mesenchymal stem cell

Phase 2Cell therapy

RRohto Pharmaceutical Co., Ltd.

mesenchymal stem cell is one of 476 biologic programs targeting Osteonecrosis. It is currently in Phase 2.

Indications

Total Trials

Active Trials

475

Competitors

Pipeline

Status by Indication[3][1]

Indication

OsteonecrosisActive, not recruiting

Erectile DysfunctionActive, not recruiting

Respiratory FailureActive, not recruiting

Bone DensityActive, not recruiting

Acute-on-Chronic Liver FailureActive, not recruiting

Acute Myocardial InfarctionActive, not recruiting

Alcoholic Liver CirrhosisActive, not recruiting

PneumoniaActive, not recruiting

Chronic Graft Versus Host DiseaseActive, not recruiting

Amyotrophic Lateral SclerosisActive, not recruiting

OsteonecrosisPhase 1

Active, not recruiting

Erectile DysfunctionPhase 1

Active, not recruiting

Respiratory FailurePhase 2

Active, not recruiting

Bone DensityPhase 2

Active, not recruiting

Acute-on-Chronic Liver FailurePhase 1/Phase 2

Active, not recruiting

Acute Myocardial InfarctionPhase 2/Phase 3

Active, not recruiting

Alcoholic Liver CirrhosisPhase 2

Active, not recruiting

PneumoniaPhase 2

Active, not recruiting

Chronic Graft Versus Host DiseasePhase 2

Active, not recruiting

Amyotrophic Lateral SclerosisPhase 1/Phase 2

Active, not recruiting

Showing 10 of 20 indications

Competition

Competitive Landscape

1931 competitors in COVID-19

#DrugCompanyPhaseTrials

mesenchymal stem cell

RRohto Pharmaceutical Co., Ltd.

Phase 2

1 2

COVID-19 Vaccine

Moderna

Preclinical

27 3

Biaxin

AbbVie

Preclinical

2 4

Activella

Rayaldee

1 6

Statins

Sanofi

Preclinical

1 7

Aprotinin

Bayer

Preclinical

1 8

Olokizumab

UCB

Preclinical

1 9

Conventional

PPopulation Health Research Institute

Preclinical

1 10

Blood Taken

HHospices Civils de Lyon

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2028

Phase 1/2Recruiting

Mesenchymal Stem Cells

NCT05939167

Phase 1Recruiting

Mesenchymal Stem Cells

NCT07212335

Q1 2029

Phase 2Not yet recruiting

Heart Disease

NCT07192211

Clinical

Trials by Indication[1]

Mesenchymal Stem Cells5 trials

Mesenchymal Stem Cells in Rotator Cuff Repair

Suspended·UUniversity of Sao Paulo·Phase 2·NCT03362424·44 enrolled

Mesenchymal Stem Cells Enhanced With PRP Versus PRP In OA Knee

Unknown status·AAditya K Aggarwal·Phase 1/2·NCT01985633·24 enrolled

Safety and Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in the Treatment of Long-Term Cytopenia After CAR-T Therapy

Recruiting·IInstitute of Hematology & Blood Diseases Hospital, China·Phase 1·NCT07212335·15 enrolled

Show 2 more trials

Safety and Efficacy of Mesenchymal Stem Cells in Newly-diagnosed Type 1 Diabetic Patients

Unknown status·UUniversity of Sao Paulo·Phase 1/2·NCT01322789·10 enrolled

Mesenchymal Stem Cells Treatment for AIDS Patients at Late Stage

Recruiting·CCell Energy Life Sciences Group Co. LTD·Phase 1/2·NCT05939167·150 enrolled

Osteoarthritis3 trials

The Effects of Intra-articular Injection of Mesenchymal Stem Cells in Knee Joint Osteoarthritis

Completed·RRoyan Institute·Phase 2·NCT01504464·40 enrolled

Articular Cartilage Resurfacing With Mesenchymal Stem Cells In Osteoarthritis Of Knee Joint

Completed·RRoyan Institute·Phase 1·NCT01207661·6 enrolled

The Effects of Stromal Vascular Fraction and Mesenchymal Stem Cells as Intra-articular Injection in Knee Joint Osteoarthritis

Withdrawn·SSCARM Institute, Tabriz, Iran·Phase 2·NCT03164083

Pneumonia3 trials

Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia

Recruiting·MM.D. Anderson Cancer Center·Phase 1/2·NCT04565665·70 enrolled

An Exploratory Study of ADR-001 in Patients with Severe Pneumonia Caused by SARS-CoV-2 Infection

Completed·RRohto Pharmaceutical Co., Ltd.·Phase 1·NCT04522986·6 enrolled

A Study of ADR-001 in Patients With Severe Pneumonia Caused by SARS-CoV-2 Infection (COVID-19)

Completed·RRohto Pharmaceutical Co., Ltd.·Phase 2·NCT04888949·15 enrolled

Cirrhosis3 trials

An Follow-Up Study of Liver Cirrhosis

Completed·RRohto Pharmaceutical Co., Ltd.··NCT03472742·19 enrolled

A Study of ADR-001 in Patients With Liver Cirrhosis

Completed·RRohto Pharmaceutical Co., Ltd.·Phase 1/2·NCT03254758·21 enrolled

A Clinical Study to Evaluate the Safety and Efficacy of Mesenchymal Stem Cells in Liver Cirrhosis

Unknown status·—·Phase 1/2·NCT01877759·20 enrolled

Mesenchymal Stem Cell Transplantation2 trials

Side Effects of Autologous Mesenchymal Stem Cell Transplantation in Ankle Joint Osteoartritis

Completed·RRoyan Institute·Phase 1·NCT01436058·6 enrolled

Allogeneic Mesenchymal Stem Cell Transplantation in Tibial Closed Diaphyseal Fractures

Completed·RRoyan Institute·Phase 2·NCT02140528·40 enrolled

19 more indications

Mesenchymal Stem Cell2 trials

Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection

Completed·MMan Clinic for Andrology, Male Infertility and Sexual Dysfunction·N/A·NCT02414295·1 enrolled

Transplantation of Bone Marrow Mesenchymal Stem Cell in Crohn's Disease

Unknown status·RRoyan Institute·Phase 1·NCT01874015·10 enrolled

Bone Density1 trial

Evaluation of Clinical and Bone Density Improvement After Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord on Osteoporosis Patients

Unknown status·AAhmad Jabir Rahyussalim·Phase 2·NCT04501354·5 enrolled

Acute Myocardial Infarction1 trial

Safety and Efficacy of Intracoronary Adult Human Mesenchymal Stem Cells After Acute Myocardial Infarction

Completed·YYonsei University·Phase 2/3·NCT01392105·80 enrolled

Nephropathy1 trial

Mesenchymal Stem Cell Transplantation in the Treatment of Chronic Allograft Nephropathy

Unknown status·FFuzhou General Hospital·Phase 1/2·NCT00659620·20 enrolled

COVID-191 trial

Mesenchymal Stromal Cells for the Treatment of Patients With COVID-19.

Withdrawn·PPaulo Brofman·Phase 1/2·NCT05433298

Renal Transplantation1 trial

A Perspective Multicenter Controlled Study On Application Of Mesenchymal Stem Cell(MSC) To Prevent Rejection After Renal Transplantation By Donation After Cardiac Death

Unknown status·QQipeng Sun·Phase 1·NCT02490020·260 enrolled

Amyotrophic Lateral Sclerosis1 trial

Mesenchymal Stem Cell Injection in Amyotrophic Lateral Sclerosis

Withdrawn·—·Phase 1/2·NCT02116634

Erectile Dysfunction1 trial

Safety of Autologous Bone Marrow Derived Mesenchymal Stem Cells in Erectile Dysfunction

Completed·PPharmicell Co., Ltd.·Phase 1·NCT02344849·10 enrolled

Lupus Nephritis1 trial

Effect of Mesenchymal Stem Cell Transplantation for Lupus Nephritis

Unknown status·OOrgan Transplant Institute, China·Phase 1/2·NCT00659217·20 enrolled

Osteonecrosis1 trial

Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head

Unknown status·JJianming Tan·Phase 1·NCT00813267·15 enrolled

Chronic Graft Versus Host Disease1 trial

Safety and Efficacy Study of Allogenic Mesenchymal Stem Cells to Treat Extensive Chronic Graft Versus Host Disease

Unknown status·GGuangdong Provincial People's Hospital·Phase 2·NCT00972660·52 enrolled

Alcoholic Liver Cirrhosis1 trial

The Effectiveness and Safety for Mesenchymal Stem Cell for Alcoholic Liver Cirrhosis

Unknown status·YYonsei University·Phase 2·NCT01741090·12 enrolled

Graft Versus Host Disease1 trial

Evaluation of the Role of Mesenchymal Stem Cells in the Treatment of Graft Versus Host Disease

Unknown status·—·Phase 1/2·NCT00314483·25 enrolled

Rheumatoid Arthritis1 trial

Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Affected Knee Osteoarthritis by Rheumatoid Arthritis

Completed·RRoyan Institute·Phase 2/3·NCT01873625·60 enrolled

Respiratory Failure1 trial

Mesenchymal Stem Cell in Patients With Acute Severe Respiratory Failure

Unknown status·—·Phase 2·NCT02112500·10 enrolled

Heart Disease1 trial

Exploratory Study of ADR-002K for Heart Failure Patients With Ischemic Heart Disease Who Undergo CABG

Not yet recruiting·RRohto Pharmaceutical Co., Ltd.·Phase 2·NCT07192211·50 enrolled

Hypertension1 trial

Hypoxia and Inflammatory Injury in Human Renovascular Hypertension

Completed·MMayo Clinic·Phase 1·NCT02266394·42 enrolled

Xerostomia1 trial

Mesenchymal Stemcells for Radiation Induced Xerostomia

Completed·RRigshospitalet, Denmark·Phase 2·NCT02513238·30 enrolled

Acute-on-Chronic Liver Failure1 trial

Safety and Efficacy of Mesenchymal Stem Cell Transplantation for Acute-on-Chronic Liver Failure

Unknown status·TTianjin Weikai Bioeng., Ltd.·Phase 1/2·NCT03863002·45 enrolled

Sources

References

[1]
ClinicalTrials.gov — 36 trial records for mesenchymal stem cell. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — mesenchymal stem cell compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for mesenchymal stem cell. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Rohto Pharmaceutical Co., Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Cell therapy[2]
Highest Phase: Phase 2[1]
Company: RRohto Pharmaceutical Co., Ltd.

mesenchymal stem cell

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2028

Q1 2029

Trials by Indication[1]

Mesenchymal Stem Cells5 trials

Osteoarthritis3 trials

Pneumonia3 trials

Cirrhosis3 trials

Mesenchymal Stem Cell Transplantation2 trials

Mesenchymal Stem Cell2 trials

Bone Density1 trial

Acute Myocardial Infarction1 trial

Nephropathy1 trial

COVID-191 trial

Renal Transplantation1 trial

Amyotrophic Lateral Sclerosis1 trial

Erectile Dysfunction1 trial

Lupus Nephritis1 trial

Osteonecrosis1 trial

Chronic Graft Versus Host Disease1 trial

Alcoholic Liver Cirrhosis1 trial

Graft Versus Host Disease1 trial

Rheumatoid Arthritis1 trial

Respiratory Failure1 trial

Heart Disease1 trial

Hypertension1 trial

Xerostomia1 trial

Acute-on-Chronic Liver Failure1 trial

References

Drug Info

Quick Facts

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