Peridex
(Chlorhexidine)ApprovedSmall molecule
Chlorhexidine is an antimicrobial rinse or wash used to kill bacteria and prevent infections in the mouth, on the skin, or in wounds. It's commonly used before surgery to clean the skin, or as a mouthwash to treat gum disease and reduce plaque buildup.[2] Peridex is currently approved and in use across 31 indications[4].[1]
Peridex is one of 541 small molecule programs targeting Acanthamoeba keratitis. It is currently in Approved.
31
Indications
75
Total Trials
13
Active Trials
540
Competitors
16
FDA Applications
NDA/BLA/ANDA regulatory filings
2
Patents
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 31 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Peridex
DDexcel Pharma Technologies Ltd.
Approved
Trodelvy
GileadPreclinical
Halaven
EisaiPreclinical
Adriamycin
GGynecologic Oncology Group
Preclinical
Gemzar
GGynecologic Oncology Group
Preclinical
Lexiscan
AstellasPreclinical
Methylthioninium Chloride
PProvepharm SAS
Preclinical
Zinecard
CChildren's Oncology Group
Preclinical
Nubain
AAultman Health Foundation
Preclinical
Chirocaine
PPurdue Pharma LP
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Chlorhexidine12 trials
Garlic With Lime Juice and Chlorhexidine Mouthwash
Unknown status·—·N/A·NCT03105960·36 enrolled
Show 9 more trials
Antibacterial Effect of Guava Leaves Extract Mouthwash Compared to Chlorhexidine Mouthwash in High Caries Risk Patients
Unknown status·—·Phase 2/3·NCT03773094·94 enrolled
Caries Prevention and Side Effects of Gum Arabic and Licorice Extracts Versus Chlorhexidine in High Caries Risk Patients
Completed·—·Phase 2/3·NCT03684993·63 enrolled
The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing
Unknown status·—·N/A·NCT02939092·60 enrolled
Periodontitis10 trials
Comparison of Inter-appointment Pain Reduction During Root Canal Treatment in Symptomatic Apical Periodontitis by Using Intracanal Medicaments; Chlorhexidine Gel and Single Antibiotic Paste Nitrofurantoin
Enrolling by invitation·—·Phase 1/2·NCT07198919·220 enrolled
Show 7 more trials
Treatment of Periodontitis by Tulsi Gel
Not yet recruiting·—·Phase 2/3·NCT06675578·24 enrolled
Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis
Completed·—·N/A·NCT06834711·78 enrolled
Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis
Unknown status·—·Phase 1·NCT05546788·30 enrolled
Colonization2 trials
41 more indications
Sepsis2 trials
Pneumonia2 trials
Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia
Completed·—·Phase 3·NCT00597688·86 enrolled
Gingival Inflammation2 trials
Low Birth Weight1 trial
Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
Completed·—·N/A·NCT00947518·60 enrolled
Prevention1 trial
Chronic Periodontitis1 trial
Effectiveness1 trial
Comparison of Effectiveness of Disinfectants
Completed·—·Phase 1·NCT06811779·124 enrolled
Chronic Obstructive Pulmonary Disease1 trial
Povidone Iodine1 trial
Chlorohexidine Versus Povidone Iodine as Apreoperative Ophthalmic Disinfectant
Unknown status·—·Phase 1·NCT03957291·100 enrolled
Alveolar Osteitis1 trial
Pregnant Women1 trial
Cesarean Section1 trial
Chlorhexidine Versus Povidone-Iodine Antisepsis for Reduction of Post Cesarean Section Surgical Site Infection
Unknown status·—·Phase 2·NCT02396329·410 enrolled
Ventilator-Associated Pneumonia1 trial
Breast Cancer1 trial
Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine
Completed·FFondazione IRCCS Istituto Nazionale dei Tumori, Milano·Phase 4·NCT02479347·2,158 enrolled
Non-Genital Warts1 trial
Chlorhexidine and Garlic Extract as Potential Topical Virucidal Therapeutic Agents of Non-Genital Warts
Unknown status·—·N/A·NCT06077032·90 enrolled
Peri-Implantitis1 trial
Antibiotic Prophylaxis1 trial
Post Operative Pain1 trial
Different Hemostatic Agents Used in Partial Pulpotomy on Pulp Survival and Postoperative Pain
Not yet recruiting·—·N/A·NCT07058727·75 enrolled
Neonatal1 trial
Neonatal Package Study in Rural District of Pakistan
Completed·—·Phase 4·NCT02279381·1,450 enrolled
Clinical Trial1 trial
Silver Diamine Fluoride1 trial
Intravitreal Injections1 trial
Head and Neck Cancer1 trial
Intracanal Medicament1 trial
Vaginal Delivery1 trial
Irrigation1 trial
General Surgery1 trial
Irrisept in Emergency General Surgery Patients
Enrolling by invitation·TThe University of Texas Health Science Center at Tyler·Phase 4·NCT07048899·400 enrolled
Carcinoma, Non-Small-Cell Lung1 trial
Unspecified4 trials
Evaluation of the Effect of Oil Pulling
Completed·—·N/A·NCT05304338·100 enrolled
Show 1 more trial
Regulatory
FDA Approval Timeline[5]
Jan 1, 1982
HIBISTAT
NDA NDA018300
Jan 1, 1982
HIBICLENS
NDA NDA017768
Jan 1, 1982
HIBICLENS
NDA NDA018423
Dec 24, 1984
EXIDINE
NDA NDA019127
Dec 24, 1984
DYNA-HEX 4
NDA NDA019125
Dec 17, 1985
EXIDINE
NDA NDA019421
Dec 17, 1985
DYNA-HEX 2
NDA NDA019422
Jul 22, 1986
CHG SCRUB
NDA NDA019258
Aug 13, 1986
PERIDEX
NDA NDA019028
Mar 27, 1987
CHLORHEXIDINE GLUCONATE
NDA NDA019490
Dec 2, 1988
PHARMASEAL SCRUB CARE
NDA NDA019793
Mar 31, 1989
BIOSCRUB
NDA NDA019822
Sep 11, 1997
CHLORHEXIDINE GLUCONATE
NDA NDA020111
May 15, 1998
PERIOCHIP
NDA NDA020774
Apr 25, 2005
CHLORHEXIDINE GLUCONATE
NDA NDA021669
Nov 20, 2018
READYPREP CHG
NDA NDA207964
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Peridex drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Chlorhexidine. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
- [7]