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Calcium hydroxide

PreclinicalSmall molecule

MMansoura University

Calcium hydroxide is used in dentistry to treat tooth decay, disinfect root canals, and promote healing inside teeth. It's also used in some medical settings to neutralize acids and promote bone healing.[1] Calcium hydroxide is currently being investigated across 5 indications[3], with its most advanced program in Preclinical.[1]

Calcium hydroxide is one of 26 small molecule programs targeting Medical Procedure. It is currently in Preclinical.

5

Indications

33

Total Trials

8

Active Trials

25

Competitors

Pipeline

Status by Indication[3][1]

Indication

Medical ProcedureActive, not recruiting

NecrosisActive, not recruiting

Indirect Pulp CapCompleted

Post-Endodontic PainCompleted

Intracanal MedicamentCompleted

Medical ProcedurePreclinical

Active, not recruiting

NecrosisPreclinical

Active, not recruiting

Indirect Pulp CapPreclinical

Completed

Post-Endodontic PainPreclinical

Completed

Intracanal MedicamentPreclinical

Completed

Competition

Competitive Landscape

21 competitors in Necrosis

#DrugCompanyPhaseTrials

Lipitor

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Integrilin

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Zoloft

VViatris Specialty LLC

Avastin

Botox

Deltasone

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Serplulimab

Shanghai Henlius Biotech

QRX-3

EEbima Clifford Okundaye

Actemra

Rocaltrol

Jazz Pharmaceuticals

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

PreclinicalRecruiting

Symptomatic Apical Periodontitis

NCT07585721

Phase 1Recruiting

Apical Periodontitis

NCT07603934

Clinical

Trials by Indication[1]

Calcium Hydroxide5 trials

Influence of Calcium Hydroxide Chlorhexidine Combination vs. Calcium Hydroxide as an Intra Canal Medicaments in Retreatment Cases

Unknown status·—·Phase 1·NCT03209115·24 enrolled

Clinical and Radiographic Evaluation of Nano Silver Fluoride Versus Calcium Hydroxide in Indirect Pulp Treatment

Completed·—·N/A·NCT04005872·40 enrolled

Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication

Recruiting·—·Phase 2/3·NCT06196515·54 enrolled

Show 2 more trials

Indirect Pulp Treatment of Young Permanent Molars Using Photo-Activated Oral Disinfection Versus Calcium Hydroxide

Completed·—·N/A·NCT03631277·32 enrolled

Effect of Using Nanochitosan Versus Calcium Hydroxide as Disinfectant on Pain and Apical Bone Healing

Unknown status·—·N/A·NCT03724266·60 enrolled

Intracanal Medicament4 trials

The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament

Recruiting·—·Phase 2/3·NCT06207253·48 enrolled

In Vivo Comparative Study of Calcium Hydroxide and Triple Antibiotic Paste in Intracanal Medicament in Emergency Pain Reduction

Completed·PPakistan Institute of Medical Sciences·N/A·NCT06174909·90 enrolled

Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp

Unknown status·—·Phase 1·NCT05666089·30 enrolled

Show 1 more trial

2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament

Unknown status·UUniversity of Southern California·Phase 3·NCT03700788·40 enrolled

Post Operative Pain3 trials

Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8

Completed·—·N/A·NCT05525013·30 enrolled

Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars

Unknown status·—·Phase 1·NCT05687760·30 enrolled

Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp

Completed·—·N/A·NCT04983524·46 enrolled

Periodontitis2 trials

Investigate"Clinically" the Effectiveness of Boswellia Based Intracanal Medication Compared to Calcium Hydroxide Ca(OH)2 and Ledermix on the Levels of Bacteria and Inflammatory Cytokines in Root Canals and Periradicular Tissues of Teeth With Apical Periodontitis

Recruiting·MMansoura University·Phase 2/3·NCT06466538·36 enrolled

Effect of Intracanal Medicaments on Post-Operative Pain in Symptomatic Apical Periodontitis: An RCT

Completed·HHITEC-Institute of Medical Sciences·N/A·NCT07123792·480 enrolled

Indirect Pulp Cap2 trials

Clinical And Radiographic Evaluation Of Premixed Bio-ceramic MTA In Indirect Pulp Capping Of Young Permanent Molars

Unknown status·—·Phase 3·NCT05928858·40 enrolled

Clinical and Radiographic Evaluation of Indirect Pulp Capping in Primary and Permanent Teeth With Different Materials

Completed·—·N/A·NCT03606681·300 enrolled

15 more indications

Treatment2 trials

Effect of Calcium Silicate-Based Root Canal Medicament After Retreatment

Completed·—·N/A·NCT06779370·60 enrolled

Role of Propolis Paste in Preventing Pain After Root Canal Treatment.

Completed·JJuzer Shabbir Saifee·Phase 3·NCT03723980·80 enrolled

Symptomatic Apical Periodontitis2 trials

Comparison of Mean Postoperative Pain After Using Double Antibiotic Paste Versus Calcium Hydroxide as an Intracanal Medicament in Teeth With Symptomatic Apical Periodontitis: A Randomized Controlled Trial

Recruiting·CCollege of Physicians and Surgeons Pakistan·Preclinical·NCT07867951·662 enrolled

Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis

Recruiting·FFuture University in Egypt·Preclinical·NCT07585721·28 enrolled

Age1 trial

Pulp Capping With Two Different Agents

Completed·OOregon Health and Science University·N/A·NCT00812877·376 enrolled

Necrosis1 trial

Regenerative Treatment of Traumatized Immature Permanent Incisors With Pulp Necrosis

Unknown status·KKarolinska Institutet·N/A·NCT04000854·180 enrolled

ALS1 trial

Effect Of Different Lining Materials in Stepwise Excavation

Unknown status·—·Phase 2·NCT01730287·100 enrolled

Primary Teeth1 trial

Indirect Pulp Treatment in Primary Teeth

Unknown status·—·N/A·NCT04763057·88 enrolled

Mineral Trioxide Aggregate1 trial

Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth

Completed·UUniversidad de los Andes, Chile·Phase 2/3·NCT02492841·169 enrolled

Inflammatory Mediators1 trial

Effect of Calcium Silicate Based Root Canal Medicament on Inflammatory Mediators

Completed·—·N/A·NCT06307678·60 enrolled

Adult1 trial

A Study Comparing Eggshell Based and Gold Standard Materials to Heal Deep Tooth Damage in Adult Molars

Not yet recruiting·UUniversity of Health Sciences Lahore·N/A·NCT07183514·54 enrolled

Endodontic Treatment1 trial

Photodynamic Therapy in Endodontic Treatment

Completed·UUniversidade Estadual Paulista Júlio de Mesquita Filho·Phase 2·NCT02824601·24 enrolled

Inflammatory Cytokines1 trial

Effectiveness of Glycyrrhizin as Intracanal Medication in Root Canal Disinfection and Inflammatory Cytokines

Recruiting·MMansoura University·Phase 2/3·NCT06453304·36 enrolled

ESS1 trial

Assessment of a New Apexification Method for Patients Presenting a Non Vital Immature Tooth

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00472173·34 enrolled

Post-endodontic Pain1 trial

Effect of DCS on Post-Endodontic Pain

Completed·MMustafa Kemal University·N/A·NCT06632015·90 enrolled

Early Childhood Caries1 trial

Evaluation of Silver Diamine Fluoride, Sodium Fluoride With Casein Phosphopeptide-Amorphous Calcium Phosphate(MI Varnish) and Dycal to Arrest Caries When Used in Indirect Pulp Capping Procedures in Children

Completed·UUniversity of Jazan·Phase 2·NCT07893756·90 enrolled

Apical Periodontitis1 trial

Evaluation of Postoperative Pain After Using Ibuprofen, Nitrofurantoin, or Calcium Hydroxide as Intracanal Medicaments in Root Canal Treatment of Necrotic Mandibular Posterior Teeth. A Randomized Controlled Trial

Recruiting·CCairo University·Phase 1·NCT07603934·111 enrolled

Sources

References

[1]
ClinicalTrials.gov — 33 trial records for Calcium hydroxide. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Calcium hydroxide compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Calcium hydroxide. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Mansoura University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: MMansoura University

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