Wellbutrin

(Bupropion)

ApprovedSmall molecule

Bupropion is used to treat depression by helping to improve mood and motivation. It's also used to help people quit smoking by reducing cravings and withdrawal symptoms.[2] Wellbutrin is currently approved and in use across 37 indications[4].[1]

Wellbutrin is one of 739 small molecule programs targeting Chronic Pancreatitis. It is currently in Approved.

Indications

167

Total Trials

Active Trials

738

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Chronic PancreatitisActive, not recruiting

Methamphetamine DependenceActive, not recruiting

Nicotine DependenceActive, not recruiting

Depressive DisorderApproved

Binge EatingActive, not recruiting

Mood DisorderActive, not recruiting

Cocaine AbuseActive, not recruiting

SuicideActive, not recruiting

Attention Deficit Hyperactivity DisorderActive, not recruiting

Pathological GamblingActive, not recruiting

Chronic PancreatitisPhase 2

Active, not recruiting

Methamphetamine DependencePhase 2

Active, not recruiting

Nicotine DependencePhase 2

Active, not recruiting

Depressive DisorderApproved

Approved

Binge EatingPhase 2

Active, not recruiting

Mood DisorderApproved

Active, not recruiting

Cocaine AbusePreclinical

Active, not recruiting

SuicidePhase 2/Phase 3

Active, not recruiting

Attention Deficit Hyperactivity DisorderPhase 2

Active, not recruiting

Pathological GamblingPreclinical

Active, not recruiting

Showing 10 of 36 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Wellbutrin

GGlaxo Dba Glaxosmithkline

Approved

1 2

Adriamycin

GGynecologic Oncology Group

Preclinical

87 3

Avastin

BBio-Thera Solutions

Preclinical

153 4

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 5

Gemzar

GGynecologic Oncology Group

Preclinical

22 6

Megace

Bristol-Myers Squibb

Preclinical

4 7

Zolymbus

AbbVie

Preclinical

1 8

Adenocard

Astellas

Preclinical

1 9

Voltaren

Novartis

Preclinical

1 10

Lupron

EEastern Cooperative Oncology Group

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Prevention

NCT04098874

Q2 2027

Phase 2Recruiting

Depression

NCT04422652

Phase 3Recruiting

Treatment

NCT05732272

Phase 3Active, not recruiting

Methamphetamine Dependence

NCT06233799

Q3 2027

Recruiting

Infants

NCT03511118

Q2 2028

Phase 3Recruiting

First-Line Treatment

NCT05973786

Clinical

Trials by Indication[1]

Smoking Cessation30 trials

Impact of Smoking Cessation on Sleep - 5

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 4·NCT00132821·59 enrolled

Concurrent Bupropion / Varenicline for Smoking Cessation

Completed·—·Phase 3·NCT01303861·702 enrolled

Combinations of Pharmacologic Smoking Cessation Treatments

Completed·UUS Department of Veterans Affairs·Phase 1·NCT00018187

Show 27 more trials

Extended Treatment for Smoking Cessation

Completed·SStanford University·Phase 4·NCT01330043·223 enrolled

Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT00332644·1,504 enrolled

Contingency Management for Smoking Cessation in Homeless Smokers

Completed·—·N/A·NCT01789710·25 enrolled

Effect of Smoking Cessation on Tuberculosis Treatment Outcomes

Completed·—·N/A·NCT04848246·292 enrolled

ISTAPS: A Stepped Primary Care Smoking Cessation Intervention

Unknown status·FFundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina·N/A·NCT00125905·3,012 enrolled

PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness

Completed·UUniversity of California, San Francisco·Phase 4·NCT03950427·131 enrolled

Bupropion and Weight Control for Smoking Cessation - 1

Completed·UUniversity of Pittsburgh·Phase 4·NCT00006170·349 enrolled

Nicotine Patch Pretreatment for Smoking Cessation in PTSD

Completed·UUS Department of Veterans Affairs·Phase 1·NCT00625131·87 enrolled

Framing Messages for Smoking Cessation With Bupropion - 6

Completed·YYale University·N/A·NCT00104598·252 enrolled

Bupropion as a Smoking Cessation Aid in Alcoholics

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 4·NCT00044434·200 enrolled

Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

Terminated·—·Phase 2/3·NCT01560507·19 enrolled

Smoking Cessation Interventions for People Living With HIV in Nairobi, Kenya

Completed·UUniversity of Maryland, Baltimore·Phase 3·NCT03342027·300 enrolled

Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

Unknown status·UUniversity of Minnesota·Phase 2/3·NCT00419731·120 enrolled

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

Completed·—·Phase 3·NCT01406223·282 enrolled

Smoking Cessation Intervention: Effectiveness in Primary Care

Completed·UUniversity of Wisconsin, Madison·Phase 4·NCT00296647·1,346 enrolled

Comparative Study of SR Bupropion for Adolescent Smoking Cessation

Unknown status·GGeha Mental Health Center·N/A·NCT00819078·80 enrolled

Metabolism-informed Care for Smoking Cessation

Completed·VVanderbilt University Medical Center·N/A·NCT03227679·82 enrolled

Disease Management for Smoking Cessation

Completed·UUniversity of Kansas Medical Center·Phase 3·NCT00440115·750 enrolled

Bupropion for Hospital-Based Smoking Cessation

Completed·UUniversity of California, San Francisco·Phase 3·NCT00261170·85 enrolled

Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts

Completed·CCentre for Addiction and Mental Health·Phase 4·NCT01023659·893 enrolled

A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 1/2·NCT00593099·5 enrolled

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban

Terminated·YYale University·Phase 4·NCT00511134·4 enrolled

Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH)

Completed·VVA Office of Research and Development·Phase 4·NCT04135937·12 enrolled

Smoking Cessation for People Living With HIV/AIDS

Unknown status·WWayne State University·N/A·NCT01965405·165 enrolled

Combining Varenicline and Bupropion for Smoking Cessation

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00943618·641 enrolled

Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women

Completed·HHenry Kranzler·Phase 2·NCT02188459·129 enrolled

CPT and Smoking Cessation

Completed·VVA Office of Research and Development·Phase 2/3·NCT01901848·69 enrolled

Depression11 trials

Effects of Bupropion in Depression

Completed·UUniversity of Oxford·N/A·NCT02104128·80 enrolled

Treatment of Depression Following Multiple Brain Tests

Completed·NNew York State Psychiatric Institute·Phase 4·NCT00296777·28 enrolled

Combination of Novel Therapies for CKD Comorbid Depression

Recruiting·SStony Brook University·Phase 2·NCT04422652·201 enrolled

Show 8 more trials

Lethargic Depression Study

Completed· GSK logo

GSK·Phase 3·NCT00064467·268 enrolled

Promoting Enhanced Pharmacotherapy Choice Through Immunomarkers Evaluation in Depression

Terminated·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT03993457·18 enrolled

Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism

Terminated·NNew York State Psychiatric Institute·Phase 4·NCT00449007·5 enrolled

A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults

Withdrawn·NNew York State Psychiatric Institute·Phase 4·NCT01942187

A Study of Diagnosis and Treatment of Depression Based on Biological Evidence of Dopamine Reward Pathway

Unknown status·PPeking University·Phase 4·NCT03148509·300 enrolled

Dichotic Listening as a Predictor of Medication Response in Depression

Completed·NNew York State Psychiatric Institute·Phase 4·NCT00404755·17 enrolled

Assessing Symptomatic Clinical Episodes in Depression

Completed·AAxsome Therapeutics, Inc.·Phase 2·NCT03595579·97 enrolled

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

Recruiting·MMayo Clinic·Approved·NCT07266545·120 enrolled

Major Depressive Disorder7 trials

Wellbutrin XL, Major Depressive Disorder and Breast Cancer

Completed·TThomas Jefferson University·Phase 4·NCT00234195·25 enrolled

Algorithm Guided Treatment Strategies for Major Depressive Disorder

Unknown status·SShanghai Mental Health Center·Phase 4·NCT01764867·1,080 enrolled

A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive Disorder

Completed·AAxsome Therapeutics, Inc.·Phase 3·NCT02741791·312 enrolled

Show 4 more trials

Interventional Study of Wellbutrin XL in Major Depressive Disorder With Atypical Features

Completed·CChi-Un Pae·Phase 4·NCT01477931·50 enrolled

Study to Evaluate the Efficacy, Safety and Tolerability of Bupropion Hydrochloride Extended-release Tablet, and Escitalopram Oxalate Capsule in Subjects With Major Depressive Disorder

Completed· GSK logo

GSK·Phase 3·NCT02191397·534 enrolled

Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive Disorder

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00351910·494 enrolled

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

Recruiting·—·Phase 3·NCT05603104·1,254 enrolled

Treatment6 trials

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

Completed·—·N/A·NCT02873754·11 enrolled

Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) Treatment

Completed·UUniversity of Tartu·Phase 4·NCT03927950·135 enrolled

Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

Recruiting·UUniversity of Kansas Medical Center·Phase 3·NCT05732272·500 enrolled

Show 3 more trials

SMART Trial to Predict Anhedonia Response to Antidepressant Treatment

Completed·MMclean Hospital·Phase 4·NCT05537584·133 enrolled

Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment

Completed·JJoseph Valentino, MD·Phase 2·NCT04634071·126 enrolled

Comparing Smoking Treatment Programs for Lighter Smokers - 1

Completed·UUniversity of Pennsylvania·Phase 2·NCT00086411·260 enrolled

Interaction6 trials

A Drug Interaction Study of Danicopan

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT04709094·52 enrolled

Drug-drug Interaction Study of KL1333 in Healthy Subjects

Completed·AAbliva AB·Phase 1·NCT04643249·14 enrolled

Evaluation of the Potential Pharmacokinetic Interactions Between Probe Drugs in the Geneva Phenotyping Cocktail

Completed·JJules Desmeules·Phase 1·NCT02391688·30 enrolled

Show 3 more trials

Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvastatin in Healthy Adult Participants

Completed·IInstitut de Recherches Internationales Servier (I.R.I.S.)·Phase 1·NCT07235748·28 enrolled

Drug-Drug Interaction Study: ASP2151 and Bupropion

Completed·MMaruho Europe Limited·Phase 1·NCT02369172·24 enrolled

Voxelotor CYP and Transporter Cocktail Interaction Study

Completed· Pfizer logo

Pfizer·Phase 1·NCT05981365·44 enrolled

73 more indications

Methamphetamine Dependence5 trials

Effectiveness of Bupropion Combined With Behavioral Therapy for Treating Methamphetamine Dependence - 2

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00135785·73 enrolled

Bupropion for the Treatment of Methamphetamine Dependence - 1

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00069251·150 enrolled

Acceptability of Pharmacologic Treatment for Methamphetamine Dependence Among MSM

Completed·SSan Francisco Department of Public Health·Phase 2·NCT00318409·30 enrolled

Show 2 more trials

Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00687713·200 enrolled

Randomized, Placebo-Controlled, Multi-Site Trial of Extended-Release Naltrexone Injection/Bupropion XL Tablets in the Treatment of Methamphetamine Use Disorder

Active, not recruiting·NNational Institute on Drug Abuse (NIDA)·Phase 3·NCT06233799·360 enrolled

Schizophrenia5 trials

Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia

Terminated·YYale University·Phase 2·NCT03132571·5 enrolled

Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia

Completed·—·Phase 2·NCT00136760·57 enrolled

Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia

Completed·—·Phase 4·NCT02420015·35 enrolled

Show 2 more trials

Naltrexone and Bupropion Combination on Obese,Smoking Patients With Schizophrenia

Completed·SShanghai Mental Health Center·Phase 4·NCT02736474·22 enrolled

Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia

Terminated·TThe University of Texas Health Science Center, Houston·Phase 1·NCT06374290·2 enrolled

Smoking5 trials

Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals

Completed·UUniversity of Tennessee·N/A·NCT00308763·594 enrolled

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

Completed·—·Phase 4·NCT02995915·45 enrolled

Pharmacogenetics, Emotional Reactivity and Smoking

Completed·MM.D. Anderson Cancer Center·Phase 2/3·NCT00507728·646 enrolled

Show 2 more trials

The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior

Completed·YYale University·Phase 2·NCT00580853·62 enrolled

CPT-SMART for Treatment of PTSD and Cigarette Smoking

Completed·VVA Office of Research and Development·Approved·NCT03978442·115 enrolled

Mood Disorder3 trials

Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study

Completed·UUniversity of Pittsburgh·Phase 4·NCT00177567·60 enrolled

Dynamic Measures of Neurochemistry in Mood Disorders

Completed·VVanderbilt University Medical Center·Phase 4·NCT00178828·42 enrolled

Integrated Treatment for Cocaine and Mood Disorders - 1

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00227812·140 enrolled

Effectiveness3 trials

Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00249509·132 enrolled

Effectiveness of Bupropion in Treating Marijuana Dependent Individuals

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00142870·30 enrolled

Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects

Recruiting·NNational Institute of Respiratory Diseases, Mexico·Phase 4·NCT06254001·134 enrolled

Cocaine Abuse2 trials

Dopamine Reuptake Inhibitors of Cocaine Abuse - 1

Terminated·YYale University·Phase 1·NCT00000276

Cocaine Abuse and Attention Deficit Disorder - 3

Completed·NNational Institute on Drug Abuse (NIDA)·N/A·NCT00000268·32 enrolled

Methamphetamine2 trials

Assessment of Potential Interactions Between Methamphetamine and Bupropion - 1

Unknown status·NNational Institute on Drug Abuse (NIDA)·Phase 1·NCT00040040·20 enrolled

Study of Medical Treatment for Methamphetamine Addiction

Completed·UUniversity of California, Los Angeles·Phase 2·NCT00833443·84 enrolled

Drug Interactions2 trials

CYP2B6 Genetics and Drug Interactions in Healthy Volunteers

Completed·IIndiana University·Phase 4·NCT02401256·70 enrolled

Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers

Completed·IIndiana University·Phase 1·NCT03420469·28 enrolled

Itching2 trials

The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette

Completed·RRose Research Center, LLC·Phase 3·NCT05205811·180 enrolled

Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes

Completed·RRose Research Center, LLC·Phase 3·NCT04388319·26 enrolled

Acute2 trials

The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

Completed·NNew York State Psychiatric Institute·Phase 1·NCT00136747·45 enrolled

The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity

Completed·AAffective Neuroscience Laboratory·Phase 1·NCT00205946·32 enrolled

Nicotine Dependence2 trials

Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 2·NCT00124683·59 enrolled

Human Laboratory Study of Varenicline and Bupropion for Nicotine Dependence

Completed·UUniversity of Minnesota·Phase 2/3·NCT00749658·121 enrolled

Tobacco Cessation2 trials

Mobile Contingency Management for Marijuana and Tobacco Cessation

Completed·—·N/A·NCT02869451·7 enrolled

The MATCH (Medication Aids for Tobacco Cessation and Health) Study

Completed·CCentre for Addiction and Mental Health·N/A·NCT02146911·968 enrolled

Binge Drinking2 trials

Buproprion for Binge Drinking

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT03169244·42 enrolled

An Open Label Trial of Bupropion and Naltrexone for Binge Drinking

Completed·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT02842073·12 enrolled

Tics2 trials

The Effect of Multiple Doses of BI 187004 on the Single-dose Pharmacokinetics of Repaglinide and Bupropion in Healthy Male Volunteers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02305901·18 enrolled

Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients

Completed· Novartis logo

Novartis·Phase 1·NCT01769768·114 enrolled

Prevention2 trials

Bupropion for the Prevention of Postpartum Smoking Relapse

Recruiting·UUniversity of Minnesota·Phase 4·NCT04098874·200 enrolled

Pharmacologic Relapse Prevention for Alcoholic Smokers

Completed·MMayo Clinic·Phase 2·NCT00000457·195 enrolled

Suicide2 trials

Treatment of Adolescent Suicide Attempters (TASA)

Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT00080158·120 enrolled

Paroxetine/Bupropion in Suicide Attempters/Ideators With Major Depression

Terminated·NNew York State Psychiatric Institute·Phase 4·NCT00429169·101 enrolled

Smokers2 trials

Bupropion and Cigarette-Related Cues in Smokers

Completed·UUniversity of California, Los Angeles·Phase 1·NCT03920319·34 enrolled

Individualizing Pharmacotherapy for African American Smokers

Completed·UUniversity of Kansas Medical Center·Phase 3·NCT03897439·392 enrolled

Midazolam2 trials

A Study to Investigate How Multiple Oral Doses of AZD2389 Affect the Pharmacokinetics of Midazolam, Caffeine, and Bupropion in Healthy Participants

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT06973005·16 enrolled

A Study in Healthy Men and Women to Test Whether BI 1569912 Influences the Amount of Repaglinide, Midazolam and Bupropion in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06367153·18 enrolled

Treatment Resistant Depression2 trials

Interpersonal Psychotherapy for Treatment Resistant Depression

Unknown status·HHospital de Clinicas de Porto Alegre·N/A·NCT01896349·74 enrolled

A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant Depression

Withdrawn· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT03852160

ESS2 trials

PRJ2215: Assessment of Buproprion Misuse/Abuse 2004-2011

Completed· GSK logo

GSK··NCT02039960·1 enrolled

A Study to Assess the Safety of Repeated Doses of GSK189075 and WELLBUTRIN SR in Healthy Male Subjects

Completed· GSK logo

GSK·Phase 1·NCT00625859·27 enrolled

Bipolar Disorder2 trials

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Terminated·UUniversity of New Mexico··NCT02893371·1,037,352 enrolled

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Completed·NNational Institute of Mental Health (NIMH)·N/A·NCT00012558·5,000 enrolled

Overweight1 trial

A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or Obesity

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06564441·34 enrolled

First-line Treatment1 trial

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Recruiting·—·Phase 3·NCT05973786·418 enrolled

Advanced Solid Tumor1 trial

A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Repaglinide or Bupropion in Advanced Solid Tumor Subjects

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT04457180·18 enrolled

Pathological Gambling1 trial

Bupropion in the Treatment of Pathological Gambling

Completed·UUniversity of Iowa·N/A·NCT00055393·80 enrolled

Esketamine1 trial

Pharmacokinetic Study of Intranasal Esketamine and Its Effects on the Pharmacokinetics of Orally-Administered Midazolam and Bupropion in Healthy Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02568176·71 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Bupropion for Treatment of Adolescent Smoking

Terminated·NNational Institute on Drug Abuse (NIDA)·Phase 2/3·NCT00248118·72 enrolled

Restless Legs Syndrome1 trial

Bupropion and Restless Legs Syndrome

Completed·—·Phase 2/3·NCT00621517·60 enrolled

Maintenance Treatment1 trial

Maintenance Treatment for Abstinent Smokers

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 3·NCT00063323·589 enrolled

Cigarette Smoker1 trial

A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.

Unknown status·HHadassah Medical Organization·N/A·NCT00396669·24 enrolled

Infants1 trial

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting·—··NCT03511118·1,600 enrolled

Transcranial Magnetic Stimulation1 trial

Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 4·NCT01583023·45 enrolled

Weight Gain1 trial

Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain

Completed·YYale University·Phase 1/2·NCT00129246·40 enrolled

Small Cell Lung Cancer1 trial

Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC)

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT01048983

Depressive Symptoms1 trial

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

Recruiting·AAxsome Therapeutics, Inc.·Phase 4·NCT06223880·350 enrolled

Hemodialysis1 trial

Bupropion for Depression in ESRD Patients on Hemodialysis

Terminated·UUniversity of Arkansas·Phase 4·NCT02238977·1 enrolled

Substance Use Disorder1 trial

Bupropion for ADHD in Adolescents With Substance Use Disorder

Completed·UUniversity of Colorado, Denver·Phase 4·NCT00936299·105 enrolled

Tobacco1 trial

Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

Unknown status·MMark Vander Weg·Phase 3·NCT01892813·411 enrolled

Metabolism1 trial

The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers

Completed·TTel-Aviv Sourasky Medical Center·N/A·NCT00267813·24 enrolled

Oral1 trial

A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03058419·16 enrolled

Smokeless Tobacco1 trial

Treating Smokeless Tobacco Use in Rural Veterans

Unknown status·MMark Vander Weg·N/A·NCT02994082·123 enrolled

Veterans1 trial

Tailored Tobacco Quitline for Rural Veterans

Completed·IIowa City Veterans Affairs Medical Center·Phase 2·NCT01592695·63 enrolled

Advanced Solid Tumors1 trial

Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors

Completed· Pfizer logo

Pfizer·Phase 1·NCT03864042·56 enrolled

Methadone1 trial

Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone

Unknown status·UUniversity of Washington·Phase 1·NCT00504413·20 enrolled

Relapse1 trial

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

Completed·—·N/A·NCT01990079·15 enrolled

Head and Neck Cancer1 trial

Symptom Burden in Head and Neck Cancer

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT01219673·1 enrolled

Drug1 trial

A Study to Evaluate the Effect of Fluconazole, Bupropion, or Itraconazole on the Drug Levels and Safety of BMS-986235

Withdrawn· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04464577

Adult1 trial

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT07223671·32 enrolled

Veteran1 trial

Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers

Completed·VVA Office of Research and Development·Phase 4·NCT02245308·133 enrolled

Adolescent1 trial

Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression

Unknown status·UUma Rao·Phase 4·NCT00106197·130 enrolled

Electroencephalography1 trial

Electroencephalography (EEG) Signal Processing

Unknown status·SSt. Joseph's Healthcare Hamilton··NCT01369290·150 enrolled

Tobacco Use Cessation1 trial

Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya

Completed·UUniversity of California, San Francisco·Phase 4·NCT05351606·580 enrolled

Antidepressants1 trial

A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression

Unknown status·YYuqi Cheng·Phase 1·NCT03623711·200 enrolled

Agitation1 trial

Addressing Dementia Via Agitation-Centered Evaluation

Completed·AAxsome Therapeutics, Inc.·Phase 2/3·NCT03226522·366 enrolled

Age1 trial

Study of Exposure to Substances Prohibited by the World Anti-Doping Agency in Healthy Volunteers.

Completed·PParc de Salut Mar·Phase 1·NCT04757532·9 enrolled

Single Dose1 trial

A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05932277·22 enrolled

Alcohol Dependence1 trial

Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence

Completed·NNational Institute on Drug Abuse (NIDA)·Phase 3·NCT00304707·143 enrolled

Apathy1 trial

Apathy Cure Through Bupropion in Huntington's Disease

Completed·—·Phase 2·NCT01914965·40 enrolled

Imaging1 trial

PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration

Completed·SSeoul National University Hospital·Phase 4·NCT00846339·12 enrolled

Cocaine Dependence1 trial

A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence

Completed·CCraig Rush·Phase 1·NCT01739192·34 enrolled

Depressed1 trial

Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)

Completed·NNYU Langone Health·Phase 1·NCT00285584·41 enrolled

Binge Eating1 trial

Craving, Binge Eating and Obesity

Completed·YYale University·Phase 2/3·NCT00414167·61 enrolled

Attention Deficit Hyperactivity Disorder1 trial

Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1

Completed·NNew York State Psychiatric Institute·Phase 2/3·NCT00061087·115 enrolled

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03301207·25 enrolled

Cohort Study1 trial

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea

Completed· Pfizer logo

Pfizer··NCT04446039·370,212 enrolled

Sexual Function1 trial

Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning

Completed·WWeill Medical College of Cornell University·Phase 4·NCT00611975·83 enrolled

Aging1 trial

Leveraging EEG for Antidepressant Prediction With Duloxetine and Bupropion

Withdrawn·AAlto Neuroscience·Phase 4·NCT04388189

Cognitive Function1 trial

Assessment of Bupropion on Cognitive Function and Behaviour in Healthy Volunteers

Completed·UUniversity Hospital, Montpellier·N/A·NCT00285155·12 enrolled

Pancreatitis, Chronic1 trial

Smoking Cessation Treatment Escalation Among Patients With Recurrent Acute Pancreatitis and Chronic Pancreatitis

Withdrawn·MMayo Clinic·Phase 2·NCT07171112

Breast Cancer1 trial

A Phase III, Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Versus Alpelisib Plus Fulvestrant in Patients With Hormone Receptor-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Who Progressed During or After CDK4/6 Inhibitor and Endocrine Combination Therapy

Active, not recruiting· Roche logo

Roche·Phase 3·NCT05646862·420 enrolled

Unspecified3 trials

Influence of Bupropion on the Effects of MDMA

Completed·UUniversity Hospital, Basel, Switzerland·Phase 1·NCT01771874·16 enrolled

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

A Phase 1, Single-Center, Repeat-Dose, Open-Label, Fixed-Sequence Drug-Drug Interaction Study of ZX008 in Healthy Male Or Female Study Participants 18 To 55 Years Of Age

Completed· UCB logo

UCB·Phase 1·NCT06679413·22 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 1985

WELLBUTRIN

NDA NDA018644

Oct 4, 1996

WELLBUTRIN SR

NDA NDA020358

May 14, 1997

ZYBAN

NDA NDA020711

Aug 28, 2003

WELLBUTRIN XL

NDA NDA021515

Apr 23, 2008

APLENZIN

NDA NDA022108

Nov 10, 2011

FORFIVO XL

NDA NDA022497

Sources

References

[1]
ClinicalTrials.gov — 167 trial records for Bupropion. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Wellbutrin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Bupropion compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Bupropion. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA022497). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Wellbutrin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Glaxo Dba Glaxosmithkline company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Dopamine Transporter Inhibitor; Norepinephrine Transporter Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: GGlaxo Dba Glaxosmithkline

Patent Landscape[6]

Patent Cliff

Aug 23, 2028

Earliest patent expiration — generic entry possible after this date

Patent #Expires

7569610Jun 27, 2026

7241805Jun 27, 2026

7645802Jun 27, 2026

7572935Jun 27, 2026

7649019Jun 27, 2026

4 more patents

7585897Jun 27, 2026

7662407Jun 27, 2026

7671094Jun 27, 2026

7674479Aug 23, 2028

Wellbutrin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q2 2027

Q3 2027

Q2 2028

Trials by Indication[1]

Smoking Cessation30 trials

Depression11 trials

Major Depressive Disorder7 trials

Treatment6 trials

Interaction6 trials

Methamphetamine Dependence5 trials

Schizophrenia5 trials

Smoking5 trials

Mood Disorder3 trials

Effectiveness3 trials

Cocaine Abuse2 trials

Methamphetamine2 trials

Drug Interactions2 trials

Itching2 trials

Acute2 trials

Nicotine Dependence2 trials

Tobacco Cessation2 trials

Binge Drinking2 trials

Tics2 trials

Prevention2 trials

Suicide2 trials

Smokers2 trials

Midazolam2 trials

Treatment Resistant Depression2 trials

ESS2 trials

Bipolar Disorder2 trials

Overweight1 trial

First-line Treatment1 trial

Advanced Solid Tumor1 trial

Pathological Gambling1 trial

Esketamine1 trial

Efficacy and Safety1 trial

Restless Legs Syndrome1 trial

Maintenance Treatment1 trial

Cigarette Smoker1 trial

Infants1 trial

Transcranial Magnetic Stimulation1 trial

Weight Gain1 trial

Small Cell Lung Cancer1 trial

Depressive Symptoms1 trial

Hemodialysis1 trial

Substance Use Disorder1 trial

Tobacco1 trial

Metabolism1 trial

Oral1 trial

Smokeless Tobacco1 trial

Veterans1 trial

Advanced Solid Tumors1 trial

Methadone1 trial

Relapse1 trial

Head and Neck Cancer1 trial

Drug1 trial

Adult1 trial

Veteran1 trial

Adolescent1 trial

Electroencephalography1 trial

Tobacco Use Cessation1 trial

Antidepressants1 trial

Agitation1 trial

Age1 trial

Single Dose1 trial

Alcohol Dependence1 trial

Apathy1 trial

Imaging1 trial

Cocaine Dependence1 trial

Depressed1 trial

Binge Eating1 trial

Attention Deficit Hyperactivity Disorder1 trial

Stimulant Use Disorder1 trial

ALS1 trial

Malignancy1 trial