S-ketamine

PreclinicalSmall molecule

PPeking University First Hospital

S-ketamine is one of 107 small molecule programs targeting Cognitive impairment. It is currently in Preclinical.

Indications

Total Trials

Active Trials

106

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cognitive ImpairmentActive, not recruiting

Postpartum DepressionActive, not recruiting

Inflammatory ResponseActive, not recruiting

Total Abdominal HysterectomyWithdrawn

Thoracic SurgeryUnknown status

Opioid Free AnesthesiaUnknown status

Cognitive ImpairmentPreclinical

Active, not recruiting

Postpartum DepressionPreclinical

Active, not recruiting

Inflammatory ResponsePreclinical

Active, not recruiting

Total Abdominal HysterectomyPreclinical

Withdrawn

Thoracic SurgeryPreclinical

Unknown status

Opioid Free AnesthesiaPreclinical

Unknown status

Competition

Competitive Landscape

72 competitors in Cognitive Impairment

#DrugCompanyPhaseTrials

Marinol

Brintellix

Intropin

Avandia

Epidiolex

Coumadin

1 7

Pradaxa

Boehringer Ingelheim

Approved

1 8

Prozac

VVitae Pharmaceuticals Inc., an Allergan affiliate

Approved

—9

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

—10

Adrenaline

SSamson Clinical Operations Pty Ltd

Approved

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2028

Not yet recruiting

Mitochondria

NCT07399756

Q3 2028

Post-ApprovalRecruiting

Brain Injury

NCT05095857

Clinical

Trials by Indication[1]

S-ketamine3 trials

The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT)

Unknown status·YYan Qiu·N/A·NCT04399070·150 enrolled

Racemic Ketamine Versus S-ketamine With Arterial Spin Labeling (ASL)-MRI in Healthy Volunteers

Completed·LLund University·N/A·NCT01506921·14 enrolled

The Preemptive Analgetic Potency of Low Dose S-Ketamine

Completed·MMedical University of Graz·Phase 3·NCT01022840·60 enrolled

Cesarean Section3 trials

The Efficacy and Safety of S-ketamine in Elective Cesarean Section

Unknown status·—·N/A·NCT04657107·402 enrolled

Effect of S-ketamine in Cesarean Section Combined Anesthesia

Completed·TThe Second Affiliated Hospital of Chongqing Medical University·Phase 4·NCT05414006·120 enrolled

The Effect of S-ketamine Combined With Sufentanil for Postoperative Analgesia in Patients Following Cesarean Section

Unknown status·LLing Dong·Phase 4·NCT05299866·216 enrolled

Postoperative Analgesia2 trials

Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia

Completed·PPeking University First Hospital·Phase 4·NCT04791059·200 enrolled

Postoperative Analgesia by Epidural vs IV Ketamine Concurrent With Caudal Anesthesia in Pediatric Orthopedic Surgery

Unknown status·TTehran University of Medical Sciences·Phase 4·NCT00532662·40 enrolled

Anesthesia2 trials

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

Completed·UUniversity of Turku·Phase 4·NCT02624401·160 enrolled

Effects of Small-dose S-ketamine on Anesthesia-induced Atelectasis in Anesthetized Patients Accessed by Pulmonary Ultrasound

Unknown status·—·Phase 1·NCT04745286·100 enrolled

Prenatal Depression1 trial

Low-dose S-ketamine in Women With Prenatal Depression

Completed·PPeking University First Hospital·N/A·NCT04414943·364 enrolled

20 more indications

Postpartum Depression1 trial

Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression

Completed·PPeking University First Hospital·N/A·NCT03927378·364 enrolled

Total Knee Arthroplasty1 trial

Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery

Unknown status·LLing Dong·Phase 4·NCT05289050·144 enrolled

General Anesthetics1 trial

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

Recruiting·PPeking University First Hospital··NCT05210764·366 enrolled

Thoracic Surgery1 trial

Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·N/A·NCT05016128·92 enrolled

Laparoscopic Cholecystectomy1 trial

Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy

Unknown status·HHvidovre University Hospital·Phase 4·NCT00209885·60 enrolled

Buprenorphine1 trial

KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine

Unknown status·EElina Brinck·Phase 1·NCT05571176·12 enrolled

Hysterectomy1 trial

Optimal Multimodal Analgesia in Abdominal Hysterectomy

Unknown status·HHvidovre University Hospital·Phase 4·NCT00209872·60 enrolled

Tics1 trial

Anesthetics and Auditory, Visceral, and Heat Evoked Potentials

Completed·TTechnical University of Munich·Phase 4·NCT00534586·60 enrolled

Brain Injury1 trial

The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury

Recruiting·RRigshospitalet, Denmark·Phase 4·NCT05095857·400 enrolled

Inflammatory Response1 trial

Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery

Unknown status·TTianjin Nankai Hospital·N/A·NCT04873479·50 enrolled

Ketamine1 trial

Effect of Perioperative i.v. Low-dose S(+) Ketamine

Completed·—·Phase 4·NCT00354029·83 enrolled

Delirium1 trial

The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery

Completed·—·Phase 1·NCT05242692·520 enrolled

Mitochondria1 trial

Mitochondrial Function After Ketamine

Not yet recruiting·SSheba Medical Center··NCT07399756·30 enrolled

Odontalgia1 trial

Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

Completed·UUniversity of Aarhus·Phase 4·NCT00115102·20 enrolled

Post Operative Pain1 trial

Efficacy of S(+)-Ketamine Administered as a Continuous Infusion for the Control of Postoperative Pain

Completed·CCentro Medico Campinas·Phase 4·NCT02421913·42 enrolled

Cognitive impairment1 trial

Effects of S-ketamine and Continuous Iliac Fascia Space Block on Perioperative Neurological Cognitive Impairment and Postoperative Rehabilitation in Elderly Patients With Hip Fracture

Unknown status·YYangzhou University·N/A·NCT05304559·108 enrolled

Opioid Free Anesthesia1 trial

Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·N/A·NCT05242081·980 enrolled

Spine Fusion1 trial

Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery

Completed·PPeking University First Hospital·Phase 4·NCT04964219·164 enrolled

Third Molar Surgery1 trial

Ketamine Analgesia in Third Molar Surgery

Completed·DDalarna County Council, Sweden·Phase 4·NCT04459377·168 enrolled

Total Abdominal Hysterectomy1 trial

The Use of S Ketamine Versus Placebo During Target Controlled Intravenous Anaesthesia to Reduce Morphine Consumption and Side-Effects After Abdominal Hysterectomy: A Randomized Control Trial

Withdrawn·KKK Women's and Children's Hospital·Preclinical·NCT02543385

Sources

References

[1]
ClinicalTrials.gov — 31 trial records for S-ketamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — S-ketamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for S-ketamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Peking University First Hospital company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: PPeking University First Hospital

S-ketamine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2028

Q3 2028

Trials by Indication[1]

S-ketamine3 trials

Cesarean Section3 trials

Postoperative Analgesia2 trials

Anesthesia2 trials

Prenatal Depression1 trial

Postpartum Depression1 trial

Total Knee Arthroplasty1 trial

General Anesthetics1 trial

Thoracic Surgery1 trial

Laparoscopic Cholecystectomy1 trial

Buprenorphine1 trial

Hysterectomy1 trial

Tics1 trial

Brain Injury1 trial

Inflammatory Response1 trial

Ketamine1 trial

Delirium1 trial

Mitochondria1 trial

Odontalgia1 trial

Post Operative Pain1 trial

Cognitive impairment1 trial

Opioid Free Anesthesia1 trial

Spine Fusion1 trial

Third Molar Surgery1 trial

Total Abdominal Hysterectomy1 trial

References

Drug Info

Quick Facts

Related News