Saccharomyces boulardii

ApprovedSmall molecule

BBiocodex

Saccharomyces boulardii is one of 250 small molecule programs targeting Liver Transplant. It is currently in Approved.

Indications

Total Trials

Active Trials

249

Competitors

Pipeline

Status by Indication[3][1]

Indication

Liver TransplantActive, not recruiting

Recurrent Urinary Tract InfectionsActive, not recruiting

Necrotizing EnterocolitisActive, not recruiting

ImmunodeficiencyActive, not recruiting

Chronic PeriodontitisActive, not recruiting

Systemic SclerosisActive, not recruiting

Heart FailureActive, not recruiting

Irritable Bowel SyndromeActive, not recruiting

GrowthActive, not recruiting

Liver TransplantPhase 2

Active, not recruiting

Recurrent Urinary Tract InfectionsPhase 1

Active, not recruiting

Necrotizing EnterocolitisPhase 3

Active, not recruiting

ImmunodeficiencyPhase 2

Active, not recruiting

Chronic PeriodontitisPhase 1/Phase 2

Active, not recruiting

Systemic SclerosisApproved

Active, not recruiting

Heart FailurePhase 2

Active, not recruiting

Irritable Bowel SyndromePhase 3

Active, not recruiting

GrowthApproved

Active, not recruiting

Competition

Competitive Landscape

687 competitors in Heart Failure

#DrugCompanyPhaseTrials

Saccharomyces boulardii

BBiocodex

Approved

2 2

Bayer Aspirin

Bayer

Preclinical

2 3

Activase

Savaysa

Bystolic

VVitae Pharmaceuticals Inc., an Allergan affiliate

Preclinical

4 6

Xifaxan

SSalix

Preclinical

2 7

Zoloft

VViatris Specialty LLC

Preclinical

2 8

Xylocaine

MMEDRx USA, Inc.

Preclinical

1 9

Tamiflu

CConrado Roberto Hoffmann Filho

Preclinical

1 10

Adriamycin

GGynecologic Oncology Group

Preclinical

—

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Bismuth Quadruple Therapy

NCT07139366

Q4 2026

Phase 3Recruiting

Irritable Bowel Syndrome

NCT07168434

Clinical

Trials by Indication[1]

Irritable Bowel Syndrome3 trials

Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome

Unknown status·—·Phase 4·NCT00543478·42 enrolled

Saccharomyces Boulardii in Irritable Bowel Syndrome

Completed·—·Phase 3·NCT00589771·72 enrolled

Saccharomyces Boulardii CNCM I-745 in Irritable Bowel Syndrome

Recruiting·BBiocodex·Phase 3·NCT07168434·406 enrolled

Helicobacter Pylori3 trials

Evaluation of Saccharomyces Boulardii Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori

Completed·HHuazhong University of Science and Technology·N/A·NCT03688828·360 enrolled

Assesment of the Efficiency and Safety Helicobacter Pylori Therapy With or Without Saccharomyces Boulardii

Unknown status·CClinical Centre of Serbia·Phase 4·NCT03997279·200 enrolled

Saccharomyces Boulardii as Pretreatment Before Rescue Therapy of Helicobacter Pylori

Completed·TThe Third Xiangya Hospital of Central South University·N/A·NCT05191875·106 enrolled

Heart Failure2 trials

GutHeart: Targeting Gut Microbiota to Treat Heart Failure

Unknown status·OOslo University Hospital·Phase 2·NCT02637167·150 enrolled

A Pilot Study of Probiotic Saccharomyces Boulardii Use in Chronic Heart Failure Patients. Estudo PROICA

Completed·UUniversidade Federal Fluminense·Phase 2·NCT01500343·20 enrolled

Prevention1 trial

Probiotic Saccharomyces Boulardii for the Prevention of Antibiotic-associated Diarrhoea

Terminated·BBernhard Nocht Institute for Tropical Medicine·Phase 3·NCT01143272·477 enrolled

Immunodeficiency1 trial

Treatment of Patients With Human Immunodeficiency Virus (HIV)-Related Chronic Diarrhea With Saccharomyces Boulardii or Placebo: A Double Blind Trial

Completed·BBiocodex·Phase 2·NCT00002088·100 enrolled

10 more indications

Helicobacter Pylori Infection1 trial

Efficacy Analysis of Saccharomyces Boulardii Combined With Minocycline in Treatment-naïve Patients With Helicobacter Pylori Infection

Not yet recruiting·ZZhongda Hospital·N/A·NCT07012785·208 enrolled

Diarrhea1 trial

Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces Boulardii in Acute Watery Diarrhea in Paediatric Patients

Completed·RRESnTEC, Institute of Research·N/A·NCT06540209·60 enrolled

Liver Transplant1 trial

Effect of Saccharomyces Boulardii in Patients in the Waiting List for Liver Transplant

Completed·FFederal University of Minas Gerais·Phase 2·NCT01762748·18 enrolled

Bismuth Quadruple Therapy1 trial

Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment

Recruiting·YYongquan Shi·Phase 4·NCT07139366·1,248 enrolled

Completed·TTatyasaheb Kore Dental College·Phase 1/2·NCT03516370·31 enrolled

Systemic Sclerosis1 trial

Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis

Completed·CCoordinación de Investigación en Salud, Mexico·Phase 4·NCT03692299·39 enrolled

Quality of Life1 trial

The Effect of Saccharomyces Boulardii in Clinical Presentation and Quality of Life Patient With IBS

Unknown status·FFakultas Kedokteran Universitas Indonesia·N/A·NCT05451433·52 enrolled

Recurrent Uti1 trial

A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections

Completed·AAnn & Robert H Lurie Children's Hospital of Chicago·Phase 1·NCT06149676·35 enrolled

Sources

References

[1]
ClinicalTrials.gov — 20 trial records for Saccharomyces boulardii. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Saccharomyces boulardii compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Saccharomyces boulardii. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Biocodex company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: BBiocodex

Saccharomyces boulardii

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Trials by Indication[1]

Irritable Bowel Syndrome3 trials

Helicobacter Pylori3 trials

Heart Failure2 trials

Prevention1 trial

Immunodeficiency1 trial

Helicobacter Pylori Infection1 trial

Diarrhea1 trial

Liver Transplant1 trial

Bismuth Quadruple Therapy1 trial

Necrotizing Enterocolitis1 trial

Growth1 trial

Chronic Periodontitis1 trial

Systemic Sclerosis1 trial

Quality of Life1 trial

Recurrent Uti1 trial

References

Drug Info

Quick Facts

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