Cortrosyn
(Cosyntropin)ApprovedSmall molecule
NovartisCosyntropin is used to test whether the adrenal glands are working properly by stimulating them to produce cortisol, a hormone the body needs to respond to stress. The doctor measures cortisol levels before and after giving the injection to determine if the adrenal glands are producing adequate amounts of this important hormone.[2] Cortrosyn is currently approved and in use across 3 indications[4].[1]
Cortrosyn is one of 24 small molecule programs targeting Adrenal insufficiency. It is currently in Approved.
3
Indications
11
Total Trials
3
Active Trials
23
Competitors
2
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Competition
Competitive Landscape
19 competitors in Adrenal Insufficiency
#DrugCompanyPhaseTrials
1Cortef
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Approved
Rayos
RRoxane Laboratories
Approved
Cortrosyn
NovartisApproved
Deltasone
PPfizer's Upjohn has merged with Mylan to form Viatris Inc.
Phase 3
Dehydroepiandrosterone
IInflabloc Pharmaceuticals
Phase 3
Fludrocortisone 0.1 Milligrams (mg)
GGanin Fertility Center
Approved
Mifeprex
DDanco
Phase 2
Infacort
NNeurocrine UK Limited
Phase 3
Megace
Bristol-Myers SquibbPreclinical
Plenadren
UUniversity of Roma La Sapienza
Phase 2
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Adrenal insufficiency2 trials
Intravenous1 trial
Headache1 trial
Stress1 trial
Stress and the Nervous System
Completed·—·N/A·NCT02339506·23 enrolled
5 more indications
Postmenopausal Women1 trial
Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women
Active, not recruiting·LLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center·Phase 1·NCT04037605·5 enrolled
Cholesterol1 trial
Perioperative Period1 trial
Hydrocortisone1 trial
Regulatory
FDA Approval Timeline[5]
Jan 1, 1982
CORTROSYN
NDA NDA016750
Feb 21, 2008
COSYNTROPIN
NDA NDA022028
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Cortrosyn drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Cosyntropin. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]