EXPAREL

ApprovedSmall molecule

Pacira Pharmaceuticals, Inc

EXPAREL is one of 222 small molecule programs targeting Rib Fracture. It is currently in Approved.

Indications

Total Trials

Active Trials

221

Competitors

Pipeline

Status by Indication[3][1]

Indication

Rib FractureActive, not recruiting

Hip FractureActive, not recruiting

HemorrhoidActive, not recruiting

Shoulder PainActive, not recruiting

Spinal FusionActive, not recruiting

Total Knee ArthroplastyActive, not recruiting

HysterectomyActive, not recruiting

Post Operative PainRecruiting

Cesarean SectionActive, not recruiting

Facial PainActive, not recruiting

Rib FractureApproved

Active, not recruiting

Hip FractureApproved

Active, not recruiting

HemorrhoidApproved

Active, not recruiting

Shoulder PainPhase 2/Phase 3

Active, not recruiting

Spinal FusionPhase 1

Active, not recruiting

Total Knee ArthroplastyPreclinical

Active, not recruiting

HysterectomyApproved

Active, not recruiting

Post Operative PainPhase 1

Recruiting

Cesarean SectionApproved

Active, not recruiting

Facial PainPhase 2

Active, not recruiting

Showing 10 of 11 indications

Competition

Competitive Landscape

275 competitors in Total Knee Arthroplasty

#DrugCompanyPhaseTrials

EXPAREL

Pacira Pharmaceuticals, Inc

Approved

7 2

Cymbalta

Alnylam Pharmaceuticals

Preclinical

5 3

Xarelto

WWim Janssens

Preclinical

5 4

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

4 5

Sufenta

LLeaf Vertical Inc.

Preclinical

3 6

Xylocaine

MMEDRx USA, Inc.

Preclinical

2 7

Zanaflex

LLegacy Health System

Preclinical

1 8

Nexium

DDexcel Pharma Technologies Ltd.

Preclinical

1 9

Epsom Salt

FFresenius Kabi Oncology Ltd.

Preclinical

1 10

Botox

AbbVie

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Pain Control

NCT05285566

Q4 2026

Post-ApprovalRecruiting

Liposomal Bupivacaine

NCT03737292

Post-ApprovalRecruiting

Mastectomy

NCT06574022

Q1 2027

Phase 1Recruiting

Postoperative Analgesia

NCT06271265

Q4 2027

Phase 3Recruiting

Renal Carcinoma

NCT07092566

Clinical

Trials by Indication[1]

Liposomal Bupivacaine11 trials

0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka

Terminated·MMontefiore Medical Center·Phase 3·NCT03303794·25 enrolled

Pain Control in Colorectal Surgery: Liposomal Bupivacaine Block Versus Intravenous Lidociane

Completed·WWake Forest University Health Sciences·Phase 4·NCT04005859·61 enrolled

Liposomal Bupivacaine Versus Interscalene Nerve Block

Completed·UUniversity of Cincinnati·Phase 4·NCT03929146·76 enrolled

Show 8 more trials

Liposomal Bupivacaine After Cesarean Delivery

Withdrawn·WWright State University·Phase 4·NCT03907813

Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

Recruiting·MMilton S. Hershey Medical Center·Phase 4·NCT03737292·40 enrolled

Liposomal Bupivacaine in Rotator Cuff Repair

Completed·UUniversity of Alabama at Birmingham·Phase 4·NCT03738696·64 enrolled

A Comparison of the Post-C/S Analgesic Effects of Neuraxial Duramorph vs Bilateral TAP Block With Liposomal Bupivacaine

Terminated·MMaimonides Medical Center·Phase 4·NCT03638011·71 enrolled

Liposomal Bupivacaine vs Bupivacaine for Pain Control After Sternotomy

Unknown status·UUniversity of Kansas Medical Center·Phase 1·NCT04585867·80 enrolled

TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery

Completed·UUniversity of California, Davis·Phase 4·NCT03080142·86 enrolled

The Effect of Liposomal Bupivacaine Nerve Block (Exparel) in Rotator Cuff Surgery

Enrolling by invitation·TThe Cooper Health System·Phase 4·NCT06139666·160 enrolled

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

Completed·UUnknown Sponsor·Phase 3·NCT03270514·60 enrolled

Total Knee Arthroplasty7 trials

Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)

Unknown status·RRothman Institute Orthopaedics·N/A·NCT02060591

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

Unknown status·—·N/A·NCT02607579·200 enrolled

Comparing Pain Relief Between Exparel® Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)

Completed·RRothman Institute Orthopaedics·N/A·NCT02739230

Show 4 more trials

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

Completed·SSt. Luke's Hospital, Pennsylvania·Phase 3·NCT04910165·100 enrolled

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02713490·140 enrolled

Liposomal Bupivacaine in Total Knee Arthroplasty

Completed·—·N/A·NCT03541265·70 enrolled

Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 2/3·NCT01683071·297 enrolled

Postsurgical Analgesia5 trials

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT04518462·121 enrolled

EXPAREL Administered by Infiltration Into the TAP for Prolonged Postsurgical Analgesia in Lower Abdominal Surgeries

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01919190·67 enrolled

Bupivacaine Liposomal Injection (Exparel) for Postsurgical Analgesia in Patient Undergoing Laparoscopic Bariatric Surgery

Completed·TThe Cleveland Clinic·Phase 4·NCT02969187·126 enrolled

Show 2 more trials

Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries

Withdrawn· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT03954639

Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety, of EXPAREL Administered as Sciatic Nerve Block (In Popliteal Fossa), for Postsurgical Analgesia in Subjects Undergoing Bunionectomy

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT04002089·45 enrolled

Post Operative Pain4 trials

Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion

Enrolling by invitation·FFoundation for Orthopaedic Research and Education·Phase 2/3·NCT06350981·76 enrolled

Efficacy of Exparel (TM) on Post-operative Pain After Laparoscopic Gastric Bypass Using Circular EEA Stapler

Completed·MMatthew Kroh·Phase 4·NCT03187379·102 enrolled

Early Post-Operative Pain Control Following Wrist Operations

Unknown status·UUniversity of Tennessee·N/A·NCT02052180·70 enrolled

Show 1 more trial

Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

Recruiting·TTexas Tech University Health Sciences Center·Phase 1·NCT06349772·130 enrolled

Adult4 trials

A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B504

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01509807·33 enrolled

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B302

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01507233·5 enrolled

A Health Economic Trial in Adult Patients Undergoing Ileostomy Reversal MA402S23B501

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01509638·47 enrolled

Show 1 more trial

Adult Patients Undergoing Open Colectomy MA402S23B303

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01507246·42 enrolled

53 more indications

Hernia3 trials

Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair

Completed·UUniversity of Kansas Medical Center·Phase 4·NCT02128646·19 enrolled

Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

Completed·TThe Cleveland Clinic·Phase 4·NCT03541941·164 enrolled

EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01801124·13 enrolled

Bupivacaine3 trials

Efficacy of EXPAREL vs. Bupivacaine

Recruiting·EEmory University·Phase 3·NCT07212114·104 enrolled

Comparison of Bupivacaine and Exparel for Carpal Tunnel Release

Withdrawn·UUniversity of Pittsburgh·N/A·NCT02141178

Postsurgical Bupivacaine Extended-release Liposome Injection for Open-reduction Internal Distal Radius Fixation.

Terminated·UUniversity of Louisville·Phase 4·NCT02515851·30 enrolled

Tics2 trials

Evaluation of Safety, Pharmacokinetics and Pharmacodynamics of EXPAREL® Administered Via a Single Intrathecal Injection to Healthy Volunteers

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT04173611·20 enrolled

Safety and Pharmacokinetics Study of Redosing EXPAREL in Healthy Volunteers

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT02210247·60 enrolled

Hip Fracture2 trials

Randomized Controlled Trial for Exparel Hip Fracture

Completed·UUniversity of Massachusetts, Worcester·Phase 4·NCT03289858·55 enrolled

EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture

Withdrawn· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT03955458

Postoperative Pain Control2 trials

Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures

Completed·LLoma Linda University·Phase 4·NCT02805504·136 enrolled

TAP Block for Postoperative Pain Control

Terminated·JJoshua Herskovic·Phase 3·NCT02652156·14 enrolled

Bunion2 trials

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

Completed·CConcentric Analgesics·Phase 2·NCT03885596·36 enrolled

Pericapsular Exparel for Pain Relief in Bunionectomy and Related Procedures

Terminated·OOhioHealth·N/A·NCT02499575·2 enrolled

ACL Reconstruction2 trials

Exparel vs. ACB With Bupivacaine for ACL Reconstruction

Unknown status·—·Phase 1·NCT06274008·96 enrolled

Exparel vs Block for ACL Reconstruction

Enrolling by invitation·RRothman Institute Orthopaedics·Phase 4·NCT06006624·154 enrolled

Pain Control2 trials

Post C-Section Pain Control Using EXPAREL

Withdrawn·UUniversity of Minnesota·Phase 4·NCT03377595

Pain Control for Undergoing Costal Cartilage Harvesting

Recruiting·MMayo Clinic·Phase 4·NCT05285566·60 enrolled

Pediatric2 trials

Multicenter Study for Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT03682302·98 enrolled

Study in Pediatric Subjects Evaluating Pharmacokinetics and Safety of EXPAREL

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT03485014·15 enrolled

Cesarean Section2 trials

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02353754·12 enrolled

Efficacy and Safety of EXPAREL Versus Standard of Care (SoC) in Subjects Undergoing Elective Cesarean Section

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT03853694·167 enrolled

Spinal Fusion2 trials

PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT02985762·15 enrolled

Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT03015961·38 enrolled

Postoperative Analgesia2 trials

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

Recruiting· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT06271265·48 enrolled

PAIN - Postoperative Analgesia INvestigation

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02111746·350 enrolled

Colorectal Surgery2 trials

Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery

Completed·MMayo Clinic·N/A·NCT02356198·209 enrolled

Modified TAP (Transverse Abdominis Plane) Block in Colorectal Surgery

Completed·OOchsner Health System·Phase 4·NCT04781075·76 enrolled

Infiltration1 trial

Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision

Unknown status·—·Phase 4·NCT03870685·43 enrolled

Hysterectomy1 trial

EXPAREL Administered Into the TAP for Analgesia in Subjects Undergoing Open Total Abdominal Hysterectomy

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01919606·1 enrolled

Liver1 trial

Evaluation Exparel Delivered in Knee Replacement

Completed·MMaimonides Medical Center·Phase 4·NCT02011464·20 enrolled

Knee Arthroplasty1 trial

EXPAREL IPSA Block in Knee Arthroplasty

Enrolling by invitation·CCampbell Clinic·Phase 4·NCT06619340·10 enrolled

Ankle Surgery1 trial

Exparel and Ankle Surgery

Completed·RRutgers, The State University of New Jersey·N/A·NCT02072135·4 enrolled

Total Knee Replacement1 trial

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

Unknown status·TThe New England Baptist Hospital·Phase 3·NCT02473198·312 enrolled

Adult Subject1 trial

Study in Adult Subjects Undergoing Posterolateral Thoracotomy

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT03428984·5 enrolled

Anesthesia1 trial

Transverse Abdominal Plane Anesthesia for Abdominal Wall Reconstruction

Withdrawn·CChester Mays·Phase 4·NCT02274077

Clinical Trial1 trial

The Transversus Abdominis Plane Block: A Prospective Randomized Clinical Trial Using EXPAREL.

Completed·CCorewell Health West·Phase 4·NCT02263963·50 enrolled

Lip1 trial

Foot and Ankle Clinic Application for Liposomal Related Anesthetic

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT02586077·36 enrolled

Hemorrhoid1 trial

Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following Hemorrhoidectomy

Terminated·SSt. Luke's-Roosevelt Hospital Center·Phase 4·NCT02104414·11 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction

Completed·EEmory University·Phase 4·NCT02189317·50 enrolled

Multimodal Pain Management1 trial

Multimodal Pain Management Following Primary TKA

Terminated·UUniversity of Utah·Phase 1·NCT02369523·84 enrolled

Laparoscopic1 trial

A Health Economic Trial in Adult Patients Undergoing Laparoscopic Colectomy

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02058290·122 enrolled

Acute Lymphoblastic Leukemia1 trial

EXPAREL for Minimally Invasive Supracervical Hysterectomies

Completed·MMaimonides Medical Center·Phase 4·NCT03769714·60 enrolled

Local Anesthetic1 trial

Comparison of Local Anesthetic Infusion Pump Versus DepoFoam Bupivacaine for Pain Management

Withdrawn·HHenry Ford Health System·Phase 4·NCT02542956

Postoperative Pain Relief1 trial

A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief

Terminated·VVirtua Health, Inc.·Phase 4·NCT03514277·19 enrolled

Tonsillectomy1 trial

Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02199574·12 enrolled

Catheter1 trial

Exparel Interscalene vs Indwelling Catheter

Terminated·MMontefiore Medical Center·Phase 2·NCT03827213·23 enrolled

Breast Reconstruction1 trial

The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery

Completed·NNorthwestern University·Phase 3·NCT05171179·60 enrolled

Bariatric Patients1 trial

Pain Control in Bariatric Patients: EXPAREL(R) vs. the On-Q(R) Pain Ball

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT02142829·101 enrolled

Epidural Analgesia1 trial

Bilateral Transversus Abdominis Plane Block With Exparel Verus Continuous Epidural Analgesia With Bupivacaine

Completed·TThe Cleveland Clinic·N/A·NCT02996227·514 enrolled

Pain Management1 trial

Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population

Recruiting·—·Phase 2·NCT06559215·100 enrolled

Nerve Block1 trial

Parasternal Nerve Block in Cardiac Patients

Completed·PPeter A Knight·Phase 2·NCT01826851·79 enrolled

Total Shoulder Arthroplasty1 trial

Exparel for Total Shoulder Arthroplasty

Completed·NNorton Healthcare·Phase 4·NCT04364867·102 enrolled

Liposome Bupivacaine1 trial

Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT01802411·191 enrolled

Spine Surgeries1 trial

Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT03927911·65 enrolled

Shoulder pain1 trial

Exparel for Total Shoulder Pain

Not yet recruiting·UUniversity of South Florida·Phase 2/3·NCT03739021·60 enrolled

Rib Fracture1 trial

Exparel for Pain Control During Care of Rib Fractures

Withdrawn·—·Phase 4·NCT02390440

Randomized Controlled Trial1 trial

Exparel Use in Peripheral Nerve Blocks and Local Infiltration for Foot and Ankle Surgery: A Randomized Controlled Trial

Unknown status·SSt. Luke's Hospital, Pennsylvania·Phase 4·NCT05494645·300 enrolled

Mastectomy1 trial

Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks

Recruiting·UUniversity of Cincinnati·Phase 4·NCT06574022·100 enrolled

Pain1 trial

Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel

Withdrawn·UUniversity of Louisville·Phase 4·NCT02571283

ART1 trial

Periarticular Injection Versus Popliteal Block

Enrolling by invitation·CCampbell Clinic·Phase 4·NCT04575688·100 enrolled

Donor1 trial

Liposomal Bupivicaine for Skin Graft Donor Sites in Burn Patients

Terminated·MMassachusetts General Hospital·Phase 1·NCT03705637·6 enrolled

Efficacy1 trial

"The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"

Terminated·—·Phase 2·NCT05355597·116 enrolled

Prostatectomy1 trial

TAP-patients With Robotic Assisted Lap Prostatectomy

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01582477·24 enrolled

Facial Pain1 trial

Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

Recruiting·SStanford University·Phase 2·NCT04930887·15 enrolled

Breast1 trial

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 1·NCT04293809·30 enrolled

Renal Carcinoma1 trial

Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

Recruiting·WWake Forest University Health Sciences·Phase 3·NCT07092566·170 enrolled

Unspecified1 trial

QL Block With Exparel in Colectomy

Completed·—·Phase 4·NCT03827291·35 enrolled

Sources

References

[1]
ClinicalTrials.gov — 99 trial records for EXPAREL. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — EXPAREL compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for EXPAREL. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pacira Pharmaceuticals, Inc company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pacira Pharmaceuticals, Inc

EXPAREL

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Q4 2027

Trials by Indication[1]

Liposomal Bupivacaine11 trials

Total Knee Arthroplasty7 trials

Postsurgical Analgesia5 trials

Post Operative Pain4 trials

Adult4 trials

Hernia3 trials

Bupivacaine3 trials

Tics2 trials

Hip Fracture2 trials

Postoperative Pain Control2 trials

Bunion2 trials

ACL Reconstruction2 trials

Pain Control2 trials

Pediatric2 trials

Cesarean Section2 trials

Spinal Fusion2 trials

Postoperative Analgesia2 trials

Colorectal Surgery2 trials

Infiltration1 trial

Hysterectomy1 trial

Liver1 trial

Knee Arthroplasty1 trial

Ankle Surgery1 trial

Total Knee Replacement1 trial

Adult Subject1 trial

Anesthesia1 trial

Clinical Trial1 trial

Lip1 trial

Hemorrhoid1 trial

Anterior Cruciate Ligament Reconstruction1 trial

Multimodal Pain Management1 trial

Laparoscopic1 trial

Acute Lymphoblastic Leukemia1 trial

Local Anesthetic1 trial

Postoperative Pain Relief1 trial

Tonsillectomy1 trial

Catheter1 trial

Breast Reconstruction1 trial

Bariatric Patients1 trial

Epidural Analgesia1 trial

Pain Management1 trial

Nerve Block1 trial

Total Shoulder Arthroplasty1 trial

Liposome Bupivacaine1 trial

Spine Surgeries1 trial

Shoulder pain1 trial

Rib Fracture1 trial

Randomized Controlled Trial1 trial

Mastectomy1 trial

Pain1 trial

ART1 trial

Donor1 trial

Efficacy1 trial

Prostatectomy1 trial

Facial Pain1 trial

Breast1 trial

Renal Carcinoma1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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