Insulin Therapy

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Chronic Obstructive Pulmonary DiseaseEffectivenessGestational Diabetes

119 competitors in Chronic Obstructive Pulmonary Disease

#DrugCompanyPhaseTrials

1

Lunsekimig

Sanofi

Phase 3

32

CM310

KKeymed Biosciences Co.Ltd

Phase 3

13

Sildenafil ODT

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Phase 2

24

Astegolimab

Roche

Phase 3

25

Tozorakimab

AstraZeneca

Phase 3

26

CM512

KKeymed Biosciences Co.Ltd

Phase 2

17

Avinza

HHikma Pharmaceuticals LLC

Phase 2

18

HSK39004

Haisco Pharmaceutical Group Co., Ltd.

Phase 2

29

Insulin Therapy

Sanofi

Phase 2

110

Calciferol

Jazz Pharmaceuticals

Preclinical

—Show 29 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Type 2 Diabetes59 trials

Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT00331851·584 enrolled

A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, With or Without OADs in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT02030600·721 enrolled

Type 2 Diabetes Management With Lantus® (Malbec: Manejo Con Lantus® de Diabéticos Tipo 2)

Terminated·Sanofi·Phase 4·NCT00627471·9 enrolled

Show 56 more trials

A Study of LY3209590 in Healthy Participants and Participants With Type 2 Diabetes

Completed·Eli Lilly·Phase 1·NCT02942914·80 enrolled

Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT00982644·1,030 enrolled

A Research Study to Compare Two Types of Insulin: Insulin 287 and Insulin Glargine in People With Type 2 Diabetes Who Have Not Used Insulin Before

Completed·Novo Nordisk·Phase 2·NCT03951805·205 enrolled

A Study Comparing Exenatide With Basal Insulin in Achieving a Target HbA1c With Minimum Weight Gain in Type 2 Diabetes Patients

Completed·AstraZeneca·Phase 3·NCT00360334·235 enrolled

A Study for Patients With Type 2 Diabetes

Completed·Eli Lilly·Phase 2·NCT01027871·289 enrolled

Liraglutide-bolus vs Glargine-bolus Therapy in Overweight/Obese Type 2 Diabetes Patients (LiraGooD)

Recruiting·TThe First Affiliated Hospital of Xiamen University·Phase 4·NCT03087032·164 enrolled

Comparison of the Blood Sugar Lowering Effect of Biphasic Insulin Aspart 30 and Insulin Glargine Both Combined With Metformin and Glimepiride in Chinese and Japanese Subjects With Type 2 Diabetes New to Insulin Treatment

Completed·Novo Nordisk·Phase 4·NCT01123980·521 enrolled

Evaluation of Toujeo Insulin in Type 2 Diabetes Patients Inadequately Control With Their Basal Insulin Treatment

Completed·Sanofi·Phase 4·NCT02967237·136 enrolled

Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes

Not yet recruiting·YYanbing Li·Phase 4·NCT07173712·324 enrolled

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)

Completed·Eli Lilly·Phase 3·NCT04093752·917 enrolled

Biphasic Insulin Aspart 30 in Type 2 Diabetes Failing OAD Therapy

Completed·Novo Nordisk·Phase 3·NCT00598793·242 enrolled

Comparison of Biphasic Insulin Aspart 70/30 Versus Insulin Glargine in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT00097877·293 enrolled

A Study of LY3209590 in Participants With Type 2 Diabetes

Completed·Eli Lilly·Phase 1·NCT03367377·70 enrolled

Assessment of Efficacy and Safety of Insuman Comb 25 Versus Novolin® 30R Twice Daily Over 24 Weeks in Type 2 Diabetes Patients With Insulin Therapy

Completed·Sanofi·Phase 3·NCT01353469·485 enrolled

Intensive Insulin Glulisine Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Basal Insulin and Oral Glucose-lowering Drugs

Completed·Sanofi·Phase 4·NCT01203111·207 enrolled

A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk

Completed·Eli Lilly·Phase 3·NCT03730662·2,002 enrolled

Safety and Effectiveness Study of Insulin Glargine (LANTUS) Initiation and Titration in Patients With Type 2 Diabetes

Completed·Sanofi·Phase 4·NCT01127269·178 enrolled

A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 Diabetes

Completed·Eli Lilly·Phase 3·NCT03952143·628 enrolled

A Research Study to Compare Two Types of Insulin, a New Weekly Insulin, Insulin Icodec and an Available Daily Insulin, Insulin Glargine, Both in Combination With Mealtime Insulin, in People With Type 2 Diabetes Who Use Daily Insulin and Mealtime Insulin (ONWARDS 4)

Completed·Novo Nordisk·Phase 3·NCT04880850·582 enrolled

A Study to Determine the Safety and Efficacy of Albiglutide in Patients With Type 2 Diabetes

Completed·GSK·Phase 3·NCT00838916·779 enrolled

Comparison of NN1250 With Insulin Glargine in Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01006291·687 enrolled

Effects of Insulin in Perceived Mood Symptoms in Patients With Type 2 Diabetes

Completed·Eli Lilly·Phase 4·NCT00191178·60 enrolled

Hyperglycemia and Cardiovascular Outcomes With Type 2 Diabetes

Completed·Eli Lilly·Phase 4·NCT00191282·1,116 enrolled

Evaluation of Insulin Glargine in Combination With Sitagliptin in Type 2 Diabetes Patients: EASIE Extension Trial

Completed·Sanofi·Phase 3·NCT00851903·112 enrolled

Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Lixisenatide on Top of Oral Anti-diabetic Drugs (OADs) With Type 2 Diabetes in Japan

Completed·Sanofi·Phase 3·NCT02749890·321 enrolled

Comparison of Two Basal Insulins for Patients With Type 2 Diabetes Taking Oral Diabetes Medicines and Exenatide

Completed·Eli Lilly·Phase 3·NCT00560417·339 enrolled

Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 2·NCT00611884·245 enrolled

A Study of Insulin Efsitora Alfa (LY3209590) Compared to Glargine in Adult Participants With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time (QWINT-1)

Completed·Eli Lilly·Phase 3·NCT05662332·795 enrolled

Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes.

Completed·Novo Nordisk·Phase 4·NCT00184626·97 enrolled

Comparison of NN5401 With Insulin Glargine, Both in Combination With Oral Antidiabetic Drugs, in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01045447·465 enrolled

A Research Study of How Overdosing of a New Once Weekly Medicine NNC0148-0287 C (Insulin 287) Influences the Blood Sugar Level in People With Type 2 Diabetes

Completed·Novo Nordisk·Phase 1·NCT03945656·43 enrolled

A Study of LY900014 Compared to Insulin Lispro in Participants With Type 2 Diabetes

Completed·Eli Lilly·Phase 3·NCT03214380·933 enrolled

Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 4·NCT00469092·480 enrolled

A Study to Compare the Effect of a Double Dose of Two Long-acting Insulin Therapies in Participants With Type 2 Diabetes

Completed·Eli Lilly·Phase 3·NCT02132637·68 enrolled

A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes

Completed·GGRADE Study Group·Phase 3·NCT01794143·7,850 enrolled

Comparison of Insulin Glargine and NPH Insulin at Night and at Hypoglycemia in Type 2 Diabetes

Completed·UUniversity of Giessen··NCT00468364·12 enrolled

Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01068678·460 enrolled

Comparison of a Basal Plus One Insulin Regimen With a Biphasic Insulin Regimen in Type 2 Diabetes Patients

Completed·Sanofi·Phase 4·NCT00965549·463 enrolled

A Research Study to Compare the Effect of Insulin Degludec and Insulin Glargine on Blood Sugar Levels in People With Type 2 Diabetes - the SWITCH PRO Study

Completed·Novo Nordisk·Phase 4·NCT03687827·498 enrolled

Effects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes

Completed·AstraZeneca·Phase 3·NCT00097500·69 enrolled

Comparison of Standard vs Higher Starting Dose of Insulin Glargine in Chinese Patients With Type 2 Diabetes (Glargine Starting Dose)

Completed·Sanofi·Phase 4·NCT02836704·892 enrolled

A Study Comparing HR17031 With Insulin Glargine in Patients With Type 2 Diabetes

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 3·NCT06881264·401 enrolled

Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga

Completed·PPopulation Health Research Institute·Phase 4·NCT02561130·154 enrolled

Comparison of Two Treatment Regimens in Patients With Type 2 Diabetes After Short-term Intensive Insulin Therapy

Completed·Sanofi·Phase 4·NCT03359837·384 enrolled

A Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes

Completed·AstraZeneca·Phase 3·NCT00960661·1,036 enrolled

Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 2·NCT00614055·178 enrolled

Comparison of NN5401 Versus Insulin Glargine, Both Combined With Metformin Treatment, in Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01045707·530 enrolled

Efficacy and Safety of Biphasic Insulin Aspart 30 in Combination With Metformin in Type 2 Diabetes

Completed·Novo Nordisk·Phase 4·NCT00619697·260 enrolled

Insulin Glulisine in Adult Subjects With Type 2 Diabetes Receiving Insulin Glargine as Basal Insulin

Completed·Sanofi·Phase 3·NCT00135057·281 enrolled

A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Glargine, in People With Type 2 Diabetes Who Have Not Used Insulin Before

Completed·Novo Nordisk·Phase 3·NCT04460885·984 enrolled

Pre-Mix Insulin Lispro Treatment for Type 2 Diabetes Patients Who Consume a Light Breakfast

Completed·Eli Lilly·Phase 4·NCT00664534·344 enrolled

A Study of Dulaglutide (LY2189265) in Chinese Participants With Type 2 Diabetes

Completed·Eli Lilly·Phase 3·NCT04591626·291 enrolled

Comparison of NN5401 With Insulin Glargine in Insulin Naive Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01272193·296 enrolled

A Trial Comparing Efficacy and Safety of Insulin Degludec and Insulin Glargine in Insulin naïve Subjects With Type 2 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01849289·833 enrolled

Efficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)

Completed·AstraZeneca·Phase 3·NCT00641056·467 enrolled

Comparison of the Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Ratio Combination to Insulin Glargine in Patients With Type 2 Diabetes Insufficiently Controlled on Basal Insulin

Completed·Sanofi·Phase 3·NCT03798080·426 enrolled

Type 2 Diabetes Mellitus34 trials

To Compare the Efficacy and Safety of INS068 and Insulin Glargine in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin.

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 3·NCT05702073·423 enrolled

A Study Comparing Insulin Intensification Therapies in Patients With Type 2 Diabetes Mellitus

Completed·Eli Lilly·Phase 4·NCT01175811·402 enrolled

A Trial Comparing the Efficacy and Safety of Insulin Degludec and Insulin Glargine 300 Units/mL in Subjects With Type 2 Diabetes Mellitus Inadequately Treated With Basal Insulin With or Without Oral Antidiabetic Drugs

Completed·Novo Nordisk·Phase 3·NCT03078478·1,609 enrolled

Show 31 more trials

A Study to Evaluate the Effectiveness and Safety Initiation and Titration of Insulin Glargine (U300) in Insulin-naïve Patients With Type 2 Diabetes Mellitus (T2DM) Controlled on Oral Antidiabetic Drug Treatment in Turkey

Completed·Sanofi·Phase 4·NCT02954692·112 enrolled

Evaluation of the Effectiveness and Safety of Physician Versus Patient-led of Insulin Glargine Initiation and Titration in Type 2 Diabetes Mellitus

Completed·Sanofi·Phase 4·NCT01169818·555 enrolled

Effect of Insulin Degludec Versus Insulin Glargine on Glycemic Variability in Patients With Type 2 Diabetes Mellitus

Completed·UUniversity of Guadalajara·Phase 4·NCT02680457·12 enrolled

A Study of the Safety and Efficacy of Omarigliptin (MK-3102) Compared With Glimepiride in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-016)

Completed·Merck & Co.·Phase 3·NCT01682759·751 enrolled

Effectiveness and Safety of Two Approaches to the Management of Type 2 Diabetes Mellitus in Australian Primary Care

Terminated·Sanofi·Phase 4·NCT00950534·25 enrolled

Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control While Taking Insulin Alone or With Other Oral Antidiabetic Agents

Completed·LLexicon Pharmaceuticals·Phase 3·NCT03285594·571 enrolled

A Study to Compare Taspoglutide and Insulin Glargine in Insulin-Naïve Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin and Sulfonylurea Combination Therapy

Terminated·Roche·Phase 3·NCT01051011·370 enrolled

A 104 Week Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Type 2 Diabetes Mellitus

Completed·Novo Nordisk·Phase 3·NCT02501161·1,012 enrolled

Comparison of Insulin Glargine/Insulin Glulisine Regimen to Insulin Aspart/Insulin Aspart Protamine 30/70 in Type 2 Diabetes Mellitus Patients (T2DM)

Completed·Sanofi·Phase 4·NCT01212913·161 enrolled

Effect of Soliqua 100/33 on Time in Range From Continuous Glucose Monitoring in Insulin-naive Patients With Very Uncontrolled Type 2 Diabetes Mellitus

Completed·Sanofi·Phase 4·NCT05114590·124 enrolled

Study of Two Titration Algorithms With Insulin Glargine 300 Units/mL in Type 2 Diabetes Mellitus Patients

Completed·Sanofi·Phase 3·NCT02401243·253 enrolled

Insulin Glulisine in Type 2 Diabetes Mellitus

Completed·Sanofi·Phase 1·NCT00310297

A Study in Participants With Type 2 Diabetes Mellitus (AWARD-4)

Completed·Eli Lilly·Phase 3·NCT01191268·884 enrolled

Evaluation of the Efficacy and Safety of Insulin Glargine 300 U/mL in Patients With Type 2 Diabetes Mellitus Uncontrolled on Other Kinds of Insulin

Completed·Sanofi·Phase 4·NCT03760991·372 enrolled

Postprandial Glucodynamic Response to Insulin Glargine/Lixisenatide Fixed Ratio Combination in Japanese Patients With Type 2 Diabetes Mellitus

Completed·Sanofi·Phase 1·NCT02713477·20 enrolled

Study of Sitagliptin for the Treatment of Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Insulin (MK-0431-260)

Completed·Merck & Co.·Phase 3·NCT01462266·660 enrolled

Insulin Glargine Injection Treatment in Place of Thiazolidinedione (TZD), Sulfonylurea, or Metformin in Triple Agent Therapy for Type 2 Diabetes Mellitus (T2DM) Adult Subjects With Unsatisfactory Control

Terminated·Sanofi·Phase 4·NCT00283049·390 enrolled

A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide Versus Insulin Glargine in Subjects With Type 2 Diabetes Mellitus

Completed·Novo Nordisk·Phase 3·NCT01952145·557 enrolled

Insulin Glulisine Administered Pre-meal Versus Post-meal in Adult Subjects With Type 2 Diabetes Mellitus Receiving Insulin Glargine as Basal Insulin

Completed·Sanofi·Phase 3·NCT00135096·345 enrolled

Evaluation of the Prandial Treatment Adjustment Effect Via Continuous Glucose Monitoring on Type 2 Diabetes Mellitus (DM) Patients Uncontrolled With a Basal Insulin or Premix Once a Day

Completed·Sanofi·Phase 4·NCT01234597·219 enrolled

Efficacy and Safety of Insulin Glulisine in Type 2 Diabetes Mellitus

Completed·Sanofi·Phase 3·NCT00290927·390 enrolled

Effectiveness and Safety of Treatment of Insulin Glargine in Type 2 Diabetes Mellitus Following Glucagon-like Peptide-1 (GLP-1) Failure

Completed·Sanofi·Phase 4·NCT01461577·89 enrolled

Safety/Efficacy Study of Subcutaneously Injected Prandial Insulins Compared to Insulin Lispro Alone in Patients With Type 2 Diabetes Mellitus

Completed·HHalozyme Therapeutics·Phase 2·NCT01194258·132 enrolled

Assessment Study of Three Different Fasting Plasma Glucose Targets in Chinese Patients With Type 2 Diabetes Mellitus (BEYOND III/FPG GOAL)

Completed·Sanofi·Phase 4·NCT02545842·947 enrolled

Variable Bolus Regimen 1-2-3 for Type 2 Diabetes Mellitus

Completed·Sanofi·Phase 3·NCT00135083·347 enrolled

ELEONOR STUDY: Insulin Glulisine in Type 2 Diabetes Mellitus.

Completed·Sanofi·Phase 3·NCT00272064·352 enrolled

A Study of LY2605541 in Participants With Type 2 Diabetes Mellitus

Completed·Eli Lilly·Phase 3·NCT01582451·466 enrolled

A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)

Terminated·Eli Lilly·Phase 4·NCT02072096·192 enrolled

A Study of Dulaglutide in Japanese Participants With Type 2 Diabetes Mellitus

Completed·Eli Lilly·Phase 3·NCT01584232·361 enrolled

Study Comparing the Efficacy and Safety of Insulin Glargine (Basal Insulin)/Lixisenatide (GLP-1 Receptor Agonist) Combination (Soliqua™) in Patients With Type 2 Diabetes Mellitus (T2DM)

Completed·Sanofi·Phase 3·NCT03767543·265 enrolled

LAPAS Study: Insulin Glargine in Type 2 Diabetes Mellitus

Completed·Sanofi··NCT00423215·1,007 enrolled

Type 1 Diabetes18 trials

A Study of LY2605541 and Glargine in Participants With Type 1 Diabetes

Completed·Eli Lilly·Phase 1·NCT01769404·25 enrolled

Autologous Hematopoietic Stem Cell Transplantation for Early Onset Type 1 Diabetes

Completed·SShanghai Jiao Tong University School of Medicine·Phase 2·NCT00807651·40 enrolled

A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetes

Completed·Eli Lilly·Phase 3·NCT03740919·751 enrolled

Show 15 more trials

Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps.

Unknown status·MMedical University of Warsaw·Phase 4·NCT02685449·70 enrolled

12 Week,Comparing Safety of HMR1964 & Insulin Aspart Used in Continuous Subcutaneous Infusion in Type 1 Diabetes.

Completed·Sanofi·Phase 3·NCT00046150·59 enrolled

A Trial Investigating the Safety, Tolerability, and Distribution and Activity in the Body of NNC0148-0000-0287 Injected Under the Skin in Healthy Subjects and in Subjects With Type 1 Diabetes

Completed·Novo Nordisk·Phase 1·NCT01730014·70 enrolled

A Trial Comparing the Effect of Exercise on Blood Glucose in Subjects With Type 1 Diabetes, Who Are Treated With Either Insulin Degludec or Insulin Glargine

Completed·Novo Nordisk·Phase 1·NCT01704417·40 enrolled

Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Insulin Aspart in Subjects With Type 1 Diabetes

Completed·Novo Nordisk·Phase 2·NCT00612040·178 enrolled

Safety and Efficacy of Insulin Detemir Plus Insulin Aspart Against Insulin Glargine Plus Insulin Aspart as Mealtime Insulin in Type 1 Diabetes

Completed·Novo Nordisk·Phase 3·NCT00095082·447 enrolled

Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetes

Completed·Novo Nordisk·Phase 3·NCT00982228·629 enrolled

The Effect of Exercise on Blood Glucose Levels in Patients With Type 1 Diabetes: A Comparison of 3 Long-acting Insulins

Completed·Novo Nordisk·Phase 4·NCT00313742·51 enrolled

A Trial Comparing the Efficacy of Insulin Degludec With Insulin Glargine on Glycaemic Control Using Continuous Glucose Monitoring in Patients With Type 1 Diabetes

Completed·Novo Nordisk·Phase 3·NCT01569841·24 enrolled

Comparison of Efficacy and Safety of Insulin Detemir and Insulin Glargine in Patients With Type 1 Diabetes

Completed·Novo Nordisk·Phase 3·NCT00312104·325 enrolled

Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings

Completed·JJing Luo·Phase 4·NCT05614089·400 enrolled

A Bioequivalence Study Comparing Two Different Strengths Formulations of Insulin Lispro in Patients With Type 1 Diabetes

Completed·Sanofi·Phase 1·NCT03903016·90 enrolled

Comparing Long-acting Insulins During Exercise in Type 1 Diabetes

Unknown status·BBuckinghamshire Healthcare NHS Trust·Phase 4·NCT01440439·30 enrolled

A Study to Look at How Safe NNC0268-0965 is in Healthy People and People With Type 1 Diabetes

Completed·Novo Nordisk·Phase 1·NCT03965013·78 enrolled

Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.

Completed·SSansum Diabetes Research Institute·Phase 4·NCT03668808·25 enrolled

Type 1 Diabetes Mellitus10 trials

Study of How Single Rising Doses of SAR161271 Are Absorbed and Act in Patients With Type 1 Diabetes Mellitus (T1DM)

Completed·Sanofi·Phase 1/2·NCT01053728·46 enrolled

Safety Study of Subcutaneously-Injected Prandial INSULIN-PH20 NP Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes Mellitus

Completed·HHalozyme Therapeutics·Phase 2·NCT00883558·48 enrolled

Repeated Dose Study With a New Insulin Glargine Formulation and Lantus® on 24-hour Glucose Profile in Japanese Patients With Type 1 Diabetes Mellitus

Completed·Sanofi·Phase 1·NCT01676233·20 enrolled

Show 7 more trials

Test of the Efficacy and Safety of Insulin Glulisine Injected Subcutaneously in Patients With Type 1 Diabetes Mellitus

Completed·Sanofi·Phase 4·NCT00964574·68 enrolled

A Study to Demonstrate Bioequivalence Between Insulin Glulisine U300 and Insulin Glulisine U100 After a Single Subcutaneous Dose Using the Euglycemic Clamp Technique, in Patients With Type 1 Diabetes Mellitus

Completed·Sanofi·Phase 1·NCT02910518·44 enrolled

Comparing Pharmacodynamic and Pharmacokinetic Properties of Insulin Degludec and Insulin Glargine 300 U/mL at Steady-state Conditions in Subjects With Type 1 Diabetes Mellitus

Completed·Novo Nordisk·Phase 1·NCT02536859·60 enrolled

Efficacy and Safety of Insulin Glulisine in Type 1 Diabetes Mellitus

Completed·Sanofi·Phase 3·NCT00290979·250 enrolled

Insulin Glulisine and Aspart in Postprandial Glycemic Control After High-GI Meal in Children With Type 1 Diabetes Mellitus

Completed·MMedical University of Warsaw·Phase 4·NCT01678235·64 enrolled

CONSISTENT 1: Metabolic and Safety Outcomes of Hylenex Recombinant (Hyaluronidase Human Injection) Preadministered at CSII Infusion Site in Participants With Type 1 Diabetes Mellitus (T1DM)

Completed·HHalozyme Therapeutics·Phase 4·NCT01848990·456 enrolled

A Study for Patients With Type 1 Diabetes Mellitus

Completed·Eli Lilly·Phase 2/3·NCT00447213·70 enrolled

Diabetes Mellitus5 trials

OPAL - Insulin Glulisine, Diabetes Mellitus

Completed·Sanofi·Phase 3·NCT00272012·396 enrolled

Insulin Glulisine in Diabetes Mellitus, Type 2

Completed·Sanofi·Phase 3·NCT00174668·311 enrolled

Insulin Glargine in Type I Diabetes Mellitus> Main Study "AT.LANTUS": A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar. Sub-study: "HALT"(Hypoglycaemia Avoidance With Lantus Trial)

Completed·Sanofi·Phase 4·NCT00390728·2,346 enrolled

Show 2 more trials

Insulin Glulisine, Insulin Lispro and Insulin Glargine in Type 1 or 2 Diabetes Mellitus

Completed·Sanofi·Phase 3·NCT00467376·485 enrolled

Relative Bioavailability and Activity of Different Formulations of Insulin Glargine and Lixisenatide in Patients With Diabetes Mellitus Type 1

Completed·Sanofi·Phase 1·NCT01146678·22 enrolled

44 more indications

Type 2 Diabetic Patients5 trials

Insulin Glulisine in Type 2 Diabetic Patients

Completed·Sanofi·Phase 4·NCT00360698·106 enrolled

A Study of the Safety, Tolerability and Effect on Glycemic Control of Taspoglutide Versus Insulin Glargine in Insulin Naive Type 2 Diabetic Patients Inadequately Controlled With Metformin Plus Sulphonylurea.

Completed·Roche·Phase 3·NCT00755287·1,072 enrolled

Efficacy and Safety of Lixisenatide Versus Insulin Glulisine on Top of Insulin Glargine With or Without Metformin in Type 2 Diabetic Patients

Completed·Sanofi·Phase 3·NCT01768559·894 enrolled

Show 2 more trials

A Study for Type 2 Diabetic Patients

Completed·Eli Lilly·Phase 4·NCT00548808·426 enrolled

Insulin Glargine in Type 2 Diabetic Patients

Completed·Sanofi·Phase 4·NCT00347100·387 enrolled

MPA3 trials

The Impact of Two Different Insulin Dose Calculation on Postprandial Glycemia After Mixed Meal.

Completed·MMedical University of Warsaw·Phase 4·NCT04124302·76 enrolled

A Pharmacokinetic and Glucodynamic Study of Subcutaneously Administered Insulin Analogs With rHuPH20 Compared to Insulin Analogs Alone

Completed·HHalozyme Therapeutics·Phase 1·NCT00979875·14 enrolled

Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose

Completed·UUniversity of Washington·Phase 4·NCT04623086·59 enrolled

Adolescent2 trials

Apidra Children & Adolescents Study

Completed·Sanofi·Phase 4·NCT01202474·100 enrolled

Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulin

Completed·YYale University·Phase 1·NCT03400501·32 enrolled

Insulin Secretion2 trials

Chronic Reduction of Fasting Glycaemia With Insulin Glargine Improves First and Second Phase Insulin Secretion in Patients With Type 2 Diabetes

Completed·RRuhr University of Bochum·Phase 4·NCT01249677·14 enrolled

Insulin Secretion in Diabetes Before and After Glycemic Control

Completed·UUS Department of Veterans Affairs·N/A·NCT00469833·17 enrolled

Safety and Efficacy2 trials

Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Older Patients With Type2 Diabetes Insufficiently Controlled on Their Current Antidiabetic Medications

Completed·Sanofi·Phase 3·NCT02320721·1,014 enrolled

Safety and Efficacy of Technosphere® Insulin Inhalation Powder and Lantus® Compared to Humalog® and Lantus® Over 16-Weeks

Terminated·MMannkind Corporation·Phase 3·NCT00700622·130 enrolled

Trial2 trials

A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NNC0148-0000-0287 in Healthy Subjects

Completed·Novo Nordisk·Phase 1·NCT01809184·84 enrolled

Insulin Glargine "All to Target" Trial

Completed·Sanofi·Phase 4·NCT00384085·588 enrolled

Type 1 Diabetic2 trials

A Study of How Insulin Peglispro (LY2605541) and Insulin Glargine Affect the Breakdown of Fat and Sugar in Type 1 Diabetics

Completed·Eli Lilly·Phase 1·NCT01925989·27 enrolled

Efficacy Study on the Control of Blood Glucose Concentration in Type 1 Diabetic Patients

Completed·Sanofi·Phase 3·NCT00271284·88 enrolled

Lip2 trials

Evaluation of Insulin Glargine Versus Sitagliptin in Insulin-naive Patients

Completed·Sanofi·Phase 4·NCT00751114·515 enrolled

Effect of Lixisenatide on Postprandial Plasma Glucose Compared to Sitagliptin in Combination With Insulin Glargine

Completed·Sanofi·Phase 4·NCT02200991·136 enrolled

Diabetes2 trials

Comparison of Insulin Therapy in Treating Post-Transplant Diabetes

Terminated·IInova Health Care Services·Phase 4·NCT01963728·2 enrolled

A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes

Completed·Eli Lilly·Phase 3·NCT02152371·300 enrolled

Metabolism2 trials

Lantus Effect on Myocardial Glucose Metabolism in T2

Completed·Sanofi·Phase 4·NCT00335465·15 enrolled

Insulin Glargine for Diabetes Metabolism(DM)Type II Patients Under Enteral Nutrition

Terminated·Sanofi·Phase 4·NCT01081938·15 enrolled

Efficacy2 trials

An Open Therapeutic Project to Confirm the Efficacy Tolerability and Safety Profile of Lantus in Everyday Medical Practice

Completed·Sanofi·Phase 4·NCT00576368·4,464 enrolled

A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulins in Insulin Naïve Patients Initiating Insulin

Completed·Sanofi·Phase 4·NCT02967224·705 enrolled

Treatment2 trials

Lantus Versus NPH: Comparison in Insulin Naive People Not Adequately Controlled With at Least One Oral Anti Diabetics (OAD) Treatment

Completed·Sanofi·Phase 4·NCT00949442·708 enrolled

Study to Optimize Insulin Treatment by Basal Regimen With Insulin Glargine in Type-2-Diabetic Patients Previously Uncontrolled on Premixed Insulin

Completed·Sanofi·Phase 4·NCT00693771·313 enrolled

Outcome1 trial

The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention)

Completed·Sanofi·Phase 3·NCT00069784·12,537 enrolled

Non-Diabetic Patients1 trial

Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery

Completed·EEmory University·Phase 4·NCT02443402·68 enrolled

Oxidative Stress1 trial

Comparison of Glycaemic Fluctuation and Oxidative Stress Between Two Short-term Therapies for Type 2 Diabetes

Unknown status·TThird Affiliated Hospital, Sun Yat-Sen University·Phase 4·NCT02526810·70 enrolled

Obese1 trial

Insulin Glulisine in Healthy Lean and Obese Subjects

Completed·Sanofi·Phase 1·NCT00311077

ESS1 trial

Assessment of Insulin Glargine in Type 2 Patients for Good Glycemic Control

Completed·Sanofi·Phase 4·NCT00701831·241 enrolled

Metformin1 trial

Lantus Versus Humalog Mix as add-on Therapy in Type Diabetes Patients Failing Sulfonylurea and Metformin Combination Treatment

Completed·Sanofi·Phase 3·NCT01336751·212 enrolled

GIST1 trial

APIDRA Registration Study

Completed·Sanofi·Phase 4·NCT00489190·45 enrolled

ART1 trial

Self Titration With Apidra to Reach Target Study (START)

Completed·Sanofi·Phase 4·NCT01013571·493 enrolled

Down syndrome1 trial

Investigation of the Safety of Intranasal Glulisine in Down Syndrome

Completed·HHealthPartners Institute·Phase 1·NCT02432716·12 enrolled

Pemphigus1 trial

Effect of Topical Insulin on Healing Rate of Pemphigus Lesions

Completed·—·Phase 2·NCT07461103·20 enrolled

Function1 trial

Insulin Glargine (Lantus) vs Sulfonylurea (SU) for BETA Cell Function (BETA Study)

Completed·Sanofi·Phase 4·NCT00562172·75 enrolled

Monotherapy1 trial

Insulin Glargine [rDNA Origin] Injection vs Pioglitazone as add-on Therapy in Patients Failing Monotherapy With Sulfonylurea or Metformin

Completed·Sanofi·Phase 4·NCT00384215·352 enrolled

Effectiveness1 trial

Cost Effectiveness of Glargine Insulin Versus NPH Insulin

Completed·TTehran University of Medical Sciences·Phase 4·NCT01832935·200 enrolled

GLP-11 trial

FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR)

Completed·UUniversity of Washington·Phase 4·NCT01524705·102 enrolled

Liraglutide1 trial

Efficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure

Completed·Sanofi·Phase 4·NCT01117350·978 enrolled

Congestive Heart Failure1 trial

Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure

Completed·AAmsterdam UMC, location VUmc·Phase 4·NCT00766857·27 enrolled

Children1 trial

The Effect of Insulin Glulisine Compared With Insulin Aspart on Breakfast Post Prandial Glucose Levels in Prepubertal Children

Completed·CCorewell Health West·Phase 4·NCT00913497·16 enrolled

Elderly1 trial

Simplified Insulin Regimen for the Elderly

Terminated·UUniversity of Miami·Phase 4·NCT03660553·7 enrolled

Pregnancy1 trial

RCT Glargine vs NPH for Treatment of DM in Pregnancy

Recruiting·LLoyola University·Phase 3·NCT06619301·160 enrolled

Hyperglycemia1 trial

Hospital Management of Hyperglycemia Study of Insulin Glargine Plus Insulin Lispro Versus Human Regular Insulin

Terminated·Eli Lilly·Phase 3·NCT01136746·16 enrolled

Prospective1 trial

Diabetes in the Elderly: Prospective Study

Completed·GGuillermo Umpierrez·Phase 4·NCT01131052·150 enrolled

Efficacy and Safety1 trial

A Clinical Trial Comparing Short-Term Efficacy and Safety of Exubera and Lantus

Completed·Pfizer·Phase 4·NCT00367445·30 enrolled

Leukemia1 trial

Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute Lymphocytic Leukemia (ALL)

Terminated·MM.D. Anderson Cancer Center·Phase 3·NCT00500240·52 enrolled

Combination Therapy1 trial

Insulin Glargine v Rosiglitazone as add-on Therapy in Patients Failing Sulfonylurea and Metformin Combination Therapy

Completed·Sanofi·Phase 4·NCT00358124·220 enrolled

Tics1 trial

Insulin Glargine Combination Therapies in Type II Diabetics

Completed·Sanofi·Phase 3·NCT00783744·375 enrolled

CAR1 trial

ADA Linagliptin in Long Term Care

Completed·EEmory University·Phase 4·NCT02061969·140 enrolled

Randomized1 trial

Randomized Sitagliptin Withdrawal Study (MK-0431-845)

Completed·Merck & Co.·Phase 3·NCT02738879·746 enrolled

Cognitive impairment1 trial

Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimer's Disease

Terminated·HHealthPartners Institute·Phase 2·NCT02503501·49 enrolled

Concentration1 trial

Single Dose Clamp Study To Compare Concentration/Time Profile And Metabolic Activity Profile Of 2 New Formulations Of Insulin Glargine With Lantus

Completed·Sanofi·Phase 1·NCT02201199·36 enrolled

LAM1 trial

Euglycemic Clamp Dose-response Study Comparing a New Insulin Glargine Formulation With Lantus®

Completed·Sanofi·Phase 1·NCT01195454·24 enrolled

Gestational Diabetes1 trial

Comparator Trial Using Insulin Glulisine vs. Insulin Lispro for Treatment of Gestational Diabetes

Completed·SSansum Diabetes Research Institute·Phase 2·NCT01662921·17 enrolled

Unspecified15 trials

Basal Insulins - Pharmacodynamics

Completed·UUniversity of Aarhus·Phase 4·NCT00566124·10 enrolled

Safety of NNC 0123-0000-0338 in Healthy Subjects

Completed·Novo Nordisk·Phase 1·NCT01334034·70 enrolled

Randomised Open Label Study of Insulin Degludec Versus Insulin Glargine U100 in Ramadan

Terminated·WWeill Cornell Medical College in Qatar·Phase 4·NCT03349840·273 enrolled

Show 12 more trials

Feasibility of Once/Daily Administered GLP/1 Receptoragonist (Lixisenatide) in Combination With Basal Insulin

Completed·MMedical University of Vienna·Phase 3·NCT02168491·10 enrolled

Insulin Glargine During and After the Period of Fasting in Ramadan

Completed·Sanofi·Phase 4·NCT00258804·450 enrolled

DOMME Dose Optimization Multicentric Mexican Evaluation

Completed·Sanofi·Phase 4·NCT00488527·371 enrolled

Better Acceptance of Single Injection Apidra Added to Once Daily Lantus Versus Twice Daily Premixed Insulin in Real Life Use Setting

Terminated·Sanofi·Phase 4·NCT01079364·52 enrolled

20 Week Bridging Study in Type II DM

Completed·Sanofi·Phase 3·NCT00563225·90 enrolled

Within-subject Variability of Insulin Detemir in Healthy Volunteers

Completed·Novo Nordisk·Phase 1·NCT01497535·40 enrolled

Glulisine Pre- and Postmeal

Completed·Sanofi·Phase 1·NCT00290043·20 enrolled

Continuous Glucose Monitoring Evaluation of Exenatide Twice Daily Versus Insulin Glargine

Completed·HHealthPartners Institute·N/A·NCT01089569·60 enrolled

Pharmacist Intervention for Glycemic Control in The Community

Completed·UUniversity of Alberta·N/A·NCT01335763·100 enrolled

Effects of Modulators of Gluconeogenesis, Glycogenolysis and Glucokinase Activity

Active, not recruiting·UUniversity of Alabama at Birmingham·Phase 3·NCT05098470·100 enrolled

Insulin Analogue With Continuous Glucose Monitoring System (CGMS) Measurement

Completed·Sanofi·Phase 4·NCT00354939·480 enrolled

LANCGMS - Lantus Continuous Glucose Monitoring Subcutaneous

Completed·Sanofi·Phase 4·NCT00322075·35 enrolled

Details

Drug Info

Related News