acetominophen

Phase 3Small molecule

Merck & Co.

acetominophen is one of 13 small molecule programs targeting Pain, Postoperative. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Pain, PostoperativeRecruiting

AcetaminophenCompleted

Gynecologic SurgeryCompleted

Pain, PostoperativePhase 3

Recruiting

AcetaminophenPreclinical

Completed

Gynecologic SurgeryPreclinical

Completed

Competition

Competitive Landscape

11 competitors in Pain, Postoperative

#DrugCompanyPhaseTrials

Decadron

AAspen Global Incorporated

Approved

4 2

Dolophine

HHikma Pharmaceuticals LLC

Approved

4 3

Tylenol

KKenvue Brands

Approved

3 4

MS Contin

HHikma Pharmaceuticals LLC

Approved

3 5

Marcaine

IInnocoll

Approved

2 6

Advil

KKenvue Brands

Approved

1 7

Tegileridine

XXin Chen

Phase 3

1 8

acetominophen

Merck & Co.

Phase 3

1 9

Liposomal Bupivacaine

TTLC Biopharmaceuticals, Inc.

Phase 2

1 10

Neurontin

VViatris Specialty LLC

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

ApprovedRecruiting

Pain, Postoperative

NCT06757075

Clinical

Trials by Indication[1]

Dental Pain1 trial

Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes

Terminated·UUniversity of Rochester·Phase 4·NCT02932579·59 enrolled

Surgical1 trial

Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

Completed·SStanford University·Phase 3·NCT02601027·120 enrolled

Acetaminophen1 trial

Impact of Acetaminophen on Performance of Guardian™ Sensor (3) in Adults

Completed·MMedtronic Diabetes·N/A·NCT04378114·104 enrolled

Gynecologic Surgery1 trial

Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery

Completed·SScripps Health·N/A·NCT03391284·75 enrolled

Ankle Surgery1 trial

Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study

Completed·PPrisma Health-Midlands··NCT04771741·72 enrolled

4 more indications

Outcome1 trial

Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever

Completed·UUniversity of Washington·N/A·NCT00890604·10 enrolled

Multimodal Pain Management1 trial

Multimodal Pain Management for Cesarean Delivery

Completed·TThe University of Texas Medical Branch, Galveston·Phase 4·NCT02922985·120 enrolled

Migraine1 trial

A Study to Test the Safety and Effectiveness of MK-0974 (Telcagepant) Co-administered With Ibuprofen or Acetaminophen in Patients With Migraines With or Without Aura (MK-0974-046)

Completed· Merck & Co. logo

Merck & Co.·Phase 2·NCT00758836·683 enrolled

Pain, Postoperative1 trial

A Comparison of Standard Dose of Ibuprofen Alone, Alternating, or Combined With Acetaminophen for the Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia

Recruiting·BBoston University·Approved·NCT06757075·75 enrolled

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for acetominophen. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — acetominophen compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for acetominophen. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Merck & Co.

acetominophen

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Trials by Indication[1]

Dental Pain1 trial

Surgical1 trial

Acetaminophen1 trial

Gynecologic Surgery1 trial

Ankle Surgery1 trial

Outcome1 trial

Multimodal Pain Management1 trial

Migraine1 trial

Pain, Postoperative1 trial

References

Drug Info

Quick Facts

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