Photodynamic Therapy

Phase 2Small molecule

RRoswell Park Cancer Institute

Photodynamic Therapy is one of 70 small molecule programs targeting Retinoblastoma. It is currently in Phase 2.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

RetinoblastomaActive, not recruiting

Oropharyngeal CancerWithdrawn

Pancreatic CancerRecruiting

RetinoblastomaPreclinical

Active, not recruiting

Oropharyngeal CancerPreclinical

Withdrawn

Pancreatic CancerPhase 2

Recruiting

Competition

Competitive Landscape

335 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

Photodynamic Therapy

RRoswell Park Cancer Institute

Phase 2

2 2

Medrol

Pfizer

Preclinical

1 3

Byetta

AstraZeneca

Preclinical

1 4

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

1 5

Ayvakit Sprinkle

MMemorial Sloan Kettering Cancer Center

Preclinical

1 6

Xylocaine

MMEDRx USA, Inc.

Preclinical

1 7

Active Comparator

Moderna

Preclinical

1 8

Sulfonylureas

Eli Lilly

Preclinical

1 9

HS-20093

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Preclinical

1 10

Hyperpolarized 13c Pyruvate

UUniversity of Maryland, Baltimore

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2029

Phase 2Recruiting

Pancreatic Cancer

NCT06381154

Clinical

Trials by Indication[1]

Pancreatic Cancer2 trials

Ultrasound-Guided Verteporfin Photodynamic Therapy for the Treatment of Unresectable Solid Pancreatic Tumors or Advanced Pancreatic Cancer, VERTPAC-02 Study

Completed·MMayo Clinic·Phase 2·NCT03033225·13 enrolled

Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer

Recruiting·MMayo Clinic·Phase 2·NCT06381154·25 enrolled

Recurrent Head and Neck Cancer2 trials

Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer

Completed·RRoswell Park Cancer Institute·Phase 1·NCT00470496·15 enrolled

Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer

Terminated·RRoswell Park Cancer Institute·Phase 2·NCT02068157·3 enrolled

Actinic Keratoses2 trials

Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy

Terminated·—·Phase 4·NCT01203878·21 enrolled

Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses

Completed·—·Phase 2·NCT04140292·75 enrolled

Malignancy2 trials

HPPH and PDT for Pleural Malignancy

Completed·—·Phase 1·NCT01673074·37 enrolled

Photodynamic Therapy During Surgery in Treating Patients With Pleural Malignancy

Withdrawn·OOhio State University Comprehensive Cancer Center·N/A·NCT02106559

Non-Small Cell Lung Cancer2 trials

Photodynamic Therapy During Surgery in Treating Patients With Non-small Cell Lung Cancer That Can Be Removed by Surgery

Completed·RRoswell Park Cancer Institute·Phase 1·NCT01854684·8 enrolled

Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease

Terminated·RRoswell Park Cancer Institute·Phase 1·NCT04836429·5 enrolled

15 more indications

Oral leukoplakia1 trial

Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia

Terminated·NNational Cancer Institute (NCI)·Phase 1·NCT00571558·15 enrolled

Myopia1 trial

Efficacy and Safety of Intravitreal Bevacizumab in the Treatment of Choroidal Neovascular Membranes Associated to High Myopia

Completed·IInstituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA·Phase 3·NCT00967850·56 enrolled

Colorectal Cancer1 trial

Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer

Suspended·RRoswell Park Cancer Institute·Phase 1/2·NCT06307548·21 enrolled

Cervical Intraepithelial Neoplasia1 trial

Photodynamic Therapy Using Lutetium Texaphyrin in Treating Patients With Cervical Intraepithelial Neoplasia

Terminated·NNational Cancer Institute (NCI)·Phase 1·NCT00005808·54 enrolled

Oral Cavity Cancer1 trial

Photodynamic Therapy With HPPH Compared to Standard of Care Surgery in Treating Patients With Oral Cavity Cancer

Terminated·RRoswell Park Cancer Institute·Phase 2·NCT03090412·2 enrolled

Benign Prostatic Hyperplasia1 trial

Dose Escalation Study With QLT0074 for Benign Prostatic Hyperplasia

Completed·QQLT Inc.·Phase 1/2·NCT00077012

Oral Lichen Planus1 trial

A Comparison of Photodynamic Therapy and Topical Clobetasol in Treatment of Oral Lichen Planus: a Split-Mouth Randomised Controlled Study

Completed·WWroclaw Medical University·Phase 2·NCT06752343·29 enrolled

Skin Cancer1 trial

Photodynamic Therapy Using Methyl-5-Aminolevulinate Hydrochloride Cream in Determining Pain Threshold in Patients With Skin Cancer

Completed·RRoswell Park Cancer Institute·Phase 1·NCT01292668·21 enrolled

Lung Cancer1 trial

Photodynamic Therapy in Treating Patients With Lung Cancer

Completed·RRoswell Park Cancer Institute·Phase 1·NCT01668823·17 enrolled

Mycosis Fungoides1 trial

Photodynamic Therapy in Treating Patients With Refractory Mycosis Fungoides

Completed·MMayo Clinic·Phase 1·NCT03281811·11 enrolled

Retinoblastoma1 trial

Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study

Completed·SSun Yat-sen University·N/A·NCT04429139·8 enrolled

Skin Microbiome1 trial

Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)

Unknown status·UUniversity of Zurich·Phase 1·NCT05676801·20 enrolled

Prostate Cancer1 trial

Photodynamic Therapy With Lutetium Texaphyrin in Treating Patients With Locally Recurrent Prostate Cancer

Terminated·NNational Cancer Institute (NCI)·Phase 1·NCT00005067·24 enrolled

T-cell non-Hodgkin lymphoma1 trial

Silicon Phthalocyanine 4 and Photodynamic Therapy in Stage IA-IIA Cutaneous T-Cell Non-Hodgkin Lymphoma

Completed·—·Phase 1·NCT01800838·11 enrolled

Oropharyngeal Cancer1 trial

Photodynamic Therapy Using Temoporfin Before Surgery in Treating Patients With Recurrent Oral Cavity or Oropharyngeal Cancer

Withdrawn·RRoswell Park Cancer Institute·N/A·NCT01718223

Sources

References

[1]
ClinicalTrials.gov — 25 trial records for Photodynamic Therapy. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Photodynamic Therapy compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Photodynamic Therapy. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Roswell Park Cancer Institute company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: RRoswell Park Cancer Institute

Photodynamic Therapy

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2029

Trials by Indication[1]

Pancreatic Cancer2 trials

Recurrent Head and Neck Cancer2 trials

Actinic Keratoses2 trials

Malignancy2 trials

Non-Small Cell Lung Cancer2 trials

Oral leukoplakia1 trial

Myopia1 trial

Colorectal Cancer1 trial

Cervical Intraepithelial Neoplasia1 trial

Oral Cavity Cancer1 trial

Benign Prostatic Hyperplasia1 trial

Oral Lichen Planus1 trial

Skin Cancer1 trial

Lung Cancer1 trial

Mycosis Fungoides1 trial

Retinoblastoma1 trial

Skin Microbiome1 trial

Prostate Cancer1 trial

T-cell non-Hodgkin lymphoma1 trial

Oropharyngeal Cancer1 trial

References

Drug Info

Quick Facts

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