Intranasal Ketamine

Phase 3Small molecule

JJavelin Pharmaceuticals

Intranasal Ketamine is one of 62 small molecule programs targeting Children. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

ChildrenUnknown status

DexmedetomidineRecruiting

ChildrenPreclinical

Unknown status

DexmedetomidinePhase 3

Recruiting

Competition

Competitive Landscape

58 competitors in Children

#DrugCompanyPhaseTrials

Promacta

GSK

Approved

2 2

Ozempic

Novo Nordisk

Approved

1 3

Gleevec

Novartis

Approved

1 4

Oncaspar

SServier

Approved

2 5

Velcade

SShilpa Grover, MD, MPH

Approved

1 6

Sprycel

KKaruna Therapeutics, Inc., a Bristol Myers Squibb company

Approved

1 7

Byetta

AstraZeneca

Phase 3

1 8

Neurontin

VViatris Specialty LLC

Phase 3

2 9

Somavaratan

Novo Nordisk

Phase 3

1 10

Veklury

Gilead

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2028

Phase 2Not yet recruiting

Children

NCT06968546

Clinical

Trials by Indication[1]

Sedation4 trials

Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.

Not yet recruiting·LLiaquat National Hospital & Medical College·Phase 1/2·NCT07180095·60 enrolled

Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment

Completed·UUniversidade Federal de Goias·Phase 4·NCT02447289·84 enrolled

Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures

Terminated·UUniversity of Alabama at Birmingham·Phase 4·NCT03781817·40 enrolled

Show 1 more trial

Intranasal Ketamine for Procedural Sedation in Pediatric Laceration Repair

Completed·RRhode Island Hospital·Phase 2·NCT00451724·45 enrolled

Children2 trials

Nasal Ketamine for Minor Procedures in Children

Unknown status·KKaplan Medical Center·N/A·NCT02839928·20 enrolled

Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.

Not yet recruiting·FFondation Lenval·Phase 2·NCT06968546·116 enrolled

Alcohol Abuse1 trial

Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse

Completed·TThe University of Texas Health Science Center, Houston·Phase 3·NCT03539887·33 enrolled

Dexmedetomidine1 trial

IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED

Recruiting·UUniversity of Oklahoma·Phase 4·NCT05934669·90 enrolled

Pilot Study1 trial

Pre-hospital Care With Intra-Nasal Ketamine for Transport (PRECINKT): A Pilot Study

Completed·UUniversity of Calgary·Phase 1·NCT02033434·30 enrolled

20 more indications

Sickle Cell Disease1 trial

Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED

Terminated·AAbigail Nixon·Phase 3·NCT04150757·5 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Intranasal Ketamine for the Treatment of Postoperative Dental Pain

Completed·JJavelin Pharmaceuticals·Phase 2·NCT00488787·40 enrolled

Cancer Pain1 trial

Intranasal (NAS) Ketamine for Cancer Pain

Completed·EEmory University·Phase 1/2·NCT03146806·10 enrolled

Abscess1 trial

IN Ketamine Vs IN Midazolam and Fentanyl for Abscess I&D

Completed·UUniversity of Tennessee·Phase 4·NCT02635282·19 enrolled

Absorption1 trial

Absolute Bioavailability and Nasopharyngeal Absorption of Intranasal Ketamine

Completed·JJavelin Pharmaceuticals·Phase 1·NCT00520169·32 enrolled

Major Depressive Disorder1 trial

Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD)

Unknown status·UUniversity of Cincinnati·Phase 4·NCT04352621·20 enrolled

Suicidal Ideation1 trial

Emergency Ketamine Treatment of Suicidal Ideation

Unknown status·UUniversity of Cincinnati·Phase 2/3·NCT02183272·60 enrolled

Nerve Block1 trial

Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain

Not yet recruiting·TTehran University of Medical Sciences·Phase 3·NCT07305883·64 enrolled

Laceration1 trial

Pain Free Laceration Repairs Using Intra-nasal Ketamine

Completed·EEvelyne D.Trottier·Phase 2·NCT03053947·42 enrolled

Buprenorphine1 trial

Reinforcing Effects of Intranasal (IN) Buprenorphine Versus Buprenorphine/Naloxone

Completed·NNew York State Psychiatric Institute·Phase 3·NCT01760473·27 enrolled

Tics1 trial

Pharmacogenetics of Naltrexone for Stimulant Abuse

Completed·NNew York State Psychiatric Institute·Phase 2·NCT03226223·18 enrolled

Oxycodone1 trial

Evaluation of Doxazosin to Alter the Abuse of Oxycodone

Terminated·NNew York State Psychiatric Institute·Phase 2·NCT03415581·13 enrolled

Drug Interactions1 trial

Determination of Drug Interactions of Certain Nasal Medications With Intranasal Ketamine

Unknown status·JJavelin Pharmaceuticals·Phase 1·NCT00520104·48 enrolled

Depression1 trial

Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders)

Completed·CCentre for Addiction and Mental Health·N/A·NCT05137938·25 enrolled

Treatment Resistant Depression1 trial

Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression

Terminated·ZZylorion Health·Phase 2·NCT05323019·6 enrolled

Depressive Disorder1 trial

Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension Study

Withdrawn·ZZylorion Health·Phase 2·NCT05438758

Randomized Controlled Trial1 trial

Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCD

Terminated·NNew York State Psychiatric Institute·Phase 2·NCT02206776·2 enrolled

Ketamine1 trial

Multiple Dose Pharmacokinetics of Intranasal Ketamine

Completed·JJavelin Pharmaceuticals·Phase 1·NCT00519987·18 enrolled

Spinal Anesthesia1 trial

Nebulized vs. IV Ketamine in Preventing Shivering Post Spinal Anesthesia

Active, not recruiting·TTanta University·N/A·NCT07055828·120 enrolled

Unspecified1 trial

INK Feasibility Study

Withdrawn·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 3·NCT05783492

Sources

References

[1]
ClinicalTrials.gov — 29 trial records for Intranasal Ketamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Intranasal Ketamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Intranasal Ketamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Javelin Pharmaceuticals company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: JJavelin Pharmaceuticals

Intranasal Ketamine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2028

Trials by Indication[1]

Sedation4 trials

Children2 trials

Alcohol Abuse1 trial

Dexmedetomidine1 trial

Pilot Study1 trial

Sickle Cell Disease1 trial

Safety and Efficacy1 trial

Cancer Pain1 trial

Abscess1 trial

Absorption1 trial

Major Depressive Disorder1 trial

Suicidal Ideation1 trial

Nerve Block1 trial

Laceration1 trial

Buprenorphine1 trial

Tics1 trial

Oxycodone1 trial

Drug Interactions1 trial

Depression1 trial

Treatment Resistant Depression1 trial

Depressive Disorder1 trial

Randomized Controlled Trial1 trial

Ketamine1 trial

Spinal Anesthesia1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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