapy-Treated Breast Cancer Patients Undergoing Radiotherapy

Completed·AAndrew H Miller·Phase 2·NCT01740323·30 enrolled

Prostate Cancer3 trials

Multicenter Study Comparing Taxotere Plus Curcumin Versus Taxotere Plus Placebo Combination in First-line Treatment of Prostate Cancer Metastatic Castration Resistant (CURTAXEL)

Terminated·CCentre Jean Perrin·Phase 2·NCT02095717·50 enrolled

Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance

Recruiting·UUniversity of Texas Southwestern Medical Center·Phase 3·NCT03769766·291 enrolled

Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT)

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2·NCT02724618·64 enrolled

Pancreatic Cancer3 trials

Trial of Curcumin in Advanced Pancreatic Cancer

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00094445·50 enrolled

Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Advance or Inoperable Pancreatic Cancer

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT00486460

Gemcitabine With Curcumin for Pancreatic Cancer

Completed·RRambam Health Care Campus·Phase 2·NCT00192842·17 enrolled

Alzheimer's Disease2 trials

Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease

Unknown status·VVA Office of Research and Development·Phase 2·NCT01811381·80 enrolled

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Not yet recruiting·ZZaparackas and Knepper LTD·Phase 2·NCT06470061·200 enrolled

56 more indications

Multiple Myeloma2 trials

Efficacy of NF-kB Inhibition for Reducing Symptoms During Maintenance Therapy in Multiple Myeloma Patients

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT01269203

Curcumin (Diferuloylmethane Derivative) With or Without Bioperine in Patients With Multiple Myeloma

Completed·MM.D. Anderson Cancer Center·N/A·NCT00113841·42 enrolled

Tics2 trials

Curcumin Pharmacokinetics

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01330810·12 enrolled

Pharmacokinetics of Curcumin in Healthy Volunteers

Completed·MMassachusetts General Hospital·N/A·NCT00181662·6 enrolled

Schizophrenia2 trials

Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia

Completed·VVA Greater Los Angeles Healthcare System·Phase 1/2·NCT02104752·39 enrolled

Curcumin Addition to Antipsychotic Treatment in Chronic Schizophrenia Patients

Completed·—·Phase 4·NCT02298985·38 enrolled

Safety and Efficacy2 trials

Safety and Efficacy of Artesunate & Curcumin in Crohn's Disease

Unknown status·SSanjay Gandhi Postgraduate Institute of Medical Sciences·Phase 2·NCT04713631·40 enrolled

A Study to Evaluate the Safety and Efficacy of RQC for AMD

Completed·PPaul A Knepper, MD PhD·Phase 2·NCT05062486·55 enrolled

Cervical Cancer2 trials

Concomitant Curcumin Palliative Radiotherapy in Advanced Cervical Cancer Trial

Recruiting·—·N/A·NCT05947513·27 enrolled

Curcumin in Advanced Cervical Cancer

Withdrawn·IInstituto Nacional de Cancerologia, Columbia·Phase 2·NCT04294836

Familial adenomatous polyposis2 trials

Curcumin in Treating Patients With Familial Adenomatous Polyposis

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00641147·44 enrolled

Use of Curcumin in the Lower Gastrointestinal Tract in Familial Adenomatous Polyposis Patients

Withdrawn·JJohns Hopkins University·Phase 2·NCT00248053

Oral Mucositis2 trials

Curcumin VS Photo-bio-modulation Therapy of Oral Mucositis in Pediatric Patients Undergoing Anti-Cancer Non-invasive Treatment

Completed·RRiyadh Elm University·Phase 1·NCT06044142·90 enrolled

Curcumin Gel On Radiation Induced Oral Mucositis

Completed·UUniversity of Baghdad·N/A·NCT05982197·40 enrolled

Oral Submucous Fibrosis2 trials

Efficacy of Curcumin in Oral Submucous Fibrosis

Unknown status·HH.K.E.S's S.Nijalingappa Institute of Dental Science and Research·Phase 2·NCT03511261·200 enrolled

Comparison of Curcumin and Intralesional Steroids in Oral Submucous Fibrosis

Not yet recruiting·SServices Institute of Medical Sciences, Pakistan·Phase 3·NCT06758739·70 enrolled

Adult Subject2 trials

Pharmacokinetics and Bioavailability of Curcumin UP 30 Capsules in Healthy Adult Subjects

Unknown status·TThe Affiliated Hospital of Qingdao University·Phase 1·NCT05334043·12 enrolled

Bioavailability of Curcumin Capsules in Healthy Adult Subjects: an Open, Randomized, Single-dose, Two-period, Two-sequence Crossover Study

Completed·TThe Affiliated Hospital of Qingdao University·Phase 1·NCT04972045·12 enrolled

Metastatic Colon Cancer1 trial

Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 3·NCT00295035·100 enrolled

Efficacy and Safety1 trial

Efficacy and Safety Curcumin in Depression

Completed·VVladimir Lerner·Phase 4·NCT01750359·40 enrolled

Alveolar Ridge Augmentation1 trial

Alveolar Ridge Augmentation With Curcumin Combined With Xenograft

Unknown status·—·Phase 4·NCT04971382·18 enrolled

Denture Stomatitis1 trial

Curcumin; Rose Bengal; Denture Stomatitis

Unknown status·KKing Saud University·Phase 3·NCT04837664·45 enrolled

Neuropathy1 trial

A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON)

Completed·MMahidol University·Phase 3·NCT00528151·70 enrolled

Sclerosing Cholangitis1 trial

A Study Evaluating the Safety and Efficacy of Curcumin in Patients With Primary Sclerosing Cholangitis (PSC)

Completed·—·Phase 1/2·NCT02978339·15 enrolled

Recurrence Free Survival1 trial

Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy

Recruiting·Yyair lotan·Phase 3·NCT02064673·608 enrolled

Gastric Cancer1 trial

Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT02782949·50 enrolled

Cervical Intraepithelial Neoplasia1 trial

Effect of Curcumin in Treatment of Squamous Cervical Intraepithelial Neoplasias (CINs)

Withdrawn·—·Phase 1·NCT02554344

Mucositis1 trial

Study to See How Safe Curcumin is and How Well it Works When Used to Treat Mucositis in Patients Getting Chemotherapy

Terminated·AAmy Beres·Phase 1/2·NCT02300727·6 enrolled

Arthritis1 trial

Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis

Enrolling by invitation·BBrent DeGeorge·Phase 1·NCT06359665·100 enrolled

Dermatitis1 trial

Oral Curcumin for Radiation Dermatitis

Completed·UUniversity of Rochester·Phase 2/3·NCT01246973·686 enrolled

Bipolar Disorder1 trial

Adjunctive Curcumin for Symptomatic Adolescents With Bipolar Disorder: Brain and Body Considerations

Terminated·SSunnybrook Health Sciences Centre·Phase 2·NCT01928043·7 enrolled

Function1 trial

Curcumin and Function in Older Adults

Completed·UUniversity of Florida·Phase 2/3·NCT03085680·17 enrolled

Clinical Trial1 trial

Glutathione vs. Curcumin Clinical Trial

Unknown status·SSouth Florida Veterans Affairs Foundation for Research and Education·Phase 1/2·NCT02848417·75 enrolled

Bleeding1 trial

Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users

Completed·OOregon Health and Science University·Phase 4·NCT04205929·58 enrolled

Sorafenib1 trial

Study of Curcumin, Vorinostat, and Sorafenib

Withdrawn·MM.D. Anderson Cancer Center·Phase 1·NCT01608139

Multiple Sclerosis1 trial

Dietary Supplement of Curcumin in Subjects With Active Relapsing Multiple Sclerosis Treated With Subcutaneous Interferon Beta 1a

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT01514370·80 enrolled

Insulin Sensitivity1 trial

Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes

Unknown status·HHospital General de México Dr. Eduardo Liceaga·Phase 4·NCT03917784·142 enrolled

Vascular Dysfunction1 trial

Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults With ADPKD

Completed·UUniversity of Colorado, Denver·Phase 4·NCT02494141·68 enrolled

Inflammation1 trial

Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With Cancer

Completed·MMayo Clinic·Phase 1·NCT02598726·9 enrolled

Acute Lymphoblastic Leukemia1 trial

Safety and Efficacy of Curcumin in Children With Acute Lymphoblastic Leukemia

Completed·—·Phase 2·NCT05045443·30 enrolled

Type 2 Diabetic Patients1 trial

Curcumin for Type 2 Diabetic Patients

Unknown status·SSrinakharinwirot University·Phase 4·NCT01052597·200 enrolled

Inflammatory Bowel Disease1 trial

Curcumin in Pediatric Inflammatory Bowel Disease

Completed·SSeattle Children's Hospital·Phase 1·NCT00889161·11 enrolled

Colon Cancer1 trial

Curcumin in Combination With 5FU for Colon Cancer

Terminated·—·Phase 1·NCT02724202·15 enrolled

Trial1 trial

Trial on Safety and Pharmacokinetics of Intravaginal Curcumin

Completed·EEmory University·Phase 1·NCT01035580·13 enrolled

Crohn Disease1 trial

Curcumin Associated With Thiopurin in the Prevention of Post-op Recurrence in Crohn Disease

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 3·NCT02255370·61 enrolled

Adenoma1 trial

Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma Patients

Unknown status·MMashhad University of Medical Sciences·Phase 1·NCT01344291·30 enrolled

Small Cell Lung Cancer1 trial

Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC)

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT01048983

Cutaneous T-cell lymphoma1 trial

Trial of Curcumin in Cutaneous T-cell Lymphoma Patients

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT00969085

Impaired glucose tolerance1 trial

Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance

Unknown status·SSrinakharinwirot University·Phase 4·NCT01052025·200 enrolled

Asthma1 trial

Evaluating Effects of Curcumin in Moderate to Severe Asthmatics

Withdrawn·LLoma Linda University·Phase 2·NCT04353310

Prostate1 trial

Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate

Withdrawn·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT04403568

Toxicity1 trial

The Effect of Curcumin Against Colistin-induced Nephrotoxicity

Unknown status·OOctober 6 University·Phase 3·NCT05613361·214 enrolled

Abdominal Aortic Aneurysm1 trial

Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 2/3·NCT01225094·606 enrolled

Memory1 trial

18-Month Study of Memory Effects of Curcumin

Completed·UUniversity of California, Los Angeles·Phase 2·NCT01383161·46 enrolled

Cervical Lesion1 trial

Topical Curcumin for Precancer Cervical Lesions

Terminated·LLisa Flowers·Phase 2·NCT02944578·7 enrolled

Chronic Lymphocytic Leukemia1 trial

Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Completed·PPaolo Caimi, MD·Phase 2·NCT02100423·35 enrolled

Phase II1 trial

Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00365209·44 enrolled

Rheumatoid Arthritis1 trial

Curcumin in Rheumatoid Arthritis

Completed·UUniversity of California, Los Angeles·Phase 1·NCT00752154·40 enrolled

Periodontal Pocket1 trial

Clinical and Anti-inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket

Unknown status·UUniversity of Baghdad·Phase 1·NCT04355416·25 enrolled

Lupus Nephritis1 trial

The Effect of Curcumin on the Clinical Outcome of Pediatric Patients with Active Lupus Nephritis

Completed·—·Phase 2·NCT05714670·72 enrolled

Adjuvant Therapy1 trial

The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue

Completed·IIndonesia University·Phase 2/3·NCT06281353·78 enrolled

Periodontitis1 trial

Efficacy of Curcumin Gel Combined With Non-surgical Periodontal Therapy on Salivary Procalcitonin Level in the Treatment of Periodontitis Patients

Completed·RReham abdelfatah·N/A·NCT05667376·54 enrolled

Oral Lichen Planus1 trial

Assessment of the Efficacy of Topical Curcumin in Treatment of Oral Lichen Planus

Completed·SShaymaa Hussein Rafat Kotb·Phase 3·NCT06605911·30 enrolled

Intracanal Dressing1 trial

Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing

Completed·—·Phase 2·NCT06342830·60 enrolled

Unspecified5 trials

Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients.

Completed·UUniversity of Sao Paulo·Phase 1·NCT02337192·24 enrolled

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

Recruiting·EEye & ENT Hospital of Fudan University·Phase 1/2·NCT05688488·100 enrolled

Effects of Curcumin on Vascular Reactivity

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 1/2·NCT01543386·21 enrolled

Show 2 more trials

The Effects of Curcuminoids on Aberrant Crypt Foci in the Human Colon

Terminated·UUniversity of Medicine and Dentistry of New Jersey·N/A·NCT00176618·60 enrolled

Testing the Bioavailability of Phytonutrients, Curcumin and Ursolic Acid

Completed·TThe University of Texas Health Science Center at San Antonio·Phase 1·NCT04421716·18 enrolled

Sources

References

[1]
ClinicalTrials.gov — 83 trial records for Curcumin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Curcumin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Curcumin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Curcumin. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Merck & Co.

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