Opioid

Phase 3Small molecule

Johnson & Johnson

Opioid is one of 184 small molecule programs targeting Acute Pancreatitis. It is currently in Phase 3.

Indications

Total Trials

Active Trials

183

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute PancreatitisActive, not recruiting

Cancer PainActive, not recruiting

Chronic PainRecruiting

Bladder CancerActive, not recruiting

Multiple MyelomaActive, not recruiting

General AnesthesiaCompleted

Acute PancreatitisPreclinical

Active, not recruiting

Cancer PainPreclinical

Active, not recruiting

Chronic PainPhase 2

Recruiting

Bladder CancerPreclinical

Active, not recruiting

Multiple MyelomaPhase 3

Active, not recruiting

General AnesthesiaPreclinical

Completed

Competition

Competitive Landscape

259 competitors in Multiple Myeloma

#DrugCompanyPhaseTrials

Belamaf

GSK

Phase 3

39 2

Fludara

Sanofi

Phase 3

47 3

Venclexta

AbbVie

Phase 3

17 4

Keytruda

Merck & Co.

Phase 3

17 5

Sarclisa

AAzienda U.S.L. 1 di Massa e Carrara

Phase 3

42 6

Biaxin

AbbVie

Phase 3

14 7

Opdivo

Bristol-Myers Squibb

Phase 3

11 8

Xpovio

KKaryopharm Therapeutics Inc

Phase 3

28 9

Azatiq

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Elranatamab

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q2 2027

Phase 3Active, not recruiting

Multiple Myeloma

NCT04459416

Q3 2027

ApprovedRecruiting

Pain, Postoperative

NCT05722002

Q4 2027

ApprovedRecruiting

Post Operative

NCT06671002

Q4 2029

Phase 2Recruiting

Chronic Pain

NCT06837857

Clinical

Trials by Indication[1]

Analgesic2 trials

Opioid Analgesic Reduction Study (OARS) - Pilot

Completed·RRutgers, The State University of New Jersey·Phase 3·NCT05283499·53 enrolled

Different Postoperative Analgesics Use After Ureteroscopy

Unknown status·PPakistan Kidney and Liver Institute and Research Center·N/A·NCT05507554·176 enrolled

Pain, Postoperative2 trials

Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone

Terminated·SStanford University·Approved·NCT04676802·73 enrolled

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

Recruiting·UUniversity of Michigan·Approved·NCT05722002·900 enrolled

Spinal Anesthesia1 trial

The Assessment of POCD After TURBT Under Spinal Anesthesia

Unknown status·MMedical University of Warsaw·Phase 4·NCT03029676·200 enrolled

Postoperative Analgesia1 trial

Erector Spinae Block vs Conventional Analgesia for Postoperative Analgesia in PCNL

Not yet recruiting·SSohag University·N/A·NCT06935006·50 enrolled

Cancer Pain1 trial

Morphine as First Drug for Cancer Pain

Completed·FFederal University of São Paulo·N/A·NCT01541124·60 enrolled

21 more indications

Colorectal Surgery1 trial

Ketamine in Colorectal Surgery

Withdrawn·MMedical College of Wisconsin·Phase 4·NCT02785003

Mastectomy1 trial

Comparison of Pain Therapeutic Effects After Benign Mastectomy

Completed·NNanjing Medical University·Phase 4·NCT00519246·2,000 enrolled

Opioid1 trial

Bioequivalence Trial of a New Opioid Combination Compared to Reference

Completed·GGrünenthal GmbH·Phase 1·NCT00460785·32 enrolled

Opioid Free Anesthesia1 trial

Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.

Completed·—··NCT06683911·98 enrolled

Pancreatitis1 trial

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Terminated·—·Phase 2·NCT04291599·23 enrolled

PONV1 trial

The Effect of PCA on PONV After Microvascular Decompression

Unknown status·SSeoul National University Hospital·N/A·NCT05189704·94 enrolled

Surgery1 trial

Opioid Free Anaesthesia in Oncologic Gynaecological Surgery: Is There Any Benefit?

Completed·IInstituto de Investigación Hospital Universitario La Paz··NCT05448586·132 enrolled

Rib Fracture1 trial

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

Completed·MMedical College of Wisconsin·Phase 4·NCT02432456·153 enrolled

Efficacy1 trial

Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT02336685·79 enrolled

Treatment1 trial

Safety of Fentanyl TAIFUN Treatment

Unknown status·AAkela Pharma, Inc.·Phase 3·NCT00822614·500 enrolled

Chronic pain1 trial

Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain

Recruiting·MMayo Clinic·Phase 2·NCT06837857·200 enrolled

Low back pain1 trial

Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain

Completed·UUniversity Hospitals Cleveland Medical Center·Phase 4·NCT02886286·17 enrolled

Marijuana1 trial

Reinforcing Effects of Marijuana and Opioids

Completed·SShanna Babalonis, PhD·Phase 1·NCT05485012·8 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy

Unknown status·TThe Second Hospital of Anhui Medical University·N/A·NCT06199011·400 enrolled

Total Knee Arthroplasty1 trial

Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty

Unknown status·GGuangzhou General Hospital of Guangzhou Military Command·Phase 4·NCT02094339·45 enrolled

Neuropathic Pain1 trial

Pregabalin add-on for Neuropathic Pain in Cervical Myelopathy

Unknown status·SSeoul National University Hospital·Phase 1·NCT03618589·60 enrolled

Acute Pancreatitis1 trial

Use of Patient-Controlled Analgesia in Acute Pancreatitis

Terminated·—··NCT04816877·7 enrolled

General Anesthesia1 trial

Pain Assessment During General Anesthesia

Completed·—·N/A·NCT01303471·75 enrolled

Bladder Cancer1 trial

Quadratus Lumborum Block vs Transversus Abdominis Plane Block in Bladder Cancer Surgeries

Unknown status·NNational Cancer Institute, Egypt·N/A·NCT04402411·63 enrolled

Post Operative1 trial

Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids (CARES for Kids) Trial

Recruiting·UUniversity of Michigan·Approved·NCT06671002·900 enrolled

Multiple Myeloma1 trial

Opioid-Sparing Pain Treatment In Myeloma And Lymphoma Patients Undergoing High-Dose Chemotherapy (OPTIMAL-HiChemo): Randomized Controlled Trial

Active, not recruiting·MMemorial Sloan Kettering Cancer Center·Phase 3·NCT04459416·299 enrolled

Sources

References

[1]
ClinicalTrials.gov — 28 trial records for Opioid. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Opioid compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Opioid. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Johnson & Johnson company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Johnson & Johnson

Opioid

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q2 2027

Q3 2027

Q4 2027

Q4 2029

Trials by Indication[1]

Analgesic2 trials

Pain, Postoperative2 trials

Spinal Anesthesia1 trial

Postoperative Analgesia1 trial

Cancer Pain1 trial

Colorectal Surgery1 trial

Mastectomy1 trial

Opioid1 trial

Opioid Free Anesthesia1 trial

Pancreatitis1 trial

PONV1 trial

Surgery1 trial

Rib Fracture1 trial

Efficacy1 trial

Treatment1 trial

Chronic pain1 trial

Low back pain1 trial

Marijuana1 trial

Laparoscopic Sleeve Gastrectomy1 trial

Total Knee Arthroplasty1 trial

Neuropathic Pain1 trial

Acute Pancreatitis1 trial

General Anesthesia1 trial

Bladder Cancer1 trial

Post Operative1 trial

Multiple Myeloma1 trial

References

Drug Info

Quick Facts

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