Endotoxin

Phase 2Small molecule

UUniversity of California, Los Angeles

Endotoxin is one of 104 small molecule programs targeting Oral. It is currently in Phase 2.

Indications

Total Trials

Active Trials

103

Competitors

Pipeline

Status by Indication[3][1]

Indication

OralCompleted

Acute Lung InflammationEnrolling by invitation

Metabolic SyndromeActive, not recruiting

Alcohol Use DisorderNot yet recruiting

AggressionNot yet recruiting

Central Nervous SystemCompleted

OralPreclinical

Completed

Acute Lung InflammationPhase 2

Enrolling by invitation

Metabolic SyndromePreclinical

Active, not recruiting

Alcohol Use DisorderPhase 2

Not yet recruiting

AggressionPhase 2

Not yet recruiting

Central Nervous SystemPreclinical

Completed

Competition

Competitive Landscape

70 competitors in Metabolic Syndrome

#DrugCompanyPhaseTrials

Actos

Takeda

Approved

5 2

Cosentyx

Novartis

Approved

3 3

Avandia

Jazz Pharmaceuticals

Approved

2 4

Victoza

Novo Nordisk

Approved

1 5

Plavix

Sanofi

Approved

1 6

Geodon

Pfizer

Approved

1 7

Ozempic

Novo Nordisk

Approved

1 8

Bayer Aspirin

Bayer

Approved

1 9

Uloric

Takeda

Approved

1 10

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2028

Phase 2Not yet recruiting

Alcohol Use Disorder

NCT07452146

Q1 2030

Phase 2Not yet recruiting

Aggression

NCT06665074

Clinical

Trials by Indication[1]

Inflammation5 trials

Inflammation and Brain Function - Main Study

Completed·KKarolinska Institutet·N/A·NCT03551184·52 enrolled

Quantifying Airway Inflammation With Radiologic Tests

Completed·WWashington University School of Medicine·Phase 1·NCT00741013·22 enrolled

Sleep Health, Inflammation, and Emotion Study

Completed·UUniversity of California, Los Angeles·Phase 1·NCT02270619·95 enrolled

Show 2 more trials

Inflammation-Induced Depressed Mood: The Role of Social Neurocognitive Mechanisms

Completed·UUniversity of California, Los Angeles·Phase 1·NCT01671150·100 enrolled

Effect of Intrapulmonary Recombinant Human Activated Protein C (APC) on Coagulation and Inflammation After Lipopolysaccharide (LPS)

Completed·—·N/A·NCT00943267·52 enrolled

Immune Response4 trials

The Antiplatelet and Immune Response Trial

Completed·SSheffield Teaching Hospitals NHS Foundation Trust·Phase 4·NCT01846559·30 enrolled

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia

Completed·RRadboud University Medical Center·N/A·NCT00785018·20 enrolled

In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II

Completed·RRadboud University Medical Center·Phase 3·NCT01766414·20 enrolled

Show 1 more trial

The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia

Completed·—·N/A·NCT02127749·16 enrolled

Endotoxemia4 trials

Blockade of Vascular Potassium Channels During Human Endotoxemia

Completed·RRadboud University Medical Center·Phase 1·NCT00185003·36 enrolled

Effects of Iron Loading and Iron Chelation Therapy on Innate Immunity During Human Endotoxemia

Completed·RRadboud University Medical Center·N/A·NCT01349699·30 enrolled

Effect of Selective iNOS Inhibition During Human Endotoxemia

Completed·RRadboud University Medical Center·Phase 1·NCT00184990·7 enrolled

Show 1 more trial

PK/PD of EA-230 During Endotoxemia

Completed·RRadboud University Medical Center·Phase 1·NCT02629874·60 enrolled

Depression3 trials

Cytokine-Associated Depression and Social Pain

Completed·UUniversity of California, Los Angeles·Phase 1·NCT00949845

Sleep and Healthy Aging Research for Depression (SHARE-D) Study

Completed·—·Phase 1·NCT03256760·160 enrolled

Sleep and Healthy Aging Research on Depression for Younger Women

Completed·UUniversity of California, Los Angeles·Phase 1·NCT03848715·40 enrolled

Lung Inflammation2 trials

Assessing NOS Uptake With PET Imaging in Lung Inflammation

Completed·WWashington University School of Medicine·Phase 1·NCT02151552·3 enrolled

Carbon Monoxide to Prevent Lung Inflammation

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 1·NCT00094406·35 enrolled

13 more indications

Metabolic Syndrome1 trial

Inflammation and the Metabolic Syndrome in Humans

Completed·UUniversity of Pennsylvania·N/A·NCT00954824·50 enrolled

Imaging1 trial

PET Imaging of Endotoxin-induced iNOS Activation

Completed·WWashington University School of Medicine·Phase 1·NCT01407796·19 enrolled

Aggression1 trial

Inflammatory Challenge in Human Aggression.

Not yet recruiting·OOhio State University·Phase 2·NCT06665074·112 enrolled

Vaccine1 trial

Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood

Completed·NNational Cancer Institute (NCI)·Phase 1/2·NCT00923910·10 enrolled

Anxiety1 trial

Aging and Reward System Response to Inflammation and Anxiety Study

Completed·UUniversity of California, Los Angeles·Phase 1·NCT05363527·40 enrolled

Intravenous1 trial

Completed·RRobert J Noveck, M.D.·Phase 1·NCT02789241·23 enrolled

LAM1 trial

An Inflammatory Challenge Using Endotoxin

Completed·UUniversity of California, Los Angeles·Phase 2·NCT04310423·20 enrolled

Oral1 trial

Endotoxin-induced Inflammatory and Behavioral Responses and Predictors of Individual Differences

Completed·KKarolinska Institutet·N/A·NCT02529592·22 enrolled

Central Nervous System1 trial

Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat?

Completed·—·N/A·NCT01452958·24 enrolled

Alcohol Consumption1 trial

Effect of Endotoxin on Alcohol Consumption

Completed·YYale University·Phase 2·NCT04527185·27 enrolled

Acute Lung Inflammation1 trial

Pulmonary Effects of Bronchial Segmental Endotoxin Instillation in Humans

Enrolling by invitation·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT02392442·58 enrolled

Alcohol Use Disorder1 trial

Understanding the Role of Inflammation in Alcohol Use Disorder: An Inflammatory Challenge Using Lipopolysaccharide

Not yet recruiting·UUniversity of California, Los Angeles·Phase 2·NCT07452146·64 enrolled

Unspecified1 trial

Adrecizumab-LPS Study

Completed·AAdrenomed AG·Phase 1·NCT03083171·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 31 trial records for Endotoxin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Endotoxin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Endotoxin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of California, Los Angeles company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: UUniversity of California, Los Angeles

Endotoxin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2028

Q1 2030

Trials by Indication[1]

Inflammation5 trials

Immune Response4 trials

Endotoxemia4 trials

Depression3 trials

Lung Inflammation2 trials

Metabolic Syndrome1 trial

Imaging1 trial

Aggression1 trial

Vaccine1 trial

Anxiety1 trial

Intravenous1 trial

LAM1 trial

Oral1 trial

Central Nervous System1 trial

Alcohol Consumption1 trial

Acute Lung Inflammation1 trial

Alcohol Use Disorder1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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