Fibrin Sealant

PreclinicalSmall molecule

GGynecologic Oncology Group

Fibrin Sealant is one of 47 small molecule programs targeting Melanoma. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

MelanomaActive, not recruiting

Breast ReconstructionTerminated

MelanomaPreclinical

Active, not recruiting

Breast ReconstructionPreclinical

Terminated

Competition

Competitive Landscape

177 competitors in Melanoma

#DrugCompanyPhaseTrials

Keytruda

Merck & Co.

Phase 3

93 2

Opdivo

Cotellic

21 4

Zelboraf

CConrado Roberto Hoffmann Filho

Phase 3

39 5

Temodar

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

35 6

Taxol

Teva

Phase 3

13 7

Mektovi

Pfizer

Phase 3

12 8

Proleukin

IIovance Biotherapeutics, Inc.

Phase 3

27 9

Lenvima

Eisai

Phase 3

9 10

Libtayo

Regeneron

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Wound Healing2 trials

Effect of Fibrin Sealant on Early Wound Healing

Completed·—·Phase 4·NCT01538927·15 enrolled

Efficacy and Safety of Fibrin Sealant (FS) VH S/D-APR for Hemostasis and Wound Healing in Endoscopic Browlift

Unknown status·NNguyen, Davis B., M.D.··NCT01320514·10 enrolled

Melanoma2 trials

Fibrin Melanoma Axillary Node Study in Patients With Melanoma

Completed·MM.D. Anderson Cancer Center·N/A·NCT00504582·121 enrolled

Evaluating the Use of Fibrin Tissue Adhesive in Melanoma Patients

Completed·MM.D. Anderson Cancer Center·N/A·NCT00506311·53 enrolled

Hemorrhage1 trial

Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage

Terminated·IIndiana University School of Medicine·Phase 2·NCT02343263·18 enrolled

Total Knee Replacement1 trial

A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement

Completed·SSingapore General Hospital·Phase 4·NCT07455591·78 enrolled

Total Knee Arthroplasty1 trial

Fibrin Sealant in Bilateral Simultaneous Total Knee Arthroplasty With Focus on Blood Loss, Pain, Swelling and Strength

Completed·HHvidovre University Hospital·Phase 4·NCT01472913·48 enrolled

6 more indications

Lymphedema1 trial

Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva

Completed·GGynecologic Oncology Group·Phase 3·NCT00028951

Low back pain1 trial

Fibrin for Chronic Multi-level Discogenic Low Back Pain

Unknown status·—·Phase 2/3·NCT04621799·400 enrolled

Surgical1 trial

Evaluation of Fibrin Sealant 2 in Vascular Surgical Procedures

Completed·EEthicon, Inc.·Phase 3·NCT00154141·150 enrolled

Breast Reconstruction1 trial

Fibrin Sealant in Preventing Fluid Build Up During Surgery in Patients Undergoing Breast Reconstruction

Terminated·OOHSU Knight Cancer Institute·N/A·NCT01649505·2 enrolled

Hernia1 trial

A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery

Withdrawn·HHobart Harris·Phase 1·NCT02584153

Esophageal Varices1 trial

Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices

Completed·BBaxter Healthcare Corporation·Phase 3·NCT00161915

Sources

References

[1]
ClinicalTrials.gov — 13 trial records for Fibrin Sealant. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Fibrin Sealant compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Fibrin Sealant. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Gynecologic Oncology Group company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: GGynecologic Oncology Group

Fibrin Sealant

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Wound Healing2 trials

Melanoma2 trials

Hemorrhage1 trial

Total Knee Replacement1 trial

Total Knee Arthroplasty1 trial

Lymphedema1 trial

Low back pain1 trial

Surgical1 trial

Breast Reconstruction1 trial

Hernia1 trial

Esophageal Varices1 trial

References

Drug Info

Quick Facts

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