Albumin

ApprovedSmall molecule

LLaboratoire français de Fractionnement et de Biotechnologies

Albumin is one of 510 small molecule programs targeting Ascites. It is currently in Approved.

Indications

Total Trials

Active Trials

509

Competitors

Pipeline

Status by Indication[3][1]

Indication

AscitesActive, not recruiting

Cerebral IschemiaActive, not recruiting

Systemic Inflammatory Response SyndromeActive, not recruiting

Liver TransplantActive, not recruiting

StrokeActive, not recruiting

Acute-on-Chronic Liver FailureActive, not recruiting

Type 2 Diabetes MellitusActive, not recruiting

MyopathyActive, not recruiting

PeritonitisActive, not recruiting

SepsisActive, not recruiting

AscitesPhase 3

Active, not recruiting

Cerebral IschemiaPhase 2

Active, not recruiting

Systemic Inflammatory Response SyndromeApproved

Active, not recruiting

Liver TransplantPreclinical

Active, not recruiting

StrokePhase 3

Active, not recruiting

Acute-on-Chronic Liver FailurePreclinical

Active, not recruiting

Type 2 Diabetes MellitusPhase 2

Active, not recruiting

MyopathyPhase 2

Active, not recruiting

PeritonitisPreclinical

Active, not recruiting

SepsisPhase 3

Active, not recruiting

Showing 10 of 22 indications

Competition

Competitive Landscape

797 competitors in Hepatocellular Carcinoma

#DrugCompanyPhaseTrials

Albumin

LLaboratoire français de Fractionnement et de Biotechnologies

Approved

1 2

Cysteine Hydrochloride

Novartis

Preclinical

1 3

Ibrance

Pfizer

Preclinical

1 4

Viread

Gilead

Preclinical

1 5

Hepsera

Coreg

2 7

Apatinib

LLaNova Medicines Zhejiang Co., Ltd.

Preclinical

16 8

Miraclid

TTechpool Bio-Pharma Co., Ltd.

Preclinical

1 9

Vermox

WWim Janssens

Preclinical

1 10

Statin

Bristol-Myers Squibb

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Encephalopathy

NCT06052176

Q1 2027

Phase 2Recruiting

Cirrhosis

NCT06812390

Q2 2027

Phase 2Recruiting

Ascites

NCT05867602

Q4 2027

Phase 3Recruiting

Stroke

NCT07263308

Post-ApprovalNot yet recruiting

Volume

NCT05463471

N/ARecruiting

Acute Kidney Injury

NCT06710353

Clinical

Trials by Indication[1]

Cirrhosis11 trials

Efficacy of Targeted And Response-Guided Albumin Therapy Versus Standard Medical Treatment In Outcomes Of Recurrent Ascites In Patients With Decompensated Cirrhosis.

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04679571·100 enrolled

Midodrine, Octreotide and Albumin: Impact on Renal Function of Patients With Liver Cirrhosis and Renal Failure

Withdrawn·AAnna Cruceta·Phase 2·NCT01587222

Evaluation of Albumin and Midodrine Versus Albumin Alone in Outcome of Refractory Ascites in Patients With Decompensated Cirrhosis.

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04816240·200 enrolled

Show 8 more trials

Albumin Infusion in Inpatients With Decompensated Cirrhosis

Unknown status·RRuijin Hospital··NCT05719051·564 enrolled

Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites

Recruiting·—·Phase 2·NCT06812390·20 enrolled

Evaluation of Low-dose Albumin and Midodrine Versus Midodrine Alone in Outcome of Recurrent Ascites in Patients With Decompensated Cirrhosis.

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06245590·100 enrolled

Effects of Long Term Albumin 20% Administration in Patients With Cirrhosis and Ascites.

Completed·IInstituto Grifols, S.A.·Phase 4·NCT00968695·33 enrolled

Efficacy and Safety of Terlipressin With Albumin Versus Midodrine With Albumin Versus Albumin Alone in Prevention of Paracentesis Induced Circulatory Dysfunction in Cirrhosis

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT03144713·150 enrolled

Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis.

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT07002827·60 enrolled

Coagulation Parameters With Albumin in Decompensated Cirrhosis (CoPA-D).

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT05937048·120 enrolled

Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis

Completed·UUS Department of Veterans Affairs·Phase 4·NCT00108355·29 enrolled

Volume3 trials

Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Withdrawn·MMontefiore Medical Center·Phase 2·NCT04109144

Fresh Frozen Plasma as a Substitute for Albumin in Patients Receiving a Large Volume Paracentesis

Withdrawn·MMontefiore Medical Center·Phase 4·NCT03202524

Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients

Not yet recruiting·PPeking Union Medical College Hospital·Phase 4·NCT05463471·500 enrolled

Peritonitis3 trials

To Compare the Efficacy of Carbepenem Versus Carbepenem Plus GM-CSF in Difficult To Treat Spontaneous Bacterial Peritonitis

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02468089·146 enrolled

Comparison of Standard Dose Versus Once a Day Intravenous Albumin in Spontaneous Bacterial Peritonitis

Completed·—·N/A·NCT02756741·40 enrolled

To Study Efficacy of Albumin in Cirrhosis With Spontaneous Bacterial Peritonitis at Low Risk for AKI Development

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04437810·100 enrolled

Encephalopathy3 trials

Efficacy of Albumin for Acute Encephalopathy in Patients With Cirrhosis

Completed·HHospital Universitari Vall d'Hebron Research Institute·Phase 4·NCT00886925·56 enrolled

Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement

Recruiting·HHunter Holmes Mcguire Veteran Affairs Medical Center·Phase 2·NCT06052176·30 enrolled

Post Transjugular Intrahepatic Portosystemic Shunt (Tips) Albumine Infusion to Prevent Hepatic Encephalopathy

Completed·UUniversity of Roma La Sapienza·Phase 4·NCT01559519·20 enrolled

Acute-on-Chronic Liver Failure2 trials

Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction In Acute-On-Chronic Liver Failure.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02467348·80 enrolled

Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04416282·70 enrolled

40 more indications

Treatment2 trials

IVIG (Gamunex-C) Treatment Study for POTS Subjects

Completed·UUniversity of Texas Southwestern Medical Center·Phase 1/2·NCT03919773·30 enrolled

A Phase 2/3 Study of GLASSIA for the Treatment of Acute GvHD

Terminated·BBaxalta now part of Shire·Phase 2/3·NCT02956122·1 enrolled

Ascites2 trials

Midodrine and Albumin in Patients With Refractory Ascites

Unknown status·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT04621617·114 enrolled

Clinical Efficacy of High-dose Albumin Administration Versus Standard Dose in Patients With Advanced Cirrhosis: Open Label Randomized Clinical Trial

Recruiting·BBaylor College of Medicine·Phase 2·NCT05867602·100 enrolled

Stroke2 trials

Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Therapy -2

Recruiting·—·Phase 3·NCT07263308·1,192 enrolled

Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients

Completed·TTianjin Huanhu Hospital·Phase 1·NCT05953623·57 enrolled

Cardiac Surgery2 trials

Albumin Administration and Outcomes in Cardiac Surgery

Completed·VVanderbilt University··NCT02878733·6,249 enrolled

Albumin in Cardiac Surgery

Completed·HHelsinki University Central Hospital·Phase 4·NCT02560519·1,386 enrolled

Acute Kidney Injury2 trials

Comparison of Safety and Efficacy of Tailored Versus Fixed Dose Albumin for the Management of Patients With Cirrhosis and Sepsis Associated Acute Kidney Injury

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06809088·100 enrolled

The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery

Recruiting·SSeoul National University Hospital·N/A·NCT06710353·190 enrolled

Liver Transplant2 trials

Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation

Completed·HHospital Clinic of Barcelona·Phase 4·NCT00839358·199 enrolled

Post-Operative Use of Salt Poor Albumin Solution in Resuscitation of Orthotopic Liver Transplant

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT00842803·100 enrolled

Fusion Rate2 trials

Infusion Rate and Volume Kinetics for Hyperoncotic Albumine in Healthy Subjects

Completed·UUniversity Hospital, Linkoeping·Phase 4·NCT03453320·12 enrolled

Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin in the Septic Patient

Unknown status·—·Phase 4·NCT03153306·60 enrolled

Septic Shock2 trials

Early Albumin Resuscitation During Septic Shock

Completed·LLaboratoire français de Fractionnement et de Biotechnologies·Phase 4·NCT00327704·794 enrolled

ALBumin Italian Outcome Septic Shock-BALANCED Trial (ALBIOSS-BALANCED)

Completed·FFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico·Phase 3·NCT03654001·1,319 enrolled

Connective Tissue Graft1 trial

A Clinical Comparison of Connective Tissue Graft and Alb-PRF for Rebuilding Interdental Papilla

Not yet recruiting·Sshaimaa hamdy·Phase 3·NCT07139392·30 enrolled

Acute Variceal Bleeding1 trial

Albumin in Acute Variceal Bleeding

Not yet recruiting·KKing George's Medical University·Phase 3·NCT07395141·60 enrolled

Double-blind1 trial

Low-dose Albumin Solution in SBP: a Randomized Double-blind Pilot Study

Unknown status·HHospital de Clinicas de Porto Alegre·Phase 2·NCT00852800·43 enrolled

Complication1 trial

Midodrine Plus Albumin Versus Midodrine Alone to Prevent Cirrhosis Related Complications in Children With Cirrhosis and Ascites

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06091345·61 enrolled

Diabetes Mellitus1 trial

A Pilot Study of Hemin Therapy for Gastroparesis (Diabetes Mellitus)

Completed·MMayo Clinic·Phase 2·NCT01206582·20 enrolled

Sepsis1 trial

Lactated Ringer Versus Albumin in Early Sepsis Therapy

Completed·UUniversity of Sao Paulo·Phase 3·NCT01337934·360 enrolled

Pediatric1 trial

Albumin vs. Plasma for PEdiAtric pRiming Trial

Completed·IIRCCS Policlinico S. Donato·Phase 4·NCT02738190·80 enrolled

Systemic Sclerosis1 trial

AIMSPRO in Established Diffuse Cutaneous Systemic Sclerosis

Unknown status·DDaval International Limited·Phase 2·NCT00769028·20 enrolled

Intracerebral Hemorrhage1 trial

Albumin for Intracerebral Hemorrhage Intervention

Terminated·GGeorgetown University·Phase 2·NCT00990509·14 enrolled

Chronic Liver Failure1 trial

Efficacy of Albumin Therapy With Standard Medical Treatment (SMT) as Compared to Standard Medical Treatment (SMT) in Improving Patient Survival and Immune Modulation in Patients With Acute on Chronic Liver Failure (ASIA Trial).

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT03754400·200 enrolled

Completed·—·Phase 3·NCT01758172·100 enrolled

Intravenous1 trial

Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study

Completed·HHospices Civils de Lyon·Phase 2·NCT02219165·30 enrolled

Type 2 Diabetes Mellitus1 trial

Safety and Efficacy of OCN19-overexpressed Human Umbilical Cord-derived Mesenchymal Stem Cells in the Treatment of Refractory Type 2 Diabetes Mellitus

Recruiting·LLu jin ，MD·Phase 2·NCT06727721·10 enrolled

Hepatocellular Carcinoma1 trial

Albumin for Hepatocellular Carcinoma

Unknown status·GGuangxi Medical University·Phase 3·NCT03974074·200 enrolled

Randomized Controlled Trial1 trial

Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT02055872·46 enrolled

Hemorrhagic Shock1 trial

Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance

Unknown status·SSeoul National University Hospital·N/A·NCT06111261·36 enrolled

Cerebral ischemia1 trial

Modulation of Cerebral Ischemia by Albumin

Not yet recruiting·UUniversity Hospital Hradec Kralove·Phase 2·NCT07415655·100 enrolled

Hepatorenal Syndrome1 trial

Angiotensin 2 for Hepatorenal Syndrome

Withdrawn·UUniversity of California, Los Angeles·Phase 2·NCT04048707

Systemic Inflammatory Response Syndrome1 trial

Biseko Versus Albumin in Systemic Inflammatory Response Syndrome (SIRS) Patients

Completed·MMedical University of Vienna·Phase 4·NCT00708747·40 enrolled

SMA1 trial

Plasma Exchange With Albumin in AMN Patients

Completed·—·Phase 2/3·NCT04303416·5 enrolled

Critically Ill Patients1 trial

Effects of Fluid Balance Control in Critically Ill Patients

Completed·—·N/A·NCT02765009·1,411 enrolled

Effectiveness1 trial

Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children

Withdrawn·HHospices Civils de Lyon·Phase 4·NCT02899702

Amyotrophic Lateral Sclerosis1 trial

Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis

Completed·IInstituto Grifols, S.A.·Phase 2·NCT02479802·13 enrolled

Infusion1 trial

To Study The Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction in Decompensated Cirrhotics Undergoing Less Than 5 Litres Of Ascitic Fluid Tap With Or Without Albumin Infusion.

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02467322·80 enrolled

Prevention1 trial

The INFECIR-2 Albumin Prevention Study

Terminated·EEASL - CLIF Consortium·Phase 4·NCT02034279·136 enrolled

Myopathy1 trial

Monotherapy IVIG Gamunex-C for HMG-CoA Reductase Auto-Antibody Positive Necrotizing Myopathy Treatment (The MIGHT Trial)

Withdrawn·UUniversity of Washington·Phase 2·NCT04450654

Cesarean Delivery1 trial

Transthoracic Echocardiographic Monitoring of Cardiac Output Effects of Colloid Preload and Crystalloid Coload During Cesarean Delivery Under Spinal Anesthesia

Completed·SSameh Fathy·N/A·NCT06654687·162 enrolled

Intensive Care1 trial

The Intensive Care Platform Trial

Recruiting·AAnders Perner·Phase 4·NCT06667999·10,000 enrolled

Ischemic stroke1 trial

Albumin in Acute Ischemic Stroke Trial

Terminated·UUniversity of Miami·Phase 3·NCT00235495·841 enrolled

Efficacy1 trial

Efficacy of Albumin Plus Midodrine v/s Albumin Alone in Reducing Incidence of Paracentesis Induced Circulatory Dysfunctions in ACLF Patients.

Unknown status·IInstitute of Liver and Biliary Sciences, India·N/A·NCT04474262·150 enrolled

Sources

References

[1]
ClinicalTrials.gov — 70 trial records for Albumin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Albumin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Albumin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Laboratoire français de Fractionnement et de Biotechnologies company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: LLaboratoire français de Fractionnement et de Biotechnologies

Albumin

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q2 2027

Q4 2027

Trials by Indication[1]

Cirrhosis11 trials

Volume3 trials

Peritonitis3 trials

Encephalopathy3 trials

Acute-on-Chronic Liver Failure2 trials

Treatment2 trials

Ascites2 trials

Stroke2 trials

Cardiac Surgery2 trials

Acute Kidney Injury2 trials

Liver Transplant2 trials

Fusion Rate2 trials

Septic Shock2 trials

Connective Tissue Graft1 trial

Acute Variceal Bleeding1 trial

Double-blind1 trial

Complication1 trial

Diabetes Mellitus1 trial

Sepsis1 trial

Pediatric1 trial

Systemic Sclerosis1 trial

Intracerebral Hemorrhage1 trial

Chronic Liver Failure1 trial

Efficacy and Safety1 trial

Safety and Efficacy1 trial

Pancreaticoduodenectomy1 trial

Intravenous1 trial

Type 2 Diabetes Mellitus1 trial

Hepatocellular Carcinoma1 trial

Randomized Controlled Trial1 trial

Hemorrhagic Shock1 trial

Cerebral ischemia1 trial

Hepatorenal Syndrome1 trial

Systemic Inflammatory Response Syndrome1 trial

SMA1 trial

Critically Ill Patients1 trial

Effectiveness1 trial

Amyotrophic Lateral Sclerosis1 trial

Infusion1 trial

Prevention1 trial

Myopathy1 trial

Cesarean Delivery1 trial

Intensive Care1 trial

Ischemic stroke1 trial

Efficacy1 trial

References

Drug Info

Quick Facts

Related News