Cannabis

Phase 2Small molecule

TTO Pharmaceuticals

Cannabis is one of 491 small molecule programs targeting Neuropathic Pain. It is currently in Phase 2.

Indications

Total Trials

Active Trials

490

Competitors

Pipeline

Status by Indication[3][1]

Indication

Neuropathic PainActive, not recruiting

Cognitive ImpairmentActive, not recruiting

Peripheral NeuropathyActive, not recruiting

Retinitis PigmentosaActive, not recruiting

TinnitusActive, not recruiting

CognitionActive, not recruiting

Tourette SyndromeActive, not recruiting

AnxietyActive, not recruiting

MemoryActive, not recruiting

GlioblastomaActive, not recruiting

Neuropathic PainPhase 1/Phase 2

Active, not recruiting

Cognitive ImpairmentPreclinical

Active, not recruiting

Peripheral NeuropathyPhase 1/Phase 2

Active, not recruiting

Retinitis PigmentosaPhase 1

Active, not recruiting

TinnitusPhase 1

Active, not recruiting

CognitionPhase 2

Active, not recruiting

Tourette SyndromePhase 2

Active, not recruiting

AnxietyPreclinical

Active, not recruiting

MemoryPhase 2

Active, not recruiting

GlioblastomaPhase 1

Active, not recruiting

Showing 10 of 19 indications

Competition

Competitive Landscape

778 competitors in Osteoarthritis

#DrugCompanyPhaseTrials

Cannabis

TTO Pharmaceuticals

Phase 2

1 2

Voltaren

CCerimon Pharmaceuticals

Preclinical

4 3

Bayer Aspirin

Lunesta

1 5

Glucophage

Boehringer Ingelheim

Preclinical

1 6

Botox

AbbVie

Preclinical

1 7

SGLT2 Inhibitor

Eli Lilly

Preclinical

1 8

Lornoxicam

PPOZEN

Preclinical

1 9

Nigella Sativa Oil

UUniversity of Health Sciences Lahore

Preclinical

1 10

Antidiabetic

FFederico II University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Cannabis

NCT07417059

Q1 2027

Phase 1Recruiting

Cannabis

NCT05602649

N/ANot yet recruiting

Pain Management

NCT03734731

N/ARecruiting

Cannabis

NCT05526196

N/ARecruiting

Cannabis

NCT04325958

Phase 1Not yet recruiting

Cannabis

NCT06755346

Clinical

Trials by Indication[1]

Cannabis19 trials

In-Vehicle Real-Time Cannabis Influenced Driving Detection

Recruiting·UUniversity of Bern·N/A·NCT07401628·45 enrolled

Repeated Administration of Cannabis Varying in THC and CBD

Suspended·NNew York State Psychiatric Institute·Phase 2·NCT05563948·100 enrolled

The Effects of Cannabis on Male Reproductive Functions

Not yet recruiting·KKanako Hayashi·Phase 1·NCT06755346·100 enrolled

Show 16 more trials

Neural Correlates of Driving and Cannabis

Unknown status·UUnity Health Toronto·Phase 1·NCT03581058·12 enrolled

Combined and Separate Effects of Cannabis and Tobacco: Psychomotor, Subjective and Physiological Outcomes

Recruiting·CCentre for Addiction and Mental Health·N/A·NCT05526196·60 enrolled

Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes

Not yet recruiting·JJohns Hopkins University·Phase 1·NCT07214155·70 enrolled

Pharmacokinetic and Pharmacodynamic Effects of Passive Cannabis Inhalation

Completed·JJohns Hopkins University·Phase 1·NCT01798186·26 enrolled

Cannabis For Cancer-Related Symptoms

Completed·PPippa Hawley·Phase 2·NCT03948074·91 enrolled

Dose-response of Cannabis and Driving

Completed·CCentre for Addiction and Mental Health·Phase 2·NCT03656029·36 enrolled

Sex Hormones Impact on Cannabis Response

Recruiting·MMaastricht University·N/A·NCT07417059·21 enrolled

Behavioral Pharmacology of Cannabis and Nicotine

Completed·JJohns Hopkins University·Phase 1·NCT04124432·26 enrolled

THC Titration of High-Potency Cannabis Concentrates

Not yet recruiting·CCentre for Addiction and Mental Health·N/A·NCT07105449·48 enrolled

Behavioral Pharmacology of Cannabis in Older Adults

Completed·UUniversity of Arkansas·Phase 1·NCT06055309·3 enrolled

Pharmacokinetic and Pharmacodynamic Effects of Oral Cannabis

Completed·JJohns Hopkins University·Phase 1·NCT02165176·24 enrolled

Pharmacokinetic and Pharmacodynamic Effects of Smoked and Vaporized Cannabis

Completed·JJohns Hopkins University·Phase 1·NCT03676166·18 enrolled

Vaporization as a Smokeless Cannabis Delivery System

Completed·CCenter for Medicinal Cannabis Research·Phase 1·NCT00241592·18 enrolled

Effects of Cannabis/Alcohol on Driving Performance and Field Sobriety Tests

Withdrawn·UUniversity of California, San Diego·Phase 1/2·NCT05273658

Age Differences in the Effects of Cannabis on Simulated Driving

Recruiting·CCentre for Addiction and Mental Health·N/A·NCT04325958·128 enrolled

The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles

Recruiting·JJohns Hopkins University·Phase 1·NCT05602649·80 enrolled

Impairment5 trials

The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking

Completed·UUniversity of California, San Diego·Phase 1/2·NCT02849587·199 enrolled

The Impact of Oral Cannabis Administration and Co-Administration of Alcohol on Impairment

Completed·JJohns Hopkins University·Phase 1·NCT04931095·60 enrolled

Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment

Recruiting·JJohns Hopkins University·Phase 1·NCT06293040·90 enrolled

Show 2 more trials

Cannabis Impairment Detection Application (CIDA)

Completed·AAdvanced Brain Monitoring, Inc.·N/A·NCT04230460·124 enrolled

Differences in Cannabis Impairment and Its Measurement Due to Route of Administration

Completed·JJohns Hopkins University·Phase 1·NCT03122691·23 enrolled

Cannabis Use4 trials

Influence of Tobacco Use on Cannabis Use

Suspended·NNew York State Psychiatric Institute·Phase 2·NCT03766971·160 enrolled

A Study of Ingested Cannabidiol in Healthy Occasional Cannabis Users

Completed·—·Phase 1/2·NCT05407285·70 enrolled

Nabilone in Cannabis Users With PTSD

Terminated·NNew York State Psychiatric Institute·Phase 1/2·NCT03251326·4 enrolled

Show 1 more trial

Lung Health and Breath Biomarkers: Acute Effects of Combusted and Vaporized Cannabis Inhalation Compared to Tobacco Cigarette Combustion in the Human Laboratory

Not yet recruiting·HHannah Harris·Phase 1·NCT07694466·12 enrolled

Neuropathic Pain3 trials

Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

Completed·UUniversity of California, San Diego·Phase 2·NCT03099005·5 enrolled

Effects of Vaporized Marijuana on Neuropathic Pain

Completed·UUniversity of California, Davis·Phase 1/2·NCT01037088·44 enrolled

Effects of Smoked Marijuana on Neuropathic Pain

Completed·CCenter for Medicinal Cannabis Research·Phase 1/2·NCT00254761·28 enrolled

Memory2 trials

Acute Effects of Cannabis on Everyday Life Memory

Completed·WWashington State University·Phase 2·NCT05488509·121 enrolled

Cannabis and Memory

Recruiting·LL. Cinnamon Bidwell··NCT07679581·64 enrolled

35 more indications

Attention2 trials

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1

Completed·UUniversity of Colorado, Boulder··NCT05868213·96 enrolled

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3

Recruiting·LL. Cinnamon Bidwell··NCT06669585·64 enrolled

Biomarker1 trial

Eye Tracking as a Biomarker of Cannabis Effects

Terminated·NNew York State Psychiatric Institute·Phase 2·NCT04100590·1 enrolled

Peripheral Neuropathy1 trial

Efficacy of Inhaled Cannabis in Diabetic Painful Peripheral Neuropathy

Completed·CCenter for Medicinal Cannabis Research·Phase 1/2·NCT00781001·17 enrolled

Tourette syndrome1 trial

Safety and Efficacy of Cannabis in Tourette Syndrome

Terminated·UUniversity Health Network, Toronto·Phase 2·NCT03247244·15 enrolled

Retinitis Pigmentosa1 trial

The Effects of Cannabis on Visual Functions in Healthy and Retinitis Pigmentosa Patients

Unknown status·HHadassah Medical Organization·Phase 1·NCT03078309·50 enrolled

Impaired Driving1 trial

Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim

Completed·TTimothy L. Brown·Phase 1·NCT04970342·13 enrolled

Osteoarthritis1 trial

Cannabinoid Profile Investigation of Vapourized Cannabis in Patients With Osteoarthritis of the Knee

Unknown status·PPrairie Plant Systems Inc.·Phase 2·NCT02324777·40 enrolled

Schizophrenia1 trial

Cannabis and Schizophrenia: Self-Medication and Agonist Treatment

Completed·—·Phase 1·NCT00946348·12 enrolled

Cardiovascular Function1 trial

Cannabis Inhalation: Effects on Cardiovascular Function During Rest and Exercise

Completed·JJamie Burr·Phase 1·NCT04693884·22 enrolled

Cognition1 trial

Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women

Completed·—·Phase 2·NCT03633721·25 enrolled

Imaging1 trial

Brain Imaging of Cannabinoid Receptors

Completed·JJohns Hopkins University·Phase 1·NCT03204305·28 enrolled

Spinal Cord Injury1 trial

Effects of Marijuana on Neuropathic Pain and Spasticity in Spinal Cord Injury Patients

Enrolling by invitation·KKhon Kaen University·Phase 1·NCT06190470·20 enrolled

Oxycodone1 trial

Cannabis Versus Oxycodone for Pain Relief

Completed·UUniversity of Colorado, Denver·Phase 3·NCT02892591·33 enrolled

Sickle Cell Disease1 trial

Vaporized Cannabis for Chronic Pain Associated With Sickle Cell Disease

Completed·UUniversity of California, San Francisco·Phase 1/2·NCT01771731·27 enrolled

Tinnitus1 trial

Effectiveness of Cannabis in the Treatment of Tinnitus Patients

Withdrawn·WWolfson Medical Center·Phase 1·NCT01969474

Marijuana1 trial

Effects of Marijuana on Symptoms of OCD

Completed·NNew York State Psychiatric Institute·Phase 1/2·NCT03274440·14 enrolled

Agitation1 trial

The Effect of Cannabis on Dementia Related Agitation and Aggression

Completed·TTO Pharmaceuticals·Phase 2·NCT03328676·64 enrolled

Trial1 trial

CAN BREATHE in COPD Trial

Unknown status·MMcGill University·Phase 2·NCT03060993·16 enrolled

Anxiety1 trial

Anxiety, Inflammation, Stress, and Cannabinoids

Completed·UUniversity of Colorado, Boulder··NCT03491384·361 enrolled

Head and Neck Cancer1 trial

To Check Safety of Ayurvedic Oral Cannabis in Breast and Head and Neck Cancer

Active, not recruiting·TTata Memorial Hospital·Phase 1·NCT05969314·12 enrolled

Drug Abuse1 trial

Effects of Cannabis on Prescription Drug Abuse Liability and Analgesia

Completed·NNew York State Psychiatric Institute·Phase 1·NCT03679949·26 enrolled

Acute Lymphoblastic Leukemia1 trial

Exploring Medically Perceived Benefits, Use and Interest in Psychedelics and Cannabinoids

Completed·EEmpower Research Inc··NCT04965740·102 enrolled

Vaping1 trial

Vaping THC From Electronic Cigarettes

Completed·UUniversity of California, San Francisco·Phase 3·NCT02955329·8 enrolled

Pain Management1 trial

Cannabis Vs Opioids Pain Management Objective Testing Comparisons

Not yet recruiting·AAmerican Association of Sensory Electrodiagnostic Medicine·N/A·NCT03734731·1,000 enrolled

Interaction1 trial

Opioid and Cannabinoid Pharmacokinetic Interactions

Completed·UUniversity of California, San Francisco·Phase 1·NCT00308555·24 enrolled

Glioblastoma1 trial

Tolerability of Cannabis in Patients Receiving Concurrent Chemoradiation for Glioblastoma

Terminated·NNew York State Psychiatric Institute·Phase 1·NCT03246113·1 enrolled

Cognitive impairment1 trial

Evaluation Prospectively the Level of Reduction in Cognitive Functions of Cancer Patients Who Are on Active Oncology Treatments and Use Cannabis. The Second Goal is to Identify High-risk Groups for Cognitive Impairment Due to Cannabis Use.

Completed·RRambam Health Care Campus·N/A·NCT01983267·100 enrolled

Drug Addiction1 trial

Imaging the Neurochemistry of Drug Addiction With PET

Completed·YYale University·Phase 1·NCT02817698·25 enrolled

Tolerance1 trial

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

Not yet recruiting·JJohns Hopkins University·Phase 1·NCT06351540·40 enrolled

Oral1 trial

Age-dependent Effects of Smoked and Oral Delta-9-THC

Recruiting·UUniversity of California, Los Angeles·Phase 1·NCT05865470·103 enrolled

Clinical Pharmacology1 trial

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Recruiting·UUniversity of California, San Francisco·Phase 2·NCT05999383·48 enrolled

Cannabis Intoxication1 trial

Pregnenolone as a Treatment for Cannabis Intoxication

Recruiting·JJohns Hopkins University·Phase 2·NCT07216690·20 enrolled

Opioid Use Disorder1 trial

Impact of Cannabis on Opioid Self-Administration

Not yet recruiting·SShanna Babalonis, PhD·Phase 1·NCT07668635·30 enrolled

Obesity1 trial

A Randomized, Placebo-Controlled Clinical Trial of Once Daily Oral Cannabis for Weight Loss in Obese Individuals

Not yet recruiting·JJoshua A. Lile, Ph.D.·Phase 2·NCT06137365·40 enrolled

Opioid Use1 trial

Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain

Completed·MMassachusetts General Hospital·Preclinical·NCT04827992·87 enrolled

Sources

References

[1]
ClinicalTrials.gov — 69 trial records for Cannabis. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Cannabis compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Cannabis. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — TO Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: TTO Pharmaceuticals

Cannabis

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Trials by Indication[1]

Cannabis19 trials

Impairment5 trials

Cannabis Use4 trials

Neuropathic Pain3 trials

Memory2 trials

Attention2 trials

Biomarker1 trial

Peripheral Neuropathy1 trial

Tourette syndrome1 trial

Retinitis Pigmentosa1 trial

Impaired Driving1 trial

Osteoarthritis1 trial

Schizophrenia1 trial

Cardiovascular Function1 trial

Cognition1 trial

Imaging1 trial

Spinal Cord Injury1 trial

Oxycodone1 trial

Sickle Cell Disease1 trial

Tinnitus1 trial

Marijuana1 trial

Agitation1 trial

Trial1 trial

Anxiety1 trial

Head and Neck Cancer1 trial

Drug Abuse1 trial

Acute Lymphoblastic Leukemia1 trial

Vaping1 trial

Pain Management1 trial

Interaction1 trial

Glioblastoma1 trial

Cognitive impairment1 trial

Drug Addiction1 trial

Tolerance1 trial

Oral1 trial

Clinical Pharmacology1 trial

Cannabis Intoxication1 trial

Opioid Use Disorder1 trial

Obesity1 trial

Opioid Use1 trial

References

Drug Info

Quick Facts

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