Norco

ApprovedSmall molecule

Pfizer

Norco is one of 75 small molecule programs targeting Nausea and vomiting. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Nausea and VomitingActive, not recruiting

Cesarean SectionActive, not recruiting

Nausea and VomitingPhase 3

Active, not recruiting

Cesarean SectionApproved

Active, not recruiting

Competition

Competitive Landscape

230 competitors in Cesarean Section

#DrugCompanyPhaseTrials

Norco

Pfizer

Approved

1 2

Marcaine

IInnocoll

Preclinical

21 3

Pitocin

RRetrophin

Preclinical

16 4

Naropin

FFresenius Kabi Oncology Ltd.

Preclinical

12 5

Neo-Synephrine

EExela Pharma Sciences, LLC.

Preclinical

11 6

Dynastat

Pfizer

Preclinical

1 7

Duragesic

CCephalon

Preclinical

6 8

Versed

CConrado Roberto Hoffmann Filho

Preclinical

4 9

Catapres

Boehringer Ingelheim

Preclinical

4 10

Ancef

BBaxter Healthcare Corporation

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2028

Post-ApprovalRecruiting

Knee Arthroscopic Surgery

NCT03858231

Clinical

Trials by Indication[1]

Concentration2 trials

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults

Withdrawn·GGrünenthal GmbH·Phase 1·NCT03137030

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults

Withdrawn·GGrünenthal GmbH·Phase 1·NCT03137017

Acetaminophen1 trial

Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco

Completed· Pfizer logo

Pfizer·Phase 1·NCT01456520·47 enrolled

Functional Endoscopic Sinus Surgery1 trial

Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT03605914·100 enrolled

Benzodiazepines1 trial

Opiates and Benzodiazepines on Driving

Completed·TTimothy L. Brown·Phase 4·NCT03447353·18 enrolled

Nausea and vomiting1 trial

A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV)

Completed·JJoseph Hazelton·Phase 3·NCT02462811·552 enrolled

8 more indications

Tonsillectomy1 trial

Post-tonsillectomy Pain Control in Adults

Terminated·UUniversity of Nebraska·Phase 4·NCT02358850·27 enrolled

Postoperative Pain Management1 trial

Postoperative Pain Management in Rhinoplasty

Completed·SStanford University·Phase 2·NCT03584152·159 enrolled

Knee Arthroscopic Surgery1 trial

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

Recruiting·SSanford Health·Phase 4·NCT03858231·148 enrolled

Rhinoplasty1 trial

Narcotics vs NSAIDs for Post-operative Analgesia in Outpatient Rhinoplasty

Completed·NNYU Langone Health·Phase 4·NCT03457116·70 enrolled

Efficacy and Safety1 trial

A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg for Acute Pain and the Prevention of OINV

Completed·CCharleston Laboratories, Inc·Phase 3·NCT03657810·349 enrolled

Pain1 trial

RCT: Suzetrigine vs Norco for Post-op Pain

Not yet recruiting·JJacob Lensing·Phase 4·NCT07195669·76 enrolled

Cesarean Section1 trial

Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT03372382·170 enrolled

Unspecified1 trial

Patient Narcotic Requirements After Outpatient Otolaryngology Procedures

Completed·LLoma Linda University·Phase 3·NCT03404518·185 enrolled

Sources

References

[1]
ClinicalTrials.gov — 14 trial records for Norco. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Norco compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Norco. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pfizer

Norco

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2028

Trials by Indication[1]

Concentration2 trials

Acetaminophen1 trial

Functional Endoscopic Sinus Surgery1 trial

Benzodiazepines1 trial

Nausea and vomiting1 trial

Tonsillectomy1 trial

Postoperative Pain Management1 trial

Knee Arthroscopic Surgery1 trial

Rhinoplasty1 trial

Efficacy and Safety1 trial

Pain1 trial

Cesarean Section1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

Related News