Propylene Glycol

ApprovedSmall molecule

TThe Cleveland Clinic

Propylene Glycol is one of 23 small molecule programs targeting Total Knee Arthroplasty. It is currently in Approved.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Total Knee ArthroplastyActive, not recruiting

Dry Eye Disease (DED)Recruiting

Total Knee ArthroplastyPhase 2

Active, not recruiting

Dry Eye Disease (DED)Approved

Recruiting

Competition

Competitive Landscape

275 competitors in Total Knee Arthroplasty

#DrugCompanyPhaseTrials

Propylene Glycol

TThe Cleveland Clinic

Approved

1 2

Xarelto

WWim Janssens

Preclinical

5 3

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

4 4

EXPAREL

Pacira Pharmaceuticals, Inc

Preclinical

7 5

Nucynta

CCollegium Pharmaceutical, Inc.

Preclinical

2 6

Xylocaine

MMEDRx USA, Inc.

Preclinical

2 7

Epsom Salt

FFresenius Kabi Oncology Ltd.

Preclinical

1 8

Zanaflex

LLegacy Health System

Preclinical

1 9

Nexium

DDexcel Pharma Technologies Ltd.

Preclinical

1 10

Bupivacain

IIstanbul University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

ApprovedRecruiting

Dry Eye Disease (DED)

NCT07676084

Clinical

Trials by Indication[1]

Homeostasis1 trial

Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients

Suspended·NNew York City Health and Hospitals Corporation·Phase 1/2·NCT03066817·60 enrolled

Total Knee Arthroplasty1 trial

Post-Operative Constipation Following Total Knee Arthroplasty

Completed·TThe Cleveland Clinic·Phase 2·NCT04380090·154 enrolled

Hyaluronic Acid1 trial

Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars

Unknown status·—·Phase 3·NCT05116306·36 enrolled

Dry Eye Disease (DED)1 trial

A Randomized, Investigator-Masked, Single-Center Study Evaluating Tolerability, Symptomatic Improvement, and Visual Functional Outcomes With the Use of Over-the-Counter Lubricating Eye Drops in Subjects With Dry Eye Disease

Recruiting·AAndover Research Eye Institute·Approved·NCT07676084·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 4 trial records for Propylene Glycol. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Propylene Glycol compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Propylene Glycol. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — The Cleveland Clinic company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: TThe Cleveland Clinic

Propylene Glycol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Trials by Indication[1]

Homeostasis1 trial

Total Knee Arthroplasty1 trial

Hyaluronic Acid1 trial

Dry Eye Disease (DED)1 trial

References

Drug Info

Quick Facts

Related News